Class 514/210.03 - Polycyclo ring system having the four-membered hetero ring as one of the cyclos

Subclass of Class 514 - Drug, bio-affecting and body treating compositions
Definition: Subject matter wherein the four-membered hetero ring is
No. of patents: 35
Last issue date: 11/03/2009

Number	Title	Issue Date
7612058	Methods for inhibiting sterol absorption The present invention provides compositions, therapeutic combinations and methods including: (a) at least one peroxisome proliferator-activated receptor activator; and (b) at least one substituted azetidinone or substituted β-lactam sterol absorption inhibitor whic...	11/03/2009
7214364	Inhalable aztreonam lysinate formulation for treatment and prevention of pulmonary bacterial infections A method and a composition for treatment of pulmonary bacterial infections caused by gram-negative bacteria suitable for treatment of infection caused by Escherichia coli, Klebsiella pneumoniae, Klebsiella oxytoca, Pseudomonas aeruginosa, Haemophilus influenzae, ...	05/08/2007
7030106	Sterol absorption inhibitor compositions The present invention provides compositions, therapeutic combinations and methods including: (a) at least one peroxisome proliferator-activated receptor activator; and (b) at least one substituted azetidinone or substituted β-lactam sterol absorption inhibitor whic...	04/18/2006
6531466	Tricyclic carbapenem compounds A compound of formula (I), salts and metabolically labile esters thereof, wherein R represents optionally substituted aryl or heteroaryl group; A represents a propylene chain or A is a chain of 3 members one of which is selected from an oxygen or sulphur ...	03/11/2003
6514962	Stabilized preparations of ଲ-lactam antibiotic Stabilized preparations which contain a ଲ-lactam antibiotic having an esterified carboxyl group attached directly to the mother nucleus, an oil and a phosphate....	02/04/2003
6489318	Ethylidene derivatives of tricyclic carbapenems Disclosed are novel ethylidene derivatives of tricyclic carbapenems of the formula I ##STR1## wherein the ring marked C and X have the meaning as in the description, in the form of pure diastereoisomers and in the form of pure geometric isomers. Nove...	12/03/2002
6218379	Tricyclic carbacephems The present invention is concerned with compounds of formula ##STR1## where A is a group of formula (b1) or (b2) ##STR2## where R3 is unsubstituted aryl or aryl substituted by one or two substituents defined herein, and R is as defined herein, ...	04/17/2001
6207823	Carbapenem antibacterial compounds, compositions containing such compounds and methods of treatment The present invention relates to tricyclic carbapenem antibacterial agents in which the carbapenem nucleus is fused to a 6 membered carbocyclic ring. The compound is further substituted with various substituent groups including at least one cationic group...	03/27/2001
6124278	Acylbenzoxazines for enhancing synaptic response Compounds based on the benzoxazine ring system that are remarkably more potent than corresponding benzoyl piperidines for enhancing synaptic responses mediated by AMPA receptors are disclosed, as are methods for the preparation thereof, and methods for th...	09/26/2000
6117863	Photocyclized rapamycin A compound of the structure ##STR1## or a 31- and/or 42-ester or ether thereof, which is useful as an immunosuppressive, antiinflammatory, antifungal, antiproliferative, and antitumor agent....	09/12/2000
6015809	Photocyclized rapamycin A compound of the structure ##STR1## or a 31- and/or 42-ester or ether thereof, which is useful as an immunosuppressive, antiinflammatory, antifungal, antiproliferative, and antitumor agent....	01/18/2000
5955458	Penicillin glycolate New solvates of penicillin, in particular amoxycillin glycolate has been provided for together with a simple one-step process to prepare the same....	09/21/1999
5824650	Topical composition containing a substance P antagoinst The invention relates to a therapeutic composition for topical application containing at least one product with an irritant side effect and a substance P antagonist for reducing or even eliminating the irritant effect of this product. It also relates to t...	10/20/1998
5712268	Compositions of tricyclic ଲ-lactams and uses thereof There are described pharmaceutical compositions comprising (a) compounds of the formula ##STR1## in which R signifies lower alkoxycarbonyl, lower alkoxy-carbonylamino, the acyl residue of an ଱- or ଲ-amino acid or a residue of the general...	01/27/1998
5693634	Urea derivatives for use in treating bacterial infections The present invention relates to compounds of formula (I) ##STR1## and salts and metabolically labile esters thereof. These compounds and compositions containing them have antibacterial activity. Processes for preparing these compounds are also discl...	12/02/1997
5665717	Carbacephalosporin compound, their preparation and use Carbacephalosporin compounds of formula (I), ##STR1## salts thereof, processes for their synthesis and uses thereof, wherein: R1 is hydrogen, methoxy or formamido; R2 is an acyl group; CO2 R3 is a carboxy g...	09/09/1997
5587374	10(1-hydroxyethyl)-11-oxo-1-azatricyclo/7.2.0.0.^3.8/ undec-2-ene-2-carboxylic acid esters and a process for preparing thereof A compound of the formula 1-cyclohexyloxycarbonyloxethyl (4S, 8S, 9R 10S, 12R)-4-methoxy-10-(1-hydroxyethyl)-11-oxo-1-azatricyclo[7.2.0.0.3,8 ]undec-2-ene-2-carboxylate which is useful as a pharmaceutical composition to treat bacterial infectio...	12/24/1996
5578592	Cephalosporin derivatives Compounds of formula (I) or salts thereof: wherein R1 is hydrogen, methoxy or formamido; R2 is an acyl group; CO2 R3 is a carboxy group or a carboxylate anion, or R3 is a readily removable carboxy pro...	11/26/1996
5576312	1-azatricyclo[7.2.0.0³,8 ]undec-2-ene-2-carboxylates as antibacterial compounds The present invention relates to compounds of formula (I) ##STR1## and salts and metabolically labile esters thereof; wherein R is a 5 or 6 membered nitrogen containing heteroaryl group, which heteroaryl group optionally contains 1 or 2 additional he...	11/19/1996
5494666	ଲ-lactam compounds Compounds of the formula ##STR1## where Z, A, and R are as disclosed herein and pharmaceutically compatible, readily hydrolyzable esters and salts of these compounds are disclosed. The compounds have ଲ-lactamase inhibiting properties and are useful ...	02/27/1996
5464617	ଲ-lactam compounds Compounds of the formula ##STR1## where Z, A, and R are as disclosed herein and pharmaceutically compatible, readily hydrolyzable esters and salts of these compounds are disclosed. The compounds have ଲ-lactamase inhibiting properties and are useful ...	11/07/1995
5426104	Tricyclic carbapenem compounds, methods of preparation and methods of use Compounds of general formula (I) ##STR1## in which R1 represents a hydrogen atom or a hydroxyl protecting group, R2 represents a hydrogen atom or a carboxyl protecting group, and R3 represents the group N(R4	06/20/1995
5407931	Derivatives of 1-azatricyclo[7.2.03,8]undec-2-ene-2-carboxyclic acid The invention relates to heterocyclic derivatives having antibacterial activity, to processes for their preparation, to compositions containing them, and to their medicinal uses. The derivatives according to the invention have the following general formul...	04/18/1995
5401735	Bridged biphenyl carbapenem antibacterial compounds Carbapenems of the formula: ##STR1## are disclosed as useful antibacterial agents....	03/28/1995
5393751	Tricyclic carbapenem compounds A compound of the formula ##STR1## wherein R1 is a hydrogen atom or a hydrocarbon group which may be substituted; COOR2 represents a carboxy group which may be esterified; and ring B is a cyclic group which may be substituted or...	02/28/1995
5374630	Bridged carbapenem antibacterial compounds Carbapenems of the formula ##STR1## are useful antibacterial agents....	12/20/1994
5372993	Bridged carbapenem compounds, compositions containing such compounds and methods of use Carbapenems of the formula ##STR1## are useful antibacterial agents. Compositions containing such compounds and methods of use are also disclosed....	12/13/1994
5061730	Carboxylic acid derivatives This invention relates to new carboxylic acid derivatives of the formula: ##STR1## wherein R1 is hydrogen, lower alkyl or aryl, and pharmaceutically acceptable salt thereof which inhibit activity of DHP-I, to a process for preparing them a...	10/29/1991
5039672	Heterocyclic compounds as aldose reductase inhibitors Certain spirocyclic heterocyclic compounds, and their pharmaceutically-acceptable salts, are inhibitors of the aldose reductase enzyme, and so are useful for the control of diabetic complications. Exemplary compounds include compounds of the formula ...	08/13/1991
4956358	Tricyclic cepham compounds and use The compounds having a 4,11-dioxo-3-oxa-8(or 7)-thia-1-azatricyclo[7,2,0,02,6 ]undecane-2-carboxylic acid skeleton as the base structures, their esters and their salts are useful antibacterial agents....	09/11/1990
4824849	଱₂ -adrenoceptor antagonistic arylquinolizines Substituted hexahydro arylquinolizines and pharmaceutically acceptable salts thereof are selective 댒 -adrenergic receptor antagonists and thereby useful as antidepressants, antihypertensives, ocular antihypertensives, antidiabetics, plat...	04/25/1989
4544557	6-(1-Hydroxyethyl)-2-(2-aminoethylthio)-3-tetrazoly-1-carbadethiapen-2-em Disclosed is the antibiotic 6-(1-hydroxyethyl)-2-substituted-thio-3-tetrazolyl-1-carbadethiapen-2-em and its pharmaceutically acceptable salts (I): ##STR1## wherein Z is C1 -C3 alkylamino, C1 -C3 alkylguani...	10/01/1985
4444771	Azeto triazolo pyrazine ଲ-lactam antibacterial agents A compound of formula (I) or a salt thereof: ##STR1## wherein R1 is an amino group, an azido group, or an acylamino group as found in antibacterially active penicillins or cephalosporins; R2 is a hydrogen atom or a C1-4 al...	04/24/1984
4415584	3-Oxo-6-oxa-2-azatricyclo 5.4.2. unadecene-4-carboxylate Compounds of the formula (II): ##STR1## wherein R1 is hydrogen or alkyl of 1 to 4 carbon atoms, CO2 R2 is a carboxyl group, a pharmaceutically acceptable salt thereof or a pharmaceutically acceptable esterified carbox...	11/15/1983
4252808	ଲ-Lactam antibacterial agents, their use in pharmaceutical compositions, the process for their preparation and intermediates for use in that process The compounds of the formula (I): ##STR1## wherein R1 is a hydrogen atom, a trityl group or an acyl group as found in known antibacterially active penicillins or cephalosporins; R2 is a hydrogen atom, a lower alkyl group or an a...	02/24/1981

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Class 514/210.03 - Polycyclo ring system having the four-membered hetero ring as one of the cyclos