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| Number | Title | Issue Date |
| 8163729 | Modulators of α7 nicotinic acetylcholine receptors and therapeutic uses thereof The present invention provides compounds of formula (I) and compositions thereof, methods of making them, and methods of using them to modulate alpha7 nicotinic acetylcholine receptors and/or to treat any of a variety of disorders, diseases, and conditions. Provided... | 04/24/2012 |
| 8119626 | Oxime derivative and preparations thereof The problem of the present invention is to provide a useful compound as a glucokinase activating agent, which is the oxime derivative of the formula [I]: wherein Ring A is aryl or heteroaryl; ... | 02/21/2012 |
| 8093236 | Weekly administration of dipeptidyl peptidase inhibitors Pharmaceutical compositions comprising 2-[6-(3-Amino-piperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethyl]-4-fluoro-benzonitrile and pharmaceutically acceptable salts thereof are provided as well as kits and articles of manufacture comprising the p... | 01/10/2012 |
| 8080543 | Pyridine derivative potassium channel inhibitors The present invention relates to pyridine substituted ethanol compounds and derivatives thereof having the structure (I) useful as potassium channel inhibitors to treat cardiac arrhythmias, and the like. ... | 12/20/2011 |
| 8063035 | Triazolyl aminopyrimidine compounds The present invention provides triazolyl aminopyrimidine compounds useful in the treatment of cancer. ... | 11/22/2011 |
| 8063034 | Oxadiazole derivatives and thiadiazole derivatives having neovascularization inhibitory activity The present invention relates to Compounds represented by the formula (I) or salts thereof. In the formula (I), the ring A represents a benzene ring, a thiophene ring, or a pyridine ring; Ra represents a hydrogen atom, a halogen atom, an alkyl group, or a... | 11/22/2011 |
| 8063036 | Benzamides and related inhibitors of factor Xa Novel benzamide compounds including their pharmaceutically acceptable isomers, salts, hydrates, solvates and prodrug derivatives having activity against mammalian factor Xa are described. Compositions containing such compounds are also described. The compounds and c... | 11/22/2011 |
| 8030300 | Ligands for nicotinic acetylcholine receptors, and methods of making and using them One aspect of the present invention relates to heterocyclic compounds that are ligands for nicotinic acetylcholine receptors. A second aspect of the invention relates to the use of a compound of the invention for modulation of a mammalian nicotinic acetylcholine rec... | 10/04/2011 |
| 7932246 | Histone deacetylase inhibitors Compounds of formula: (I), and salts, N-oxides, hydrates and solvates thereof are histone deacetylase inhibitors and are useful in the treatment of cell proliferative diseases, including cancers: (I) wherein Q, V and W independently represent —N═ or —C═; B i... | 04/26/2011 |
| 7919488 | Therapeutic compounds The present invention provides compounds of formula (I), or pharmaceutically acceptable salts or solvates thereof, methods for their preparation, methods for their use, and pharmaceutical formulations comprising them. ... | 04/05/2011 |
| 7906503 | Substituted 3-alkyl and 3-alkenyl azetidine derivatives Novel compounds of the structural formula (I) are antagonists and/or inverse agonists of the Cannabinoid-1 (CB1) receptor and are useful in the treatment, prevention and suppression of diseases mediated by the CB1 receptor. The compounds of the present invention are... | 03/15/2011 |
| 7902181 | Compounds 010 The present invention provides compounds of formula (I) in which n, y, X1, X2, A, B, R1, R2, R3, R4 and R5 are as defined in the specification, a ... | 03/08/2011 |
| 7879838 | Heteroaryl substituted pyrazinyl-piperazine-piperidines with CXCR3 antagonist activity The present application discloses a compound, or enantiomers, stereoisomers, rotamers, tautomers, racemates or prodrug of said compound, or pharmaceutically acceptable salts or solvates of said compound, or of said prodrug, said compound having the general structure... | 02/01/2011 |
| 7879839 | Potassium channel inhibitors The present invention relates to compounds having the structure useful as potassium channel inhibitors to treat cardiac arrhythmias, and the like. ... | 02/01/2011 |
| 7871999 | Substituted thiazoles and their use for producing drugs The present invention relates to substituted thiazoles, to methods for the production thereof, to medicaments containing these compounds and to the use thereof for producing medicaments. ... | 01/18/2011 |
| 7851463 | Heterocyclic compounds suitable for treating disorders that respond to modulation of the dopamine Dreceptor The invention relates to compounds of the formula (I). The invention also relates to the use of a compound of the formula I or a pharmaceutically acceptable salt thereof for preparing a pharmaceutical composition for the treatment of a medical disorder susceptible t... | 12/14/2010 |
| 7786104 | N-(aminoheteroaryl)-1H-indole-2-carboxamide derivatives, and preparation and therapeutic application thereof The invention concerns compounds of general formula (I): Wherein n, X1, X2, X3, X4, Y, Z, Z1, Z2, Z3 and Z4 are as defined herein. The ... | 08/31/2010 |
| 7687492 | 1,2,4-Oxadiazole derivatives as dipeptidyl peptidase-IV inhibitors for the treatment or prevention of diabetes The present invention is directed to novel 1,2,4-oxadiazole derivatives which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DP-IV inhibitors”) and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is... | 03/30/2010 |
| 7662811 | 1,2,3,4-tetrahydropyrazin-2-yl acetamides and methods of use Selected compounds are effective for treatment of pain and diseases, such as inflammation mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for... | 02/16/2010 |
| 7655644 | Piperidine and azetidine derivatives as GlyT1 inhibitors The present invention provides compounds of formula (I), wherein both p's are one or two, R1 is generally heteroaryl or cycloalkyl, R2 is C3-6cycloalkyl or phenyl and R3 is heteroaryl, and pharmaceutically acceptable salts... | 02/02/2010 |
| 7585853 | Compounds having selective inhibiting effect at GSK3 The present invention relates to new compounds of formula (I) wherein: Z is N and X is CH or N; Y is CONR5; P is phenyl or a 5 or 6 membered heteroaromatic ring containing one or more heteroatoms selected from N, O or S; Q is phenyl or a 5 or 6 membered a... | 09/08/2009 |
| 7442672 | Picolinamine derivatives and their use as fungicides Compound of general formula (I), in which: Y and G together with carbon atoms 3 and 4, form a 5 or 6 member ring chosen from the following structures (A) to (F), the other substituents being as defined in the description. Process for preparing this compound. Fungici... | 10/28/2008 |
| 7432254 | Method for treating glaucoma IC Provided is a method of treating or ameliorating or preventing glaucoma, decreasing intraocular pressure or improving or amemliorting ocular accommodation in an animal, including a human comprising administering an intraocular pressure decreasing or accommodation im... | 10/07/2008 |
| 7393842 | Pyrazole analogs acting on cannabinoid receptors One aspect of the invention is concerned with cannabimimetic pyrazole analogs. Another aspect of the invention is concerned with new and improved pyrazole analogs having high affinities and/or selectivities for the CB1 cannabinoid receptor. A further aspect of the i... | 07/01/2008 |
| 7361682 | Indole derivatives as H3 inverse agonists The present invention relates to compounds of formula I: wherein X, R1, R2, R3, R4 and R5 are as defined in the description and claims, and pharmaceutically acceptable ... | 04/22/2008 |
| 7354929 | Cannabinoid receptor ligands and uses thereof Compounds of Formula (I) that act as cannabinoid receptor ligands and their uses in the treatment of diseases linked to the mediation of the cannabinoid receptors in animals are described herein ... | 04/08/2008 |
| 7351702 | Caspase inhibitors and uses thereof This invention provides compounds of formula I: wherein Z is oxygen or sulfur; R1 is hydrogen, —CHN2, R, CH2OR, CH2SR, or —CH2Y; next to R3 represents a... | 04/01/2008 |
| 7335658 | Pyridazine derivatives and their use as therapeutic agents Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I): ... | 02/26/2008 |
| 7335753 | Bifunctional heterocyclic compounds and methods of making and using same The invention provides a family of bifunctional heterocyclic compounds useful as anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents. The invention also provides methods of making the bifunctional heterocyclic compounds, and methods of using... | 02/26/2008 |
| 7323456 | Carboxylic acid derivatives compounds and agents comprising the compounds as active ingredient A compound of formula (I) (wherein all symbols are as defined in the specification) and a salt thereof, and peroxisome proliferator activated receptor regulator comprising thereof as active ingredient. Because a ... | 01/29/2008 |
| 7312235 | Benzamide inhibitors of factor Xa Novel benzamide compounds, their salts and compositions related thereto having activity against mammalian Factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders. ... | 12/25/2007 |
| 7273882 | Aminoacetamide acyl guanidines as β-secretase inhibitors There is provided a series of substituted acyl guanidines of Formula (Ik) or a stereoisomer; or a pharmaceutically acceptable salt thereof, wherein R2, R3, R4, R5, R | 09/25/2007 |
| 7265227 | Piperidine derivatives useful as modulators of chemokine receptor activity The invention provides compounds of formula (I) wherein: T is C(O) or S(O)2; W is C(O) or S(O)2; X is CH2, O or NH; Y is CR11 or N; n is 0, 1 or 2; m is 1 or, when Y is CR11 m is 0; R1 is optionally s... | 09/04/2007 |
| 7235544 | 3-sulfonylamino-pyrrolidine-2-one derivatives as inhibitors of factor Xa The invention relates to compounds of formula (I): wherein substituents are as defined. ... | 06/26/2007 |
| 7220737 | Noribogaine in the treatment of pain and drug addiction The present invention is directed to methods of treating patients for pain by administering noribogaine. Noribogaine may also be used to treat patients for the symptoms associated with withdrawal from drug dependency. In the latter case, the noribogaine treatment sh... | 05/22/2007 |
| 7214694 | 3-ox(adi)azolylpropanohydroxamic acids useful as procollagen C-proteinase inhibitors Compounds of formula (I): wherein the substituents are as defined herein, and their salt, solvates, and prodrugs are procollagen C-proteinase (PCP) inhibitors useful in treating conditions mediated by PCP. ... | 05/08/2007 |
| 7199124 | JNK inhibitor The present invention relates to a c-Jun N-terminal kinase inhibitor containing an azole compound (I) substituted by a nitrogen-containing aromatic group having substituent(s)(except a compound represented by the formula: ... | 04/03/2007 |
| 7196105 | Treatment of human multiple myeloma by curcumin All multiple myeloma cell lines examined showed constitutively active IκB kinase (IKK), IκBα phosphorylation and constitutively active NF-κB. Curcumin, a chemopreventive agent, suppressed constitutive IκBα phosphorylation through inhibition of IKK activity and... | 03/27/2007 |
| 7186735 | Acylated arylcycloalkylamines and their use as pharmaceuticals The present invention relates to acylated arylcycloalkylamines, to pharmaceutical compositions comprising such compounds, to methods for the stimulation of the expression of endothelial NO synthase, and methods of treatment comprising administering such compounds. | 03/06/2007 |
| 7157472 | Neuropeptide Y Y5 receptor antagonists The present invention discloses compounds which, are receptor antagonists for NPY Y5 as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such NPY Y5 receptor antagonists as well as me... | 01/02/2007 |
