Did You Know...
...that one person who claimed to be the inventor of the television is Russian emigre Vladimir Zworykin? In 1929 David Sarnoff, founder of RCA, asked Zworykin what it would take to develop TV for commercial use. He said: a year and a half and $100,000. In reality, it took 20 years and $50 million! Before his death in 1982 at the age of 92, Zworykin said of his invention: "The technique is wonderful. It is beyond my expectations. But the programs! I would never let my children even come close to this thing."
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| Number | Title | Issue Date |
| 7341993 | Cross-linked glycopeptide—cephalosporin antibiotics This invention provides cross-linked glycopeptide-cephalosporin compounds and pharmaceutically acceptable salts thereof which are useful as antibiotics. This invention also provides pharmaceutical compositions containing such compounds; methods for treating bacteria... | 03/11/2008 |
| 7279487 | Hydroxynaphthyridinone carboxamides useful as HIV integrase inhibitors Hydroxynaphthyridinone carboxamides of formula: are described as inhibitors of HIV integrase and inhibitors of HIV replication, wherein L, R1a, R1b, R1c, R2a, R2b | 10/09/2007 |
| 7262183 | Substituted 5-membered n-heterocyclic compounds and their uses for treating or preventing neurodegenerative diseases This invention relates to substituted 5-membered N-Herterocyclic neurotrophic compounds of formula (I) or pharmaceutically acceptable salts or hydrates thereof, wherein R1, R2, R3, R4, V, W, X, Y, and Z are as defined in t... | 08/28/2007 |
| 6906054 | Compositions for inhibiting beta-lactamase The invention provides pharmaceutical compositions comprising compounds of formula I and IV: wherein R1-R11 and A have any of the values defined in the specification, and ... | 06/14/2005 |
| 6613807 | Therapeutic polyanhydride compounds for drug delivery Polyanhydrides which link low molecular weight drugs containing a carboxylic acid group and an amine, thiol, alcohol or phenol group within their structure into polymeric drug delivery systems are provided. Also provided are methods of producing polymeric... | 09/02/2003 |
| 6599892 | 7-alkylidene cephalosporanic acid derivatives and methods of using the same Derivatives of 7-alkylidene cephalosporanic acid sulfone and the pharmaceutically active salts thereof are found to be potent inhibitors of ଲ-lactamase enzymes.... | 07/29/2003 |
| 6489319 | Neurotherapeutic use of carboxypeptidase inhibitors Administration of inhibitors of carboxypeptidase E provides significant neurotropic effects in warm-blooded vertebrates evidenced inter alia by anxiolytic and anti-aggressive behavior and enhanced cognition. Certain ଲ-Lactam antibiotics, most signif... | 12/03/2002 |
| 6486214 | Polyanhydride linkers for production of drug polymers and drug polymer compositions produced thereby Polyanhydrides which link low molecular weight drugs containing a carboxylic acid group and an amine, thiol, alcohol or phenol group within their structure into polymeric drug delivery systems are provided. Also provided are methods of producing polymeric... | 11/26/2002 |
| 6303592 | 7-alkylidene cephalosporanic acid derivatives and methods of using the same Derivatives of 7-alkylidene cephalosporanic acid sulfone and the pharmaceutically active salts thereof are found to be potent inhibitors of ଲ-lactamase enzymes.... | 10/16/2001 |
| 6013647 | Benzoxazinedione derivatives, method of producing them and uses thereof This invention relates to new benzoxazinedione derivatives corresponding to the formula I: ##STR1## wherein R1 =H or carboxyalkyl, R2 =H, alkyl or phenyl, and R3 represents different acid groups derived from amino aci... | 01/11/2000 |
| 5994340 | Azetidinone derivatives as ଲ-lactamase inhibitors New 2-oxo-1-azetidine sulfonic acid derivatives with an aminoalkyl substituted "anti" (E-isomer) oxyimino group in the acylamino substituent at the 3 position of the monobactam ring. These compounds are potent inhibitors of bacterial ଲ-lactamases. T... | 11/30/1999 |
| 5994086 | Method for assessing infertility by binding of mannose to sperm cells Methods for labeling mannose lectins on the surface of mammalian sperm cells are described, and methods of categorizing and quantifying the numbers of cells exhibiting particular labeling patterns are also provided. These methods provide ways of detecting... | 11/30/1999 |
| 5681563 | 7-vinylidene cephalosporins and methods of using the same Cephalosporins with an exocyclic allene in the 7-position and their pharmaceutically active salts are potent inhibitors of ଲ-lactamases and are therefore useful in the treatment of penicillin resistant infections.... | 10/28/1997 |
| 5663162 | Cephem derivatives Compounds represented by the following formula (I), that is, cephem derivatives having substituted or unsubstituted imidazo[5,1-b]thiazolium-6-yl as a substituent at the 3-position of the cephem ring: ##STR1## wherein X represents CH or N, R | 09/02/1997 |
| 5629306 | 7-alkylidene cephalosporanic acid derivatives and methods of using the same Derivatives of 7-alkylidene cephalosporanic acid sulfone and the pharmaceutically active salts thereof are found to be potent inhibitors of ଲ-lactamase enzymes.... | 05/13/1997 |
| 5602117 | Cephalosporin compounds ଲ-lactam antibiotics of formula (I) or a salt thereof, wherein R1 is hydrogen, methoxy of formamido; R2 is an acyl group, in particular that of an antibacterially active cephalosporin; CO2 R3 is a carboxy ... | 02/11/1997 |
| 5597817 | 7-vinylidene cephalosporins and methods of using the same Cephalosporins with an exocyclic allene in the 7-position and their pharmaceutically active salts are potent inhibitors of ଲ-lactamases and are therefore useful in the treatment of penicillin resistant infections.... | 01/28/1997 |
| 5514561 | Fluorogenic and chromogenic ଲ-lactamase substrates Chromogenic and fluorogenic substrates for ଲ-lactamase, methods for synthesis thereof and methods for detecting ଲ-lactamase in a sample are provided. The substrates are substantially colorless or substantially nonfluorescent ଲ-lactam com... | 05/07/1996 |
| 5446037 | 2-[(substituted) methylene]cephalosporin sulfones as antiinflammatory, antidegenerative and antithrombin agents This invention relates to 2-[(substituted)methylene]cephalosporin sulfones and in particular 2-[(heteroaryl substituted)methylene]cephalosporin sulfones which are effective elastase inhibitors as well as effective thrombin inhibitors and therefore are use... | 08/29/1995 |
| 5436250 | Isatineoxime derivatives, their preparation and use A compound having the formula ##STR1## wherein R4 and R5 independently are hydrogen, halogen, CF3, CN, NO2 or SO2 NR1 R2 wherein R1 is hydrogen or C1-6 -alk... | 07/25/1995 |
| 5409917 | Topical treatment of acne with cephalosporins A method and composition for topically treating acne and acneiform dermal disorders includes applying an amount of a cephalosporin antibiotic effective to treat the acne and acneiform dermal disorders. The antibiotic is blended with a carrier suitable for... | 04/25/1995 |
| 5364848 | Substituted cephalosporin sulfones as anti-inflammatory and antidegenerative agents New substituted cephalosporin sulfones are found to be potent elastase inhibitors and thereby useful anti-inflammatory/antidegenerative agents.... | 11/15/1994 |
| 5348951 | Cephalosporins Cephalosporin compounds having a 3-position substituent of the formula (I) are described, --CH2 --Y--Q (I) wherein Y is a bond or a linking group --NR4 --Y'--, --O--Y'--, --S--Y'-- wherein R4 | 09/20/1994 |
| 5312813 | Biofilm reduction method A method of killing microorganisms which form a biofilm on a tissue or implant surfaces in a patient, and which are refractory to a biocide at a dose which is effective to kill the microorganism in planktonic form. The effect of the biocide is potentiated... | 05/17/1994 |
| 5275816 | Cephalosporin derivatives 7 -formamido cephalosporin derivatives having a 3[N-(optionally substituted)aminothiopyridinium thiomethyl] substituent have anti-bacterial activity and are of use in anti-bacterial therapy. Processes for the preparation thereof and intermediates f... | 01/04/1994 |
| 5264429 | 2-spirocyclopropyl cephalosporin sulfone derivatives Derivatives of 2-spirocyclopropyl cephalosporin sulfone of the structural formula I ##STR1## are provided which are useful as potent elastase inhibitors.... | 11/23/1993 |
| 5262410 | 3-heterocyclic thiomethyl cephalosporins Cephalosporin compounds having a 3-position substituent of the formula (I) are described: --CH2 --S--Q--(Y)n --P wherein Q is a 5- or 6-membered heterocyclic ring, P is a benzene ring substituted by groups R1 and R2 ... | 11/16/1993 |
| 5258377 | 2-spirocyclopropyl 4-acylcephems Derivatives of 2-spirocyclopropyl 4-acylcephem sulfones of the formula (I) ##STR1## are provided which are useful as potent elastase inhibitors and hence are useful in the prevention, control and treatment of inflammatory conditions, especially arthr... | 11/02/1993 |
| 5246926 | Cephalosporin derivatives ଲ-Lactam compounds of the formula (Ia) including pharmaceutically acceptable salts and in vivo hydrolysable esters, processes for their preparation and their use as antibiotics: ##STR1## wherein R1 is hydrogen, methoxy or formamido; ... | 09/21/1993 |
| 5232918 | Cephalosporin derivatives Cephalosporin derivatives having a 3-position substituent of formula I are described: ##STR1## wherein R1 is hydrogen, alkenyl or optionally substituted alkyl, Het is a 5- or 6-membered heterocyclic ring bonded via a carbon atom to the ... | 08/03/1993 |
| 5219848 | Cephem compounds Cephalosporin antibiotics having a 3-position substituent of the formula: ##STR1## are described, wherein X is --CO--, --SO2 -- or --COCH2 --; Y is --CO--, --SO2 -- or --CH2 --; Q is a benzene, pyridine or ... | 06/15/1993 |
| 5214037 | Thioalkylthio cephalosporin derivatives A novel thioalkylthio cephalosporin antibiotic compound of formula I: ##STR1## wherein Acyl is C1 -C12 acyl; Het is optionally substituted monocyclic heteroaromatic group containing one or more hetero atoms; R1 is a s... | 05/25/1993 |
| 5190748 | Absorption enhancement of antibiotics The absorption of antibiotics given through oral and rectal routes of administration is significantly enhanced by use of the antibiotic in conjunction with a two-component absorption enhancing system made up of an ether of a C6 to C18 | 03/02/1993 |
| 5158946 | Cephalosporin derivatives and pharmaceutical compositions ଲ-Lactam compounds of the formula (I) including pharmaceutically acceptable salts and in vivo hydrolysable esters, processes for their preparation and their use as antibiotics: ##STR1## wherein R1 is hydrogen, methoxy or formamido; R... | 10/27/1992 |
| 5147871 | Anti-bacterial cephalosporin compounds There are presented anti-bacterial cephalosporins having broad antimicrobial activity of the formula ##STR1## wherein R1 is an antibiotically active quinolonyl; R2 is selected from the group consisting of hydrogen, lower alkoxy,... | 09/15/1992 |
| 5143910 | Piperaziniocephalosporins Antibacterial hydroxyarylpiperazinocephalosporins of the formula: ##STR1## wherein R1 is amino or acylamino; R2 is H or methoxy; R3 is alkyl; R4 is --(P--C--Q)n --, where P and Q each are H, alkyl or ... | 09/01/1992 |
| 5134138 | Phenacylpyridiniothiocephalosporins An antibacterial 3-vic-dihydroxyaroylmethylpyridiniothiomethyl cephalosporin (I) and its salts represented by the following formula: ##STR1## (wherein, R1 is amino group or acylamino; R2 is hydrogen or methoxy; R3 is ... | 07/28/1992 |
| 5132301 | Substituted cephalosporin sulfones as anti-inflammatory and anti-degenerative agents New substituted cephalosporin sulfones are found to be potent elastase inhibitors and thereby useful anti-inflammatory/antidegenerative agents.... | 07/21/1992 |
| 5114933 | Cephalosporin compounds Cephalosporin compounds having a 3-position substituent of the formula (I) are described: --CH2 --Y--Q (I) wherein Y is a bond or a linking group --NR4 --Y'--, --O--Y'--, 13 S--Y'-- wherein R4... | 05/19/1992 |
| 5106842 | Antibiotic C-3 cyclobutenedione substituted (1-carba)cephalosporin compounds, compositions, and methods of use thereof A compound of formula I ##STR1## wherein X is sulfur or CH2 ; R1 is hydrogen, hydroxy, amino, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, phenyl optionally substituted with one to three C1-6 | 04/21/1992 |
