Did You Know...
...that after Parker Brothers executives turned down the game of Monopoly because it had "52 fundamental errors" (including taking too long to play), a copy of the game wound up in the home of the company president who stayed up until 1 a.m. to finish playing it? He was so impressed by the game that the next day he wrote to inventor Charles Darrow and offered to buy it!
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| Number | Title | Issue Date |
| 7893047 | Biocide composition comprising pyrithione and pyrrole derivatives The present invention is directed to a biocidal composition comprising a blend of one or more pyrithione compounds, and one or more pyrrole compounds of Formula I wherein said biocidal composition is copper free or low copper content. ... | 02/22/2011 |
| 7884077 | Methods for the treatment of mood disorders The invention features methods of treating mood disorders, such as manic disorders, and stabilizing moods by administering a kappa agonist or partial agonist to a subject in need thereof. ... | 02/08/2011 |
| 7871996 | Methods of inhibiting nitric oxide synthase using corrin derivatives The present invention provides methods of inhibiting nitric oxide synthase (NOS) using corrin derivatives that bind NOS but do not bind NO. It also provides methods of inhibiting NOS in vivo by administering corrin derivatives, and methods of treating diseases and m... | 01/18/2011 |
| 7375215 | Compounds for PDT A tetrakis(hydroxyphenyl)chlorin, bacteriochlorin or isobacteriochlorin, derivatised at one or more of the hydroxy groups by addition reaction with a diisocyanate, diisothiocyanate or isocyanate-isothiocyanate at one isocyanate or isothiocyanate group thereof, the o... | 05/20/2008 |
| 7351840 | Perindopril A pharmaceutically acceptable salt of perindopril of formula (I) is made from a protected precursor compound of formula (II) wherein R represents a carboxyl protecting group, which process comprises subjecting a compound of formula (II) to deprotection of the carbox... | 04/01/2008 |
| 7345046 | Heteroaryl-fused pyrimidinyl compounds as anticancer agents Heteroaryl-fused pyrimidinyl compounds, pharmaceutically acceptable salts, and prodrugs thereof; compositions that include a pharmaceutically acceptable carrier and one or more of the heteroaryl-fused pyrimidinyl compounds, either alone or in combination with at lea... | 03/18/2008 |
| 7338946 | Compositions containing a ruthenium(III) complex and a heterocycle Compositions, containing a ruthenium(III) complex and a heterocycle, methods for their manufacture, medicament containing these compositions and a kit. The invention relates to a composition (A), obtained by reacting a compound of the general formula (I) ... | 03/04/2008 |
| 7316996 | Bisacyloxypropylcysteine conjugates and the use thereof The invention provides lipopeptide conjugates in which a cysteine that is double-substituted by a fatty acid is bonded by means of the carboxyl group to a highly soluble, physiologically compatible and non-immunogenic, polymeric conjugate group. The conjugates exhib... | 01/08/2008 |
| 7138520 | Coordination complexes having tethered therapeutic agents and/or targeting moieties, and methods of making and using the same In part, the present invention is directed to coordination complexes comprising a therapeutic agent. In one aspect, the subject compositions comprise a platinum metal center and a covalently attached therapeutic agent. ... | 11/21/2006 |
| 7135197 | Stable pharmaceutical composition useful for treating gastrointestinal disorders The present invention provides a pharmaceutical composition comprising at least one pharmaceutically acceptable bismuth-containing compound, at least one pharmaceutically acceptable non-clay-derived suspending agent, and water. The suspension exhibits reduced upward... | 11/14/2006 |
| 7094546 | Inhibitors of the inositol polyphosphate 5-phosphatase SHIP2 molecule The present invention is related to an inhibitor of the inositol polyphosphate 5-phosphatase SHIP2 protein or its encoding nucleotide sequence identified by SEQ ID NO. 1 or of SHIP2 mRNA expression. The present invention is also related to a pharmaceutical compositi... | 08/22/2006 |
| 7091351 | Vanadium compounds for treating cancer The invention provides methods for treating cancer and compounds that are useful for the treatment of tumors, as well as pharmaceutical compositions comprising the compounds, and synthetic methods and intermediates useful for preparing the compounds. ... | 08/15/2006 |
| 7078059 | Treatment of bone diseases The invention provides a method for enhancing bone formation, inhibiting osteoclastic differentiation and/or activating osteoblastic differentiation whereby to manage, treat or achieve prophylaxis of bone disease which comprises administering to a human or animal su... | 07/18/2006 |
| 7030147 | Combinations comprising an antidiarrheal agent and an epothilone or an epothilone derivative Epothilone derivatives are co-administered with an antidiarrheal agent, e.g., a DPP-IV inhibitor, in the treatment of a proliferative disease. ... | 04/18/2006 |
| 7026846 | Synthesizer structures and methods that reduce spurious signals Synthesizers are provided to generate synthesizer signals in response to primary digital signal representations that are created by a signal generator. In an important feature, the synthesizers further include a signal corrector that inserts correction digital signa... | 04/11/2006 |
| 7012072 | Pharmaceutical oxaliplatinum preparation for parenteral administration and method for obtaining same The present invention relates to a stable pharmaceutical preparation of oxaliplatin for parenteral administration, in which the oxaliplatin is in solution in a solvent at a concentration of at least 7 mg/ml, which has been subjected to an operation of wet heat treat... | 03/14/2006 |
| 7011854 | Method for treating a mammal by administration of a compound having the ability to release CO, compounds having the ability to release CO and pharmaceutical compositions thereof Several classes of in vivo carbon monoxide-releasing compounds are useful for the treatment and/or prevention of diseases, such as chronic inflammatory, e.g., rheumatoid arthritis, and of diseases with a strong inflammatory component, such as atherosclerosis, stroke... | 03/14/2006 |
| 7011839 | Otic microbial combination for treatment of animals with ruptured tympanic membrane Disclosed herein is an improved composition that is useful in treating otic infections comprising an antimicrobial and silver sulfadiazine in a therapeutically effective combination to treat otic infections in animals, the improvement comprising the composition whic... | 03/14/2006 |
| 7004976 | Biopolymers modified with superoxide dismutase mimics This invention provides modified biopolymers comprising biopolymers attached to at least one non-proteinaceous catalyst capable of dismutating superoxide in the biological system or precursor ligand thereof. The invention further provides pharmaceutical compositions... | 02/28/2006 |
| 6958359 | Vanadium compounds as anti-angiogenic agents Vanadium compounds for inhibiting angiogenesis useful for treating or preventing diabetic retinopathy, hemangiomas, cancers with abnormal blood vessel supply, restenosis following vascular injury, and the like. ... | 10/25/2005 |
| 6936452 | Inhibitors of the inositol polyphosphate 5-phosphate SHIP2 molecule The present invention is related to an inhibitor of the inositol polyphosphate 5-phosphatase SHIP2 protein or its encoding nucleotide sequence identified by SEQ ID NO. 1 or of SHIP2 mRNA expression. The present invention is also related to a pharmaceutical compositi... | 08/30/2005 |
| 6932960 | N-substituted 3-hydroxy-4-pyridinones and pharmaceuticals containing thereof N-substituted 3-hydroxy-4-pyridinones and metal chelates, methods of preparing N-substituted 3-hydroxy-4-pyridinones and metal chelates, and pharmaceutical compositions containing new N-substituted 3-hydroxy-4-pyridinones and/or their metal chelates. Use of N-substi... | 08/23/2005 |
| 6916799 | Substituted porphyrins The present invention relates, in general, to a method of modulating physiological and pathological processes and, in particular, to a method of modulating cellular levels of oxidants and thereby processes in which such oxidants are a participant. The invention also... | 07/12/2005 |
| 6903100 | USE OF REGULARLY SCHEDULED HIGH DOSE INTRAVENOUS METHOTREXATE THERAPY, WITH INTERIM ADMINISTRATION OF IMMUNOMODULATORY AGENTS, TO TREAT MULTIPLE SCLEROSIS AND OTHER DISEASES OF THE CENTRAL NERVOUS SYSTEM The present invention is directed to the treatment of multiple sclerosis by periodically administering a high dose of methotrexate at a level sufficiently high to cross the blood brain barrier. The methotrexate administration is accompanied by leucovorin rescue of t... | 06/07/2005 |
| 6900198 | Synthetic catalytic free radical scavengers useful as antioxidants for prevention and therapy of disease The invention provides antioxidant salen-metal complexes, compositions of such antioxidant salen-metal complexes having superoxide activity, catalase activity, and/or peroxidase activity, compositions of salen-metal complexes in a form suitable for pharmaceutical ad... | 05/31/2005 |
| 6878388 | Vanadium compounds for treating proliferative cell disorders Vanadium compounds useful to prevent and/or inhibit adhesion, migration, and invasion of proliferative cells into surrounding tissue. ... | 04/12/2005 |
| 6867217 | Substituted polycyclic aryl and heteroaryl pyridones useful for selective inhibition of the coagulation cascade The invention relates to substituted polycyclic aryl and heteroaryl pyridone compounds useful as inhibitors of serine proteases of the coagulation cascade and compounds, compositions and methods for anticoagulant therapy for the treatment and prevention of a variety... | 03/15/2005 |
| 6821326 | Small particle copper pyrithione Disclosed herein is a composition comprising a non-dusting copper pyrithione dispersion comprising small solid particles of copper pyrithione dispersed in a liquid dispersant, said solid particles having a particle size within a range of from about 0.1 to about 10 m... | 11/23/2004 |
| 6809091 | Substances capable of inducing apoptosis A method for the manufacture of a substance having an apoptosis-inducing ability characterized in including a step of subjecting at least one compound selected from the following (a), (b), (c) and (d) [excluding uronic acid and/or uronic acid derivatives; and compou... | 10/26/2004 |
| 6777404 | Use of corticotropin releasing factor antagonists and related compositions The present invention relates to compositions and methods of achieving a therapeutic effect including, the treatment or prevention of Syndrome X in an animal, preferably a mammal including a human subject or a companion animal, using a corticotropin releasing factor... | 08/17/2004 |
| 6753016 | Preservation of wood products A method for the protection of wood and other wood materials without affecting dimensional stability or surface integrity of the treated material is described. The method involves treating wood material with an iron salt and selected oxidants where the iron salt is ... | 06/22/2004 |
| 6743786 | Vanadium compounds for treating cancer The invention provides methods for treating cancer and compounds that are useful for the treatment of tumors, as well as pharmaceutical compositions comprising the compounds, and synthetic methods and intermediates useful for preparing the compounds. ... | 06/01/2004 |
| 6686344 | Organic-arsonic compounds Novel organic arsonic compounds are described as tumor inhibiting, and cancer treating compounds. Methods and compositions for inhibiting tumor cells and treating cancer are also provided.... | 02/03/2004 |
| 6667339 | Vanadium (IV) complexes containing catecholate ligand and having spermicidal activity Vanadium (IV) complexes containing a substituted or unsubstituted catecholate ligand, and the spermicidal activity of such compounds. Preferred compounds are vanadocene (IV) complexes containing alkyl substituted catecholate ligands.... | 12/23/2003 |
| 6608049 | Indazoles The invention relates to new indazole derivatives, processes for their preparation, and their use in medicaments.... | 08/19/2003 |
| 6562807 | Glucagon antagonists/inverse agonists A novel class of compounds, which act to antagonize the action of the glucagon hormone on the glucagon receptor. Owing to their antagonizing effect of the glucagon receptor the compounds may be suitable for the treatment and/or prevention of any diseases ... | 05/13/2003 |
| 6544504 | Combined use of interleukin 10 and methotrexate for immuno-modulatory therapy A combination of interleukin 10 and methotrexate is used to suppress autoimmune diseases including arthritis and psoriasis. It has been discovered that administration of a combination of interleukin 10 and methotrexate causes suppression of T cell prolife... | 04/08/2003 |
| 6514960 | Use of bismuth subgallate in inhibition of production of nitric oxide synthase The present invention discloses the use of bismuth subgallate in the inhibition of the production of nitric acid synthase. Also disclosed is the synergistic efficacy of bismuth subgallate in combination with borneol in the inhibition of the production of ... | 02/04/2003 |
| 6506770 | Antiviral compounds The present invention is drawn to novel antiviral compounds, pharmaceutical compositions and their use. More specifically this invention is drawn to derivatives of monocyclic polyamines which have activity in standard tests against HIV-infected cells as w... | 01/14/2003 |
| 6482814 | Biocidal composition and its use A composition comprising a C3-5 -alkyl-1,2-benzisothiazolin-3-one and the metal complex of a cyclic thiohydroxamic acid such as the 2:1 zinc salt of either 3-hydroxy-4-methylthiazol-2(3H)-thione or 1-hydroxypyridine-2-thione.... | 11/19/2002 |
