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| Number | Title | Issue Date |
| 8110565 | Enhanced drug delivery in transdermal systems A composition for transdermal administration resulting from an admixture includes: a therapeutically effective amount of a drug that includes a parent drug and a prodrug; and a pharmaceutically acceptable carrier, wherein the parent drug and prodrug are individually... | 02/07/2012 |
| 8101594 | Method for improving pancreatic functions Compounds such as 4-methylcholest-7-en-3-ol, 4-methylergost-7-en-3-ol and 4-methylstigmast-7-en-3-ol which have an activity for improving pancreatic function are used as an active ingredient of a pancreas function improving drug and food or drink. ... | 01/24/2012 |
| 8101595 | Antiviral indoles Compounds of the formula (I) wherein A, B, D, M, Ar, W, X, Y, Z and R1 are as defined herein, are useful in the prevention and treatment of hepatitis C infections. The compounds, their preparation, pharmaceutical compositions containing them and their use... | 01/24/2012 |
| 8097608 | Methods for treatment of cardiovascular disorders and diseases Propargylamine, propargylamine derivatives including N-propargyl-1-aminoindan, enantiomers and analogs thereof, and pharmaceutically acceptable salts thereof, are useful for prevention or treatment of cardiovascular disorders, diseases and conditions. ... | 01/17/2012 |
| 8097607 | Low dose rifalazil compositions The invention features low-dosage rifalazil compositions which are useful for the treatment of bacterial infections. ... | 01/17/2012 |
| 8093235 | Macrocyclic compounds which stabilize G-Quadruplex DNA and RNA The invention provides compounds of formula I: wherein A, B, D, E, R1, R2, R3, R4, R5, X, and ----- have any values defined herein, as well as salts thereof. The compou... | 01/10/2012 |
| 8093234 | Method of increasing thymic output in HIV-negative patients by treatment with antiretroviral agents A method of increasing thymic output in an HIV-negative patient, comprising the steps of (a) identifying a HIV-negative patient who is in need of increased thymic output and (b) supplying an effective amount of antiretroviral agent to the patient such that the patie... | 01/10/2012 |
| 8088759 | 1,4-benzodiazepine-2,5-diones with therapeutic properties The present invention relates to novel chemical compounds, methods for their discovery, and their therapeutic use. In particular, the present invention provides novel 1,4-benzodiazepine-2,5-dione compounds, and methods of using novel 1,4-benzodiazepine-2,5-dione com... | 01/03/2012 |
| 8084447 | Pharmaceutical composition comprising gabapentin or an analogue thereof and an α-aminoamide and its analgesic use There is disclosed a pharmaceutical composition comprising gabapentin or an analogue thereof (pregabalin or tiagabine) and an α-aminoamide and its analgesic use. A synergistic effect of the respective analgesic activities without concomitant increase of side effect... | 12/27/2011 |
| 8071580 | Medium-chain length fatty alcohols as stimulators of hematopoiesis Medium-chain length fatty alcohols such as octanol, decanol, dodecanol, or analogues thereof can be used as a stimulator of hematopoiesis, hematopoietic stem cell proliferation, and/or proliferation of one or more of the progenitors of red or white blood cells (e.g.... | 12/06/2011 |
| 8071579 | DNA damage repair inhibitors for the treatment of cancer The present invention relates to the recognition that inhibition of the base excision repair pathway is selectively lethal in cells which are deficient in HR dependent DNA DSB repair. Methods and means relating to the treatment of cancers which are deficient in HR d... | 12/06/2011 |
| RE43003 | Epothilone derivatives The present invention relates to compounds of the formula in which the variables G, W, Q, X, Y, B1, B2, Z1, Z2, and R1–R7 are as defined herein, methods fo... | 12/06/2011 |
| 8067403 | Methods and systems for preparing an antimicrobial composition A coating system and method are described. In some embodiments, a system may include a composition. The composition may include one or more bridged polycyclic compounds. At least one of the bridged polycyclic compounds may include at least two cyclic groups, and at ... | 11/29/2011 |
| 8067402 | Methods and systems for coating an oral surface A coating system and method are described. In some embodiments, a system may include a composition. The composition may include one or more bridged polycyclic compounds. At least one of the bridged polycyclic compounds may include at least two cyclic groups, and at ... | 11/29/2011 |
| 8063032 | Histamine H3 inverse agonists and antagonists and methods of use thereof Provided herein are fused imidazolyl compounds, methods of synthesis, and methods of use thereof. The compounds provided herein are useful for the treatment, prevention, and/or management of various disorders, such as neurological disorders and metabolic disorders. ... | 11/22/2011 |
| 8053429 | Solid oral dosage form containing an enhancer The invention relates to a solid oral dosage form comprising a pharmaceutically active ingredient in combination with an enhancer which enhances the bioavailability and/or the absorption of the active ingredient. Accordingly, a solid oral dosage form comprises a dru... | 11/08/2011 |
| 8053428 | Vinorelbine derivatives The present invention relates to novel vinorelbine derivatives. Pharmaceutical compositions containing these compounds as well as processes of preparation and processes of use for treatment of various conditions are also disclosed. ... | 11/08/2011 |
| 8053430 | Treatment of renal cell carcinoma Methods are provided of treating renal cancer by administration of certain 3,3′,4,4′-tetrahydroxy-2,2′-bipyridine-N,N′-dioxide compounds, especially 3,3′,4,4′-tetrahydroxy-2,2′-bipyridine-N,N′-dioxide (Orellanine), using particular administration pro... | 11/08/2011 |
| 8048870 | Apoptosis-inducing antineoplastic silver (I) coordination complexes The present invention describes chemotherapeutic compositions, a method for making the same, and methods for inducing apoptosis in tumor cells and/or inhibiting tumors. The compositions are metal coordination complexes of a cytotoxic metal, such as silver(I) and a c... | 11/01/2011 |
| 8048871 | Compositions and methods for inhibiting cytochrome P450 Methods of inhibiting cytochrome P450 enzymes are provided that can be used for improving the treatment of diseases by preventing degradation of drugs or other molecules by cytochrome P450. Pharmaceutical compositions are provided that can act as boosters to improve... | 11/01/2011 |
| 8048873 | Synergistic pharmaceutical combination for the prevention or treatment of diabetes The invention refers to a synergistic pharmaceutical combination which comprises (a) a first pharmaceutical composition containing an antidiabetic or anti-hyperlipidemic active agent and one or more conventional carrier(s), and (b) a second pharmaceutical compositio... | 11/01/2011 |
| 8048872 | Treatment of hyperproliferative diseases with vinca alkaloid N-oxide and analogs The present invention relates to vinca alkaloid and analog N-oxides having activity for treating hyperproliferative disorders. Further, the invention relates to pharmaceutical compositions and methods of using vinca alkaloid and analog N-oxides, alone or in combinat... | 11/01/2011 |
| 8039454 | Macrolide compounds with antibiotic and antineoplastic properties The invention is drawn to novel macrolide compounds of formula I having antibiotic and antineoplastic activities, useful as medicaments and/or agrochemicals for microorganism infections, in particularly for infectious diseases involving drug-resistant Staphylococ... | 10/18/2011 |
| 8039456 | Method of stimulating the motility of the gastrointestinal system using ipamorelin The present invention provides a method of stimulating the motility of the gastrointestinal system in a subject in need thereof, wherein the subject suffers from maladies (i.e., disorders, diseases, conditions, or drug- or surgery-induced dysfunction) of the gastroi... | 10/18/2011 |
| 8039452 | Antifungal medicinal compositions An object of the present invention is to provide a medicinal composition useful for external application in the treatment of a fungal infection reaching the lower part of a thick keratin layer. Provided is an antifungal medicinal composition, comprising: (1) a film-... | 10/18/2011 |
| 8039453 | Vinca derivatives The present invention relates to derivatives of vinca alkaloids. Pharmaceutical compositions containing these compounds as well as processes of preparation and treatment of various conditions are also disclosed. ... | 10/18/2011 |
| 8039455 | Macrocyclic compounds useful as BACE inhibitors The invention relates to novel macrocyclic compounds of the formula in which all of the variables are as defined in the specification, in free base form or in acid addition salt form, to their preparation, to their use as m... | 10/18/2011 |
| 8039457 | Method of stimulating the motility of the gastrointestinal system using growth hormone secretagogues The present invention relates to a method of stimulating the motility of the gastrointestinal system in a subject in need thereof, wherein the subject suffers from maladies (i.e., disorders or diseases) of the gastrointestinal system. The method comprises administer... | 10/18/2011 |
| 8034802 | Administration of TLR7 ligands and prodrugs thereof for treatment of infection by hepatitis C virus This invention relates to methods for treating or preventing hepatitis C virus infections in mammals using Toll-Like Receptor (TLR)7 ligands and prodrugs thereof. More particularly, this invention relates to methods of orally administering a therapeutically effectiv... | 10/11/2011 |
| 8034799 | Preventing and/or treating cardiovascular disease and/or associated heart failure Methods are provided for reducing copper values for, by way of example, treating, preventing or ameliorating tissue damage such as, for example, tissue damage that may be caused by (i) disorders of the heart muscle (for example, cardiomyopathy or myocarditis) such a... | 10/11/2011 |
| 8034800 | Antiviral macrocycle derivatives and metal complexes, incorporating bridged macrocycles A compound of Formulae (1), (2) or (3), A1-Ph (1) or A1-Ar-A2 (2) or A1-(A2)A′-A3 (3) wherein A1, A2 and A3 are selected from Formulae 4, 5 and 6: ... | 10/11/2011 |
| 8034801 | Analgesic agent A pharmaceutical preparation useful for alleviating or treating a pain, e.g., a chronic pain (particularly, a neuropathic pain) is provided. The pharmaceutical preparation contains (a) a propionic acid-derived nonsteroidal anti-inflammatory agent (e.g., ibuprofen), ... | 10/11/2011 |
| 8026230 | Methods and compositions for treating cancer using proteasome inhibitors The present invention relates to therapeutic compositions for treating cancer or preventing the growth of cancer cells, e.g., tumor growth, in a subject. The present invention also relates to methods for treating cancer, e.g., inhibiting tumor growth, in a subject w... | 09/27/2011 |
| 8026231 | Aminothiolester compounds, pharmaceutical and cosmetic compositions containing same and uses thereof The invention relates to novel aminothiol ester compounds having the general formula (I): and to a method for preparing them and to their use in pharmaceutical compositions intended for use in human or veterinary medicine (... | 09/27/2011 |
| 8022054 | Liquid ganaxolone formulations and methods for the making and use thereof In certain embodiments, the invention is directed to composition comprising stable particles comprising ganaxolone, wherein the volume weighted median diameter (D50) of the particles is from about 50 nm to about 500 nm. ... | 09/20/2011 |
| 8022055 | Betulinic acid derivatives The invention relates to novel betulinic acid derivatives of formula (I), wherein R is C(═CH2)CH3 or CH(CH3)2; R2 together with the adjacent carbonyl group forms a carboxylic acid, carboxylic acid ester or ami... | 09/20/2011 |
| 8022056 | Compositions and methods for the treatment of cancer The present invention relates to the use of specific compounds related to the indolocarbazole K252a, for the preparation of pharmaceutical compositions for the treatment of various forms of cancer. ... | 09/20/2011 |
| 8017598 | Compositions of R(+) and S(−) pramipexole and methods of using the same Compositions of predetermined amounts of R(+) pramipexole and S(−) pramipexole and methods of using the same, including for the treatment and prevention of Parkinson's disease, are provided. ... | 09/13/2011 |
| 8012953 | Macrocyclic beta-secretase inhibitors Disclosed are novel compounds of the formula or a pharmaceutically acceptable salt or solvate thereof, wherein R1, R2, R3, n and X are as defined in the specification. Also disclosed are pha... | 09/06/2011 |
| 8008281 | Methods for the treatment of cancer Compositions and methods for the treatment of malignancy and chronic viral infection are disclosed. ... | 08/30/2011 |
