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| Number | Title | Issue Date |
| 7655480 | Method for predicting sepsis or an acute infectious inflammatory response The present invention in one embodiment is an early detection marker for chronic or acute inflammatory-associated diseases. Chronic diseases may include atherosclerosis, Alzheimer's disease, asthma, rheumatoid arthritis, osteoarthritis, and inflammatory diseases of ... | 02/02/2010 |
| 7645616 | Use of lipocalin-2 as a diagnostic marker and therapeutic target Methods and compositions for identifying and treating obesity and obesity-induced metabolic disorders are provided. One aspect provides a method for the evaluation of risk and progression of glucose tolerance, insulin resistance and Type 2 diabetes in mammalian subj... | 01/12/2010 |
| 7611910 | Method for diagnosis of alzheimer's disease The invention relates to a method of treating Alzheimer's disease in a mammal comprising administering to the mammal an anti-microbial agent having anti-Chlamydia pneumoniae activity. The invention also relates to a method of diagnosing Alzheimer's disease in... | 11/03/2009 |
| 7560290 | Method for the identification of a risk for a thrombogenic disorder by determining the TAFI-Ile347 polymorphism The present invention is directed to a method identifying a risk for a thrombogenic disorder, to a method for selecting patients with a risk for a thrombogenic disorder, to a method for identifying a pharmaceutical for the therapy or prophylaxis of a thrombogenic di... | 07/14/2009 |
| 7482174 | Disease markers for early stage atherosclerosis The invention relates to methods of diagnosing early stages of atherosclerosis. ... | 01/27/2009 |
| 7439026 | Methods and kits for detecting ITA in a biological sample Methods for detecting invasive trophoblast antigen (ITA) in biological samples comprise screening the samples for ITA using antibodies that bind to the ITA. The methods are useful to detect pregnancy, trophoblastic diseases, and Down's syndrome in fetuses of pregnan... | 10/21/2008 |
| 7427490 | Diagnostic markers of stroke and cerebral injury and methods of use thereof The present invention relates to methods for the diagnosis and evaluation of stroke and transient ischemic attacks. In a particular aspect, patient samples are analyzed for the presence or amount of a panel of markers comprising one or more specific markers for cere... | 09/23/2008 |
| 7424437 | Personal health card accessed secure medical data storage system A secure medical records maintenance system and associated removable memory storage device referred to as a “personal health card” for accessing the system. The secure medical records maintenance system includes a first remote server that stores patient identifi... | 09/09/2008 |
| 7413906 | Quantitative, high-throughput screening method for protein stability In proteomic research, it is often necessary to screen a large number of polypeptides for the presence of stable structure. Described herein are methods (referred to as MALDI MS-HX and SUPREX) for measuring the stability of proteins in a rapid, high-throughput fashi... | 08/19/2008 |
| 7410807 | Pregnancy and sex identification test based on saliva or other bodily fluids A method of testing an animal for pregnancy or sex identification comprising the steps of first, providing a first vessel containing a liquid and having a removable surface wherein said removable surface is at least partially coated with an antibody and then introdu... | 08/12/2008 |
| 7390631 | Diagnosis and monitoring of systemic lupus erythematosus and of scleroderma Methods for diagnosing and monitoring systemic lupus erythematosus (SLE) or scleroderma by determining, in a blood sample from the individual being diagnosed or monitored, complement component C4d deposited on surfaces of red blood cells in the sample, and optionall... | 06/24/2008 |
| 7368247 | Diagnostic assay for transmissible spongiform encephalopathies Heart and brain fatty acid binding proteins (H-FABP, B-FABP) are markers for TSEs, especially CJD. The invention provides a diagnostic assay for either of these markers, preferably by enzyme immunoassay using a specific antibody thereto. Since H-FABP is also a marke... | 05/06/2008 |
| 7361517 | Real time method of detecting acute inflammatory conditions This invention relates to the diagnosis and/or monitoring of patients with inflammatory diseases or conditions, including systemic lupus erythematosus, particularly for diagnosis of the acute stage of the disease, including methods and kits for carrying out this act... | 04/22/2008 |
| 7345144 | Cyclic peptides for treatment of cachexia A highly selective melanocortin-4 receptor antagonist cyclic hexapeptide of the formula where R1, R2, R3a, R3b, R4, R5, x, y and z are as defined in the spec... | 03/18/2008 |
| 7342089 | Cyclic peptides for treatment for cachexia A highly selective melanocortin-4 receptor antagonist cyclic peptide of the formula where R1, R2, R3, R4a, R4b, R5, R6, R7, x, y and z ... | 03/11/2008 |
| 7323346 | Screening for gestational disorders The invention relates to methods and compositions for identifying pregnant subjects having, or predisposed to having, gestational diabetes, preeclampsia, and gestational hypertension. The methods are applicable to urine and/or blood samples and can be conducted prio... | 01/29/2008 |
| 7312073 | Method for the detection of viable microorganisms Method for the detection and enumeration of viable microorganisms. A liquid that comprises one or more markers incorporated in a liquid sol-gel precursor, is provided. A transparent slide is coated with a thin uniform layer of the liquid sol-gel precursor compositio... | 12/25/2007 |
| 7309611 | Prewetting stop flow test strip A test strip and method for detecting an analyte present in a sample. The test strip comprising: a buffer addition zone to which a buffer may be added; an absorbent zone proximal to the buffer addition zone; one or more test zones distal to the buffer addition zone,... | 12/18/2007 |
| 7306949 | Combination of CRP and D-dimer for in vitro diagnosis of deep venous thrombosis (DVT) The present invention relates to an in vitro diagnostic method for patients with suspected deep venous thrombosis wherein by combined testing of patients' samples for D-dimer and CRP both the sensitivity and the negative predictive value of DVT diagnostics can be in... | 12/11/2007 |
| 7297556 | Method of diagnosing nephrotic syndrome This invention provides organic biomolecule markers (e.g., proteins) useful for differentiating minimal change nephrotic syndrome (MCNS) from focal segmental glomerulosclerosis (FCS), membranous nephrothropy (MN), and membranoproliferative glomerulonephritis (MPGN).... | 11/20/2007 |
| 7285218 | Method for the extra-corporeal qualitative and/or quantitative recording of neurotoxic substances in the blood plasma of an individual The invention relates to a method for the extra-corporeal qualitative and/or quantitative recording of neuro-toxic substances in the blood plasma of an individual. According to said method, a system containing neurones or neuronal networks, which have been cultivate... | 10/23/2007 |
| 7270995 | Analyzing device The present invention is an analytical device which comprises a porous piece assembly consisting of a liquid reagent-receiving porous piece (1), a labeled substance-retaining piece (2), a test piece (3) comprising a detection site (4) and... | 09/18/2007 |
| 7264938 | Method of detecting native proBNP The present invention relates to antibodies specifically binding to native proBNP, a method for specific detection of native proBNP, a method of correlating the level of native proBNP to the diagnosis of heart failure, a kit for detection of native proBNP and to a h... | 09/04/2007 |
| 7264939 | Method of detecting native proBNP The present invention relates to antibodies specifically binding to native proBNP, a method for specific detection of native proBNP, a method of correlating the level of native proBNP to the diagnosis of heart failure, a kit for detection of native proBNP and to a h... | 09/04/2007 |
| 7258994 | Saliva immunoassay for detection of antibodies for cardiovascular disease A method for diagnosing the likelihood and severity of cardiovascular disease in a patient is disclosed. The method determines the levels of antibodies against autoantigens, including myosin, oxidized LDL, β-2-glycoprotein, heat shock protein-60, platelet glycoprot... | 08/21/2007 |
| 7235625 | Multiple agent therapy for sexual dysfunction Multiple agent therapy for treatment of sexual dysfunction, including male erectile dysfunction, with sequential administration a type V phosphodiesterase inhibitor (PDE-5), such as sildenafil, preferably wherein the PDE-5 inhibitor is administered by oral dose mean... | 06/26/2007 |
| 7229839 | Bidirectional lateral flow test strip and method A test strip adapted to receive a sample and detect an analyte therein is provided. The test strip comprises a sample addition zone to which a sample may be added; an absorbent zone proximal to the sample addition zone; one or more test zones distal to the sample ad... | 06/12/2007 |
| 7223534 | Diffraction-based diagnostic devices A biosensor includes a substrate with a layer of receptive material disposed thereon. The receptive material is specific for an analyte of interest. A pattern of active and deactivated areas of the receptive material are defined in the receptive material layer by a ... | 05/29/2007 |
| 7208299 | Composition and method for regulating the adhesion of cells and biomolecules to hydrophobic surfaces The present invention is directed to a composition and method for regulating the adhesion of cells and biomolecules to hydrophobic surfaces and hydrophobic coated surfaces. The composition is a biomolecule conjugated end-group activated polymer (EGAP). The biomolecu... | 04/24/2007 |
| 7198954 | Methods for predicting pregnancy outcome in a subject by hCG assay The present invention provides a method of predicting pregnancy outcome in a subject by determining the amount of an early pregnancy associated molecular isoform of hCG in a sample. The present invention further provides a method for determining the amount of early ... | 04/03/2007 |
| 7192716 | Organ transplant rejection and associated conditions Protein markers associated with organ transplant rejection and associated conditions are disclosed, and in particular materials and methods relating to the diagnosis and treatment of acute rejection. Examples of markers include a-Crystallin b-chain Tropomyosin a-cha... | 03/20/2007 |
| 7192779 | Diagnosis of Smith-Lemli-Optiz syndrome The invention provides a non-invasive assay for the detection of a SLOS affected individual by determining the ratio of at least one of the specific SLOS steroid analytes, dehydro-estriol (8-DHE3) and a dehydro-pregnanetriol (7-DHPT) to their normal steroid counterp... | 03/20/2007 |
| 7176279 | Cyclic peptide compositions and methods for treatment of sexual dysfunction A cyclic peptide with a C-terminus —OH group. Further provided are compositions and methods for treatment of sexual dysfunction in mammals, including male sexual dysfunction, such as erectile dysfunction, and female sexual dysfunction, by administration of a cycli... | 02/13/2007 |
| 7166473 | Transferrin assay The invention relates to an assay method for assessing a transferrin variant or combination of transferrin variants for the diagnosis and monitoring of alcoholism, and to kits for performing the assay. In particular, the invention provides a method of producing an a... | 01/23/2007 |
| 7161034 | Lidocaine analogs and methods of making and using same Lidocaine analogs, latex particle-analog conjugates, and methods of making and using the same. The analogs have the formula: wherein Z comprises a nucleophilic group and optiona... | 01/09/2007 |
| 7148071 | Quantitative, high-throughput screening method for protein stability In proteomic research, it is often necessary to screen a large number of polypeptides for the presence of stable structure. Described herein are methods (referred to as MALDI MS-HX and SUPREX) for measuring the stability of proteins in a rapid, high-throughput fashi... | 12/12/2006 |
| 7148025 | Method of detecting native proBNP The present invention relates to antibodies specifically binding to native proBNP, a method for specific detection of native proBNP, a method of correlating the level of native proBNP to the diagnosis of heart failure, a kit for detection of native proBNP and to a h... | 12/12/2006 |
| 7144705 | Diagnostic assay for stroke Heart and brain fatty acid binding proteins (H-FABP, B-FABP) are markers for stroke. The invention provides a diagnostic assay for either of these markers, preferably by ELISA using anti-H-FABP or B-FABP antibody. Since H-FABP is also a marker for acute myocardial i... | 12/05/2006 |
| 7138237 | Diagnosis, prevention and treatment of Crohn's disease using the OmpC antigen The present invention provides a method of diagnosing Crohn's disease in a subject by determining the presence or absence of IgA anti-OmpC antibodies in the subject, where the presence of the IgA anti-OmpC antibodies indicates that the subject has Crohn's disease. | 11/21/2006 |
| 7138239 | Method and reagent for testing for multiple organ failure in SIRS by cytochrome C measurement A method for testing for multiple organ failure in SIRS, which comprises determining cytochrome C in body fluid and using the determined result as an index of the multiple organ failure, and a reagent for testing for multiple organ failure in SIRS, which comprises a... | 11/21/2006 |