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Class 436/67 - Glycosylated hemoglobin


Subclass of Class 436 - Chemistry: analytical and immunological testing
Definition: Processes wherein glycosylated hemoglobin is subject to
No. of patents: 140
Last issue date: 01/10/2012


1        
NumberTitleIssue Date
8093057System for quantitative measurement of glycohemoglobin and method for measuring glycohemoglobin
The present disclosure provides a device for simultaneously detecting hemoglobin and glycohemoglobin in blood. The device includes a lateral flow assay strip, a laser-induced epifluorescence detection device, and an LED detection device. The present disclosure furth...
01/10/2012
8080423Reagent containing protease reaction promoter and/or colorant stabilizer
Stabilizers for colorants used for detection of enzymatic reactions, having a cyclodextrin and a catalase; reagents including stabilizers; and methods of use of such stabilizers and reagents. ...
12/20/2011
8021887Method of measuring glycated hemoglobin concentration
The present invention relates to a method and an apparatus that measure the concentration of glycated hemoglobin by an optical technique. A wavelength in which the molecular extinction coefficient of oxyhemoglobin agrees or substantially agrees with the molecular ex...
09/20/2011
8008085Method of measuring HbA1c
A method of measuring HbA1c is provided that, even with a whole blood sample after storage, measurement accuracy substantially equal to a whole blood sample right after collection can be maintained. Whole blood is stored in a presence of a glycolytic inhibitor and p...
08/30/2011
7998742Fluorescent assay
A method and apparatus to estimate the concentration of a non-fluorescent substance (e.g. haemoglobin) in a fluorescent assay by separately estimating the non time dependent alteration attributed to inherent filter effects from the time dependent alteration caused b...
08/16/2011
7943385Methods for assaying percentage of glycated hemoglobin
The invention provides enzymatic methods for direct determination of percentage of glycated hemoglobin in blood samples without the need of a separated measurement of total hemoglobin content in blood samples. The methods utilizes one or two different types of oxidi...
05/17/2011
7855079Methods for assaying percentage of glycated hemoglobin
The invention provides enzymatic methods for direct determination of percentage of glycated hemoglobin in blood samples without the need of a separated measurement of total hemoglobin content in blood samples. The methods utilizes one or two different types of oxidi...
12/21/2010
7592182Assay
Compositions and assay methods for and relating to the detection of glycated hemoglobin are provided. In particular, the presence and level of glycated hemoglobin can be detected in a blood sample. The compositions comprise microparticles which have zinc coating for...
09/22/2009
7534618Systems and methods for measuring glycated hemoglobin
Systems and methods for fractionating components of a sample are disclosed herein. A method of fractionating components of a sample includes establishing a solution density gradient in a capillary channel, applying the sample to the capillary channel, and centrifugi...
05/19/2009
7361513Cellular controls for glycated hemoglobin Hb A1c
Disclosed are cellular hemoglobin A1c (Hb A1c) normal and abnormal (high) controls for use in detecting Hb A1c levels. The present invention also relates to methods for generating cellular Hb A1c controls using red blood cells and methods for using the cellular cont...
04/22/2008
7347617Mixing in microfluidic devices
Mixing of liquids in a microfluidic device is accomplished by dispensing the liquids into a first chamber to produce combined liquid. The liquids are thereafter discharged through at least one capillary from the first chamber into a second chamber for complete mixin...
03/25/2008
7316700Self optimizing lancing device with adaptation means to temporal variations in cutaneous properties
A lancing device, an embodiment of which controls the advancement and retraction of a lancet by monitoring the position of the lancet in conjunction with a lancet controller which incorporates a feedback loop for modulating the lancet driver to follow a predetermine...
01/08/2008
7294312Test cartridge holder for blood samples
Improved methods and apparatus that make more accurate and reduces risk of filling reaction chambers of cartridge cells with blood samples to conduct blood coagulation tests of the type employing the plunger technique are disclosed. A cartridge holder is provided th...
11/13/2007
7288412Method and device for determining distribution of glycation of erythrocytic membranes
A method for determining the distribution of glycation of erythrocytic membranes includes steps of bonding magnetic beads having a boric acid group with sugars on the surfaces of erythrocytic membranes, and moving the erythrocytes bonded with the boric acid-magnetic...
10/30/2007
7267017Method to test indoor air quality
A method that allows an individual to personally test for contaminants in an air supply. The method consists of purchasing the test kit, placing the test kit on a device that produces air circulation and blowing air through the test kit. The test kit is then removed...
09/11/2007
7259846Lab in a cuvette
The present disclosure provides an apparatus for handling a liquid sample, wherein the apparatus includes integrated sample processing and sample evaluating components. The sample processing and evaluating components can include solid matrices that allow for optical...
08/21/2007
7238535Test cell for evaluating phosphor
An test cell is adapted for both making and testing samples. The cell includes a bottom plate and a top plate having concentric apertures defining a central test cavity. A post attached to the bottom plate closes off the bottom of the test cavity. A slide closes off...
07/03/2007
7235378Method of selectively determining glycated hemoglobin
A method of determining glycated hemoglobin is provided, by which a ratio of the glycated hemoglobin in a sample can be determined accurately and easily. The ratio of glycated hemoglobin can be determined by degrading a glycated hemoglobin in a whole blood sample se...
06/26/2007
7226790Method for measurement using sodium azide
A method of measuring an analyte in a sample with excellent sensitivity using a redox reaction is provided. In this method, a reducing substance or an oxidizing substance derived from the analyte is measured in the presence of a tetrazolium compound and sodium azide...
06/05/2007
7223728Synergistic use of thiazolidinediones with glucagon-like peptide-1 and agonists thereof to treat metabolic instability associated with non-insulin dependent diabetes
Thiazolidinedione (TZD) and its pharmacologically active derivatives can be used, in combination with agonists of glucagon-like peptide-1 (GLP-1), to treat non-insulin dependent diabetes mellitus, optionally with other therapies, by improving glycemic control while ...
05/29/2007
7195923Ratiometric determination of glycated protein
The present invention provides methods for determining a ratio of an amount of a glycated form of a protein to a total amount of the protein in a sample containing the glycated protein, the glycosylated protein, or the glycoprotein. The method incorporates lateral f...
03/27/2007
7150995Methods and systems for point of care bodily fluid analysis
The invention provides a system for quantitative measurement of percent glycated hemoglobin as hemoglobin A1c in whole blood having extended shelf life at room temperature. The system comprising a blood dilution solution and a device adapted for receiving at least a...
12/19/2006
7138091Reaction cuvette having anti-wicking features for use in an automatic clinical analyzer
A reaction cuvette having anti-wicking wall fillets that inhibit liquid wicking along an interior wall surface so that the reaction cuvette may be used in a cuvette-rewashing system in an automated analyzer and not be adversely affected by any reagent contaminants r...
11/21/2006
7125711Method and apparatus for splitting of specimens into multiple channels of a microfluidic device
A microliter liquid sample, particularly a biological sample, is analyzed in a device employing centrifugal and capillary forces. The sample is moved by capillary forces into one or more metering wells which define the amount of the sample to be analyzed in subseque...
10/24/2006
7108833Sample tab
A sample tab for retaining a sample during spectroscopic analysis includes a base plate, a sample well, and a cover plate. The sample well may vary in size to accommodate different sample volumes, and the base of the sample well may be positioned above or below the ...
09/19/2006
7094354Method and apparatus for separation of particles in a microfluidic device
A microfluidic device provides separation of particles in a liquid sample, particularly, separation of a sample of whole blood into its components for further analysis. Separation into red blood cells and plasma occurs within a few seconds after the blood sample has...
08/22/2006
7045310Redox reversible bipyridyl-osmium complex conjugates
Novel bipyridyl-osmium complex conjugates and their use in electrochemical assays are described. The redox reversible-osmium complexes can be prepared to exhibit unique reversible redox potentials and can thus be used in combination with other electroactive redox re...
05/16/2006
7034126Lactoferrin in the treatment of diabetes mellitus
The present invention relates to methods of using a composition of lactoferrin for the treatment of diabetes mellitus as manifested by a reduction in the levels of serum glucose, blood pressure, obesity, or glycosylated hemoglobin (HbAlc). ...
04/25/2006
7005273Method for the determination of glycated hemoglobin
A method of determining the percentage of glycated hemoglobin in a blood sample is disclosed wherein at least one of the assay steps is performed electrochemically. The method includes determining the total amount of hemoglobin in a sample by electrochemically measu...
02/28/2006
6977173Apparatus and method for analyte detection
Disclosed is a testing device and methods for the identification of an analyte of interest in a sample. In a preferred embodiment, the testing device includes a front panel having at least one sample application aperture; a rear panel having at least one solvent app...
12/20/2005
6951728Multilayer reagent test strips to quantify glycated protein in a physiological sample
Multilayer reagent test strips for quantitating glycated protein in a fluid sample, as well as methods for using the same, are provided. The subject multilayer test strips include at least a filter layer, a proteinase layer and a ketoamine oxidase signal producing a...
10/04/2005
6949384Method for monitoring degradation of Hb-based blood substitutes
The present invention provides a method for monitoring degradation of Hb-based blood substitutes, in a sample. This method involves determining a concentration of met-Hb within the sample, by applying a calibration algorithm for met-Hb to an absorbance obtained from...
09/27/2005
6911427No-modified hemoglobins and uses therefore
S-nitrosohemoglobin (SNO-Hb) can be formed by reaction of Hb with S-nitrosothiol and by other methods described herein which do not result in oxidation of the heme Fe. Other methods can be used which are not specific only for thiol groups, but which nitrosate Hb mor...
06/28/2005
6906183Process for the separation of glycosylated and nonglycosylated proteins
A process for the partial or complete separation of glycosylated and nonglycosylated proteins is described, in which: a) a triazine dye immobilized on a matrix is incubated with a mixture of glycosylated and nonglycosylated proteins, b) the matrix is then washed to ...
06/14/2005
6844195Method for determining location of gastrointestinal bleeding
A method for determining if blood in a stool sample originated from the upper or lower gastrointestinal tract. This includes a method for purifying and concentrating hemoglobin and its products from a stool sample to allow a simple and sensitive spectrophotometric a...
01/18/2005
6790665Method of quantifying hemoglobin and method of measuring glycation ratio of hemoglobin
A method of determining Hb is provided, by which an amount of Hb can be determined easily and accurately without fear of damage to the environment. Hemoglobin in a sample is denatured with a tetrazolium compound to give denatured hemoglobin, and an amount of an opti...
09/14/2004
6677158Method for measurement of glycated hemoglobin by a rapid strip test procedure
The present invention is directed to a novel method for measurement of glycated hemoglobin, as well as assay methods and processes that can be used outside the medical laboratory setting to determine the fraction of total hemoglobin that is glycated....
01/13/2004
6582964Method and apparatus for rapid measurement of HbA1c
Described is a method and apparatus for determining a diabetic patient's compliance with their insulin dosing regime. The method and apparatus involves taking a blood sample from a patient by a routine finger prick and placing it in a special sample tab w...
06/24/2003
6562581Method for quantitative determination of glycated hemoglobin
A method and a system for separating glycated hemoglobin from non-glycated hemoglobin, and a method for one-read quantitative determination of the glycated hemoglobin and % HbA1c that does not require an additional measurement of total hemoglob...
05/13/2003
6562625Distinguishing test types through spectral analysis
A method and apparatus for automatically selecting test types for an analytical meter system based on the insertion into the meter of a test element. The test element can be an analytical element, formed by a test strip with a fluid such as blood applied ...
05/13/2003
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