Did You Know...
...that Thomas Edison's patent application on his phonograph was approved by the Patent Office in just seven weeks? In contrast, it took Gordon Gould, the inventor of the laser, 30 years to obtain his patent -- finally awarded in 1988!
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| Number | Title | Issue Date |
| 8012756 | Charge perturbation detection system for DNA and other molecules Methods and apparatus for direct detection of chemical reactions are provided. In a preferred embodiment, electric charge perturbations of the local environment during enzyme-catalyzed reactions are sensed by an electrode system with an immobilized target molecule. ... | 09/06/2011 |
| 7981677 | Identifying a high oil phenotype in maize by detecting a marker locus genetically linked with a QTL6 region Compositions related to the quantitative trait locus 6 (QTL6) in maize and methods for their use are provided. The compositions are novel molecular marker loci that are genetically linked with QTL6 and which are associated with increased oil content and/or increased... | 07/19/2011 |
| 7955853 | Method and device for creating and analyzing an at temerature and pressure oxidation-reduction potential signature in hot water systems for preventing corrosion Disclosed is a method of creating a real-time oxidation-reduction potential signature in a hot water system to detect REDOX stress and inhibit corrosion in the hot water system. The method includes defining one or more operational protective zones in the hot water s... | 06/07/2011 |
| 7951596 | Nucleic acid nanotube liquid crystals and use for NMR structure determination of membrane proteins Compositions and methods for preparing nucleic acid nanotubes using DNA origami techniques are described, which provide for nanotubes of predictable and uniform length. The nucleic acid nanotubes thus formed are suitable as liquid crystal preparations enabling liqui... | 05/31/2011 |
| 7871820 | High frequency of neurexin 1β signal peptide structural variants in patients with autism The three β-neurexins have similar roles in synaptogenesis and interact with the neuroligins. Mutations located within the gene encoding neurexin 1 have been identified as molecular markers associated with autism and autism-related disorders. The estimated attribut... | 01/18/2011 |
| 7846734 | Polynucleotides for use as tags and tag complements, manufacture and use thereof A family of minimally cross-hybridizing nucleotide sequences, methods of use, etc. A specific family of 210 24 mers is described. ... | 12/07/2010 |
| 7807465 | Methods for identifying an individual at increased risk of developing coronary artery disease The present invention provides methods of identifying a subject having an increased or decreased risk of developing cardiovascular disease, comprising: a) correlating the presence of one or more genetic markers in chromosome 3q13.31 with an increased or decreased ri... | 10/05/2010 |
| 7709262 | Method for detecting and quantifying rare mutations/polymorphisms The present invention is directed to a method for detecting and quantifying rare mutations in a nucleic acid sample. The nucleic acid molecules under investigation can be either DNA or RNA. The rare mutation can be any type of functional or non-functional nucleic ac... | 05/04/2010 |
| 7700359 | Gene products differentially expressed in cancerous cells The present invention provides polynucleotides, as well as polypeptides encoded thereby, that are differentially expressed in cancer cells. These polynucleotides are useful in a variety of diagnostic and therapeutic methods. The present invention further provides me... | 04/20/2010 |
| 7670840 | Micro-RNA expression abnormalities of pancreatic, endocrine and acinar tumors The present invention provides novel methods and compositions for the diagnosis, prognosis and treatment of pancreatic cancer. The invention also provides methods of identifying anti-pancreatic cancer agent. ... | 03/02/2010 |
| 7604996 | Compositions and methods for preparing oligonucleotide solutions The present invention is directed to methods and compositions for generating a pool of oligonucleotides. The invention finds use in preparing a population or subpopulations of oligonucleotides in solution. The pool of oligonucleotides finds use in a variety of nucle... | 10/20/2009 |
| 7601538 | Method for analyzing impurity This method for analyzing impurity includes: a step of immersing each of sets of two evaluation silicon wafers into a washing solution, thereby contaminating the evaluation silicon wafers to be in a same state of contamination; a step of dissolving each of a surface... | 10/13/2009 |
| 7588941 | Dispersion of carbon nanotubes by nucleic acids Nucleic acid molecules in a stabilized solution such as single stranded DNA and RNA were able to disperse high concentration of bundled carbon nanotubes into aqueous solution. ... | 09/15/2009 |
| 7585677 | Method of evaluating corrosion resistance of material under ammonium bisulfide environment It is an object to establish a test method that enables a high-concentration ammonium bisulfide environment to be reproduced at a laboratory level, and enables the corrosivity of a material to be evaluated easily and highly accurately. According to the test method, ... | 09/08/2009 |
| 7569392 | Multiplex spatial profiling of gene expression The present invention provides mass tag complexes that permit simultaneously obtaining information of a plurality of biological molecules. The biological molecules may be RNA or protein, and the information includes both level of expression as well as spatial dispos... | 08/04/2009 |
| 7566569 | Method for measuring surface temperature The present invention relates to a method for measuring a surface temperature using is a fluorescent temperature sensor or optical thermometer. The sensor includes a solution of 1,3-bis(1-pyrenyl)propane within a 1-butyl-1-1-methyl pyrrolidinium bis(trifluoromethyls... | 07/28/2009 |
| 7459311 | Method of sequencing DNA The present invention provides a method of identifying a base at a target position in a sample nucleic acid sequence, said method comprising: subjecting a primer hybridised to said sample nucleic acid immediately adjacent to the target position, to a polymerase prim... | 12/02/2008 |
| 7371382 | Methods of inhibiting αβ-mediated binding with αβ-specific antibodies The invention provides enhanced LM609 grafted antibodies exhibiting selective binding affinity to αVβ3, or a functional fragment thereof. The invention also provides nucleic acid molecules encoding the enhanced LM609 grafted antibodies. Addit... | 05/13/2008 |
| 7371833 | Nucleic acid molecules with specific recognition of native PrP, production and use The invention relates to a method for isolating nucleic acid molecules which are capable of specific interaction with native PrPSc and can differentiate between native PrPc and native PrPSc. The inventive method comprises the followi... | 05/13/2008 |
| 7368086 | Functionalized fluorescent nanocrystals, and methods for their preparation and use Functionalized fluorescent nanocrystal compositions and methods for making and using these compositions are disclosed. The compositions are fluorescent nanocrystals coated with at least one material. The coating material has chemical compounds or ligands with functi... | 05/06/2008 |
| 7368242 | Method and kits for multiplex hybridization assays The invention provides a method for genotyping interfering polymorphic loci in a target polynucleotide, such as a strand of genomic DNA, in a multiplex hybridization-based assay. The invention also provides nucleic acid standards for validating the performance of su... | 05/06/2008 |
| 7364904 | Methods and composition for diagnosing and treating and related conditions Methods and compositions are provided for diagnosing and treating Pseudoxanthoma elasticum (PXE) patients and PXE carriers. Methods and compositions are based on the discovery that PXE mutations are located in the MRP6 (ABCC6) gene. ... | 04/29/2008 |
| 7343249 | Vectorization of sequence alignment computation using distance matrix reshaping A method for comparing data sequences includes accepting first and second data sequences of data elements. A distance matrix is computed. The matrix includes rows and columns of matrix elements, describing distances between the data elements of the first sequence an... | 03/11/2008 |
| 7332275 | Methods for detecting methylated nucleotides A method for detecting methylated nucleotides within a nucleic acid sample is provided. The method includes the steps of splitting a nucleic acid sample into separate reaction vessels; contacting nucleic acid in one reaction vessel with bisulfite; amplifying the nuc... | 02/19/2008 |
| 7309588 | Nucleic acid assays The present invention relates to the detection of specific nucleic acid sequences after an amplification process, or directly without amplification. In particular, the invention provides for the automation of the amplification and detection process, the amplificatio... | 12/18/2007 |
| 7303869 | Solid-phase reactions The present invention relates to systems, compositions, and methods for the detection and characterization of nucleic acid sequences and variations in nucleic acid sequences. The present invention relates to methods for attaching nucleic acids to solid supports and ... | 12/04/2007 |
| 7303725 | Automated high volume slide staining system An automated slide processing apparatus includes a plurality of work stations arranged in a stack, and a transport/elevator for transporting slides between the various work stations. ... | 12/04/2007 |
| 7294487 | Combinatorial oligonucleotide PCR: a method for rapid, global expression analysis The present invention relates to a method for the detection of gene expression and analysis of both known and unknown genes. The invention is a highly sensitive, rapid and cost-effective means of monitoring gene expression, as well as for the analysis and quantitati... | 11/13/2007 |
| 7270969 | Methods of constructing and screening diverse expression libraries The present invention provides novel methods for producing nucleic acid fragment libraries that express highly diverse peptides or protein domains and, in particular, methods for producing nucleic acid fragment libraries wherein the nucleic acid fragments of the lib... | 09/18/2007 |
| 7264963 | Protein(poly)peptide libraries The present invention relates to synthetic DNA sequences which encode one or more collections of homologous proteins/(poly)peptides, and methods for generating and applying libraries of these DNA sequences. In particular, the invention relates to the preparation of ... | 09/04/2007 |
| 7262008 | Nucleic acid assays The present invention relates to the detection of specific nucleic acid sequences, either by a process of amplification of specific nucleic acid sequences or not. More particularly the invention provides for improved compositions and methods for reducing the chance ... | 08/28/2007 |
| 7253435 | Particles with light-polarizing codes Systems using coded particles for multiplexed analysis of biological samples or reagents, in which the codes on the particles are at least partially defined by light-polarizing materials. ... | 08/07/2007 |
| 7246516 | Device for coupling thermogravimetric analyses and acoustic emission measurements The present invention relates to a device comprising a thermobalance equipped with a detector (5) for measuring acoustic signals emitted by a sample (6) hanging from the balance beam and a preamplifier (2) incorporated in the vicinity of the hea... | 07/24/2007 |
| 7246627 | Monitoring of cleaning process An apparatus for monitoring a cleaning process for a medical device includes a cleaning chamber for receiving and cleaning the instrument with a cleaning liquid, a receiving well within the cleaning chamber, a removable soil standard receivable within the receiving ... | 07/24/2007 |
| 7244500 | Smart coating system An active coating system capable of collecting, analyzing, managing and adapting to data and/or its environment in real time. An exemplary embodiment of our inventive active coating system is corrosion resistant and includes a flexible sensor layer, a switch layer a... | 07/17/2007 |
| 7238263 | Corrosion tester A portable, handheld, automatic protection level interpreting cathodic protection meter for testing the level of protection being afforded to metallic structures protected by either sacrificial anode or impressed current cathodic protection systems, or both. The met... | 07/03/2007 |
| 7238795 | Nucleic acid binding compounds containing pyrazolo[3,4-d]pyrimidine analogues of purin-2,6-diamine and their uses The present invention is in the field of nucleic acid binding compounds comprising 7-substituted 7-deaza-8aza-2,6-diamino-purine bases, compounds useful for the preparation of such compounds, various uses thereof and methods for the determination of nucleic acids us... | 07/03/2007 |
| 7238530 | Isolation and amplification of nucleic acid materials The invention relates to methods for easily separating single stranded nucleic acid material from double stranded nucleic acid material in a sample containing both. By the right choice of at lease one chaotropic agent, preferably a guanidine salt, at a selected conc... | 07/03/2007 |
| 7238488 | Therapeutic and diagnostic applications of perlecan domain I splice variants A method of producing antibodies comprising the step of encoding a peptide sequence from a Domain I perlecan splice variant, wherein the peptide sequence is used to produce anti-peptide antibodies. ... | 07/03/2007 |
| 7238323 | Microfluidic sequencing systems Integrated systems, apparatus, software, and methods for performing biochemical analysis, including DNA sequencing, genomic screening, purification of nucleic acids and other biological components and drug screening are provided. Microfluidic devices, systems and me... | 07/03/2007 |
