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| Number | Title | Issue Date |
| 7687483 | Derivatives of branch-chain lipophilic molecular and uses thereof Novel phospho-derivatives of branched-chain lipophilic molecules useful for permeabilizing biological barriers and for inhibiting tumor growth are disclosed. Pharmaceutical compositions comprising phospho-derivatives of branched-chain lipophilic molecules and their ... | 03/30/2010 |
| 7625883 | Glycerophosphoinositol derivatives as modulators of cytosolic A2 phospholipase Optionally O-substituted glycero-phosphoinositol derivatives, their analogues and their salts wherein the substitutents: R′1, R′2, R2, R3, R4, R5, R6 have the described meaning, their synthesis and their pharmacological effect as modulators of the activation or ... | 12/01/2009 |
| 7605149 | Modulation of the phospholipase A2 pathway as a therapeutic There is provided a method of modifying vasoactivity by regulating a soluble Aβ pro-inflammatory pathway. Also provided is a method of modifying inflammatory reactions in microglia and neurons by regulating a soluble Aβ pro-inflammatory pathway. A method of treati... | 10/20/2009 |
| 7220780 | Naaladase inhibitors for treating retinal disorders and glaucoma The present invention relates to pharmaceutical compositions and methods for treating a retinal disorder or glaucoma using NAALADase inhibitors. ... | 05/22/2007 |
| 7053071 | Induction of apoptosis in cancer cells The present invention provides compounds that are inducers or inhibitors of apoptosis or apoptosis preceded by cell-cycle arrest. In addition, the present invention provides pharmaceutical compositions and methods for treating mammals with leukemia or other forms of... | 05/30/2006 |
| 6964949 | Pharmaceutical compositions for promoting the growth of gram-positive bacilli and increasing the acidity in the vagina and the use thereof The present invention relates to a pharmaceutical formulation for stimulating the growth of gram-positive bacilli and increasing the acidity in the vagina which comprises sucrose and/to maltose, to the use of certain sucrose and/or maltose, in preparing the pharmace... | 11/15/2005 |
| 6812231 | Benzamidine derivative Benzamidine derivatives of the following formula, analogs thereof and pharmaceutically acceptable salts thereof are provided. These compounds have an effect of inhibiting activated blood-coagulation factor X, and they are useful as agents for preventing or treating ... | 11/02/2004 |
| 6774123 | Methods and compositions for inactivating viruses Methods and compositions for selectively inactivating viruses in biological compositions, including contacting the composition with an organic solvent and an ethyleneimine oligomer inactivating agent, are disclosed. ... | 08/10/2004 |
| 6649646 | Insecticidal and miticidal compositions The invention relates to an insecticidal and miticidal composition which contains as active ingredients chlorfenapyr in combination with one or more organophosphoric acid ester-type compounds and to a method for controlling insecticidal or miticidal pests... | 11/18/2003 |
| 6566304 | Biogenic control and limitation of the reproduction of parasitic earth nematodes in stock culture The invention relates to use of (a) compounds of phosphorus containing at least partly lipophilic organic radicals together with (b) urea and/or urea derivatives in selected quantity ratios of (a) to (b) as a soil additive for biologically controlling pla... | 05/20/2003 |
| 6413949 | Prodrugs with enhanced penetration into cells The invention relates to a pharmaceutically acceptable prodrug which is a covalent conjugate of a pharmacologically active compound and an intracellular transporting adjuvant, characterized by the presence of a covalent bond which is scission-sensitive to... | 07/02/2002 |
| 6410538 | Benzamidine derivatives Benzamidine derivatives of the following formula, analogs thereof and pharmaceutically acceptable salts thereof are provided. These compounds have an effect of inhibiting activated blood-coagulation factor X, and they are useful as agents for preventing o... | 06/25/2002 |
| 6369045 | Phospholipase A2 inhibitors thereof and use of same in diagnosis and therapy The enzyme Lp-PLA2 in purified form, an isolated nucleic acid molecule incoding Lp-PLA2, the use of an inhibitor of the enzyme Lp-PLA2 in therapy and a method of screening compounds to identify those compounds which inhibi... | 04/09/2002 |
| 6369048 | Methods and compositions for inactivating viruses Methods and compositions for selectively inactivating viruses in biological compositions, including contacting the composition with an organic solvent and an ethyleneimine oligomer inactivating agent, are disclosed.... | 04/09/2002 |
| 6197777 | Synthesis, anti-human immunodeficiency virus, and anti-hepatitis B virus activities of 1,3-oxaselenolane nucleosides A method and composition for the treatment of HIV infection, HBV infection, or abnormal cellular proliferation in humans and other host animals is disclosed that includes the administration of an effective amount of a 1,3-oxaselenolane nucleoside or a pha... | 03/06/2001 |
| 6172119 | Method of treating acute renal failure This invention relates to a method of treating patients afflicted with acute renal failure. The method includes administering to a patient in need of treatment an effective amount of a thiol or reducible disulfide compound according to the formula set for... | 01/09/2001 |
| 6165997 | Phospholipids having antimicrobial activity with or without the presence of antimicrobials A pharmaceutical formulation for stimulating growth of Gram-positive Bacilli and increasing the acidity in vagina comprises sucrose and/or maltose, optionally with other sugars, viscous base, and anti-fungal and/or anti-bacterial agents.... | 12/26/2000 |
| 6159958 | Treatment or prophylaxis of retinal pathology and spinal cord injury Compositions containing 2-(phosphonomethyl)-pentanedioic acid (PMPA) and pha. and ଲ N-acetyl-aspartyl-glutamate (NAAG) are appropriate means for treatment of neuronal tissue injury that may result from such factors as injury, toxicity, hypoxia or i... | 12/12/2000 |
| 6133249 | Phospholipid and propylene glycol based lubricant A method of lubrication of a mammalian joint or other physiological articulation which comprises administering a composition comprising one or more phospholipids in association with propylene glycol.... | 10/17/2000 |
| 5972324 | Monohydric alcohol derived urethanes and their use in cosmetic formulations The present invention relates to a dimeric urethane compounds derived from monohydric alcohols, generally fatty alcohols, and a diisocyanate according to the following reaction scheme: ##STR1## wherein R1 is selected from the group of satu... | 10/26/1999 |
| 5866514 | Pesticidal composition to noxious organisms A pesticidal composition to noxious organisms which comprises a diarylalkane and an active component effective for killing or repelling noxious organisms and the diarylalkane is at least one member selected from the group consisting of butyl diphenylmetha... | 02/02/1999 |
| 5846955 | Acylated phospholipid drugs This invention relates to a method for improving the efficiency of a drug containing a free carboxy group, the improvement comprising esterifying said carboxy group to the hydroxy group of the glycerol portion of a glycerolphospholipid ester having the fo... | 12/08/1998 |
| 5776438 | External preparation An external preparation containing DL--tocopherol 2- L-ascorbic phosphoric diester and/or a salt thereof, and at least one ultraviolet absorbing agent. The cross-linking of collagen is suppressed and an excellent cutaneous aging resisting effect is... | 07/07/1998 |
| 5760022 | Pharmaceutical composition with improved bioavailability of inositol phosphate The invention relates to an inositol phosphate containing pharmaceutical composition which comprises an aliphatic ester or ether for improvement of the bioavailability of the inositol phosphate in mammals including man at non-parenteral administration. Th... | 06/02/1998 |
| 5676742 | Mono and dibenzoate ester blends as caulk plasticizers that are bioresistant to fungal growth The present invention comprises dipropylene glycol dibenzoate and diethylene glycol dibenzoate, the improvement comprising the addition of dipropylene glycol monobenzoate or diethylene glycol monobenzoate, whereby the plasticizer is resistant to fungal gr... | 10/14/1997 |
| 5597809 | Treatment of optic neuritis Methods of treating optic neuritis comprising administering a protective agent which inhibits glutamate-mediated retinal cell damage to a mammal at risk of developing optic neuritis.... | 01/28/1997 |
| 5508273 | Substituted phosphonic acids and derivatives useful in treating bone wasting diseases Compounds represented by the formula I: ##STR1## are disclosed as agents for use in treating bone wasting diseases.... | 04/16/1996 |
| 5478815 | Liver protectant tocophery-ascorbyl-phosphate A liver protectant comprising a phosphoric diester compound of the following formula (wherein R1 and R2 are the same or different and each represents hydrogen or methyl) or a pharmacologically acceptable salt thereof. ##STR1## ... | 12/26/1995 |
| 5455249 | Phosphorylcarbamates of rapamycin and oxime derivatives thereof Background of the structure ##STR1## wherein R1 and R2 are each, independently, hydrogen, or ##STR2## R3 and R4 are each, independently, hydrogen, Ar, or --(CR6 R7)a Y(... | 10/03/1995 |
| 5451573 | Substituted cyclohexane derivatives for the treatment of diseases Substituted cyclohexane derivatives for the treatment of diseases Esters of cyclohexane derivatives of the formula I ##STR1## in which A--B, R3, R4, R5, Y and Z have the meanings indicated, for use as inhibitors of th... | 09/19/1995 |
| 5447923 | Methods and compositions of diphenyl ether phosphate esters for the treatment of gastrointestinal disorders Methods for the treatment of a human or lower animal subject having an H. pylori-mediated upper gastrointestinal disorder comprising administering to said subject a safe and effective amount of a diphenyl ether phosphate ester of the following formula: ... | 09/05/1995 |
| 5182271 | Thioether, keto-ester and alkyl phospholipids useful in treating multiple sclerosis The invention discloses certain thioether, keto-ester and alkyl phospholipids which are useful in treating multiple sclerosis.... | 01/26/1993 |
| 5057541 | Composition for external application An emulsion-like or creamy composition for external application is disclosed. The composition is prepared by applying a shear force to an aqueous suspension comprising 0.1 to 20% by weight of one or more specific types of polyvalent metal alkyl phosphates... | 10/15/1991 |
| 5053222 | Hair cosmetic composition A hair cosmetic composition containing, as an active component, a diester of phosphoric acid with ascorbic acid and tocopherol, having the formula (I), and/or a salt thereof: ##STR1## wherein R1 represents H or CH3 and R2 | 10/01/1991 |
| 4948787 | Inhibition of mercaptan odor in organothiophosphate biocides Mercaptan odors in a thiophosphate compound or formulation are suppressed by treatment of the compound during preparation of the formulation with treatment agents selected from iodine, and alkali and alkaline earth metal hydroxides, hypochlorites and ioda... | 08/14/1990 |
| 4938797 | Process for the preparation of microcapsules The invention relates to a process for the preparation of microcapsules having a capsule wall of polyurea and encapsulating a water-immiscible pesticide. The process comprises first dispersing a solution of a polyisocyanate in the sparingly water-soluble ... | 07/03/1990 |
| 4828844 | Pulmonary surfactant A pulmonary surfactant for the treatment of dyspnea syndromes, containing dipalmitoyl phosphatidyl choline (DPPC) and dipalmitoyl phosphatidyl glycerol (DPPG) in a ratio of from 9:1 to 8:2 and a sugar, in the form of a redispersable powder, which is obtai... | 05/09/1989 |
| 4686211 | Medical composition for external application A medical composition for external application comprises a dialkyl phosphate represented by the formula: ##STR1## wherein R1 and R2 independently represent a hydrocarbon group having from 6 to 24 carbon atoms, R3 and ... | 08/11/1987 |
| 4536519 | Emulsifying agent and emulsified cosmetics Disclosed herein is an emulsifying agent comprising (a) a partially or completely neutralized product, with a basic substance, of a phosphoric acid ester which contains a phosphoric acid monoester represented by the general formula (I) and a phosphoric ac... | 08/20/1985 |
| 4514392 | Pesticidal aryl N-(alkylthio-phosphorothio)acyl-N-alkylcarbamates Novel, aryl N-(alkylthio-phosphorothio)acyl carbamates represented by structure: ##STR1## wherein the R groups represent various alkyl substituents, and Ar represents an aryl radical with various organic substituents, which exhibit superior inse... | 04/30/1985 |
