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| Number | Title | Issue Date |
| 7973029 | Inhaled aztreonam lysine for the treatment of deficits in health-related quality-of-life in lung diseases Provided is a method of treating the health-related quality-of-life (HRQOL) symptoms of a lung disease, comprising the administration of an inhalable aerosol of aztreonam lysine. The method is suitable for the short term and sustainable long term treatment of HRQOL ... | 07/05/2011 |
| 7846920 | Heterosubstituted N-thiolated beta-lactam compounds and methods of use The invention relates to heterosubstituted N-thiolated beta-lactams, compositions comprising these compounds, methods for their production, and methods of use as antibiotics to inhibit the growth of bacteria. In one embodiment, the compounds have the structure shown... | 12/07/2010 |
| 7635693 | Methods for preventing and treating cancer using -thiolated β-lactam compounds and analogs thereof The subject invention concerns N-thiolated β-lactam compounds of formula A, wherein R1 is a hydrocarbon group having 1-8 carbon atoms; R3 is an organothio group; and R4 is alkyl, alkenyl, a... | 12/22/2009 |
| 7439253 | Heterocyclic compounds, their preparation and their use as medicaments, in particular as antibacterials and beta-lactamase inhibitors The invention relates to novel heterocyclic compounds of general formula (I), and their salts with a base or an acid: The invention also relates to a method for preparing these compounds, and to their use as medicaments, in p... | 10/21/2008 |
| 7358093 | Aztreonam L-lysine and methods for the preparation and analysis thereof The present invention relates to the L-lysine salt of aztreonam and methods for making the L-lysine salt of aztreonam. ... | 04/15/2008 |
| 7282221 | Antiviral product, use and formulation thereof An antiviral product is comprised of at least three dosages forms, each of which has a different release profile, with the Cmax for the antiviral product being reached in less than about twelve hours. In one embodiment, there is an immediate release dosag... | 10/16/2007 |
| 7262293 | Aztreonam L-lysine and methods for the preparation thereof The present invention relates to the L-lysine salt of aztreonam and methods for making the L-lysine salt of aztreonam. ... | 08/28/2007 |
| 7214364 | Inhalable aztreonam lysinate formulation for treatment and prevention of pulmonary bacterial infections A method and a composition for treatment of pulmonary bacterial infections caused by gram-negative bacteria suitable for treatment of infection caused by Escherichia coli, Klebsiella pneumoniae, Klebsiella oxytoca, Pseudomonas aeruginosa, Haemophilus influenzae, ... | 05/08/2007 |
| 6946458 | N-thiolated beta-lactams: novel antibacterial agents for methicillin-resistant Staphylococcus aureus The invention relates generally to novel N-thiolated β-lactams. More specially, the invention relates to the use of these novel antibacterial agents in the treatment or inhibition of methicillin-resistant Staphylococcus aureaus. ... | 09/20/2005 |
| 6916803 | 3-(Heteroaryl acetamido)-2-oxo-azetidine-1-sulfonic acids derivatives as antibacterial agents The present invention relates to novel Syn isomers of racemates and optical isomers of 3-(heteroaryl acetamido)-2-oxo-azetidine-1-sulfonic acids of the following formula: and their use in treating infections caused by ... | 07/12/2005 |
| 6821963 | 4-Bromo or 4-iodo phenylamino benzhydroxamic acid derivatives and their use as MEK inhibitors Phenylamino benzhydroxamic acid derivatives of formula (I) where R1, R2, R3, R4, R5, and R6 are hydrogen or substituent groups such as alkyl, and where R7 is hydrogen or an organic radical,... | 11/23/2004 |
| 6476015 | N-thiolated ଲ-lactam antibiotics Substituted monocyclic ଲ-lactam compounds that are N-1-thiolated monolactams, and which exhibit wide-ranging antibacterial activities, having a single 4-membered azetidinone ring in which: the N-1 nitrogen atom of the azetidinone ring is bonded to s... | 11/05/2002 |
| 6335324 | Beta lactam compounds and their use as inhibitors of tryptase Compounds of the formulas: ##STR1## are disclosed. These compounds inhibit tryptase as well as other enzyme systems or are selective tryptase inhibitors and are useful as antiinflammatory agents particularly in the treatment of chronic asthma.... | 01/01/2002 |
| 6034077 | 4-substituted-3-(2-amino-2-cycloalkyl methyl)-acetamido azetidin-2-one derivatives as cysteine proteinase regulators In accordance with the present invention, there are provided 4-substituted-3-(2-amino-2-cycloalkyl methyl)-acetamido azetidin-2-one derivatives of the formula: ##STR1## wherein n is 1, 2 or 3; in which R1, R2 and R3 a... | 03/07/2000 |
| 5994340 | Azetidinone derivatives as ଲ-lactamase inhibitors New 2-oxo-1-azetidine sulfonic acid derivatives with an aminoalkyl substituted "anti" (E-isomer) oxyimino group in the acylamino substituent at the 3 position of the monobactam ring. These compounds are potent inhibitors of bacterial ଲ-lactamases. T... | 11/30/1999 |
| 5916887 | 4-substituted-3-(2-amino-2-cycloalkyl methyl)-acetamido azetidin-2-one derivatives as cysteine proteinase regulators In accordance with the present invention, there are provided 4-substituted-3-(2-amino-2-cycloalkyl methyl)-acetamido azetidin-2-one derivatives of the formula: ##STR1## wherein n is 1, 2 or 3; in which R1, R2 and R3 a... | 06/29/1999 |
| 5888998 | 2-oxo-1-azetidine sulfonic acid derivatives as potent ଲ-lactamase inhibitors A compound of formula (I) ##STR1## wherein R1 is selected from the group consisting of 2-thienyl, 2-furyl, 2-pyrrolyl, 1-methyl-2-pyrrolyl, 2-amino-1-thiazolyl and 5-isothiazolyl; R2 is selected from the group consisting of: ... | 03/30/1999 |
| 5318963 | Heterocyclic hydrazide derivatives of monocyclic ଲ-lactam antibiotics Antibacterial activity has been found in compounds of the formula. Compounds having the formula ##STR1## and pharmaceutically acceptable salts thereof, wherein: A is a bond or alkylene; Q completes a 5- or 6-membered saturated or unsaturated (including ... | 06/07/1994 |
| 5250525 | 4-oxo-azetidine-2-sulfonic acids and their salts, processes for the preparation thereof and their use The invention relates to novel 4-oxo-azetidine-2-sulfonic acids and their salts or the formula I ##STR1## wherein: R1 =hydrogen, halogen, phenylacetamido; R2 =hydrogen, halogen, phenylacetamido, phenoxyacetamido, phthalimido, 5-... | 10/05/1993 |
| 5143913 | [3S(Z)]-3-[[(2-amino-4- thiazolyl)[[2-(hydroxyamino)-2-oxoethoxy]imino]acetyl]amino]-2,2-dimethyl -4-oxo-1-azetidinyl sulfate The compound [3S(Z)]-3-[[(2-amino-4-thiazolyl)[[2-(hydroxyamino)-2-oxoethoxy]imino]acet yl]amino]-2,2-dimethyl-4-oxo-1-azetidinyl sulfate has gram-positive and gram-negative activity and good oral absorption.... | 09/01/1992 |
| 5120729 | Beta-lactams as antihypercholesterolemics This application relates to compounds of formula (I), which are useful as antihypercholesterolemic agents. ##STR1##... | 06/09/1992 |
| 5110812 | Azetidin-2-one derivatives as serine protease inhibitors The present invention relates to new 3-guanidinoalkyl-2-azetidinones of the formula ##STR1## wherein: U and W can be the same or different and are selected from the group consisting of hydrogen and an amino protecting group; n is 1 to 3; X is a membe... | 05/05/1992 |
| 5057512 | 3-amino-2-oxo-azetidine-1-sulfonic acids Novel syn isomers of reacemates and optical isomers of 3-amino-2-oxo-azetidine-1-sulfonic acids of the formula ##STR1## wherein R is difluoromethyl, R1 is --(CH2)n --X, n is an integer from 1 to 4, X is selected from ... | 10/15/1991 |
| 5039672 | Heterocyclic compounds as aldose reductase inhibitors Certain spirocyclic heterocyclic compounds, and their pharmaceutically-acceptable salts, are inhibitors of the aldose reductase enzyme, and so are useful for the control of diabetic complications. Exemplary compounds include compounds of the formula ... | 08/13/1991 |
| 4983597 | Beta-lactams as anticholesterolemic agents Compounds of formula (I), which are useful as antihypercholesterolemic agents, are disclosed. ##STR1##... | 01/08/1991 |
| 4946838 | Crystalline anhydrous aztreonam The crystalline anhydrous form of [3S-[3(Z), 4ଲ]]-3-[[(2-amino-4-thiazolyl) [(1-carboxy-1-methylethoxy)imino]acetyl]amino]-4-methyl-2-oxo-1-azetidines ulfonic acid is prepared.... | 08/07/1990 |
| 4900728 | Novel 3-amino-2-oxo-azetidine-1-sulfonic acids Novel syn isomers of racemates and optical isomers of 3-amino-2-oxo-azetidine-1-sulfonic acids of the formula ##STR1## wherein R is selected from the group consisting of hydrogen linear or branched optionally substituted alkyl of 1 to 12 carbon atoms... | 02/13/1990 |
| 4822788 | 1-sulfo-2-oxozetidine derivatives and their product ion Disclosed are compounds of the general formula: ##STR1## wherein R1 is amino, an acylated amino or a protected amino group, X is hydrogen or methoxy, and R' is hydrogen, R or R4 wherein R is an organic residue attached to the az... | 04/18/1989 |
| 4822790 | 1-Sulfo-2-oxoazetidine derivatives and their production Disclosed are compounds of the general formula: ##STR1## wherein R1 is amino, an acylated amino or a protected amino group, X is hydrogen or methoxy, and R' is hydrogen, R or R4 where R is an organic residue attached to the azet... | 04/18/1989 |
| 4794108 | 1-carboxymethoxy acetidinones and their production A 2-azetidinone derivative having a group of the formula ##STR1## wherein R1 and R2 are the same or different and each represents a hydrogen atom, alkyl, aryl or arylalkyl which may have a substituent at the 1-position and an am... | 12/27/1988 |
| 4775670 | 2-oxo-1-azetidinesulfonic acid salts Antibacterial activity is exhibited by ଲ-lactams having a sulfonic acid salt substituent in the 1-position and an amino or acylamino substituent in the 3-position.... | 10/04/1988 |
| 4771045 | 2-oxozetidinone derivatives, their production and use Novel 1-sulfo-2-oxoazetidine derivatives and their production and use. These 1-sulfo-2-oxoazetidine derivatives exhibit excellent antimicrobial activity against gram-positive and gram-negative bacteria, and ଲ-lactamase inhibitory activity, thus being of ... | 09/13/1988 |
| 4751220 | Crystalline salts of [3S(Z)]-2[[[1-(2-amino-4-thiazolyl)-2-[[2,2-dimethyl-4-oxo-1-(sulfooxy)- 3-azetidinyl]amino]-2-oxoethylidene]-amino]oxy]acetic acid In accordance with the present invention an orally active monosulfactam antibiotics having a crystalline structure and thereby improved stability are disclosed. The antibiotics comprise the dierythromycin (M.sym.=erythromycin.H.sup..sym.) salt ... | 06/14/1988 |
| 4725591 | ଲ-lactamase inhibitory composition Compounds having one or two substituents at the 3-position, represented by the general formula ##STR1## wherein R1 is an optionally acylated or protected amino group and X is hydrogen atom or methoxy group, or a pharmaceutically acceptable... | 02/16/1988 |
| 4680388 | O-sulfated spiro ଲ-lactam hydroxamic acids Antibacterial activity is exhibited by compounds having the formula and pharmaceutically acceptable salts thereof.... | 07/14/1987 |
| 4680391 | Substituted azetidinones as anti-inflammatory and antidegenerative agents New substituted azetidinones are found to be potent elastase inhibitors and thereby useful anti-inflammatory/antidegenerative agents.... | 07/14/1987 |
| 4665067 | 1-Sulfo-2-oxoazetidine derivatives and their production Disclosed are compounds of the general formula: ##STR1## wherein R1 is amino, an acylated amino or a protected amino group, X is hydrogen or methoxy, and R' is hydrogen, R or R4 wherein R is an organic residue attached to the az... | 05/12/1987 |
| 4647558 | Antibacterial agents, their preparation and use A monocyclic ଲ-lactam antibiotic having a formamido substituent at the 3S-position, including compounds of the formula (I): ##STR1## and salts thereof wherein R is --SO3 H; --PO(OH)Y wherein Y is C1-6 alkoxy, hydroxy, aryl... | 03/03/1987 |
| 4572801 | 4-Carbamoyloxymethyl-1-sulfo-2-oxoazetidine derivatives and their production Disclosed are compounds of the general formula: ##STR1## wherein R1 is a hydrogen atom or a lower alkyl group and R2 is a hydrogen atom or an ester residue, said derivative having the (3S,4S)-configuration; and pharmaceutically ... | 02/25/1986 |
| 4551276 | 2-Oxoazetidin-1-yloxymethyl sulfonic acid and analogs Antibiotic activity is exhibited by ଲ-lactams having an ##STR1## substituent in the 1-position and an acylamino substituent in the 3-position.... | 11/05/1985 |
