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| Number | Title | Issue Date |
| 8173632 | Process for the modification of the solid state of a compound and co-amorphous compositions produced with same The invention provides a process for preparing non-crystalline organic compositions and non-crystalline, co-amorphous blends of organic compounds. ... | 05/08/2012 |
| 8063033 | Therapeutic beta-lactams Compounds comprising or a pharmaceutically acceptable salt or a prodrug thereof, are disclosed, wherein Y is A is —(CH2)6—, cis —CH2CH═CH... | 11/22/2011 |
| 8048874 | Beta-lactamyl phenylalanine, cysteine, and serine vasopressin antagonists Substituted 2-(azetidin-2-on-1-yl)alkoxyalkylalkanoic acids and 2-(azetidin-2-on-1-yl)arylalkylalkanoic acids, and analogs and derivatives thereof are described. Methods for using the described compounds, and pharmaceutical compositions thereof, to treat disease sta... | 11/01/2011 |
| 8039458 | HIV integrase inhibitors The invention encompasses a series bicyclic pyrimidinone compounds of Formula I which inhibit HIV integrase and prevent viral integration into human DNA. This action makes the compounds useful for treating HIV infection and AIDS. The invention also encompasses pharm... | 10/18/2011 |
| 8003636 | Certain crystalline diphenylazetidinone hydrates, pharmaceutical compositions thereof and methods for their use Provided are certain crystalline hydrates of the formula I in which n has a value of from 0.5 to 1.8. The compound may be suitable, for example, as a hypolipidemic. ... | 08/23/2011 |
| RE42461 | Hydroxy-substituted azetidinone compounds useful as hypocholesterolemic agents Hydroxy-substituted azetidinone hypocholesterolemic agents of the formula or a pharmaceutically acceptable salt thereof, wherein: Ar1 and Ar2 are aryl or R4-substituted aryl; | 06/14/2011 |
| 7951793 | Substituted heterocyclic derivatives useful as antidiabetic and antiobesity agents and method Compounds are provided which have the structure wherein Z1 is (CH2)q or C═O; Z2 is (CH2)p or C═O; | 05/31/2011 |
| 7906502 | 2-azetidinone derivatives as cholesterol absorption inhibitors for the treatment of hyperlipidaemic conditions Compounds of formula (I) (wherein variable groups are as defined within) pharmaceutically acceptable salts, solvates, solvates of such salts and prodrugs thereof and their use as cholesterol absorption inhibitors for the treatment of hyperlipidaemia are described. P... | 03/15/2011 |
| 7897593 | HIV integrase inhibitors The invention encompasses series bicyclic pyrimidinone compounds of Formula I which inhibit HIV integrase and prevent viral integration into human DNA. This action makes the compounds useful for treating HIV infection and AIDS. The invention also encompasses pharmac... | 03/01/2011 |
| 7897592 | HIV integrase inhibitors The invention encompasses a series bicyclic pyrimidinone compounds of Formula I which inhibit HIV integrase and prevent viral integration into human DNA. This action makes the compounds useful for treating HIV infection and AIDS. The invention also encompasses pharm... | 03/01/2011 |
| 7893048 | 2-azetidinone derivatives as cholesterol absorption inhibitors for the treatment of hyperlipidaemic conditions Compounds of formula (I): (wherein variable groups are as defined within) pharmaceutically acceptable salts, solvates, solvates of such salts and prodrugs thereof and their use as cholesterol absorption inhibitors for the treatment of hyperlipidaemia are described. ... | 02/22/2011 |
| 7871998 | Diphenylazetidinone derivatives possessing cholesterol absorption inhibitory activity Compounds of formula (I): (wherein variable groups are as defined within) pharmaceutically acceptable salts, solvates, solvates of such salts and prodrugs thereof and their use as cholesterol absorption inhibitors for the treatment of hyperlipidaemia are described. ... | 01/18/2011 |
| 7863265 | 2-azetidinone derivatives and their use as cholesterol absorption inhibitors for the treatment of hyperlipidaemia Compounds of formula (I) (wherein variable groups are as defined within) pharmaceutically acceptable salts, solvates, solvates of such salts and prodrugs thereof and their use as cholesterol absorption inhibitors for the treatment of hyperlipidaemia are described. P... | 01/04/2011 |
| 7842684 | Diphenylazetidinone derivatives possessing cholesterol absorption inhibitor activity The present invention provides 2-azetidinone derivatives, or pharmaceutically acceptable salts, solvates, solvates of such salts and prodrugs thereof, comprising formula (I): wherein the substituents are as herein defined. ... | 11/30/2010 |
| 7795245 | Heterobicyclic metalloprotease inhibitors The present invention relates generally to amide group containing pharmaceutical agents, and in particular, to amide containing heterobicyclic metalloprotease inhibitor compounds having the following formulas: wherein R | 09/14/2010 |
| 7786103 | Method for isolating an intestinal cholesterol binding protein The invention describes a method for isolating an intestinal protein which is able to bind cholesterol and/or cholesterol uptake inhibitors. ... | 08/31/2010 |
| 7781424 | Modified release pharmaceutical formulation A modified release pharmaceutical composition comprising, as active ingredient, a compound of formula (I), wherein R1 represents C1-2 alkyl substituted by one or more fluoro substituents; R2 represents hydrogen, hydroxy, methoxy or e... | 08/24/2010 |
| 7718643 | Pharmaceutical formulation The instant invention provides a pharmaceutical composition comprised of a cholesterol absorption inhibitor and an HMG-CoA reductase inhibitor, one or more anti-oxidants, microcrystalline cellulose, hydroxypropyl methylcellulose, magnesium stearate and lactose. The ... | 05/18/2010 |
| 7704988 | Anti-hypercholesterolemic compounds This invention provides cholesterol absorption inhibitors of Formula I: and the pharmaceutically acceptable salts and esters thereof. The compounds are useful for lowering plasma cholesterol levels, particularly LDL cholest... | 04/27/2010 |
| 7700582 | Pharmaceutical formulation An oral pharmaceutical formulation comprising iota-carrageenan, one or more neutral gelling polymers and a basic pharmaceutically active ingredient; which formulation inhibits the release of the basic pharmaceutically active ingredient from the formulation at acidic... | 04/20/2010 |
| 7674786 | Therapeutic β-lactams Compounds comprising: or a pharmaceutically acceptable salt or a prodrug thereof, are disclosed, wherein Y is a carboxylic acid functional group, sulfonic acid functional group, or phosphonic acid functional group; or an amid... | 03/09/2010 |
| 7671047 | Cationically substituted diphenylazetidinones, process for their preparation, medicaments comprising these compounds, and their use One embodiment of the invention relates to compounds of the formula I, in which R1, R2, R3, R4, R5 and R6 have the meanings given in the specification. Other embodiments of the invention relate to physiologically acceptable... | 03/02/2010 |
| 7645751 | Mandelic acid derivatives and their use as thrombin inhibitors There is provided a compound of formula (I) wherein Ra, R1, R2, Y and R3 have meanings given in the description and pharmaceutically-acceptable derivatives (including prodrugs) thereof, which compounds and derivatives are ... | 01/12/2010 |
| 7592332 | Cytokine inhibitors Disclosed are compounds of formula (I) which inhibit production of cytokines involved in inflammatory processes and are thus useful for treating diseases and pathological conditions involving inflammation such as chronic in... | 09/22/2009 |
| 7579339 | Ring-substituted diphenylazetidinones, process for their preparation, medicaments comprising these compounds, and their use One embodiment of the invention relates to compounds of the formula I, in which R1, R2, R3, R4, R5 and R6 have the meanings given in the specification. Other embodiments of the invention relate to physiologically acceptable... | 08/25/2009 |
| 7550453 | 2-alkoxy-3,4,5-trihydroxy-alkylamides, preparation thereof, compositions containing them and use thereof The invention relates particularly to 2-alkoxy-3,4,5-trihydroxy-alkylamides, preparation thereof, compositions containing them and use thereof as a medicament, particularly as anti-cancer agents. ... | 06/23/2009 |
| 7501404 | Substituted azetidinones Compounds are provided which have the structure Wherein A, B, C, D, m, Y, Ra, Rc, Rd, and Rd′ are as described herein, and which are useful as inhibitors of tryptase, thrombin, trypsin, Factor Xa, Factor VIIa, Factor XIa,... | 03/10/2009 |
| 7459447 | Method for treating hyperlipidemia Provided is a method for treating hyperlipidemia or hypercholesterolemia, which comprises administering effective doses of ezetimibe and pitavastatin or a salt or lactone derivative thereof. ... | 12/02/2008 |
| 7435727 | Method for isolating an intestinal cholesterol binding protein The invention describes a method for isolating an intestinal protein which is able to bind cholesterol and/or cholesterol uptake inhibitors. Methods of identifying inhibitors of cholesterol uptake and related pharmaceuticals and methods of treatment also are describ... | 10/14/2008 |
| 7407938 | Ring-substituted diphenylazetidinones, process for their preparation, medicaments comprising these compounds, and their use One embodiment of the invention relates to compounds of the formula I, in which R1, R2, R3, R4, R5 and R6 have the meanings given in the specification. Other embodiments of the invention relate to physiologically acceptable... | 08/05/2008 |
| 7388004 | Acid-group-substituted diphenylazetidinones, process for their preparation, medicaments comprising these compounds, and their use One embodiment of the invention relates to compounds of the formula I: in which R1, R2, R3, R4, R5 and R6 have the meanings given in the specification. Other embodiments of the invention relate to physiologically acceptable... | 06/17/2008 |
| 7378397 | TRH-degrading ectoenzyme inhibitors Peptide derivatives useful as inhibitors of activity of thyrotropin-releasing hormone-degrading ectoenzyme (TRH-DE) are of formula Ia: wherein: R1 is an optionally su... | 05/27/2008 |
| 7320972 | 4-Biarylyl-1-phenylazetidin-2-ones 4-Biarylyl-1-phenylazetidin-2-ones useful for the treatment of hypercholesterolemia are disclosed. The compounds are of the general formula in which represen... | 01/22/2008 |
| 7291728 | Spirolactams and their synthesis The present invention is directed to a compound of formula I: wherein R1 and R2 are independently selected from H, halogen, protected or unprotected hydroxy, alkylsilyloxy, substituted or un... | 11/06/2007 |
| 7285545 | Cytokine inhibitors Disclosed are compounds of formula (I) which inhibit production of cytokines involved in inflammatory processes and are thus useful for treating diseases and pathological conditions involving inflammation such as... | 10/23/2007 |
| 7273862 | Aminoalkyl substituted (benzodioxan, benzofuran or benzopyran) derivatives The present invention concerns compounds of formula (I) a stereochemically isomeric form thereof, an N-oxide form thereof or a pharmaceutically acceptable acid addition salt thereof, wherein -Z1-Z... | 09/25/2007 |
| 7268125 | β-lactamyl vasopressin V antagonists Novel 2-(azetidin-2-on-1-yl)alkanedioic acid derivatives and 2-(azetidin-2-on-1-yl)alkoxyalkanoic acid derivatives are described for use in the treatment of disease states responsive to antagonism of the vasopressin V1a receptor | 09/11/2007 |
| 7241757 | Amidino derivatives and their use as thrombin inhibitors There is provided compounds of formula I wherein R1, Rx, Y, Ry, n and B have meanings given in the description which are useful as competitive inhibitors of trypsin-like proteases... | 07/10/2007 |
| 7235543 | Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof The present invention provides compounds represented by the structural formula (I): or pharmaceutically acceptable isomers, salts, solvates or esters of the compound of Formula (I), wherein each of the substituen... | 06/26/2007 |
| 7229982 | Pharmaceutical formulation The instant invention provides a pharmaceutical composition comprised of a cholesterol absorption inhibitor and an HMG-CoA reductase inhibitor, one or more anti-oxidants, microcrystalline cellulose, hydroxypropyl methylcellulose, magnesium stearate and lactose. The ... | 06/12/2007 |
