Did You Know...
...that the inventor of the electric motor was a blacksmith named Thomas Davenport? Described as "a brilliantly unsuccessful inventor", Davenport invented the first rotary electric motor. In 1836 he headed out -- on foot -- from his Vermont home to file a patent application at the Patent Office in Washington, D.C. By the time he got there, he had squandered away his money and couldn't afford the $30 filing fee so he turned around and went home. When he later mailed in his application with money he'd raised, the Patent office was destroyed in a fire. He did finally get credit for his invention on Feb. 5, 1837.
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| Number | Title | Issue Date |
| 7534781 | Crystalline amoxicillin trihydrate powder The invention relates to crystalline amoxicillin trihydrate powder having a bulk density higher than 0.45 g/ml. The invention also relates to a process for preparing crystalline amoxicillin trihydrate powder, said process comprising: crystallizing amoxicillin trihyd... | 05/19/2009 |
| 7250176 | Method of treating a bacterial infection Bacterial infections may be treated using a high dosage regimen of amoxicillin and potassium clavulanate. Preferably, the dosage is provided by a bilayer tablet. ... | 07/31/2007 |
| 7208497 | Substituted piperazines and diazepanes A novel class of substituted piperazines and diazepanes, pharmaceutical compositions comprising them and use thereof in the treatment of diseases and disorders related to the histamine H3 receptor. More particularly, the compounds are useful for the treatment of dis... | 04/24/2007 |
| 7166626 | Therapeutic treatment for sexual dysfunction A method for improving sexual function is described. A mammal suffering from sexual dysfunction or otherwise in need of enhanced sexual function is administered a compound selected from those that are capable of inhibiting the activity of β-lactams, penicillin-bind... | 01/23/2007 |
| 6979735 | Agglomerates by crystallization The present invention describes novel agglomerates in crystalline form of β-lactam compounds. Furthermore, a process for the preparation of said agglomerates, wherein a solution or suspension of at least one β-lactam compound in a solvent is mixed with one or more... | 12/27/2005 |
| 6627625 | Treatment of behavioral disorders with ଲ-lactam compounds Administration of ଲ-lactam compounds including ଲ-lactam antibiotics and ଲ-lactamase inhibitors provides significant neurotropic effects in warm-blooded vertebrates evidenced inter alia by anxiolytic and anti-aggressive behavior modificat... | 09/30/2003 |
| 6613807 | Therapeutic polyanhydride compounds for drug delivery Polyanhydrides which link low molecular weight drugs containing a carboxylic acid group and an amine, thiol, alcohol or phenol group within their structure into polymeric drug delivery systems are provided. Also provided are methods of producing polymeric... | 09/02/2003 |
| 6511972 | Pharmaceutical suspension formulation comprising amoxycillin clavulanic acid and cellulose A liquid aqueous pharmaceutical suspension formulation containing as amoxycillin trihydrate, potassium clavulanate and microcrystalline cellulose filler is provided.... | 01/28/2003 |
| 6495539 | B-lactam-like chaperone inhibitors Compounds of the formula ##STR1## and the salts, esters and amides thereof wherein Z is S, SO, SO2 or O; each of R1, R2 and R3 is independently H or substituted or unsubstituted alkyl (1-10C), substituted or unsubsti... | 12/17/2002 |
| 6489317 | Method for eradication of Helicobacter pylori The invention provides methods for the treatment and/or prevention of recurrence of a gastrointestinal disorder associated with Helicobacter pylori in a patient requiring said treatment and/or prevention, which comprise administering to the patient a ther... | 12/03/2002 |
| 6486214 | Polyanhydride linkers for production of drug polymers and drug polymer compositions produced thereby Polyanhydrides which link low molecular weight drugs containing a carboxylic acid group and an amine, thiol, alcohol or phenol group within their structure into polymeric drug delivery systems are provided. Also provided are methods of producing polymeric... | 11/26/2002 |
| 6436398 | 2 ଲ-substituted-6-alkylidene penicillanic acid derivatives as ଲ-lactamase inhibitors Compound of formula I: ##STR1## wherein R1, R2, R3, R4 and n have any of the values defined in the specification, and their pharmaceutically acceptable salts, are useful for inhibiting ଲ-lactamase enzymes,... | 08/20/2002 |
| 6380181 | Synthetic catechol derivatives, method for production and use thereof Catechol derivatives of general formula (I) ##STR1## in which R1 denotes O-acyl and R2 represents amino acid residues in the 3- and/or 4-position function as siderophores and/or as biological chelating agents for iron in gram-negativ... | 04/30/2002 |
| 6316015 | Hyperbactericidal surfaces A surface is provided with antibiotic or antiseptic properties. A solid substrate is modified by covalently fixing one or more spacers having reactive extremities via a proximate reactive extremity, and one or more antibiotic, bactericidal, viricidal or f... | 11/13/2001 |
| 6294526 | Use of flavone derivatives for induction of ଲ-lactam-sensitivity of MRSA A novel screening system for detecting a non-antibiotic compound having ଲ-lactam-sensitivity-inducing activity comprising a non-antibiotic compound and a ଲ-lactam antibiotic two times serially diluted series and a pharmaceutical composition ha... | 09/25/2001 |
| 6232305 | Substituted amino bicyclic-ଲ-lactam penam and cepham derivatives as cysteine protease inhibitors The present invention provides substituted amino bicyclic-ଲ-lactam penam derivatives and substituted amino bicyclic-ଲ-lactam cepham derivatives and their diastereoisomers of formula I, as well as compositions, methods of making, and methods of... | 05/15/2001 |
| 6177421 | Amoxicillin and clavulanate composition A storage-stable combination of at least one ଲ-lactam antibiotic and at least one ଲ-lactam inhibitor compressed into tablet form having a hardness of greater than 30 KP is disclosed.... | 01/23/2001 |
| 6156745 | 2ଲ-substituted-6-alkylidene penicillanic acid derivatives as ଲ-lactamase inhibitors Compounds of formula I: ##STR1## wherein R1, R2, R3, R4 and n have any of the values defined in the specification, and their pharmaceutically acceptable salts, are useful for inhibiting ଲ-lactamase en... | 12/05/2000 |
| 6127355 | High molecular weight polymer-based prodrugs The present invention is directed compositions of the formula: ##STR1## wherein: D is a residue of a biologically active moiety; X is an electron withdrawing group; Y and Y' are independently O or S; (n) is zero (0) or a positive integer, preferably from 1 to ... | 10/03/2000 |
| 6066629 | Storage stable amoxycillin and clavulanate suspension composition A dry powder formulation of antibiotic and ଲ-lactam inhibitor is provided which is suitable for use in a liquid suspension.... | 05/23/2000 |
| 6048852 | ଲ-thiopropionyl-aminoacid derivatives and their use as ଲ-lactamase inhibitors A method of treatment of bacterial infections in humans or animals which comprises administering, in combination with a ଲ-lactam antibiotic, a therapeutically effective amount of an amino acid derivative of Formula (I) or a pharmaceutically acceptab... | 04/11/2000 |
| 6013647 | Benzoxazinedione derivatives, method of producing them and uses thereof This invention relates to new benzoxazinedione derivatives corresponding to the formula I: ##STR1## wherein R1 =H or carboxyalkyl, R2 =H, alkyl or phenyl, and R3 represents different acid groups derived from amino aci... | 01/11/2000 |
| 5994340 | Azetidinone derivatives as ଲ-lactamase inhibitors New 2-oxo-1-azetidine sulfonic acid derivatives with an aminoalkyl substituted "anti" (E-isomer) oxyimino group in the acylamino substituent at the 3 position of the monobactam ring. These compounds are potent inhibitors of bacterial ଲ-lactamases. T... | 11/30/1999 |
| 5948773 | Formulation comprising antibacterial substance and antiulcer substance The present invention includes a formulation which comprises an antibacterial substance and an antiulcer substance, wherein at least either of them is formulated into a gastrointestinal mucosa-adherent solid preparation. The formulation of the present inv... | 09/07/1999 |
| 5900413 | Treatment of H. pylori infections An infection with Helicobacter may successfully be treated with a compound of the formula ##STR1## wherein R1 is hydrogen or methyl and R2 is hydrogen or L-alanine-L-alanyl, and the pharmaceutically acceptable acid additive ... | 05/04/1999 |
| 5883074 | Potentiators of antibacterial agents Methods for screening for compounds which potentiate the activity of antibacterial agents against bacteria resistant to the antibacterial agent alone, pharmaceutical compositions including such potentiators, and methods of treating bacterial infections us... | 03/16/1999 |
| 5849797 | D-ଲ-lysylmethanediamine derivatives and preparation thereof Now are provided (R)-3,6-diamino-N-(ω-aminoalkyl)-hexanamides which are novel compounds having the general formula (I): ##STR1## wherein n stands for 2-5, and which may be for example, (R)-3,6-diamino-N-(2-aminoethyl)hexanamide (n=2) and (R)-3,... | 12/15/1998 |
| 5801153 | Method of enhancing the antimicrobial properties of antibacterial antibiotics to massively control and prevent bacterial, fungal, and viral diseases in plants A method for controlling plant diseases utilizes a mixture of antibiotics and food additives or food preservatives. The mixture is sprayed on the plants twice per week for three weeks, then once every three weeks. Such a regimen has been found to cure pla... | 09/01/1998 |
| 5747483 | Penem derivatives, their preparation and pharmaceutical compositions containing them Penem derivatives of general formula (I), below, and pharmaceutically acceptable salts thereof are disclosed. ##STR1## wherein: R1 is H, C1 -C6 alkoxy, C3 -C7 cycloalkyl, or an optionally protect... | 05/05/1998 |
| 5681563 | 7-vinylidene cephalosporins and methods of using the same Cephalosporins with an exocyclic allene in the 7-position and their pharmaceutically active salts are potent inhibitors of ଲ-lactamases and are therefore useful in the treatment of penicillin resistant infections.... | 10/28/1997 |
| 5668130 | Medicament for treating gastrointestinal disorders The use is described of both (i) ranitidine bismuth citrate and (ii) one or more Helicobacter pylori-inhibiting antibiotics in treating or preventing gastrointestinal disorders. Pharmaceutical compositions containing both (i) and (ii) and methods for the ... | 09/16/1997 |
| 5474993 | Lactam inhibitors of cholesterol esterase The present invention is related to compounds which inhibit pancreatic cholesterol esterase. The compounds have the formula: ##STR1## wherein R1 is H or C1-6 alkyl; R2 is H or C1-6 alkyl; R3 is H or C... | 12/12/1995 |
| 5122377 | Oral delivery system for veterinary drugs A veterinary drug delivery system suitable for oral administration to animals comprising a suitable medication, a nonvolatile oil, silicone dioxide, capric/caprylic triglyceride and/or capric/caprylic/stearic triglyceride. Flavorings can be added to enhan... | 06/16/1992 |
| 5069899 | Anti-thrombogenic, anti-microbial compositions containing heparin Anti-thrombobenic, anti-microbial compositions containing heparin reacted with quaternary ammonium components and bound with water-insoluble polymers are disclosed. Such compositions may also contain additional quaternary ammonium compounds not reacted wi... | 12/03/1991 |
| 4997830 | Pharmaceutical composition for the treatment of periodontitis A pharmaceutical combination of Metronidazole and Amoxicillin for the treatment of periodontitis. Conventional therapeutic doses of both the Metronidazole and Amoxicillin given as a combination therapy has been unexpectedly found to effectively treat peri... | 03/05/1991 |
| 4988679 | Liquid sustained release composition There is provided an orally ingestible liquid composition for suspending therein an orally administrable pharmaceutically active composition releasable over an extended period of time comprises triglyceride of a medium chain length alkanoic acid or distil... | 01/29/1991 |
| 4966899 | Antibacterial lyophilized preparation of aspoxicillin An antibacterial lyophilized preparation which comprises as an active ingredient aspoxicillin and a basic salt of aspoxicillin in a molar ratio of 1 : about 0.7 to 7 and optionally an alkali metal halide as a stabilizer, and a method for preparing the sam... | 10/30/1990 |
| 4919932 | Pharmaceutical formulation for the treatment of bacterial infections A pharmaceutical formulation having a synergistic anti-bacterial activity and comprising (a) a cephalosporin derivative or a physiologically acceptable salt or ester thereof and (b) a penem antibiotic of the basic structure (B) ##STR1## or a physiolo... | 04/24/1990 |
| 4898728 | Process for production of composition containing lecithin and polyvinylpyrrolidone A process for the production of a sterile composition containing lecithin and polyvinyl pyrrolidone is disclosed in which the lecithin and polyvinyl pyrrolidone, optionally with one or more preservative powders are admixed in a solvent comprising about 75... | 02/06/1990 |
| 4898731 | Antibiotic combinations of penicillins An antibacterial synergistic composition consisting essentially of a mixture of a penicillin or cephalosporin derivative of the formula ##STR1## and a penicillin of the formula ##STR2## preferably in association with a pharmaceutical carrier.... | 02/06/1990 |
