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| Number | Title | Issue Date |
| 7723127 | Immunoassay with extended dynamic range The present invention provides a method of performing a competitive assay for the detection and quantification of an analyte over an extended dynamic range. This is achieved by a multi-step sample addition method whereby different concentrations of sample are added ... | 05/25/2010 |
| 7371829 | Haptens, immunogens, antibodies and conjugates to ketamine and its metabolites The invention provides haptens, immunogens comprising such haptens coupled to an antigenicity-conferring carrier material, conjugates comprising such haptens bonded to a labelling agent as well as, antibodies raised against such immunogens and capable of binding wit... | 05/13/2008 |
| 7355079 | Thyronamine derivatives and analogs and methods of use thereof Thyronamine derivatives and analogs, methods of using such compounds, and pharmaceutical compositions containing them are disclosed. Methods of preparing such compounds are also disclosed. ... | 04/08/2008 |
| 7332344 | Luminescence assays A method of detecting an analyte is described in which an up-converting luminescent species that is excited by absorption of long wavelength light is provided as a donor of energy to an acceptor species that can be bound to, or generated in proximity to, the lumines... | 02/19/2008 |
| 7241578 | Immunoassay method/equipment, biological component measurable toilet, anti-albumin monoclonal antibody, cell strain producing the same, and albumin detection kit The immunoassay method of this invention measures the content of a subject substance in a sample. The method includes the steps of: (a) preparing a mixed solution by mixing the sample and an antibody solution including a first monoclonal antibody and a second monocl... | 07/10/2007 |
| 7230088 | Compounds for dual photodiagnosis and therapy The invention discloses compounds and compositions for dual phototherapy and combined therapy and diagnosis of tumors and other lesions. The compounds have a Dye that, when photoactivated, operates via Type I and/or Type II mechanisms. Other Dye or azide components ... | 06/12/2007 |
| 7217518 | Fluorescence polarization assay The present invention relates to methods for detecting the presence of one or more analytes of interest in a sample by measuring changes in fluorescence anisotropy as a result of binding of the analytes to specific aptamers. The aptamers are immobilized on a solid s... | 05/15/2007 |
| 7211440 | Dissociative fluorescence enhancement assay The invention relates to an enhancement solution for an assay technology using lanthanide ions or their chelates as labels and dissociative fluorescence enhancement as a tool for detection, wherein said enhancement solution comprises a β-diketone of formula I | 05/01/2007 |
| 7189555 | Proteases from gram-positive organisms The present invention relates to the identification of novel metallo-proteases (MP) in Gram-positive microorganisms. The present invention provides the nucleic acid and amino acid sequences for Bacillus (MP). The present invention also provides host cells hav... | 03/13/2007 |
| 7166475 | Compositions and methods for monitoring the modification state of a pair of polypeptides This invention relates to a method for analyzing a sample comprising: immobilising a polypeptide to a physical support; contacting the immobilised polypeptide with a test sample which may contain an agent capable of modifying the immobilised polypeptide; contacting ... | 01/23/2007 |
| 7154007 | Luminous compounds and labeling reagents using the same This invention provides: a compound represented by formula (I): R—Y—(—X-Phe-COCH2COCnF2n+1)m (I) wherein R denotes hydrogen, alkyl, phenyl, or a group capable of binding to a protein, peptid... | 12/26/2006 |
| 7144709 | Diagnostics based on tetrazolium compounds A reagent is suitable for measuring the concentration of an analyte in a hemoglobin-containing biological fluid, such as whole blood. The reagent comprises a flavin-dependent enzyme that has specificity for the analyte, a flavin cofactor if, and only if, a flavin is... | 12/05/2006 |
| 7122383 | Fluorescent polymer superquenching-based bioassays A chemical composition including a fluorescent polymer and a receptor that is specific for both a target biological agent and a chemical moiety including (a) a recognition element, (b) a tethering element, and (c) a property-altering element is disclosed. Both the f... | 10/17/2006 |
| 7115383 | Assays for amphetamine and methamphetamine Methods, compositions and kits are disclosed. The compounds disclosed comprise an amphetamine moiety and a methamphetamine moiety linked together by a first linking group. A second linking group depends from the first linking group and comprises a functional group. ... | 10/03/2006 |
| 7109043 | Fluorescent probe for magnesium ion determination A fluorescent probe for measuring magnesium ion, which can selectively form a complex with magnesium ion in aqueous system is disclosed. The fluorescent probe for measuring magnesium ion according to the present invention has the structure represented by the followi... | 09/19/2006 |
| 7101980 | Derivatives, conjugates, and antibodies for detecting ecstasy-class analytes Compounds including haptens, intermediates, and immunogens that are useful in the production of antibodies specific for the methylenedioxy class of amphetamine derivatives are described. Antibodies specific for the methylenedioxy class of amphetamine derivatives, re... | 09/05/2006 |
| 7098039 | Analysis of a sample to determine its characteristic cycle time An analysis for determining a characteristic cycle time of a sample. Active elements in the sample are excited with sufficient intensity and duration larger than the characteristic cycle time that at least some of the active elements are re-excited to an excited sta... | 08/29/2006 |
| 7037669 | Assays for amphetamine and methamphetamine using stereospecific reagents Methods, compositions and kits are disclosed. Enzyme conjugates of Formula I may be employed in assays for the determination of an amphetamine and/or a methamphetamine. Immunogenic conjugates of Formula I may be employed to prepare antibodies for an amphetamine and/... | 05/02/2006 |
| 7029919 | Electro-optical device and methods for hybridization and detection The invention provides an apparatus and method for detection of a target molecule. The apparatus includes a probe labeled with a transition metal-ligand complex that hybridizes with the target to form an initial complex, a metal ion for doping the initial complex an... | 04/18/2006 |
| 7029856 | Methods for determination of an analyte The invention relates to analytical methods in which the partition of a labeled substance between a liquid and a solid phase is determined. The assays include solid-phase reagents which can be particulate or monolithic such as, for example, a coated tube. Assays of ... | 04/18/2006 |
| 7026166 | Fluorogenic dyes The present invention relates to the use of fluorogenic or chromogenic dyes as reporter molecules for detecting cell entry by a specific molecule. ... | 04/11/2006 |
| 7022492 | Ecstasy haptens and immunogens Methods, compositions and kits are disclosed. Enzyme conjugates of Formula I are employed in assays for the determination of an methylenedioxyamphetamine, a methylene-dioxyethamphetamine, and/or a methylenedioxymethamphetamine. Immunogenic conjugates of Formula I ar... | 04/04/2006 |
| 7011955 | Quantitative determination of analytes in a heterogeneous system The invention concerns a method for quantitative or qualitative determination of an analyte or its interaction or reaction kinetics in a system with at least two different phases, comprising the step of taking at least one measurement signal from at least one of the... | 03/14/2006 |
| 7011954 | Diagnostics based on tetrazolium compounds A reagent is suitable for measuring the concentration of an analyte in a hemoglobin-containing biological fluid, such as whole blood. The reagent comprises a flavin-dependent enzyme that has specificity for the analyte, a flavin cofactor if, and only if, a flavin is... | 03/14/2006 |
| 6991939 | Optical array device and methods of use thereof for screening, analysis and manipulation of particles Methods and devices are provided for the trapping, including optical trapping; analysis; and selective manipulation of particles on an optical array. A multi-channel device parcels a light source into many points of light transmitted through an optical array of fibe... | 01/31/2006 |
| 6977141 | Direct adsorption scintillation assay for measuring enzyme activity and assaying biochemical processes Methods and materials for scintillation assays are disclosed. The scintillation assays rely on differences in general molecular property-based binding interactions, such as charge or hydrophobicity, to localize a radioactive substance near a scintillating material, ... | 12/20/2005 |
| 6974703 | Electro-optical devices and methods for hybridization and detection The invention provides an apparatus and method for detection of a target molecule. The apparatus includes a probe labeled with a transition metal-ligand complex that hybridizes with the target to form an initial complex, a metal ion for doping the initial complex an... | 12/13/2005 |
| 6962820 | Analyte detection system An analyte detection system utilizing a combination of fluorescent labels for labeling particles and an analyte specific fluorescent analyte detection dye. The particles contain a combination of fluorescent labels for coding the particles and an analyte specific flu... | 11/08/2005 |
| 6939721 | Fluorescence immunoassays using organo-metallic complexes for energy transfer The invention includes a composition of matter and method that utilizes energy transfer between one or more donor and acceptor molecules. The composition of matter includes an encapsulation vesicle having a matrix, a surface coating of an organo-metallic complex and... | 09/06/2005 |
| 6913935 | Multiple assay method A method for the assay of N samples each containing a compound to be tested, comprises providing N reaction vessels each containing a population of carrier beads and other reagents for performing the assay, where N is at least 2 e.g. 80-4000. Each population of carr... | 07/05/2005 |
| 6908769 | Dye pair for fluorescence resonance energy transfer (FRET) measurements The present invention concerns new fluorescent dye systems especially for fluorescence resonance energy transfer determinations for example combined with the time-resolved measurement of the resulting fluorescence. The invention also concerns the use of these dyes t... | 06/21/2005 |
| 6908915 | Tricyclic compounds and their uses as antiarrhythmic antifibrillatory and defibrillatory agents A compound having a general formula (II) wherein R1 is saturated or unsaturated alkyl, amino-alcohol, diamino, cycloalkyl, and C(═O)(CH2)nNR′R″, (CH2)nCHOHCH2NR′R″, wherein n is an integer, ... | 06/21/2005 |
| 6887712 | Methods and compositions to lower plasma cholesterol levels A method is disclosed for determining whether a compound binds to a lipoprotein such as LDL or VLDL in a manner which will lower plasma cholesterol. The method provided includes assessing the ability of the compound to form a complex with the lipoprotein, and then d... | 05/03/2005 |
| 6841392 | Method and apparatus for selective biological material detection The present invention relates to bioassay materials useful for the detection of toxic substances and, more particularly, to packaging materials for food and other products, along with methods for their manufacture and use. The invention provides a unique composite m... | 01/11/2005 |
| 6753156 | Homogeneous method for detecting and/or determining phosphorylating activity in a biological material The invention relates to a novel homogeneous method of detecting and/or determining the phosphorylating activity of a biological material towards a substrate containing tyrosine and/or serine and/or threonine, and to a kit for carrying out this method. ... | 06/22/2004 |
| 6723567 | Screening method for apoptosis and necrosis The present invention relates to a method for the determination of non-, anti-, or pro-apoptotic and necrotic conditions of cells, newly designed vectors coding for marker proteins, cell lines transfected with such vector, and a method to assay the non-, pro- or ant... | 04/20/2004 |
| 6716640 | Stabilization and amplification of electrochemiluminescence signals The invention concerns the stabilization and amplification of electrochemiluminescence signals in detection methods. ... | 04/06/2004 |
| 6682898 | High-throughput screening assays for modulators of STAT4 activity This invention provides receptor peptides that have a high affinity for STAT4 and STAT6 polypeptides. Also provided are assays that are useful for identifying compounds that modulate the interaction between STAT4 and STAT6 polypeptides and their respectiv... | 01/27/2004 |
| 6667179 | Semiconductor luminescence quenchers for detecting proximal molecular binding events The invention provides methods and compositions for detecting binding or unbinding of a molecule to a substrate. The molecule comprises a luminophore and the substrate comprises a semiconductor which acts as a luminescence quencher to provide distance-dep... | 12/23/2003 |
| 6660532 | Modular assembly for reagentless affinity separation and detection of analyte The invention provides a reagentless assay kit for analyte in a sample comprising a modular affinity assembly including at least one sensor unit comprising a ligand having binding affinity for the analyte (affinity module) operatively associated with a re... | 12/09/2003 |
