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3M employee and church chorister Art Fry needed something to temporarily mark pages in his hymnal. He was in luck because his colleague, Spencer Silver, accidentally developed a glue that was too weak for other purposes. After initially discouraging consumer response, Post-it Notes became a hit in 1979.
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| Number | Title | Issue Date |
| 8183048 | Assay for screening/ranking antioxidants based on their effects on membrane sterol lateral organization A method of screening an antioxidant for potency and/or toxicity in vitro, the method includes contacting the antioxidant with a model system containing a sterol superlattice formation capable of generating a detectable signal, wherein the detectable signal changes ... | 05/22/2012 |
| 8173435 | Method for evaluating oil-and-fat amount in seed and method for screening for plant exhibiting varied level of oil-and-fat content This invention is intended to evaluate the oil-and-fat amount in a seed and genetic changes thereof. A fusion protein of an oil body-specific protein, such as the oleosin-GFP fusion protein, and a fluorescent protein is expressed, and the oil-and-fat amount in a pla... | 05/08/2012 |
| 8158435 | Tandem mass spectrometry for detecting and/or screening for conditions associated with altered sterols Embodiments of the present invention provide for detecting and/or screening for conditions associated with altered sterols by derivatization of sterols to provide suitable sensitivity and selectivity of detection using tandem mass spectrometry with electrospray ioni... | 04/17/2012 |
| 8137978 | Diagnostic method for biomarkers of adverse coronary events A diagnostic method using biomarkers to predict future adverse coronary events is provided. More particularly, the present invention is directed to diagnostic tests for characterizing an individual's risk of developing or having cardiovascular disease. In certain em... | 03/20/2012 |
| 8137977 | Lipidomic approaches to determining drug response phenotypes in cardiovascular disease The present invention concerns the application of lipidomics to statin treatment for disorders such as cardiovascular disorders. Hence, the invention provides, among other things, a method of correlating a lipid profile with a positive or negative response to a stat... | 03/20/2012 |
| 8124415 | Method and test for blood serum component analysis The discovery that apolipoprotein B exhibits spectral features in the mid IR spectrum that make it identifiable within blood serum leads to the invented use of a statistical correlation between a concentration of apolipoprotein-B (apoB) in a sample of blood serum an... | 02/28/2012 |
| 8097462 | Aerosol preparation of intact lipoproteins A medical diagnostic method and instrumentation system for analyzing noncovalently bonded agglomerated biological particles is described. The method and system comprises: a method of preparation for the biological particles; an electrospray generator; an alpha parti... | 01/17/2012 |
| 8093058 | Method of predicting phospolipidosis inducing properties of a substance The present invention is directed to a method for predicting the risk of a substance exhibiting phospholipidosis inducing properties, the method including adding the substance to an anionic surfactant to form a mixture of the substance and the surfactant, and determ... | 01/10/2012 |
| 8088625 | Method for detection of familial combined hyperlipidemia An object of the present invention is to provide an excellent method for detection and diagnosis of familial combined hyperlipidemia. The present invention relates to a method for detection of familial combined hyperlipidemia by measuring the concentration of small,... | 01/03/2012 |
| 8084261 | Method for predicting responsiveness to a pharmaceutical therapy for obesity Methods for using TRL V6 as a biomarker for the modulation of triglyceride and/or lipoprotein metabolism in a mammal induced by a weight loss pharmaceutical agent. The biomarker may be used for determining if an individual patient will likely respond favorably to a ... | 12/27/2011 |
| 8080425 | Quantitative analysis of a biological sample of unknown quantity Disclosed is a method for testing a modified specimen such as a dried blood spot, plasma or serum specimen, for an analyte of interest, such as cholesterol. In accordance with the disclosed subject matter, the level of the analyte of interest in the medium from whic... | 12/20/2011 |
| 8076145 | Method and apparatus for analyzing vitamin E in lipoproteins A method of analyzing vitamin E components in a lipoprotein by subjecting a lipoprotein-containing sample to ion exchange chromatography to separate the lipoprotein, reacting the separated lipoprotein to a pretreating solution containing an organic solvent and a sur... | 12/13/2011 |
| 8039263 | Estimation and biological consequences of oxidative metabolism The present invention relates to monitoring of oxidative metabolism and is, particularly, directed to a method for estimation of the lipid peroxide load or the consequent inflammatory state of a subject by measuring the concentration of the subject's oxidized HDL (h... | 10/18/2011 |
| 8030081 | Reagent for quantitative determination of small, dense LDLs A reagent for fractional measurement of small, dense LDLs without pretreatment of a specimen, which is adaptable to a rapid and convenient autoanalyzer, is provided. A method for quantitatively determining cholesterol in small, dense LDLs in a sample is further prov... | 10/04/2011 |
| 7981683 | Method and apparatus for analyzing vitamin E in lipoproteins A method of analyzing vitamin E components in a lipoproteinby subjecting a lipoprotein-containing sample to ion exchange chromatography to separate the lipoprotein, reacting the separated lipoprotein to a pretreating solution containing an organic solvent and a surf... | 07/19/2011 |
| 7927878 | Process for the determination of lipoproteins in body fluids The invention describes a process for the determination of the concentration distribution and size distribution of lipoprotein classes in body fluids, e.g. blood. For this purpose, NMR spectra of a sample to be analysed are measured by magnetic field gradient intens... | 04/19/2011 |
| 7858375 | Air-stable supported lipid bilayer membranes The present invention relates to methods for fabricating air-stable supported lipid bilayer membranes. In one embodiment, the present invention relates to methods of producing supported lipid bilayer membranes stabilized by sterol groups that are covalently tethered... | 12/28/2010 |
| 7851224 | Method of assessing a lipid-related health risk based on ion mobility analysis of lipoproteins A medical diagnostic method and instrumentation system for analyzing noncovalently bonded agglomerated biological particles is described. The method and system comprises: a method of preparation for the biological particles; an electrospray generator; an alpha parti... | 12/14/2010 |
| 7842506 | Apolipoprotein E genotyping and accompanying internet-based health management system The invention provides a system for monitoring a patient that includes: 1) a blood test that measures an Apo E genotype or a derivative thereof from the patient to generate Apo B information; 2) a database that receives and stores the patient's Apo E information; an... | 11/30/2010 |
| 7833795 | Assessment of cardiovascular risk using isoprostane biomarkers and COX-2 selective inhibitors The instant invention is drawn to methods and compositions useful for the assessment of cardiovascular risk in a mammal. The methods utilize biomarkers including prostanoid metabolites and isoprostanes as sensitive and stable markers of cardiovascular risk. The meth... | 11/16/2010 |
| 7811826 | Method of quantitatively measuring small particle low density lipoproteins The present invention provides a fast and simple method for fractional measurement of small particle low density lipoprotein (LDL). The method for quantifying small particle LDL in a test sample entails a first step of separating the small particle LDL from other lo... | 10/12/2010 |
| 7807469 | Methods for determining the feeding habits of an animal A method of determining whether an animal has ingested a plant of interest is provided. The method includes screening the animal for the presence of at least one indicator of a plant of interest. ... | 10/05/2010 |
| 7790465 | Methods, systems and computer programs for assessing CHD risk using adjusted LDL particle number measurements Methods, computer program products and apparatus determine a subject's risk of having or developing CHD using a calculated LDL particle risk number and/or a mathematical model of risk associated with LDL particles that adjusts concentrations of at least one of small... | 09/07/2010 |
| 7772007 | Assay device for direct measurement of LDL cholesterol An assay device and method for measuring the concentration of LDL-associated cholesterol in a blood-fluid sample are described. The method employs selective precipitation of VLDL and chylomicrons and immunoseparation of HDL from a blood fluid sample. The assay devic... | 08/10/2010 |
| 7713744 | Determining the risk of cardiovascular disease using ion mobility of lipoproteins A medical diagnostic method and instrumentation system for analyzing noncovalently bonded agglomerated biological particles is described. The method and system comprises: a method of preparation for the biological particles; an electrospray generator; an alpha parti... | 05/11/2010 |
| 7700360 | Optical method and system to determine distribution of lipid particles in a sample The system and method of the present invention relate to characterizing lipoproteins in a sample. The system includes a light source that delivers electromagnetic energy in a predetermined range of wavelengths to the sample and a sensor that senses an intensity spec... | 04/20/2010 |
| 7695971 | Use of non-absorbable fat in determining dietary fat absorption The use of sucrose polyester containing behenate fatty acid chains as a non-absorbable fat marker to determine total dietary fat absorption by the digestive tract of a subject. A test food for use in measuring fat absorption contains a non-absorbable fat and a dieta... | 04/13/2010 |
| 7687272 | Method and apparatus for determining blood oxygen transport The present invention relates to a method and apparatus for determining blood oxygen transport, and to measure lipid levels by correlating these levels with the rate at which oxygen diffuses through the red blood cell membrane. ... | 03/30/2010 |
| 7682831 | Method of measuring lipid in specific lipoprotein A method of measuring a lipid in a specific lipoprotein characterized by using a polycyclic polyoxyalkylene derivative at least in the step of determining the specificity of the measurement of the target lipid. ... | 03/23/2010 |
| 7638340 | Method of eliminating reactivity of lipoarabinomannan and application of the same A method of eliminating the reactivity of lipoarabinomannan contained in a sample to a Limulus reagent including at least the step of allowing the sample containing lipoarabinomannan to coexist together with a metal salt or a buffer; and a method of assaying ... | 12/29/2009 |
| 7582484 | High-density lipoprotein assay device and method An assay device and method for measuring the concentration of HDL-associated cholesterol in a blood-fluid sample are described. The assay design is such that removal of non-HDL lipoproteins from a sample and assay of HDL cholesterol in the sample occur without inter... | 09/01/2009 |
| 7566570 | Method for the separation of phospholipids from phospholipid-containing materials Methods are disclosed for extracting and separating polar lipids, including phospholipids, from materials containing oil, polar lipid, protein, ash, and/or carbohydrate, such as egg yolks and other phospholipid-containing materials. In particular, methods for extrac... | 07/28/2009 |
| 7544515 | Method of quantifying small-sized low density lipoprotein A fast and simple method for fractional measurement of a small particle LDL entails separating the small particle LDL and HDL from other lipoproteins, and then measuring cholesterol, triglycerides, or proteins in the separated small particle LDL. ... | 06/09/2009 |
| 7521248 | Apo B measurement system and method A system and method for measuring apolipoprotein B100 (apo B) during the cholesterol subclass measurement process is provided which obviates the need for a separate apo B test. ... | 04/21/2009 |
| 7510880 | Multidimensional mass spectrometry of serum and cellular lipids directly from biologic extracts A method for determination of at least one of the lipid species in a biological sample comprising subjecting the sample to lipid extraction to obtain a lipid extract and subjecting the resulting lipid extract to multidimensional electrospray ionization mass spectrom... | 03/31/2009 |
| 7491542 | Test device for determining the concentration of LDL-cholesterol in a sample The present invention provides a test device for determining the concentration of LDL-cholesterol in a sample. The test device has a continuous solid surface with at least one reaction area on the continuous solid surface, and the reaction area has, in dry form, a n... | 02/17/2009 |
| 7491543 | Biological markers for longevity and diseases and uses thereof This invention provides methods of using of the sizes and levels of high-density lipoprotein (HDL) and low-density lipoprotein (LDL) particles, the -641 allele of the promoter of the gene encoding apolipoprotein C-3 (APOC-3), the 405 allele of the gene encoding chol... | 02/17/2009 |
| 7482166 | Method and apparatus for preparing lipidic mesophase material A coupling system can utilize a first receptacle and a second receptacle to couple syringes together. Syringes can be used to mix viscous material and/or dispense the viscous material. Furthermore, a kit can be provided that contains parts used in mixing and/or disp... | 01/27/2009 |
| 7479392 | Quantitative analysis of a biological sample of unknown quantity Disclosed is a method for testing a modified specimen such as a dried blood spot, plasma or serum specimen, for an analyte of interest, such as cholesterol. In accordance with the disclosed subject matter, the level of the analyte of interest in the medium from whic... | 01/20/2009 |
| H2225 | Method for testing for bioaccumulation For use in estimating or predicting bioaccumulation of a chemical analyte, even a surfactant, log Pow values for the analyte may be determined by calculating the log of the ratio of the concentrations of the analyte in n-octanol and in water, equilibrated... | 10/07/2008 |
