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| Number | Title | Issue Date |
| 8153588 | Methods useful in the treatment of bone resorption diseases The invention relates to a combined pharmaceutical preparation comprising parathyroid hormone and a bone resorption inhibitor, said preparation being adapted for (a) the administration of parathyroid hormone during a period of approximately 6 to 24 months; (b) after... | 04/10/2012 |
| 8093231 | Sulfonylethyl phosphorodiamidates Sulfonylethyl and thioethyl phosphorodiamidates, their preparation and intermediates in their preparation, formulations containing them, and their pharmaceutical use. The compounds are useful for treating cancer, alone and in combination with other anticancer therap... | 01/10/2012 |
| 8071574 | Implant improving local bone formation A bone implant comprises an active agent on at least a portion thereof. The active agent is locally deliverable to bone proximate the implant in at least a two-phased release scheme. A first phase rapidly releases a first quantity of the active agent, and at least a... | 12/06/2011 |
| 7989435 | Phytic citrate compounds and process for preparing the same The present invention provides a chemical compound or a salt thereof having the chemical formula of: wherein said R is H or citrate and wherein at least one R is citrate. The salt of the chemical compound is the Na+ | 08/02/2011 |
| 7919481 | Inositol pyrophosphates, and methods of use thereof The present invention comprises compounds, compositions thereof, and methods capable of delivering modified inositol hexaphospahte (IHP) comprising an internal pyrophosphate ring to the cytoplasm of mammalian cells. In certain embodiments, the present invention rela... | 04/05/2011 |
| 7745423 | Calcium/sodium salt of inositol tripyrophosphate as an allosteric effector of hemoglobin The present invention relates to mixed calcium/sodium salt of inositol tripyrophosphate, methods of preparing and methods of use. The mixed calcium/sodium salt may be a monocalcium tetrasodium salt of inositol tripyrophosphate. Methods of use include administering t... | 06/29/2010 |
| 7696183 | Ibandronate sodium propylene glycol solvate and processes for the preparation thereof A novel form of Ibandronate sodium which is particularly suitable for pharmaceutical applications, and a process for preparing said novel form. ... | 04/13/2010 |
| 7687482 | Bisphosphonate compounds and methods The invention provides, inter alia, novel bisphosphonate compounds and methods of making and using. In embodiments, the invention provides compounds and methods in connection with research and therapeutic applications, e.g., for tumor cell growth inhibition, activat... | 03/30/2010 |
| 7683045 | Class of γδ T cells activators and use thereof The present invention relates to a new class of compounds having γδ T cells activating properties referred to herein as angelyl or tiglyl phosphoesters, compositions comprising any of these compounds and methods for regulating an immune response in a subject compr... | 03/23/2010 |
| 7648970 | Inositol pyrophosphates, and methods of use thereof The present invention comprises compounds, compositions thereof, and methods capable of delivering modified inositol hexaphosphate (IHP) comprising an internal pyrophosphate ring to the cytoplasm of mammalian cells. In certain embodiments, the present invention rela... | 01/19/2010 |
| 7618954 | Inositol pyrophosphates, and methods of use thereof The present invention comprises compounds, compositions thereof, and methods capable of delivering modified inositol hexaphospahte (IHP) comprising an internal pyrophosphate ring to the cytoplasm of mammalian cells. In certain embodiments, the present invention rela... | 11/17/2009 |
| 7612052 | Combinations comprising epothilones and pharmaceutical uses thereof The invention relates to a combination which comprises (a) a bisphosphonate, a platinum compound or a vasculostatic compound and (b) an epothilone derivative of formula I wherein A represents O or NRN, wherein R | 11/03/2009 |
| 7605148 | Aqueous oral solution of bisphosphonic acid The present invention relates to stable aqueous oral formulation of bisphosphonic acid or its pharmaceutically acceptable salts. More particularly, the present invention relates to stable aqueous oral formulation of alendronate sodium. The present invention also rel... | 10/20/2009 |
| 7579333 | Therapy using a combination of raloxifene and alendronate Provided are methods of treating bone disease including, but not limited to, osteoporosis, metastatic bone disease, or Paget's disease, by administering a combination of raloxifene and alendronate in a manner that mitigates the formation of ulcerative adverse events... | 08/25/2009 |
| 7517868 | Phytic citrate compounds and process for preparing the same The present invention provides a chemical compound or a salt thereof having the chemical formula of: wherein said R is H or citrate and wherein at least one R is citrate. The salt of the chemical compound is the Na+ | 04/14/2009 |
| 7399756 | Organo-phosphorous compounds for activating gamma/delta T cells The present invention describes organophosphorus compounds of general formula (I) their preparation and their uses in the activation of gamma/delta T-cells, in the screening of GcpE and LytB enzyme inhibitors and in the pro... | 07/15/2008 |
| 7342122 | Bisphosphonate complexes Bisphosphonate compounds are disclosed, particularly bisphosonate conjugates useful in the treatment of soft tissues surrounding bone and bone-related diseases, such as bone cancer and osteoporosis. ... | 03/11/2008 |
| 7342078 | Transition metal compound, ligand system, catalyst system and the use of the latter for polymerisation and copolymerisation of olefins A process for the polymerization of olefins, in particular a process for the copolymerization of propylene with further olefins, is carried out in the presence of highly active catalyst systems comprising specifically selected metallocenes, in particular ones which ... | 03/11/2008 |
| 7309698 | Compositions for delivering bisphosphonates Compounds and compositions for the delivery of bisphosphonates are provided. Methods of preparation, administration and treatment are provided as well. ... | 12/18/2007 |
| 7288535 | Methods and compositions for stimulating bone growth using nitric oxide releasing bisphosphonate conjugates The invention relates to compositions and methods for use in treating skeletal system disorders in a vertebrate at risk for bone loss, and in treating conditions that are characterized by the need for bone growth, in treating fractures, and in treating cartilage dis... | 10/30/2007 |
| 7268124 | Geranylgeranyl pyrophosphate synthase inhibitors The invention provides novel pyrophosphate synthase inhibitors of formula I as well as compositions comprising such inhibitors and methods for their use. ... | 09/11/2007 |
| 7262182 | Sulfonylethyl phosphorodiamidates Sulfonylethyl and thioethyl phosphorodiamidates, their preparation and intermediates in their preparation, formulations containing them, and their pharmaceutical use. The compounds are useful for treating cancer, alone and in combination with other anticancer therap... | 08/28/2007 |
| 7217703 | 8-(2-hydroxyphenoxy)octyldiethanolamine and salts thereof for delivery of active agents The present invention provides 8-(2-hydroxyphenoxy)octyldiethanolamine) and salts thereof, compositions containing the same and one or more active agents, and methods of administering active agents with the same. The delivery agents of the present invention are well... | 05/15/2007 |
| 7199113 | Pharmaceutically active compounds and methods of use thereof The invention includes pharmaceutically active compounds and methods of treatment and pharmaceutical compositions that utilize or comprise one or more such compounds. Compounds of the invention are particularly useful for treatment or prophylaxis of undesired thromb... | 04/03/2007 |
| 7192938 | Method of treatment using bisphosphonic acid The present invention refers to a pharmaceutical composition of a bisphosphonic acid or salt thereof, and an excipient thereof, and a method of treating disorder characterized by pathologically increased bone resorption comprising orally administering at least 150% ... | 03/20/2007 |
| 7176191 | Antimicrobial compounds and methods for their use The present invention provides protonated compounds having antimicrobial activity. The invention also provides antimicrobial compositions comprising protonated compounds of the invention. The protonated compounds of the invention provide efficacious antimicrobial ac... | 02/13/2007 |
| 7148210 | Method of treating bone metastasis The invention provides a drug combination for the treatment of diseases associated with bone metastasis. The combination provides adenosine or a derivative thereof, a bisphosphonate, and a targeting agent(s) to decrease the signs or symptoms associated with such dis... | 12/12/2006 |
| 7135191 | Urogenital or anorectal transmucosal vaccine delivery system The invention is directed to a suppository based vaccine delivery system for immunizing against urogenital and anorectally transmitted infectious disease in humans and animals and a method for treating the same. More particularly, this invention is directed to a sup... | 11/14/2006 |
| 7112577 | Pharmaceutically acceptable alendronate salts in amorphous form A pharmaceutically acceptable alendronate salt in an amorphous form. ... | 09/26/2006 |
| 7109184 | Phosphate transport inhibitors Disclosed is a phosphate transport inhibiting compound represented by Structural Formula (I): R1 and R2 are independently —H, an electron withdrawing group or a C1–C10... | 09/19/2006 |
| 7109181 | Joint lubrication with P2Y purinergic receptor agonists The present invention is directed to a method of altering the amount or composition of synovial fluids secreted from joints in a subject in need of such treatment. The method comprises administering to a subject a pharmaceutical composition comprising a P2Y purinerg... | 09/19/2006 |
| 7101711 | Phosphoepoxides, method for making same and uses The invention provides compounds comprising at least one phosphoepoxide group of the formula: where R1 is selected from among —CH3 and —CH2—CH3, ... | 09/05/2006 |
| 7101907 | Topical administration of statins for treatment of bone disorders The topical administration of statins for the treatment of bone disorders is disclosed. ... | 09/05/2006 |
| 7090865 | Composition and method for treating autoimmune hemolytic anemia Disclosed are a composition and method to treat or prevent antibody-induced anemia and particularly, autoimmune hemolytic anemia. The composition comprises a bisphosphonate and a pharmaceutically acceptable carrier. In a preferred embodiment, the composition compris... | 08/15/2006 |
| 7084115 | Inositol pyrophosphates, and methods of use thereof The present invention comprises compounds, compositions thereof, and methods capable of delivering modified inositol hexaphospahte (IHP) comprising an internal pyrophosphate ring to the cytoplasm of mammalian cells. In certain embodiments, the present invention rela... | 08/01/2006 |
| 7084126 | Methods and compositions for enhancing cellular function through protection of tissue components Methods and composisions for enhancing cellular function through protection of a tissue components such receptors, proteins, lipids, nucleic acids, carbohydrates, hormones, vitamins, and cofactors, by administering pyrophosphate analogs or related compounds. ... | 08/01/2006 |
| 7078059 | Treatment of bone diseases The invention provides a method for enhancing bone formation, inhibiting osteoclastic differentiation and/or activating osteoblastic differentiation whereby to manage, treat or achieve prophylaxis of bone disease which comprises administering to a human or animal su... | 07/18/2006 |
| 7041309 | Spinal fusion using an HMG-CoA reductase inhibitor An improved technique for spinal fusion including administration of an HMG-CoA reductase inhibitor to the fusion site. The HMG-CoA reductase inhibitor is preferably delivered to the site by a carrier. More preferably, the HMG-CoA reductase inhibitor is delivered to ... | 05/09/2006 |
| 7018982 | Methods useful in the treatment of bone resorption diseases The invention relates to a combined pharmaceutical preparation comprising parathyroid hormone and a bone resorption inhibitor, said preparation being adapted for (a) the administration of parathyroid hormone during a period of approximately 6 to 24 months; (b) after... | 03/28/2006 |
| 7008645 | Method of inhibiting restenosis using bisphosphonates A method of inhibiting the activity or production of cytokines or growth factors associated with vascular restenosis, by administering to an individual an effective amount of an active ingredient comprising a bisphosphonate particle or a bisphosphonate particulate. ... | 03/07/2006 |
