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| Number | Title | Issue Date |
| 8247236 | Detecting leucine and its isomers using differential esterification mass spectrometry Methods of evaluating molecular isomers of branched-chain amino acids are featured. The methods can include: derivatizing one or more molecular isomers of branched-chain amino acids in a sample comprising a branched-chain amino acid labeled with one or more heavy at... | 08/21/2012 |
| 7932092 | Computerized method and apparatus for analyzing amino acids A method for analyzing a plurality of amino acids in a fluid sample by a user is provided comprising the steps of introducing the sample into a buffer solution, passing the sample in the buffer solution through a separation column and setting a lithium ion concentra... | 04/26/2011 |
| 7632684 | Assay of isomerised and/or optically inverted proteins and protein fragments In an in vitro diagnostic test for osteoarthritis or rheumatoid arthritis, the amount or presence in a sample of anisomerised or optically inverted protein fragment is measured which derives from perlecan, bigylcan, decorin, fibrillin-1 or protocadherin or which is ... | 12/15/2009 |
| 7432108 | Computerized method and apparatus for analyzing amino acids A method for analyzing a plurality of amino acids in a fluid sample by a user is provided comprising the steps of introducing the sample into a buffer solution, passing the sample in the buffer solution through a separation column and setting a lithium ion concentra... | 10/07/2008 |
| 7429727 | Method, apparatus, and program product for quickly selecting complex molecules from a data base of molecules The disclosed technology relates to the analysis of dissociation spectrum data that includes spectral peaks that represent fragments of a parent ion. The parent ion includes molecular subunits that are connected at cleavage sites. The technology accesses the dissoci... | 09/30/2008 |
| 7384790 | Method of analyzing peptide for determining C-terminal amino acid sequence The present invention provides a method for analyzing the C-terminal amino acid sequence of a peptide by applying reaction technique for successively releasing the C-terminal amino acids therefrom, which method can suppress, when releasing the C-terminal amino acids... | 06/10/2008 |
| 7371517 | High purity X-chromosome bearing and Y-chromosome bearing populations of spermatozoa Isolated non-naturally occurring populations of spermatozoa (15) having high purity and technologies to differentiate spermatozoa (28) based on characteristics such as mass, volume, orientation, or emitted light including methods of analysis and appara... | 05/13/2008 |
| 7297940 | Method, apparatus, and program product for classifying ionized molecular fragments Apparatus, methods, and program products are disclosed that classify spectral peaks in dissociation spectrum data and thereby improves the efficiency of molecular sequencing. ... | 11/20/2007 |
| 7297548 | Solid-phase saccharide sensing compounds The present invention provides solid-phase saccharide dyes. The dyes are bisboronic acids covalently bonded to a solid substrate. The dyes selectively conjugate with saccharides, particularly glucose, and register a signal. The signal is proportional to the quantity... | 11/20/2007 |
| 7273921 | Method for producing acylated peptides The present invention provides a method for acylating one or more amino groups of a peptide where the acylation reaction is to be performed in an aqueous mixture containing less than 10% w/w aprotic polar solvent. ... | 09/25/2007 |
| 7256002 | Screening for neurotoxic amino acid associated with neurological disorders Methods for screening for neurological disorders are disclosed. Specifically, methods are disclosed for screening for neurological disorders in a subject by analyzing a tissue sample obtained from the subject for the presence of elevated levels of neurotoxic amino a... | 08/14/2007 |
| 7229835 | Amine detection method and materials A compound linked to a solid support (R) through a divalent linker moiety (X) and which is represented by the following formula: is disclosed. In particular, the 1-hydroxybenzotriazole-6-carboxylic acid is direct... | 06/12/2007 |
| 7198955 | Method and apparatus for measurement of blood substitutes A method is disclosed whereby the concentration of a blood substitute, such as cross-linked hemoglobin, in a serum or plasma specimen is rapidly and accurately identified and quantified. The method further takes the measured concentration of the blood substitute and... | 04/03/2007 |
| 7169548 | Sperm cell processing and preservation systems Methods and apparatus are disclosed for processing sperm cells to accomplish preservation for future use while minimizing the adverse effects of such preservation. Sperm cells may be collected from a male animal and subjected to a first preservation step, including ... | 01/30/2007 |
| 7153692 | Diagnostic methods for determining susceptibility to convulsive conditions The present invention exploits the discovery that amounts of uracil and thymine metabolites, especially β-aminoisobutyric acid, in various bodily fluids, especially urine, are correlated with the occurrence of epilepsy when compared to matched control subjects. Ana... | 12/26/2006 |
| 7024316 | Transiently dynamic flow cytometer analysis system A flow cytometry apparatus and methods to process information incident to particles or cells entrained in a sheath fluid stream allowing assessment, differentiation, assignment, and separation of such particles or cells even at high rates of speed. A first signal pr... | 04/04/2006 |
| 7008800 | Biopolymer marker indicative of disease state having a molecular weight of 1077 daltons The instant invention involves the use of a combination of preparatory steps in conjunction with mass spectroscopy and time-of-flight detection procedures to maximize the diversity of biopolymers which are verifiable within a particular sample. The cohort of biopoly... | 03/07/2006 |
| 6890763 | Biopolymer marker indicative of disease state having a molecular weight of 1350 daltons The instant invention involves the use of a combination of preparatory steps in conjunction with mass spectroscopy and time-of-flight detection procedures to maximize the diversity of biopolymers which are verifiable within a particular sample. The cohort of biopoly... | 05/10/2005 |
| 6825045 | System and method of infrared matrix-assisted laser desorption/ionization mass spectrometry in polyacrylamide gels A system and method for desorption and ionization of analytes in an ablation medium. In one embodiment, the method includes the steps of preparing a sample having analytes in a medium including at least one component, freezing the sample at a sufficiently low temper... | 11/30/2004 |
| 6800486 | Method for quantitative determination of amino acids A novel method for the determination of amino acids by HPLC using pre-column derivatization is described. In this procedure, the aminno acids are derivatized with 2-chlorobenzoxazole to yield highly fluroresent N-(2-benzoxazolyl)-amino acids (BOX-AAs) for detection ... | 10/05/2004 |
| 6730518 | Method for preventing photooxidation or air oxidation in food, pharmaceuticals and plastics Disclosed is a method of reducing photooxidation or air oxidation in susceptible materials such as food, plastics or pharmaceuticals comprising mixing the material with an antioxidation composition comprising at least one amino acid, at least one metal ion, and at l... | 05/04/2004 |
| 6620624 | Mass spectrometry interface, a mass spectrometer and a mass spectrometry With rotating and translating a rotation-translation drum installed in a vacuum chamber of a mass spectrometry interface to constitute a mass spectro-meter, a liquid sample incorporating a dissolved substance to be analyzed in its mass is emitted for the ... | 09/16/2003 |
| 6605472 | Microfluidic devices connected to glass capillaries with minimal dead volume A method is provided for joining a microchip device to a capillary tube. The microchip device has a capillary channel opening onto an edge surface of the device. A short hole is drilled into the edge surface, aligned with the capillary channel. The drilli... | 08/12/2003 |
| 6582965 | Method for de novo peptide sequence determination The present invention relates to a method for generating a library of peptides based on a peptide of a predetermined molecular mass and to a method of determining the amino acid sequence of the peptide from the library. A set of amino acids that can be pr... | 06/24/2003 |
| 6566338 | Caspase inhibitors for the treatment and prevention of chemotherapy and radiation therapy induced cell death The use of caspase inhibitors for treating, ameliorating, and preventing non-cancer cell death during chemotherapy and radiation therapy and for treating and ameliorating the side effects of chemotherapy and radiation therapy of cancer is disclosed.... | 05/20/2003 |
| 6451974 | Method of acylating peptides and novel acylating agents Provided is a method for acylating one or more amino groups of a peptide or protein such as GLP-1. This method includes (a) reacting a peptide or protein having at least one free amino group with an acylating agent of formula I ##STR1## wherein n is ... | 09/17/2002 |
| 6451543 | Lipid matrix-assisted chemical ligation and synthesis of membrane polypeptides The present invention relates to methods and compositions for lipid matrix-assisted chemical ligation and synthesis of membrane polypeptides that are incorporated in a lipid matrix. The invention is exemplified in production of a prefolded membrane polype... | 09/17/2002 |
| 6432716 | Method to identify a surface-bound molecule The present invention relates to a method of identifying a molecule of a molecule-substrate complex, wherein the molecule is covalently attached directly to a substrate or indirectly by means of a linking moiety, comprising: (a) bombarding the molecule-su... | 08/13/2002 |
| 6426229 | Chelating agent and detergent comprising the same The present invention relates to a biodegradable amino-carboxylic acid chelating agent excellent in biodegradability and for use as a chelating agent, which is in the form of a solid, aqueous solution or slurry excellent in handling ability, wherein the c... | 07/30/2002 |
| 6316266 | Sample presentation apparatus for mass spectrometry A sample presentation device, with a surface-bound complex including at least one molecule which chemically modifies a biomolecule, is prepared and exposed to a biomolecule. The molecular weights of the chemically modified biomolecule is then determined b... | 11/13/2001 |
| 6277958 | Method for preparing peptide thiol ester The present invention provides a method for producing a peptide thiol ester using fluoren-9-ylmethoxycarbonylamino acid (Fmoc-amino acid). The method is for peptide synthesis and involves (1) using and removing the Fmoc group bound as the protective group... | 08/21/2001 |
| 6127189 | Compositions and methods for detection of an amine compound in a fingerprint The invention includes compositions comprising and methods of using 1,2-indanedione derivatives for detecting an amine compound such as an amino acid. Methods of detecting and recording the pattern of a fingerprint on a surface are also included, as are a... | 10/03/2000 |
| 6046053 | Method for amino acid sequencing of protein or peptide from carboxy terminus thereof A process is disclosed for sequencing proteins or peptides from the C-terminal end. The process comprises the steps of reacting the peptide or protein with an alkyl acid anhydride to convert the carboxy-terminal thereof into oxazolone, liberating the C-te... | 04/04/2000 |
| 6004770 | Sample presentation apparatus for mass spectrometry A sample presentation device, with a surface-bound complex including at least one molecule which chemically modifies a biomolecule, is prepared and exposed to a biomolecule. The molecular weights of the chemically modified biomolecule is then determined b... | 12/21/1999 |
| 6004933 | Cysteine protease inhibitors The present invention relates to cysteine protease inhibitors of the general formula (I): ##STR1## wherein Z is a cysteine protease binding moiety; X and Y are S, O or optionally substituted N; and R1 is optionally substituted alkyl or ... | 12/21/1999 |
| 5968834 | Method of carboxy terminal protein or peptide sequencing The present invention provides for an efficient and novel method for the C-terminal sequencing of proteins or peptides by use of acetyl chloride or phosphoryl chloride by reaction with a suitable isothiocyanate for derivitation of the carboxy terminus to ... | 10/19/1999 |
| 5786218 | Method for monitoring solid phase reactions A novel method for monitoring the success or the yield of chemical reactions involving a reactant bound to a solid phase support, or to forecast the success of such reactions, or to quantify the number of deuterium containing groups present in a solid-pha... | 07/28/1998 |
| 5744101 | Photolabile nucleoside protecting groups A synthetic strategy for the creation of large scale chemical diversity. Solid-phase chemistry, photolabile protecting groups, and photolithography are used to achieve light-directed spatially-addressable parallel chemical synthesis. Binary masking techni... | 04/28/1998 |
| 5665603 | Thiohydantoin formation and selective modification of the carboxy terminus of an aspartic acid- and/or glutamic acid-containing protein A method of forming a thiohydantoin from an N-protected amino acid is described. The method employs a phosphate compound selected from the group consisting of (R1 O)(R2 O)P(.dbd.O)X and (R1 O)(R2 O)P(.dbd.O)--O--P(.d... | 09/09/1997 |
| 5641685 | Method carboxy terminal protein or peptide sequencing The present invention provides for an efficient and novel method for the C-terminal sequencing of proteins or peptides by use of acetyl chloride or phosphoryl chloride by reaction with a suitable isothiocyanate for derivitazation of the carboxy terminus t... | 06/24/1997 |
