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...that the first rickshaw was invented in 1869 by an American Baptist minister, the Rev. E. Jonathan Scobie, to transport his invalid wife around the streets of Yokohama?
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| Number | Title | Issue Date |
| 8138156 | Ophthalmic compositions containing diglycine Ophthalmic composition comprising one or more polyglycines selected from the group consisting of diglycine, triglycine, tetraglycine and pentaglycine, or the salts of each thereof and one or more boron buffering compounds. The ophthalmic composition will have an osm... | 03/20/2012 |
| 8097590 | α-MSH-antagonist dipeptide conjugates The invention relates to a dipeptide conjugate having general formula I, AA2-AA1-NH2, wherein A represent the radical corresponding to a monocarboxylic acid with general formula II, HOOC—R, in which: R represents a linear or branched aliphatic radical a... | 01/17/2012 |
| 8093216 | Method of treating cancer by inhibition of p95HER-2 production There is disclosed an initial identification of an N-terminally truncated HER-2/neu product. This product is a 95 kDa polypeptide having in vitro kinase activity (as determined by western blotting). Moreover, immunoprecipitations using domain specific antibodies was... | 01/10/2012 |
| 7985730 | 3-aminopyrrolidine derivatives as modulators of chemokine receptors The present invention relates to 3-aminopyrrolidine derivatives of the formula I: (wherein R1, R2, R3, R4, R5, R6, R7, R8, X, Y and X a... | 07/26/2011 |
| 7910553 | Peptidyl prodrugs that resist P-glycoprotein mediated drug efflux A method of treating a patient for a condition wherein the bioactive agent of choice is DRUG, wherein DRUG is a substrate that is effluxed by the P-gp transporter, is provided, the method comprising administering to the patient an effective amount of a compound of f... | 03/22/2011 |
| 7906486 | Method of treating or preventing tissue deterioration, injury or damage due to disease of mucosa An immunomodulatory compound is utilized to treat mucosa disease. ... | 03/15/2011 |
| 7884079 | 4-aminopyridine and a pharmaceutical composition for treatment of neuronal disorders A composition is provided having the formula where R1 and R2 are each independently H or a C1-C4 hydrocarbon; R3 is H, and R4 is a moiety capable of crossing... | 02/08/2011 |
| 7842671 | Peptidomimetic inhibitors of STAT activity and uses thereof The subject invention concerns compositions and methods for blocking cancer cell growth or proliferation and/or inducing cancer cell death. Compositions of the present invention are peptidomimetics that inhibit STAT function. Peptidomimetics of the invention include... | 11/30/2010 |
| 7829539 | Compounds and methods for reducing undesired toxicity of chemotherapeutic agents Novel compositions and formulations are disclosed that have use as toxicity-reducing agents for various chemotherapeutic agents and as treatment for certain diseases and conditions. The compositions of matter are amino acid and peptide heteroconjugated disulfides of... | 11/09/2010 |
| 7829541 | Compounds and methods for reducing undesired toxicity of chemotherapeutic agents Novel compositions and formulations are disclosed that have use as toxicity-reducing agents for various chemotherapeutic agents and as treatment for certain diseases and conditions. The compositions of matter are amino acid and peptide heteroconjugated disulfides of... | 11/09/2010 |
| 7829538 | Compounds and methods for reducing undesired toxicity of chemotherapeutic agents Novel compositions and formulations are disclosed that have use as toxicity-reducing agents for various chemotherapeutic agents and as treatment for certain diseases and conditions. The compositions of matter are amino acid and peptide heteroconjugated disulfides of... | 11/09/2010 |
| 7829540 | Compounds and methods for reducing undesired toxicity of chemotherapeutic agents Novel compositions and formulations are disclosed that have use as toxicity-reducing agents for various chemotherapeutic agents and as treatment for certain diseases and conditions. The compositions of matter are amino acid and peptide heteroconjugated disulfides of... | 11/09/2010 |
| 7816327 | Inhibition of allergic contact dermatitis by N-L-alpha-aspartyl-L-phenylalanine 1-methyl ester It has now been found that N-L-alpha-aspartyl-L-phenylalanine 1-methyl ester (APM) and/or one of its lower alkyl derivatives can be used to treat allergic contact dermatitis associated with irritating oils such as catechol-containing plant-derived antigens such as p... | 10/19/2010 |
| 7799762 | Acyl pseudodipeptides which carry a functionalised auxialiary arm The present invention is directed in particular to dipeptide-like compounds derived from functionally substituted amino acids, having fatty acid chains bound thereto through amidification of the amine functional groups of said dipeptide-like compounds, one end porti... | 09/21/2010 |
| 7786086 | Peptide nanostructures containing end-capping modified peptides and methods of generating and using the same A nanostructure composed of a plurality of peptides, each peptide containing at least one aromatic amino acid, whereby one or more of these peptides is end-capping modified, is disclosed. The nanostructure can take a tubular, fibrillar, planar or spherical shape, an... | 08/31/2010 |
| 7772190 | Didepsipeptide-based endoparasiticides, new didepsipeptides and process for preparing the same The present invention relates to the use of didepsipeptides of the general formula (I) and their salts in which the radicals have the meaning given in the description, and to new didepsipeptides and processe... | 08/10/2010 |
| 7767649 | Amino acid conjugates providing for sustained systemic concentrations of GABA analogues This invention is directed to compounds that provide for sustained systemic concentrations of GABA analogs following administration to animals. This invention is also directed to pharmaceutical compositions including and methods using such compounds. ... | 08/03/2010 |
| 7759313 | Induction method for cell differentiation The invention relates to peptide derivatives which function as differentiation-inducing factors. The peptide derivatives are useful for treating cancer, particularly melanoma, for increasing the efficacy of melanoma immunotherapy, and for reducing hematological toxi... | 07/20/2010 |
| 7754692 | Arginyl-glutamine dipeptide for treatment of pathological vascular proliferation The subject invention provides dipeptides useful in preventing pathological proliferation of blood vessels. The dipeptides of the subject invention are particularly advantageous because they are stable, bioavailable, and can be formulated in an aqueous solution.... | 07/13/2010 |
| 7749969 | N- or C- terminally modified small peptides N- or C-terminally modified small peptides having antiarrhythmic properties are disclosed, and in particular small peptides that possess improved pharmacokinetic properties such as having a reduced tendency to inhibit the activity of isozyme 3A4 of cytochrome P 450 ... | 07/06/2010 |
| 7745413 | Collection of traceable compounds and uses thereof The use of a collection of compounds of general formula (I), wherein: n is 0 or 1; p represents an integer between 1 and 6; r represents an integer between 1 and 12; R1 and R′1 represent in particular a hydrogen atom; R2 represents... | 06/29/2010 |
| 7727964 | Peptidomimetic inhibitors of post-proline cleaving enzymes The present invention relates to inhibitors of post-proline cleaving enzymes, such as inhibitors of dipeptidyl peptidase IV, as well as pharmaceutical compositions thereof, and methods for using such inhibitors. In particular, the inhibitors of the present invention... | 06/01/2010 |
| 7723308 | Plant-derived elastin binding protein ligands and methods of using the same The present invention describes novel plant derived elastin-like peptides and peptidomimetics that may serve as functional ligands for elastin receptors and stimulate elastogenesis. The novel plant derived peptides provide an alternative (non-animal derived) source ... | 05/25/2010 |
| 7723307 | Amino acid derivatives and pharmaceutical uses thereof Novel Amino Acid Derivatives and Pharmaceutical Uses Thereof Provided are novel compounds of Formula I: wherein ‘X’ represents an amino acid group, ‘n’ is an integer between 1 and 4, ‘R | 05/25/2010 |
| 7704957 | Composition for inhibiting HIV activity extracted from sp. (Tochu-kaso) J300 The present invention relates to a composition for inhibiting HIV activity comprising the extract of Paecilomyces sp. (Tochu-kaso) J300. More particularly, the present invention relates to a composition for inhibiting HIV activity comprising 3-[5-(methoxy-eth... | 04/27/2010 |
| 7683034 | Use of enzyme inhibitors of aminopeptidase N and/or dipeptidylpeptidase IV The invention relates to a process for the-inhibition of the DNA synthesis necessary for the proliferation of human sebaceous cells (sebocytes) by the isolated or joint effect of inhibitors of alanyl aminopeptidase (APN) and dipetidyl peptidase IV (DP IV) expressed ... | 03/23/2010 |
| 7671033 | Amphiphilic dendritic dipeptides and their self-assembly into helical pores An amphiphilic dendritic dipeptide, comprises a dipeptide(s) comprising one or more of a naturally occurring or synthetic amino acids and a dendron. These are suitable for use in various formulations, films, coatings, membranes and sensors, among other applications.... | 03/02/2010 |
| 7655631 | Pharmaceutical preparations and methods for inhibiting tumors The invention provides pharmaceutical compositions and method for inhibiting growth of prostatic adenocarcinoma, stomach cancer, breast cancer, endometrial, ovarian or other cancers of epithelial secretion, or benign prostate hyperplasia (BPH) In one embodiment the ... | 02/02/2010 |
| 7589066 | Potent and specific immunoproteasome inhibitors Compounds and methods of selectively inhibiting an immunoproteasome are described. Also described are methods of treating a cancer, an inflammation, and/or an autoimmune disease and methods of suppressing endogenous antigenic peptide generation by administering to a... | 09/15/2009 |
| 7589065 | Catalysis of the cis/trans-isomerisation of secondary amide peptide compounds The present invention is based on the finding that the cis/trans isomerisation of secondary amide peptide bonds in oligo- and polypeptides can be catalytically promoted. This catalysis is effected by enzymes which are hereinafter called “secondary amide peptide bo... | 09/15/2009 |
| 7585846 | Compounds for delivering amino acids or peptides with antioxidant activity into mitochondria and use thereof Disclosed are hydrophilic choline/N-heterocycle ester compounds containing single amino acids, peptides, or derivatives thereof which have the potential to express anti-oxidant activity capable of reducing reactive oxygen species in cells. These compounds may be use... | 09/08/2009 |
| 7579323 | Hemiasterlin analogs This invention provides analogs of hemiasterlin, methods of synthesis of the analogs and use of the analogs as cytotoxic and anti-mitotic agents. ... | 08/25/2009 |
| 7576062 | Compounds with growth hormone releasing properties Disclosed are compounds of formula I wherein R1, R2, R5, R6, R7, R8, G, J, L, M, a, b, c, d, e, and f are as defined in the specification, and compositions c... | 08/18/2009 |
| 7553816 | -amidobenzylethers in drug delivery agents Compounds of the formulas LAn-Z-X—WwD and BZ-X—WwD wherein: D is a drug moiety; L is a ligand; B is a blocking group; A is an optional acyl unit; Z is an amino acid or a peptide; X is an aminobenzyl ether self... | 06/30/2009 |
| 7547678 | Method for treating a disease, disorder or adverse effect caused by an elevated serum concentration of an UGT1A1 substrate The present invention is directed to a method for inducing UGT1A1 isoform expression for treatment of a disease, disorder or adverse effect caused by an elevated serum concentration of an UGT1A1 substrate comprising the step of administering to a subject an effectiv... | 06/16/2009 |
| 7531517 | Inhibitors of cancer cell, T-cell and keratinocyte proliferation The invention relates to compounds of the general formula (I) and salts and physiologically functional derivatives thereof, wherein Y is —NRaRb, —NRcC═ONRaR | 05/12/2009 |
| 7514409 | VLA-4 antagonists Compounds of Formula I are antagonists of VLA-4, and as such are useful in the inhibition or prevention of cell adhesion and cell-adhesion mediated pathologies. These compounds may be formulated into pharmaceutical compositions and are suitable for use in the treatm... | 04/07/2009 |
| 7504382 | Protease inhibitors for coronaviruses and SARS-CoV and the use thereof Disclosed are protease inhibitors for coronaviruses and SARS-CoV, or picornaviruses, and the use of these protease inhibitors for preventing, reducing, ameliorating and treating a disease or condition caused by coronaviruses and SARS-CoV, or picornaviruses. Also dis... | 03/17/2009 |
| 7504383 | Peptide nanostructures encapsulating a foreign material and method of manufacturing same A composition comprising a material at least partially enclosed by a tubular, spherical or planar nanostructure composed of a plurality of peptides, wherein each of the plurality of peptides includes no more than 4 amino acids and whereas at least one of the 4 amino... | 03/17/2009 |
| 7491705 | Alpha-ketoamide derivative, and production method and use thereof The present invention provides a compound represented by the formula (I): (wherein R1 is a lower alkyl substituted by a lower alkoxy or a heterocyclic group, or a heterocyclic g... | 02/17/2009 |
