Celebrity Inventors
Glam girl Heddy Lamar may have used her good looks to good effect on the silver screen, but she put her smarts to better use as an inventor. During World War II, she co-patented a frequency-switching system for torpedo guidance that was considered years ahead of its time.
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| Number | Title | Issue Date |
| 8178521 | Cefazolin sodium pentahydrate crystal and its molecular assembly preparation method The present invention relates to cefazolin sodium pentahydrate crystal and a method for assembly and preparation of the crystal molecule. The cefazolin sodium pentahydrate crystal molecule contains five water molecules, orthorhombic system, space group of C222(1), i... | 05/15/2012 |
| 7833998 | Oral neurotherapeutic cephalosporin sulfoxide and sulfone-containing compositions The treatment of neurological disorders using cephalosporin sulfoxide-containing and/or cephalosporin sulfone-containing compositions and pharmaceutical compositions including oral dosage forms that include cephalosporin sulfoxide and/or sulfone-containing compositi... | 11/16/2010 |
| 7754707 | Methods of treatment of chronic immune disease Methods for treating a host suffering from a chronic immune disease, e.g., MS or CFS, are provided. In practicing the subject methods, an effective amount of an elastase inhibitory agent, e.g., a β-lactam containing compound, is administered to the host. Also provi... | 07/13/2010 |
| 7384928 | Broad spectrum cephem compounds A compound of the formula: (wherein, T is S, SO or O; X is halogen, CN, carbamoyl optionally substituted with lower alkyl, lower alkyl, lower alkoxy, or lower alkylthio; A is substitut... | 06/10/2008 |
| 7341993 | Cross-linked glycopeptide—cephalosporin antibiotics This invention provides cross-linked glycopeptide-cephalosporin compounds and pharmaceutically acceptable salts thereof which are useful as antibiotics. This invention also provides pharmaceutical compositions containing such compounds; methods for treating bacteria... | 03/11/2008 |
| 7339055 | Process for the preparation of cephalosporin antibiotic A process for the preparation of cephalosporin antibiotic of the formula (I) which comprises: (i) activating the compound of formula (III) as acid halide in an organic solvent | 03/04/2008 |
| 7332471 | Cross-linked glycopeptide-cephalosporin antibiotics This invention provides cross-linked glycopeptide—cephalosporin compounds and pharmaceutically acceptable salts thereof which are useful as antibiotics. This invention also provides pharmaceutical compositions containing such compounds; methods for treating bacter... | 02/19/2008 |
| 7125986 | Penicillanic acid derivative compounds and methods of making Compounds of formula I: wherein R1, R2, R3, R4 and n have any of the values defined in the specification, and their pharmaceutically acceptable salts, are useful for in... | 10/24/2006 |
| 7092864 | Signal override for simulation models A method, system, and data structure for overriding a signal during model simulation. An override signal port is instantiated within a model for delivering an override signal from an instrumentation entity to a signal selection means, wherein the signal selection me... | 08/15/2006 |
| 6995134 | Use of yneS, essential bacterial genes and polypeptides Disclosed is a gene, termed “S-yneS,” found in Streptococcus pneumoniae, which is essential for survival for a wide range of bacteria. This gene and the S-yneS polypeptide that it encodes, as well as homologs and orthologs thereof (collectively referred t... | 02/07/2006 |
| 6974797 | Cross-linked glycopeptide-cephalosporin antibiotics This invention provides cross-linked glycopeptide—cephalosporin compounds and pharmaceutically acceptable salts thereof which are useful as antibiotics. This invention also provides pharmaceutical compositions containing such compounds; methods for treating bacter... | 12/13/2005 |
| 6916801 | 7-Alkylidene-3-substituted-3-cephem-4-carboxylates as β-lactamase inhibitors The invention provides compounds of formula (I): wherein: R1-R4 and A have any of the values defined in the specification, and their pharmaceutically acceptable salts, are useful for inhibiting β... | 07/12/2005 |
| 6906054 | Compositions for inhibiting beta-lactamase The invention provides pharmaceutical compositions comprising compounds of formula I and IV: wherein R1-R11 and A have any of the values defined in the specification, and ... | 06/14/2005 |
| 6599892 | 7-alkylidene cephalosporanic acid derivatives and methods of using the same Derivatives of 7-alkylidene cephalosporanic acid sulfone and the pharmaceutically active salts thereof are found to be potent inhibitors of ଲ-lactamase enzymes.... | 07/29/2003 |
| 6599893 | Cephalosporin antibiotics and prodrugs thereof The present invention relates to chemical compounds having the formula: ##STR1## or a pharmaceutically acceptable salt thereof. R1 is selected from the group consisting of: ##STR2## R2 is selected from the group consisting of hydroge... | 07/29/2003 |
| 6531465 | Antibacterial cephalosporins A compound of formula ##STR1## wherein Ac, R1 and R2 have various meanings, a process for a preparation thereof and its use as a pharmaceutical, i.e. as antibacterial agent.... | 03/11/2003 |
| 6486149 | Composition comprising a crystallographically stable, amorphous cephalosporin and processes for the preparation thereof Processes are provided for the preparation of orally administrable, yellow and powdery compositions essentially consisting of particles composed of a homogeneous mixture of an amorphous Cefditoren pivoxil substance with a water soluble high-molecular addi... | 11/26/2002 |
| 6440957 | Cephalosporines having cyclic aminoguanidine substituents as antibiotics A compound useful as an anti-bacterial agent, having the formula ##STR1## wherein R2 together with the nitrogen atom to which it is attached forms a cyclic aminoguanidine group or derivative thereof as defined ##STR2## ##STR3##... | 08/27/2002 |
| 6407091 | ଲ-lactamase inhibiting compounds The invention provides compounds of formula I and IV: ##STR1## wherein R1 -R11 and A have any of the values defined in the specification, and their pharmaceutically acceptable salts, are useful for inhibiting ଲ-lactamase enzyme... | 06/18/2002 |
| 6303592 | 7-alkylidene cephalosporanic acid derivatives and methods of using the same Derivatives of 7-alkylidene cephalosporanic acid sulfone and the pharmaceutically active salts thereof are found to be potent inhibitors of ଲ-lactamase enzymes.... | 10/16/2001 |
| 6159961 | Cephem compounds A compound of the formula: ##STR1## wherein R1 is amino or protected amino, R2 is hydrogen or hydroxy protective group, R3 is carboxy or protected carboxy, R4 is hydrogen, lower alkenyl, acyloxy(lower)alkenyl, option... | 12/12/2000 |
| 6159706 | Application of enzyme prodrugs as anti-infective agents The present invention provides a method for targeting toxic antimetabolites to gram negative infections. It provides a means of taking advantage of a key disease resistance mechanism to activate these drugs locally, and to overcome the resistance phenotyp... | 12/12/2000 |
| 6150350 | Antimicrobial compositions The invention relates to antimicrobial compositions comprising a combination of (1) a therapeutically effective amount of a compound of formula I ##STR1## with (2) a second ingredient selected from carbapenem antibiotics or with ଲ-lactamas... | 11/21/2000 |
| 6133254 | Use of aspirochlorine or derivatives thereof as immunosuppressive agents Use of a compound of formula (I) wherein R represents hydrogen or chlorine, for preparing an immunosuppressive medicament.... | 10/17/2000 |
| 6090801 | Pharmaceutical compositions containing ceftriaxone and penems Pharmaceutical formulations comprising ceftriaxone in combination with a penem of formula (I) in which R1 is hydrogen or an organic group; R2 is a ring system of formula (II), wherein R4 and R5 are hydrogen or o... | 07/18/2000 |
| 6087355 | Cephalosporin antibiotics The present invention includes novel compounds of formula ##STR1## where A, B, D, and E are selected from the group consisting of carbon, nitrogen and sulfur, R99 is selected from the group consisting of sulfur, SO, SO2, NH, N-a... | 07/11/2000 |
| 6066630 | Cephalosporin antibiotics The present invention includes novel compounds of formula ##STR1## where R99 is selected from the group consisting of sulfur, SO, SO2, NH, N-alkyl, oxygen, C.dbd.C (cis or trans), and C.tbd.C, and R12 is ##STR2##... | 05/23/2000 |
| 6063778 | Cephalosporin derivatives and processes for the preparation thereof The invention provides novel cephalosporin derivatives of the formula (I) ##STR1## and salts thereof for use in pharmaceutical compositions. Also novel precursors for synthesis of the cephalosporins are disclosed.... | 05/16/2000 |
| 6030965 | Cephalosporin antibiotics The present invention includes novel compounds of formula where A, B, D, and E are selected from the group consisting of carbon, nitrogen and sulfur, R99 is selected from the group consisting of sulfur, SO, S02, NH, N-alkyl, oxygen, ... | 02/29/2000 |
| 6025352 | Cephalosporin antibiotics The present invention includes novel compounds of formula ##STR1## where G, H, J, L and M are carbon or nitrogen, R99 is selected from the group consisting of sulfur, SO, SO2, NH, N-alkyl, oxygen, C.tbd.C (cis or trans), and C.t... | 02/15/2000 |
| 5994340 | Azetidinone derivatives as ଲ-lactamase inhibitors New 2-oxo-1-azetidine sulfonic acid derivatives with an aminoalkyl substituted "anti" (E-isomer) oxyimino group in the acylamino substituent at the 3 position of the monobactam ring. These compounds are potent inhibitors of bacterial ଲ-lactamases. T... | 11/30/1999 |
| 5958914 | Cephem compounds A compound of the formula: ##STR1## wherein R1 is amino, R2 is hydrogen, R3 is carboxy, R4 is heterocyclic(lower)alkylthio wherein said heterocyclic group is pyrazolyl and said lower alkyl group is methyl, and R... | 09/28/1999 |
| 5958915 | Antibacterial composition for oral administration A new, antibacterial composition for use in oral administration is now provided, which composition comprises a mixture of Cefditoren pivoxyl with a water soluble casein salt. This composition has a reduced bitter taste of Cefditoren pivoxyl and also has i... | 09/28/1999 |
| 5830884 | Pharmaceutical products containing thermally-inhibited starches Thermally-inhibited starches and flours are used in pharmaceutical products as a diluent, filler, carrier, binder, disintegrant, coating, thickener, moisture sink, and the like. The starches and flours are inhibited by dehydrating the starch or flour to s... | 11/03/1998 |
| 5827845 | Cephalosporin derivative A cephalosporin derivative which has a substituted or unsubstituted 2-(5-thiazolyl)vinyl group at the 3-position and is represented by the following formula (I) ##STR1## wherein X is CH or N, R1 is an amino group or a protected amino ... | 10/27/1998 |
| 5804577 | Cephalosporin derivatives The present invention relates to compounds of formula I ##STR1## wherein R1 is a group selected from 2-, 3-, and 4-hydroxyphenyl, 3-nitrophenyl, and 3-fluoro-4-hydroxyphenyl; as well as readily hydroyzable esters thereof, pharmaceutically ... | 09/08/1998 |
| 5736151 | Antibiotic oil suspensions The present invention provides for the inclusion of small amounts of water in oil suspensions of active drugs, such as ceftiofur hydrochloride of formula I. The resulting suspensions have improved resuspendability. Improved resuspendability results in an ... | 04/07/1998 |
| 5728691 | Quinolonylcarboxamidocephalosporin derivatives and pharmaceutical compositions containing them Derivatives of 7-aminoceph-3-em-4-carboxylic acid with 6-fluoroquinolone derivatives in which the cephem and 6-fluoroquinolone moieties are bound to each other through a carboxamido bond as well as the pharmaceutical compositions containing them are descr... | 03/17/1998 |
| 5721229 | Soluble forms of cephalosporins and treatment of animals A dry solid mixture of a hydroxypolycarboxylic acid and a cephalosporin where the hydroxypolycarboxylic acid of the formula ##STR1## where x and y are 0 or 1 and z is 0 to 3, in the weight ration of hydroxypolycarboxylic acid to cephalosporin of at l... | 02/24/1998 |
| 5712268 | Compositions of tricyclic ଲ-lactams and uses thereof There are described pharmaceutical compositions comprising (a) compounds of the formula ##STR1## in which R signifies lower alkoxycarbonyl, lower alkoxy-carbonylamino, the acyl residue of an - or ଲ-amino acid or a residue of the general... | 01/27/1998 |
