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| Number | Title | Issue Date |
| 8076322 | [6,6] and [6,7]-bicyclic GPR119 G protein-coupled receptor agonists Novel compounds are provided which are GPR119 G protein-coupled receptor modulators. GPR119 G protein-coupled receptor modulators are useful in treating, preventing, or slowing the progression of diseases requiring GPR119 G protein-coupled receptor modulator therapy... | 12/13/2011 |
| 8063037 | Progesterone receptor modulators The present invention provides new progesterone receptor modulators which are dibenzo[b,f]pyrido[1,2-d]oxazepine-2-amines or dibenzo[b,f]prido[1,2-d]thiazepine-2-amines, and uses thereof. ... | 11/22/2011 |
| 7989442 | Progesterone receptor modulators The present invention provides new progesterone receptor modulators which are (cis)-8-fluorodibenzo[b,f]pyrido[1,2-d]oxazepine-1-amine compounds and uses thereof. ... | 08/02/2011 |
| 7915251 | Alpha-helix mimetics and methods relating to the treatment of fibrosis The invention provides α-helix mimetic structures of formula (I) with the definitions of A, B, D, E, G, W, R1 and R2 as set out in the description and a chemical library relating thereto. The compounds, pharmaceutical compositions comprising t... | 03/29/2011 |
| 7888343 | Substituted, bicyclic 8-pyrrolidinoxanthines, and methods for their use as inhibitors of dipeptidyl peptidase The present invention involves substituted bicyclic 8-pyrrolidinoxanthines and their derivatives of formula I: wherein the various R groups are defined herein. The present invention also comprises pharmaceutical composition... | 02/15/2011 |
| 7803792 | Quaternary ammonium compounds A method for inhibiting ileal bile acid transporter activity in a subject, comprising administering to said subject an effective amount of a compound represented by formula (1): ... | 09/28/2010 |
| 7795247 | Tetracyclic indole derivatives as antiviral agents The present invention relates to tetracyclic indole compounds of formula (I): wherein R1, R2, A, Ar, W, X, Y and Z are defined herein, and pharmaceutically acceptable salts thereof, pharmaceutical comp... | 09/14/2010 |
| 7737136 | Non-steroidal progesterone receptor modulators The present invention provides compounds according to general Formula (I), a prodrug thereof, a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable salt of a prodrug thereof. More particularly, the present invention provides high affinity non-... | 06/15/2010 |
| 7666861 | Cytoskeletal active compounds, composition and use The present invention is directed to synthetic cytoskeletal active compounds that are related to natural Latrunculin A or Latrunculin B. The present invention is also directed to pharmaceutical compositions comprising such compounds and a pharmaceutically acceptable... | 02/23/2010 |
| 7625887 | Receptor agonists It is intended to provide a TGR5 receptor agonist containing a fused ring compound represented by the following general formula, its salt or a prodrug thereof: (1) wherein ring A represents an optionally substituted aromatic ring; and the ring B′ represents a 5- t... | 12/01/2009 |
| 7585854 | Method for treating endometriosis A drug effective for prevention and therapy of endometriosis is disclosed. The drug for prevention and/or therapy of endometriosis according to the present invention comprises an antiallergic agent as an effective ingredient. ... | 09/08/2009 |
| 7572783 | Substituted benzofused heterocycles The present invention relates to the compounds of Formula I, their preparation and pharmaceutical compositions comprising them. The compounds and pharmaceutical compositions are useful, for example, for the treatment and prevention of obesity, obesity-related disord... | 08/11/2009 |
| 7544678 | Anti-arrythmic and heart failure drugs that target the leak in the ryanodine receptor (RyR2) The present invention provides novel 1,4-benzothiazepine intermediates and derivatives, methods for synthesizing same, and methods for assaying same. The present invention also provides methods for using these novel compounds to limit or prevent a decrease in the le... | 06/09/2009 |
| 7534783 | Receptor agonists It is intended to provide a TGR5 receptor agonist containing a fused ring compound represented by the following general formula, its salt or a prodrug thereof: (1) wherein ring A represents an optionally substituted aromatic ring; and the ring B′ represents a 5- t... | 05/19/2009 |
| 7514421 | Use of an IBAT inhibitor for the treatment of constipation A method of treatment of functional constipation or C-IBS in a warm-blooded animal is disclosed, which comprises the administration of an IBAT inhibitor. ... | 04/07/2009 |
| 7491714 | Quinolines and nitrogenated derivatives thereof and their use as antibacterial agents Quinoline and naphthridine derivatives useful in the treatment of bacterial infections in mammals, particularly humans. ... | 02/17/2009 |
| 7482337 | Xanthine derivatives, the preparation thereof and their use as pharmaceutical compositions Disclosed are substituted xanthines of general formula wherein R1 to R4 are defined hereinbelow, the tautomers, the stereoisomers, the mixtures thereof, the prodrugs thereof and the salts thereof, whic... | 01/27/2009 |
| 7419974 | Cyclohexyl(alkyl)propanolamines, preparation method and pharmaceutical compositions containing same The present invention relates to the compounds of formula (I): in which A is a group of formula (a) or (b) in which R represents a hydrogen or halogen atom, an —S(O)z... | 09/02/2008 |
| 7410961 | 2,6-disubstituted piperiddines as modulators The present invention is further directed to compounds of formula (I): wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R16, R17, R | 08/12/2008 |
| 7407950 | -(heteroaryl)-1-indole-2-carboxamide derivatives and their use as vanilloid TRPV1 receptor ligands The invention concerns compounds of general formula (I), wherein n, X1, X2, X3, X4, Z1, Z2, Z3, Z4, Z5 and W are as defined herein. | 08/05/2008 |
| 7390798 | Carboxamide spirolactam CGRP receptor antagonists The present invention is directed to compounds of Formula I: I (where variables A1, A2, B, J, K, m, n, R4, R5a, R5b and R5c are as defined herein) useful as antagonists of CGRP receptors and useful in... | 06/24/2008 |
| 7358238 | Pharmaceutical use of fused 1,2,4-triazoles The use of fused 1,2,4-triazoles for modulating the activity of 11β-hydroxysteroid dehydrogenase type 1 (11βHSD1) and the use of these compounds as pharmaceutical compositions has been described. Also a novel class of fused 1,2,4-triazoles, their use in therapy, p... | 04/15/2008 |
| 7355069 | Ortho-substituted benzoic acid derivatives for the treatment of insulin resistance The present invention provides a compound of formula (I), wherein n is 0, 1 or 2 and R1 represents halo, a C1-4alkyl group which is optionally substituted by one or more fluoro, a C1-4alkoxy group which is optionally substituted by o... | 04/08/2008 |
| 7323455 | 7-aryl 1,5-dihydro-4,1-benzoxazepin-2(3)-one derivatives and their use as progesterone receptor modulators This invention provides progesterone receptor modulators having the structure: wherein R1 to R7, X, and Q are as defined in the specification; or a pharmaceutically acceptable salt thereof. ... | 01/29/2008 |
| 7320974 | Cytoskeletal active compounds, compositions and use The present invention is directed to synthetic cytoskeletal active compounds that are related to natural Latrunculin A or Latrunculin B. The present invention is also directed to pharmaceutical compositions comprising such compounds and a pharmaceutically acceptable... | 01/22/2008 |
| 7314731 | Method for selecting therapeutic agents for cancer The present invention discloses in vitro methods for screening candidate therapeutic and/or chemotherapeutic agents for in vivo efficacy in a specific patient. The invention also includes methods for determining the optimal dosage of a therapeutic agent for a specif... | 01/01/2008 |
| 7312208 | Quaternary ammonium compounds Drugs useful for the treatment and prevention of hyperlipidemia, moreover drugs useful for the treatment and prevention of cholestasis-caused hepatopathy, particularly primary biliary cirrhosis and primary sclerosing cholangitis, and drugs for the treatment and prev... | 12/25/2007 |
| 7262318 | Substituted heteroaryl- and phenylsulfamoyl compounds The present invention is directed at substituted heteroaryl- and phenylsulfamoyl compounds, pharmaceutical compositions containing such compounds and the use of such compounds as peroxisome proliferator activator receptor (PPAR) agonists. PPAR alpha activators, phar... | 08/28/2007 |
| 7253211 | (R)-chiral halogenated substituted fused heterocyclic amino compounds useful for inhibiting cholesterol ester transfer protein activity The invention relates to substituted aryl and heteroaryl (R)-Chiral Halogenated 1-Substitutedamino-(n+1)-Alkanol compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and methods for ... | 08/07/2007 |
| 7238685 | Benzo-fused heterocycles as endothelin antagonists The invention relates to novel benzo-fused heterocycles and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compos... | 07/03/2007 |
| 7202241 | Benzoxazine derivatives and uses thereof Compounds of the formula (I): or pharmaceutically acceptable salts, solvates or prodrugs thereof, where R1, R2, R3, R4, R5, R6, R7, R | 04/10/2007 |
| 7192945 | Benzothiazepine derivatives The present invention relates to compounds of the formula (I): (wherein variable groups are as defined within) pharmaceutically acceptable salts, solvates, solvates of such salts and prodrugs thereof and their use as ileal bile acid transport (IBAT) inhibitors for t... | 03/20/2007 |
| 7192947 | Peptides derivatives comprising thiazepine group for the treatment of hyperlipidemic conditions The present invention relates to compounds of formula (I): (wherein variable groups are as defined within) pharmaceutically acceptable salts, solvates, solvates of such salts and prodrugs thereof and their use as ileal bile acid transport (IBAT) inhibitors for the t... | 03/20/2007 |
| 7192946 | Benzothiazepine derivatives The present invention relates to compounds of formula (I), wherein variable groups are as defined within; pharmaceutically acceptable salts, solvates, solvates of such salts and prodrugs thereof and their use as ileal bile acid transport (IBAT) inhibitors for the tr... | 03/20/2007 |
| 7183271 | 4,4-difluoro-1,2,3,4-tetrahydro-5h-1-benzazepine derivative or salt thereof A novel 4,4-difluoro-1,2,3,4-tetrahydro-5H-1-benzazepine derivative or a pharmaceutically acceptable salt thereof, which is useful as an agent for treating or preventing nocturia and/or diabetes insipidus, is provided. ... | 02/27/2007 |
| 7176195 | Fused azepine derivatives and their use as antidiuretic agents Compounds according to general formulae (1 and 2), wherein G1 is an azepine derivative and G2 is a group according to general formulae (9–11) are new. Compounds according to the invention are vasopressin V2 receptor agonists. Pharm... | 02/13/2007 |
| 7141555 | Modafinil compound and cyclodextrin mixtures Mixtures of a modafinil compound with a cyclodextrin, methods for their use, and compositions thereof are disclosed, along with complexes comprising a modafinil compound and a cyclodextrin which are taste-masked and suitable for oral consumption in an aqueous soluti... | 11/28/2006 |
| 7141565 | Substituted quinobenzoxazine analogs The present invention relates to quinobenzoxazines analogs having the general formula: and pharmaceutically acceptable salts, esters and prodrugs thereof; wherein A, U, V, W, X and Z are substituents. | 11/28/2006 |
| 7132416 | Benzothiazepine and benzothiazepine derivatives with ileal bile acid transport (IBAT) inhibotory activity for the treatment hyperlipidaemia The present invention relates to compounds of formula (I) wherein Rv, R1, R2, Rx, Ry, M, Rz, v, R3, R4, R5 and R6 are as defined within; pharmaceutically ac... | 11/07/2006 |
| 7129235 | Amides useful for treating pain The present invention relates to compounds of formula (I-VII) or a pharmaceutically acceptable salt or prodrug thereof, in which A, L, R6, R7 and R8 are defined herein. The presen... | 10/31/2006 |
