"What, sir, would you make a ship sail against the wind and currents by lighting a bonfire under her deck? I pray you, excuse me, I have not the time to listen to such nonsense."
Napoleon Bonaparte ; When told of the Robert Fulton steamboat
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| Number | Title | Issue Date |
| 8445287 | Method and apparatus for determining anticoagulant therapy factors Methods and apparatus are disclosed for determining new anticoagulant therapy factors for monitoring oral anticoagulant therapy to help prevent excessive bleeding or deleterious blood clots that might otherwise occur before, during or after surgery. The inventive me... | 05/21/2013 |
| 8435792 | Methods and compositions for treating bleeding disorders Aspects of the invention include methods for enhancing blood coagulation in a subject. In practicing methods according to certain embodiments, an amount of a non-anticoagulant sulfated polysaccharide (NASP) is administered to a subject to enhance blood coagulation i... | 05/07/2013 |
| 8357539 | Activated partial thromboplastin time measuring reagent, activated partial thromboplastin time measuring method, and determination method for determining presence or absence of blood coagulation inhibitor An activated partial thromboplastin time measuring reagent, including a first reagent containing a phospholipid and an activator and a second reagent containing a herparin neutralizer and a calcium salt is disclosed. An activated partial thromboplastin time measurin... | 01/22/2013 |
| 8236568 | Method for analyzing hemostasis A method and device for blood hemostasis analysis is disclosed. A blood sample is displaced to reach a resonant state. The resonant frequency of the blood sample is determined before, during and after a hemostasis process. The changes in the resonant frequency of th... | 08/07/2012 |
| 8088624 | Method of detecting thrombosis by measuring von Willenbrand factor-cleaving protease A method of detecting thrombosis or the degree of thrombophilia by measuring a von Willebrand factor cleaving protease, and a kit for detecting thrombosis or the degree of thrombophilia, comprising an antibody or a fragment thereof specifically binding to a von Will... | 01/03/2012 |
| 8076144 | Protocol for risk stratification of ischemic events and optimized individualized treatment A hemostasis analyzer, such as the Thrombelastograph® (TEG®) hemostasis analyzer is utilized to measure continuously in real time, the hemostasis process from the initial fibrin formation, through platelet-fibrin interaction and lysis to generate blood hemostasis ... | 12/13/2011 |
| 8058073 | Immunodiagnostic test cards having indicating indicia An immunodiagnostic test card includes a plurality of transparent chambers wherein each chamber includes a quantity of testing material that combines with a patient sample, when mixed, to produce an agglutination reaction. A plurality of indicia are disposed to aid ... | 11/15/2011 |
| 8008086 | Protocol for monitoring direct thrombin inhibition A hemostasis analyzer, such as the Thrombelastograph® (TEG®) hemostasis analyzer is utilized to measure continuously in real time, the hemostasis process from the initial fibrin formation, through platelet-fibrin interaction and lysis to generate blood hemostasis ... | 08/30/2011 |
| 7977106 | Method for assaying coagulation in fluid samples This invention is a disposable cartridge for use at the patient side to perform traditional coagulation assays on fresh whole blood or blood derivative samples. The cartridge, in use with an electronic analyzer allows a fluid sample to be metered and quantitatively ... | 07/12/2011 |
| 7947505 | Method for testing efficacy of antithrombotic agent The present invention provides a method for testing quickly and easily the manner in which an antithrombotic agent inhibits the acceleration of blood coagulation when a platelet agonist causes acceleration of blood coagulation. The invention is a test method wherein... | 05/24/2011 |
| 7939329 | Protocol for risk stratification of ischemic events and optimized individualized treatment A hemostasis analyzer, such as the Thrombelastograph® (TEG®) hemostasis analyzer is utilized to measure continuously in real time, the hemostasis process from the initial fibrin formation, through platelet-fibrin interaction and lysis to generate blood hemostasis ... | 05/10/2011 |
| 7923256 | Method for assaying coagulation in fluid samples This invention is a disposable cartridge for use at the patient side to perform traditional coagulation assays on fresh whole blood or blood derivative samples. The cartridge, in use with an electronic analyzer allows a fluid sample to be metered and quantitatively ... | 04/12/2011 |
| 7923255 | Method of detecting platelet thrombosis or organ failure A method of detecting platelet thrombosis or organ failure in a patient suffering from disseminated intravascular coagulation (DIC) or systemic inflammatory response syndrome (SIRS), comprising analyzing a von Willebrand factor-cleaving protease and/or a cleaving fa... | 04/12/2011 |
| 7915049 | Method for investigating the thrombocyte function of the blood A method for investigating the thrombocyte function of the blood, and particularly of platelet aggregation, wherein the following steps are carried out: a) cross-flowing an aperture with blood or blood components; b) determining the active radius of the aperture dep... | 03/29/2011 |
| 7906338 | Systems and methods for measuring fluid properties A fluid property measurement system for measuring free stream particulates includes a fluid movement device positioned within a fluid container which is configured to cause fluid flow within the fluid container along a fluid flow path when a fluid is present. A cons... | 03/15/2011 |
| 7892842 | Procedure for the determination of the activity of the protease which activates factor VII from protein solutions The present application relates to procedures for the determination of the activity of the protease which activates factor VII, also known as factor VII activating protease or FSAP. The application also relates to a method of detecting whether an individual has incr... | 02/22/2011 |
| 7879615 | Hemostasis analyzer and method A method and device for blood hemostasis analysis is disclosed. A blood sample is displaced to reach a resonant state. The resonant frequency of the blood sample is determined before, during and after a hemostasis process. The changes in the resonant frequency of th... | 02/01/2011 |
| 7867771 | Reagent for measuring clotting time and method for stabilizing tissue factor The present invention provides a reagent for measuring clotting time including a nonionic surfactant, a nickel ion and a tissue factor. A method for stabilizing a tissue factor, and use of a nonionic surfactant and a nickel salt for stabilizing a tissue factor are a... | 01/11/2011 |
| 7785891 | Device and methods for identifying and treating aspirin non-responsive patients The present invention relates to methods and compositions for identifying and treating subjects in need of antithrombotic therapies but who are not responsive to aspirin. ... | 08/31/2010 |
| 7767459 | Method for determining prothrombin time A method for determining prothrombin time of a plasma or whole blood sample includes measuring prothrombin time for at least two different dilutions for a test sample to determine tmin or INRmin. The prothrombin time for at least two different ... | 08/03/2010 |
| 7767458 | Method for determining coagulation activation and device for carrying out said method A method is disclosed of assaying circulating microparticles contained in a sample of whole blood or blood plasma from a patient to determine the patient's ability to generate thrombin or Factor Xa as blood-clotting factors, wherein the circulating microparticles ar... | 08/03/2010 |
| 7754489 | Protocol for risk stratification of ischemic events and optimized individualized treatment A hemostasis analyzer, such as the Thrombelastograph® (TEG®) hemostasis analyzer is utilized to measure continuously in real time, the hemostasis process from the initial fibrin formation, through platelet-fibrin interaction and lysis to generate blood hemostasis ... | 07/13/2010 |
| 7745223 | Device with novel and improved surface properties To increase the adhesion strength of coagulated blood on a surface by increasing the surface interaction of blood-inherent components like fibrin/fibrinogen and thrombocytes it is described to treat the surface by exposing it to ionized atoms or molecules. The surfa... | 06/29/2010 |
| 7745224 | Procedure for the standardization of coagulation tests The present invention lies in the field of coagulation diagnosis and relates to a procedure for the standardization of coagulation tests, where calibrators are used to which a discrete standard coagulation time is assigned. The procedure is particularly suitable for... | 06/29/2010 |
| 7741124 | Detection procedures for fibrinogen and/or fibrinogen derivatives Described are determination procedures for fibrinogen and/or fibrinogen-derivatives by matrix-independent turbidimetry. In the FIFTA called procedure the fibrinogen activity is preferably determined in an undiluted sample by addition of thrombin and/or albumin, as w... | 06/22/2010 |
| 7732213 | Method of evaluating patient hemostasis A hemostasis analyzer, such as the Thrombelastograph® (TEG®) hemostasis analyzer is utilized to measure continuously in real time, the hemostasis process from the initial fibrin formation, through platelet-fibrin interaction and lysis to generate blood hemostasis ... | 06/08/2010 |
| 7544514 | Method and system for determining platelet-mediated clot formation The present subject matter concerns methods for determining platelet medicated clot formation. Specifically, the subject matter provides a method for determining platelet-medicated clot formation in a blood sample. The method may include obtaining sample of blood, a... | 06/09/2009 |
| 7534620 | Method and device for monitoring platelet function The invention provides a method of monitoring platelet function in a mammal by passing blood removed from the body of the mammal through a passageway to contact an obstruction or irregularity in the passageway to generate a platelet mass in the passageway, and monit... | 05/19/2009 |
| 7521247 | Cartridge for monitoring the function of a device for testing blood platelet function, method for function monitoring, and use of a test fluid A cartridge for monitoring the function of a device for blood platelet diagnosis has a housing which includes a test chamber and a holding chamber. A fluid volume of a test fluid is present inside the holding chamber. An air cushion is arranged above the fluid volum... | 04/21/2009 |
| 7510879 | Detection procedures for fibrinogen and/or fibrinogen derivatives Described are determination procedures for fibrinogen and/or fibrinogen-derivatives by matrix-independent turbidimetry. In the FIFTA called procedure the fibrinogen activity is preferably determined in an undiluted sample by addition of thrombin and/or albumin, as w... | 03/31/2009 |
| 7439069 | Blood coagulation test cartridge, system, and method A system and method for determining a coagulation time, e.g., thrombin time, PT, aPTT, and ACT, of a blood sample deposited in a test cartridge is disclosed. The test cartridge includes a blood receptacle that is open to the atmosphere into which a blood sample is t... | 10/21/2008 |
| 7422905 | Blood coagulation test cartridge, system, and method A system and method for determining a coagulation time, e.g., TT, PT, aPTT, and ACT, of a test sample deposited in a test cartridge is disclosed. A cartridge housing having upper and lower major sides and a minor sidewall encloses a test chamber having a test chambe... | 09/09/2008 |
| 7399637 | Blood coagulation test cartridge, system, and method A system and method for determining a coagulation time, e.g., TT, PT, aPTT, and ACT, of a blood test sample deposited in a test cartridge is disclosed. A cartridge housing having upper and lower major sides and a minor sidewall encloses a test chamber having a test ... | 07/15/2008 |
| 7393690 | Systems and methods for measuring fluid properties A method for measuring properties of a fluid including placing a quantity of fluid in a container; inducing flow in the fluid wherein the flow is substantially streamlined in at least a measuring region of the container by constricting flow, and wherein the fluid is... | 07/01/2008 |
| 7387880 | Method for monitoring resting and activated platelets in unfixed blood samples The amount of platelet surface proteins in a sample may be measured by collecting a sample containing platelets into a collection tube containing a platelet stabilizing composition, labeling the platelet surface protein and detecting by cytometry. ... | 06/17/2008 |
| 7361306 | Device and method for measuring coagulation time and platelet activity The present invention refers to a novel device for measuring coagulation time and platelet activity wherein the patient can measure his or her coagulation time and platelet activity without the aid of medical professionals due to the fact that this device is fully a... | 04/22/2008 |
| 7357016 | Process and device for determining viscosity A process and a device for determining the viscosity of a fluid are proposed. Very simple and accurate determination is enabled in that the magnetic particles in the fluid are set into vibration by a magnetic field which varies over time. A measurement of the amplit... | 04/15/2008 |
| 7357916 | Method for creating a uniform vascular wound in zebrafish or zebrafish larva Disclosed are improved methods for creating a uniform vascular wound in a zebrafish larva or zebrafish. The methods illustratively include subjecting a zebrafish larva to laser irradiation in an amount and for a period of time effective to cause a uniform vascular w... | 04/15/2008 |
| 7358337 | Assay for low molecular weight heparin A prothrombin time reagent for determination of low molecular weight heparin in frsh whole blood and in anti-coagulant treated blood is provided. The reagent is composed of recombinant animal tissue factor, and a mixture of synthetic phospholipids, which mixture inc... | 04/15/2008 |
| 7358091 | Device and methods for identifying and treating aspirin non-responsive patients The present invention relates to methods and compositions for identifying and treating subjects in need of antithrombotic therapies but who are not responsive to aspirin. ... | 04/15/2008 |