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| Number | Title | Issue Date |
| 7387772 | Chimeric, human and humanized anti-CSAP monoclonal antibodies The present invention provides humanized, chimeric and human anti-CSAp antibodies and anti-CSAp antibody fusion proteins that are useful for the treatment and diagnosis of various cancers, including colon cancer. ... | 06/17/2008 |
| 7371562 | Guided mode resonant filter biosensor using a linear grating surface structure Methods and compositions are provided for detecting biomolecular interactions. The use of labels is not required and the methods can be performed in a high-throughput manner. The invention also provides optical devices useful as narrow band filters. ... | 05/13/2008 |
| 7332290 | Dectection of AMACR cancer markers in urine The present invention relates to compositions and methods for cancer diagnostics, including but not limited to, cancer markers. In particular, the present invention provides gene expression profiles associated with prostate cancers. The present invention also provid... | 02/19/2008 |
| 7282345 | C-erbB-2 external domain: GP75 Disclosed are methods and compositions for identifying malignant tumors that overexpress the c-erbB-2 oncogene. Assays useful for diagnosis and prognosis of neoplastic disease are provided which detect the external domain of c-erbB-2, the glycoprotein gp75 and quant... | 10/16/2007 |
| 7262058 | Method for determining lipid associated sialoprotein in body fluids The amount of lipid associated sialoprotein (LSP) in body fluids such as cerebrospinal fluid, peritoneal fluid, pleural fluid, bronchial washings, saliva and sputum samples, may be determined by a method which may be automated, involving the following steps to be pe... | 08/28/2007 |
| 7236815 | Method for probabilistically classifying tissue in vitro and in vivo using fluorescence spectroscopy Fluorescence spectral data acquired from tissues in vivo or in vitro is processed in accordance with a multivariate statistical method to achieve the ability to probabilistically classify tissue in a diagnostically useful manner, such as by histopathological classif... | 06/26/2007 |
| 7223842 | Detection of proteins whose absence is associated with a neoplasm This invention relates to nucleic acid, or fragments thereof, encoding the retinoblastoma polypeptide, the retinoblastoma polypeptide itself, methods of detecting a defective retinoblastoma gene in human patients, and methods of treating these patients. ... | 05/29/2007 |
| 7202334 | Compositions and methods for the therapy and diagnosis of ovarian cancer Compositions and methods for the therapy and diagnosis of cancer, such as ovarian cancer, are disclosed. Compositions may comprise one or more ovarian carcinoma proteins, immunogenic portions thereof, polynucleotides that encode such portions or antibodies or immune... | 04/10/2007 |
| 7192698 | EphA2 as a diagnostic target for metastatic cancer Method and kits are provided for the detection and diagnosis of metastatic disease. More particularly, the methods and kits employ compounds that can detect EphA2, a specific epithelial cell tyrosine kinase that is overexpressed in metastatic tumor cells. In one emb... | 03/20/2007 |
| 7148332 | High affinity monoclonal antibody for recognizing the estrogen receptor (ER) and method for creating the antibody High affinity monoclonal antibodies for recognizing estrogen receptor (clone SP1) with immunohistochemistry and methods for creating such an antibody are disclosed. The lagomorph derived ER antibody provides a significant advantage over the currently available mouse... | 12/12/2006 |
| 7070943 | Detection of protein conformations in single cells Methods, reagents, and kits are provided that permit flow cytometric determination of the phosphorylation status of retinoblastoma susceptibility gene protein (pRB) in individual cells. Methods are described that permit the hypophosphorylated, active, form of pRB to... | 07/04/2006 |
| 7026132 | Method of monitoring the effect of Cathepsin S inhibitors The present invention relates to a method for monitoring the effect of in vivo administration of Cathepsin S inhibitors by measuring accumulation of an intermediate degradation product of invariant chain (Ii), in particular the p10 Ii fragment, in blood of dosed sub... | 04/11/2006 |
| 6991776 | Intracorporeal medicaments for high energy phototherapeutic treatment of disease New intracorporeal radiodense medicaments and certain medical uses and methods for use of such high energy phototherapeutic medicaments for treatment of human or animal tissue are described, wherein a primary active component of such medicaments is a halogenated xan... | 01/31/2006 |
| 6977173 | Apparatus and method for analyte detection Disclosed is a testing device and methods for the identification of an analyte of interest in a sample. In a preferred embodiment, the testing device includes a front panel having at least one sample application aperture; a rear panel having at least one solvent app... | 12/20/2005 |
| 6962808 | Method and apparatus for measurement of the effect of test compounds on signal transduction at the level of biological receptors There is provided an apparatus for screening pharmacological agents for agents which induce regression of cancer. The apparatus includes an evanescent sensing device, at least one sensor having affixed to its surface molecules of a first type, which have affinity fo... | 11/08/2005 |
| 6942985 | Methods of and kits and compositions for diagnosing colorectal tumors and metastasis thereof In vitro methods of determining whether or not an individual has metastasized colorectal cancer cells are disclosed. In vitro methods of determining whether or not tumor cells are colorectal in origin are disclosed. In vitro kits for practicing the methods of the in... | 09/13/2005 |
| 6855508 | ELISA for VEGF The vascular endothelial growth factor (VEGF) activity in a patient's bloodstream or other biological sample can serve as a diagnostic and prognostic index for cancer, diabetes, heart conditions, and other pathologies. Antibody-sandwich ELISA method and kits for VEG... | 02/15/2005 |
| 6844165 | Retentate chromatography and protein chip arrays with applications in biology and medicine This invention provides methods of retentate chromatography for resolving analytes in a sample. The methods involve adsorbing the analytes to a substrate under a plurality of different selectivity conditions, and detecting the analytes retained on the substrate by d... | 01/18/2005 |
| 6828431 | Compositions and methods for the therapy and diagnosis of breast cancer Compositions and methods for the therapy and diagnosis of cancer, particularly breast cancer, are disclosed. Illustrative compositions comprise one or more breast tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antige... | 12/07/2004 |
| 6794150 | Assay for YKL-40 as a marker for degradation of mammalian connective tissue matrices The invention is a method of identifying the presence of, and monitoring, a disease state in a mammal which is associated with degradation of connective tissue in the mammal. The method detects and determines whether diagnostically or prognostically significant leve... | 09/21/2004 |
| 6767711 | Treatment and diagnosis of prostate cancer The present invention is directed to the use of antibodies or binding portions thereof or probes which recognize an antigen of normal, benign, hyperplastic, and cancerous prostate epithelial cells or portions thereof. These antibodies or binding portions thereof or ... | 07/27/2004 |
| 6762032 | Compositions, assay kits, and methods for use related to a disease condition comprising multiple sclerosis and/or a pro-MS immune response Provided are methods, and assay kits, and compositions useful for generating an indicator of a disease condition selected from the group consisting of multiple sclerosis (MS), a pro-MS immune response, and a combination thereof. A method for assaying a sample of an ... | 07/13/2004 |
| 6727072 | EGF-r detection kit A kit containing the reagents necessary for the qualitative or quantitative demonstration of epidermal growth factor receptor (EGFR) in formalin-fixed, paraffin-embedded tissue sections. A immunohistochemical staining procedure is employed which utilizes a primary m... | 04/27/2004 |
| 6720146 | Compositions and methods for the therapy and diagnosis of ovarian cancer Compositions and methods for the therapy and diagnosis of cancer, particularly ovarian cancer, are disclosed. Illustrative compositions comprise one or more ovarian tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, anti... | 04/13/2004 |
| 6667156 | Diagnosis and treatment of neuroectodermal tumors The present invention provides fusion proteins for the detection and treatment of neuroectodermal tumors. Previous work demonstrated that chlorotoxin is specific for glial-derived or meningioma-derived tumor cells. The current invention has extended the u... | 12/23/2003 |
| 6656480 | Compositions and methods for the treatment and diagnosis of breast cancer Compositions and methods for the detection and therapy of breast cancer are disclosed. The compounds provided include nucleotide sequences that are preferentially expressed in breast tumor tissue, as well as polypeptides encoded by such nucleotide sequenc... | 12/02/2003 |
| 6632620 | Compositions for identification and isolation of stem cells The invention provides monoclonal antibodies that selectively bind to ectodermally- and endodermally-derived stem cells and methods for the diagnosis of a neoplasm in a subject by contacting a tissue sample from the subject with the antibodies. Also discl... | 10/14/2003 |
| 6632832 | Anti-cancer activity of carvedilol and its isomers The present invention provides for pharmaceutical compositions comprising carvedilol for treatment of cancer. More particularly the invention relates to the use of carvedilol for treatment of cancers of the colon, ovary, breast, prostate, pancreas, lung, ... | 10/14/2003 |
| 6613515 | Ovarian tumor sequences and methods of use therefor Compositions and methods for the therapy and diagnosis of cancer, such as ovarian cancer, are disclosed. Compositions may comprise one or more ovarian carcinoma proteins, portions thereof, polynucleotides that encode such portions or antibodies or immune ... | 09/02/2003 |
| 6602659 | Methods of and kits and compositions for diagnosing colorectal tumors and metastasis thereof In vitro methods of determining whether or not an individual has metastasized colorectal cancer cells are disclosed. In vitro methods of determining whether or not tumor cells are colorectal in origin are disclosed. In vitro kits for practicing the method... | 08/05/2003 |
| 6579684 | Assay of YKL-40 as a marker for cancer This invention is a method of identifying the presence of, and monitoring, a disease state in a mammal which is associated with degradation of connective tissue in the mammal. The method detects and determines whether diagnostically or prognostically sign... | 06/17/2003 |
| 6500633 | Method of detecting carcinomas The present invention relates to methods of detecting carcinomas by measuring the level of a glycero compound, such as glycerol-3-phosphate, in a plasma, serum, or urine specimen from a patient. The method is particularly useful as a screening test for ov... | 12/31/2002 |
| 6489113 | In-vitro diagnostic methods for determining whether a primary breast tumor is clinically metastatic A system of diagnostic test methods are provided for diagnosing whether a primary breast tumor from an individual human subject is a clinically metastatic tumor. These in-vitro diagnostic methods detect and utilize the presence or absence of a 55 kilodalt... | 12/03/2002 |
| 6451609 | Method of detecting gynecological carcinomas Methods for detecting or diagnosing gynecological carcinomas in a patient are provided. One method The method, which involves assaying for the presence of lysophosphatidic acid in a plasma sample of the patient, is useful for detecting ovarian carcinoma, ... | 09/17/2002 |
| 6448086 | Insulin-like growth factor system and cancer Method of monitoring or diagnosing disease conditions, including disease of the prostate, that involve measuring a combination of tumor markers and at least one component of the IGF axis. The invention is exemplified with prostate cancer and benign prosta... | 09/10/2002 |
| 6429018 | Prenatal screening for Down's syndrome using hyperglycosylated gonadotropin A prenatal screening method for Down's syndrome involves assaying for hyperglycosylated gonadotropin in biological test samples such as urine, plasma or serum obtained from pregnant women. Hyperglycosylated gonadotropin comprises a variant population of c... | 08/06/2002 |
| 6423503 | Forms of free prostate-specific antigen (PSA) and their association with prostate tissues from prostate peripheral zone and transition zone A method of distinguishing prostate cancer from benign prostatic hyperplasia (BPH) is provided. The mathematical combination or ratio of proPSA and BPSA serum or tissue markers may be used for distinguishing benign prostatic hyperplasia (BPH) from prostat... | 07/23/2002 |
| 6410333 | Assessment of human skin damage following exposure to harmful agents The present invention relates to the assessment of ultraviolet radiation UV effects on sunscreen-treated and non-treated human skin using a more sensitive technique.... | 06/25/2002 |
| 6335173 | Methods for detecting an analyte of interest using tyramide coating technology The present invention relates to methods of tyramide coating live cells for flow cytometry, using catalyzed reporter deposition and serial amplification staining. A catalyzed reporter deposition or an analyte dependent enzyme activation system is describe... | 01/01/2002 |
| 6335159 | Retinoic acid receptor &3xb5;(rar&3xb5;) This invention relates to substantially purified Retinoic Acid Receptor &3xb5; (RAR&3xb5;), having the amino acid sequence given in FIG. 1, and to the isolated nucleic acid encoding RAR&3xb5;. In addition, polypeptides comprising, and nucleic acids encodi... | 01/01/2002 |
