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"The abolishment of pain in surgery is a chimera. It is absurd to go on seeking it...knife and pain are two words in surgery that must forever be associated in the consciousness of the patient."
Dr. Alfred Velpeau, French surgeon ; 1839
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| Number | Title | Issue Date |
| 7776829 | Use of 15-deoxyspergualin for the treatment of hyperreactive inflammatory diseases and autoimmune diseases The invention describes the use of deoxyspergualin (DSG) or an analogue thereof for the preparation of a medicament for the treatment of and/or prophylaxis against hyperreactive inflammatory diseases and autoimmune diseases, wherein the treatment is performed in cyc... | 08/17/2010 |
| 7759314 | Treatment of muscular dystrophies and related disorders The invention provides, among other aspects, compositions and methods for treating, preventing, and diagnosing diseases or conditions associated with an abnormal level or activity of biglycan; diseases or conditions associated with an abnormal level or activity of c... | 07/20/2010 |
| 7700565 | Peptide nucleic acid based guanidinium compounds Disclosed herein are transmembrane transporter compounds containing guanidinium groups to enhance transport of a polymer backbone across biomembranes. Therapeutic and other biologically active moieties may be attached to the compounds. The polymer backbone may inclu... | 04/20/2010 |
| 7348333 | Cycloalkyl derivatives as inhibitors of bone resorption and vitronectin receptor antagonists There are described cycloalkyl derivatives of the formula (I) R1—Y-A-B-D-E-F-G (I) in which R1, Y, A, B, D, E, F and G have the meaning indicated herein, their preparation and their use as medicaments. The compounds a... | 03/25/2008 |
| 7322369 | Methods of detaching microorganisms from, or of inhibiting microbial attachment to, animal or poultry carcasses or seafood or parts thereof Methods of detaching microorganisms (e.g., bacteria) from, or of inhibiting microbial (e.g., bacterial) attachment to, animal or poultry carcasses or seafood or parts thereof, wherein the method involves contacting animal or poultry carcasses or seafood or parts the... | 01/29/2008 |
| 7297689 | Method for preparing peritoneal dialysate Carbonyl compounds generated and accumulated in the peritoneal dialysate can be inactivated or eliminated by a carbonyl compound-trapping agent such as aminoguanidine. Carbonyl compounds generated during sterilization and storage of the peritoneal dialysate can be e... | 11/20/2007 |
| 7288526 | Dipeptide and related compounds which inhibit leukocyte adhesion mediated by VLA-4 Disclosed are compounds which bind VLA-4. Certain of these compounds aslo inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such compounds are useful in the treatment of inflammatory diseases in a mammalian patient, e.g., human, su... | 10/30/2007 |
| 7256176 | Methods of modulating β cell function Methods of modulating pancreatic function by modulating MCH signaling in a β cell. ... | 08/14/2007 |
| 7232803 | Antimicrobial compounds and formulations The invention relates to the use of a molecule comprising a backbone of 2 to 35 non-hydrogen atoms in length, having covalently attached thereto at least two bulky and lipophilic groups and having at least one more cationic than anionic moiety, in the manufacture of... | 06/19/2007 |
| 7205291 | Carbapenem compounds A compound or its pharmaceutically acceptable salt represented by the following formula: The invention is a carbapenem compound which has a potent antibacterial activity over a broad range of Gram negative and Gr... | 04/17/2007 |
| 7169814 | Guanidinium transport reagents and conjugates Transport reagents and conjugates of therapeutic agents linked to transport reagents are described. In particular, the transport reagents have a plurality of guanidinium moieties that are either contiguous or spaced along a backbone, but are sufficiently removed fro... | 01/30/2007 |
| 7166580 | Compounds which inhibit leukocyte adhesion mediated by VLA-4 Disclosed are compounds which bind VLA-4. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such compounds are useful in the treatment of inflammatory diseases in a mammalian patient, e.g., human, su... | 01/23/2007 |
| 7163921 | Peptide derivatives and medicinal compositions The present invention to novel nociceptin receptor agonists which are peptide derivatives represented by the following general formula (1): (in which A is alkylene, —CH2) | 01/16/2007 |
| 7101855 | Pyroglutamic acid derivatives and related compounds which inhibit leukocyte adhesion mediated by VLA-4 Disclosed are pyroglutamic acid derivatives and related compounds which bind VLA-4. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such compounds are useful in the treatment of inflammatory diseas... | 09/05/2006 |
| 7067698 | Bi-directional synthesis of oligoguanidine transport agents Synthesis routes that can be adapted to large scale synthesis of oligoguanidine compounds such as oligoarginine compounds are described which use a perguanidinylation step to convert a group of ω-amino groups to the corresponding guanidinyl groups. These compounds ... | 06/27/2006 |
| 7060708 | Active agent delivery systems and methods for protecting and administering active agents The present invention relates to active agent delivery systems and more specifically to compositions that comprise amino acids, as single amino acids or peptides, covalently attached to active agents and methods for administering conjugated active agent compositions... | 06/13/2006 |
| 7034002 | Angiotensin converting enzyme inhibitor The present invention provides an angiotensin converting enzyme inhibitor having strong activity of inhibiting angiotensin converting enzyme, good hue and easily to take in which is a composition containing peptides obtained by digesting a fish meat with thermolysin... | 04/25/2006 |
| 7030213 | Conformationally stabilized cell adhesion peptides Novel synthetic Arg-Gly-Asp containing peptides which have high affinity and specificity for their receptors by virtue of restrictions on their stereochemical conformation. Such restrictions can be provided by cyclization, by inclusion into a constraining conformati... | 04/18/2006 |
| 7026297 | Neuroprotective agents Compounds of formula (I) wherein: Q represents an amidino group, a cyano group or a group of formula XYN—, (where X and Y are hydrogen or various groups); Ra represents alkylene; Rb and Rc each represents alkylene, the total number... | 04/11/2006 |
| 7022677 | Amide derivatives as growth hormone secretagogues Disclosed are the novel compounds as growth hormone secretagogues represented by structural Formula (I), wherein R1 is, substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted alkoxy, substituted or unsubs... | 04/04/2006 |
| 7005433 | Heteroaryl, heterocyclic and aryl compounds which inhibit leukocyte adhesion mediated by VLA-4 Disclosed are compounds which bind VLA-4. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such compounds are useful in the treatment of inflammatory diseases in a mammalian patient, e.g., human, su... | 02/28/2006 |
| 6962905 | Pharmaceutical formulation comprising a low molecular weight thrombin inhibitor and its prodrug A kit of parts containing (a) a pharmaceutical formulation including a low molecular weight thrombin inhibitor, or a pharmaceutically acceptable derivative thereof, in admixture with a pharmaceutically acceptable adjuvant, diluent or carrier, and (b) a pharmaceutica... | 11/08/2005 |
| 6939855 | Anti-inflammatory compositions and method The disclosed invention includes pharmaceutical compositions and methods for treating inflammatory conditions, particularly those that are characterized by increased binding of alpha-9 integrin to one or more of its ligands. Also disclosed are methods for selecting ... | 09/06/2005 |
| 6906092 | Method of inhibiting matrix metalloproteinases The present invention relates to a method of inhibiting matrix metalloproteinases using compounds that are dibenzofuran sulfonamide derivatives having the Formula I More particularly, the present invention relates to a m... | 06/14/2005 |
| 6906199 | Process for preparing distamycin derivatives It is described a process for preparing, in high yields and purity and without the need of carrying out several steps and/or isolating many intermediates which could lead to undesired by-products, a distamycin derivative of formula | 06/14/2005 |
| 6869934 | Method of purifying calcium ion-binding protein The present invention relates to a method for purifying a calcium ion-binding protein by cation exchange chromatography. The present invention provide a method for isolating and purifying a calcium ion-binding protein in a simple and efficient manner from a liquid s... | 03/22/2005 |
| 6833136 | Vaccine for preventing pythiosis in humans and animals The present invention provides antigen vaccines and methods of use thereof for the treatment of Pythium insidiosum infections, as well as prophylaxis against these infections, in humans and mammals. Further, the present invention provides a method for prepari... | 12/21/2004 |
| 6797699 | Neuroprotective agents Compounds of formula (I) wherein: Q represents an amidino group, a cyano group or a group of formula XYN—, (where X and Y are hydrogen or various groups); Ra represents alkylene; Rb and Rc each represents alkylene, the total number... | 09/28/2004 |
| 6753316 | Acryloyl derivatives analogous to distamycin, process for preparing them, and their use as antitumor agents Compounds which are acryloyl substituted distamycin derivatives of formula (I) wherein: n is 2, 3 or 4; m is 1 or 2; X and Y are the same or different and are selected, independently for each heterocyclic ring of the polyetherocyclic chain, from N and CH; R1 | 06/22/2004 |
| 6689754 | Heterocyclic glycyl ଲ-alanine derivatives The present invention relates to a class of compounds represented by the Formula I ##STR1## or a pharmaceutically acceptable salts thereof, pharmaceutical compositions containing such compounds and methods of treating conditions mediated by the ... | 02/10/2004 |
| 6566330 | Positively charged non-natural amino acids, methods of making and using thereof in peptides This invention relates to positively charged non-natural amino acids, methods of making thereof, and utilization thereof in peptides.... | 05/20/2003 |
| 6503881 | Compositions and methods for treating infections using cationic peptides alone or in combination with antibiotics Compositions and methods for treating infections, especially bacterial infections, are provided. Indolicidin peptide analogues containing at least two basic amino acids are prepared. The analogues are administered as modified peptides, preferably containi... | 01/07/2003 |
| 6492350 | Chitin oligosaccharides and/or chitosan oligosaccharides for preventing or treating common cold or treating pain A new method is presented which is useful in the prevention of the common cold (also called non-allergic rhinitis, viral upper respiratory tract infection, viral URI, etc and for this presentation will be referred to as the "common cold") in mammals, incl... | 12/10/2002 |
| 6455502 | Compounds and compositions as protease inhibitors The present invention relates to novel N-cyanomethyl amides which are cysteine protease inhibitors, the pharmaceutically acceptable salts and N-oxides thereof, their uses as therapeutic agents and the methods of their making.... | 09/24/2002 |
| 6440937 | Dipeptide benzamidine as a kininogenase inhibitor Compounds of the formula I ##STR1## where R, R1, R2, R3, R4, R5 and R6, and l, m and n have the meanings stated in the description, and their preparation are described. The novel compounds ... | 08/27/2002 |
| 6433017 | Amphiphilic polyamine compounds In accordance with the present invention, there are provided amphiphilic polyamine compounds and derivatives thereof having the property of promoting transfection of polynucleotides and polypeptides into cells, and formulations comprising said compounds.... | 08/13/2002 |
| 6417161 | Amino acid amidinohydrazones, alkoxyguanidines and aminoguanidines as protease inhibitors The present invention is directed to aminoguanidine and alkoxyguanidine compounds, including compounds of Formula I: ##STR1## wherein X is O or NR19 and A1, A2, R7 -R10, R18, Ra,... | 07/09/2002 |
| 6410598 | Compositions and methods for advanced glycosylation endproduct-mediated modulation of amyloidosis The present invention relates generally to the non-enzymatic glycosylation of amyloidogenic proteins and the consequent formation of advanced glycosylation endproducts (AGEs). It has been found that formation of AGE-amyloidogenic proteins can enhance amyl... | 06/25/2002 |
| 6362165 | Hydroxyphenyl derivatives with HIV integrase inhibitory properties An hydroxyphenyl derivative selected from the group consisting of a compound of formula ##STR1## and when a compound of formula I comprises a carboxylic acid group pharmaceutically acceptable salts thereof and when a compound of formula I comprises a... | 03/26/2002 |
| 6358928 | Peptidyl sulfonyl imidazolides as selective inhibitors of serine proteases Novel -amino and peptidyl sulfonyl imidazolides, a method for their synthesis, and a method for inhibiting serine proteases therewith are disclosed. Pharmaceutical compositions containing -amino and peptidyl sulfonyl imidazolides and their u... | 03/19/2002 |
