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| Number | Title | Issue Date |
| 8188047 | Therapeutic and cosmetic compositions for treatment of skin The present invention is directed to a skin cream containing L-glutathione and methyl sulfone in combination with perfluorodecalin and various vitamins such as Vitamin D and C. The cream can be used to treat cancerous and precancerous diseases found in or on the ski... | 05/29/2012 |
| 8017581 | MSH-agonist tripeptide conjugates The invention relates to a tripeptide conjugate having general formula I, A-AA1-AA2-AA3-NH2, wherein A represents the radical corresponding to a monocarboxylic acid with general formula II, HOOC—R, in which: R represents a linear or branched aliphatic r... | 09/13/2011 |
| 7915224 | Method of preparing peptide The present invention provides a method of preparing an intermediate for LHRH antagonists, which requires fewer steps than conventional methods and provides the intermediate in high yield and high purity. ... | 03/29/2011 |
| 7879804 | Blood pressure lowering peptides in a single enzymatic step A process to produce IPP and VPP from a protein source that comprises the -I-P-P- and -V-P-P- sequence in its protein sequence and whereby at least 40% of -I-P-P- sequence present in the protein source is converted into the peptide IPP and at least 40% of the -V-P-P... | 02/01/2011 |
| 7851448 | Methods for modulating activities in plants The invention relates to methods for modulating, treating and preventing conditions in seeds and plants. The methods include the use of a composition comprising SEQ ID NO: 1, optionally with one or two conservative substitutions or a nucleic acid of the above. ... | 12/14/2010 |
| 7833986 | Anti-inflammatory peptides Methods for inhibiting an inflammatory reaction in a mammal and pharmaceutical compositions are provided. The methods comprise administering to the mammal an effective amount of a peptide of the formula: X1-X2... | 11/16/2010 |
| 7833985 | Angiotensin-converting enzyme inhibitory peptides It is intended to provide ACE inhibitory tripeptides which are not easily digested by digestive enzymes after being orally taken and thus have fewer tendencies to lose their ACE inhibitory activity in vivo. More specifically, 3 tripeptides having an ACE inhibitory a... | 11/16/2010 |
| 7816326 | Sulfur compounds as inhibitors of hepatitis C virus NS3 serine protease The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of us... | 10/19/2010 |
| 7803776 | Combined use of enzyme inhibitors and of pharmaceutical compositions thereof Provided are combinations of inhibitors of dipeptidyl peptidase IV (DP IV) and of enzymes having the same substrate specificity (DP IV-analogous enzymatic activity) and inhibitors of alanyl aminopeptidase (aminopeptidase N, APN) and of enzymes having the same substr... | 09/28/2010 |
| 7799761 | Pharmaceutical compositions including low dosages of desmopressin The present invention is directed to a pharmaceutical composition comprising 0.5 ng to 20 μg desmopressin and a pharmaceutically acceptable carrier. The present invention is also directed to a pharmaceutical composition comprising desmopressin and a pharmaceuticall... | 09/21/2010 |
| 7795226 | Control of radiation injury Methods of treating radiation injury of a subject in need thereof comprising administering to the subject a peptide consisting of the amino acid sequence AQGV. The invention provides for administration of the amino acid composition prior to and following exposure of... | 09/14/2010 |
| 7781405 | Methods for reducing oxidative damage The invention provides a method for reducing oxidative damage in a mammal, a removed organ, or a cell in need thereof. The method comprises administering an effective amount of an aromatic cationic peptide. The aromatic cationic peptide has (a) at least one net posi... | 08/24/2010 |
| 7767648 | Tissue specific prodrugs The invention provides novel peptide prodrugs which contain cleavage sites specifically cleaved by prostate specific membrane antigen (PSMA). These prodrugs are useful for substantially inhibiting the non-specific toxicity of a variety of therapeutic drugs. PSMA is ... | 08/03/2010 |
| 7727961 | Antioxidant constituents An object of the present invention is to provide an antioxidant composition that is effective in the living body against active oxygen species produced in the body. The present invention provides an antioxidant composition having the effect of suppressing three acti... | 06/01/2010 |
| 7727963 | Synthetic peptide amides The invention relates to synthetic tetrapeptide amide ligands of the kappa opioid receptor and particularly to agonists of the kappa opioid receptor that exhibit low P450 CYP inhibition and low penetration into the brain. An exemplary synthetic tetrapepti... | 06/01/2010 |
| 7727962 | Powder comprising new compositions of oligosaccharides and methods for their preparation The present invention concerns powders containing a pharmaceutical active substance and a combination of excipients comprising at least one 1,4 O-linked saccharose derivative selected from the compounds: 1,4 O-linked D-Gal-saccharose (lactosucrose), 1,4 O-linked D-G... | 06/01/2010 |
| 7723306 | Spray-dried powder comprising at least one 1,4 O-linked saccharose-derivative and methods for their preparation The present invention relates to a spray-dried powder and method for its manufacture. A spray dried powder containing a pharmaceutical active substance and one or more 1,4 O-linked saccharose derivatives chosen from the compounds: 1,4 O-linked D-gal-saccharose (lact... | 05/25/2010 |
| 7718620 | Methods for preventing or treating ischemia-reperfusion injury of the kidney The invention provides a method of treating or preventing ischemia-reperfusion injury of the kidney in a mammal. The method comprises administering an effective amount of an aromatic-cationic peptide having at least one net positive charge; a minimum of four amino a... | 05/18/2010 |
| 7713937 | Synthetic peptide amides and dimeric forms thereof The invention relates to synthetic peptide amides that are ligands of the kappa opioid receptor and particularly to agonists of the kappa opioid receptor that exhibit low P450 CYP inhibition and low penetration into the brain. The synthetic peptide amides... | 05/11/2010 |
| 7704956 | Glutathione-based delivery system A delivery system. The delivery system includes a carrier having a surface, an active compound comprising small molecule compounds or peptides for use as an analgesic encapsulated into the carrier, and a glutathione or a glutathione derivative grafted on the surface... | 04/27/2010 |
| 7704954 | Method and carrier complexes for delivering molecules to cells The invention relates to carrier complexes and methods for delivering molecules to cells. The carrier complexes comprises a molecule and an aromatic cationic peptide in accordance with the invention. In one embodiment, the method for delivering a molecule to a cell ... | 04/27/2010 |
| 7704955 | Methods and compositions for modulating conditions in both mammals and plants The invention relates to compositions comprising of SEQ NO: 1-244, 248-249, and any homologs, analogs, and fragments thereof. Such compositions can be used to treat, prevent, and modulate pain, inflammation, and metabolic processes in various organisms including pla... | 04/27/2010 |
| 7700564 | Glutathione based delivery system A delivery system. The delivery system includes a carrier or an active compound and a glutathione or a glutathione derivative grafted thereon. The invention also provides a compound including a moiety comprising a vitamin E derivative or a phospholipid derivative, a... | 04/20/2010 |
| 7700562 | Use of —furin—“convertase” inhibitors in the treatment of fibrosis and scarring The present invention relates to use of convertase inhibitors for the reduction of scarring during the healing of wounds and also for reducing fibrosis in the treatment of fibrotic conditions. ... | 04/20/2010 |
| 7700563 | Synthetic heparin-binding factor analogs The invention provides synthetic heparin-binding growth factor analogs having at least one peptide chain, and preferably two peptide chains branched from a dipeptide branch moiety composed of two trifunctional amino acid residues, which peptide chain or chains bind ... | 04/20/2010 |
| 7691819 | Modulation of cell fates and activities by phthalazinediones Phthalazinediones that function as intracellular redox modulators are useful in treating cells in various disease states where intracellular redox status is impaired. By buffering aberrant redox states, phthalazinediones enable cellular processes essential for survi... | 04/06/2010 |
| 7683033 | Inhibitors of serine proteases, particularly HCV NS3-NS4A protease The present invention relates to compounds of formula I: or a pharmaceutically acceptable salt or mixtures thereof that inhibit serine protease activity, particularly the activity of hepatitis C virus NS3-NS4A protease. As ... | 03/23/2010 |
| 7674775 | Substantially cell membrane impermeable compound and use thereof The present invention relates to a compound according to Formula (I): A-(L-Y)p, wherein A comprises at least one substantially cell-membrane impermeable pendant group; L comprises any suitable linker and/or spacer group; Y comprises at least one arsenoxid... | 03/09/2010 |
| 7671032 | HCV NS-3 serine protease inhibitors Peptidomimetic compounds are described which inhibit the NS3 protease of the hepatitis C virus (HCV). The compounds have the formula where the variable definitions are as provided in the specification. The compounds comprise a carbocyclic P2 unit in conjunction with... | 03/02/2010 |
| 7662789 | Peptide substance restoring myocardium function The invention refers to the pharmaceutical means for the treatment of cardiovascular diseases and can be used as a substance restoring myocardium function in the course of treatment for different forms of this pathology. There is proposed a new tetrapeptide a... | 02/16/2010 |
| 7659255 | Methods of inhibiting glutamate receptors by administering the tripeptide KDI The present invention relates to a method of using biologically active peptide compounds comprising the tri-peptide motif KDI derived from the neurite outgrowth-promoting domain of laminin-1 as inhibitors of ionotropic glutamate receptors. The peptide compounds are ... | 02/09/2010 |
| 7642245 | Antibacterial compounds having a (pyrrole carboxamide)-(benzamide)-(imidazole carboxamide) motif Compounds of the formula (I) where Ar and R are as defined herein, possess antibacterial properties. ... | 01/05/2010 |
| 7638495 | Peptides as solubilizing excipients for transforming growth factor β proteins The present invention relates to compositions comprising excipients or solubilizing agents for proteins. The invention relates to the discovery that a peptide derived from the N-terminus extension of the T266 isoform of rhBMP-2 has properties that enhance the solubi... | 12/29/2009 |
| 7635683 | Quinoxalinyl tripeptide hepatitis C virus inhibitors The present invention relates to compounds of Formula I, or a pharmaceutically acceptable salt, ester, or prodrug, thereof: which inhibit serine protease activity, particularly the activity of hepatitis C virus (HCV) NS3-NS... | 12/22/2009 |
| 7632819 | Methods and compositions for inhibiting PKC delta cleavage for treatment and prevention of neurodegeneration and apoptosis Methods and compositions are provided which inhibit the apoptotic activity associated with oxidative stress in many disease states. According to the invention, inhibition of chemical cleavage of PKCδ by caspase-3 results in reduction of apoptosis. Novel peptide inh... | 12/15/2009 |
| 7632818 | Method for treating conditions associated with the Metabolic Syndrome (Syndrome X) The present invention is directed to a method for treating individuals having inflammation or preventing inflammation in individuals at risk for inflammation, more specifically individuals with chronic inflammation as evidenced by elevated C-reactive protein, serum ... | 12/15/2009 |
| 7629319 | Heteroaryl peptidomimetics as thrombin receptor antagonists The invention is directed to novel heteroaryl peptidomimetic compounds which are useful as thrombin receptor antagonists for the treatment of diseases associated with thrombosis, restenosis, hypertension, heart failure, arrhythmia, inflammation, angina, stroke, athe... | 12/08/2009 |
| 7625870 | Peptide substance restoring respiratory organs function The invention refers to the medicinal remedies for respiratory system diseases treatment and may be applied as a substance, capable of restoring respiratory organs functions and used for treatment of different forms of lung pathology. There is proposed a biologicall... | 12/01/2009 |
| 7622446 | Polypeptides, derivatives and uses thereof The invention provides a compound having formula X1-Arg-Xaa-Arg-X2 in which X1 and X2 are up to 30 amino acid residues and Xaa is an amino acid residue. A preferred compound is the tripeptide Arg-Glu-Arg which corresponds ... | 11/24/2009 |
| 7622447 | Use of glutathione synthesis stimulating compounds in reducing insulin resistance There is provided a method of reducing insulin resistance in a mammalian patient comprising selecting a patient suffering from insulin resistance and administering a compound which increases hepatic glutathione and a compound which increases hepatic nitric oxide. | 11/24/2009 |
