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| Number | Title | Issue Date |
| 8030095 | Gel microdrop composition and method of using the same A gel microdrop composition is provided. In certain embodiments, the gel microdrop composition contains a polymer matrix, an effector particle that releases an effector molecule into the polymer matrix, a first reporter particle that emits a first optically detectab... | 10/04/2011 |
| 7985601 | Tunable, semi-interpenetrating polymer networks (sIPNS) for medicine and biotechnology The present invention provides a class of semi-interpenetrating polymeric networks that include a linear polymer molecule functionalized with a bioactive moiety. The linear polymer is physically entangled within a matrix based upon a thermo-responsive polymer. The b... | 07/26/2011 |
| 7767468 | Repetitive affinity separation and uses therefor Improved methods for the separation, isolation, enrichment, or detection of target molecules, such as nucleic acids and proteins, within dilute or heterogeneous samples, such as bodily fluids, excreta or tissue samples, are disclosed. The methods include repetitivel... | 08/03/2010 |
| 7648845 | Porous materials embedded with nanospecies, methods of fabrication thereof, and methods of use thereof Briefly described, embodiments of this disclosure include structures, methods of forming the structures, and methods of using the structures. One exemplary structure, among others, includes a nanospecies and a porous material. The nanospecies has a first characteris... | 01/19/2010 |
| 7582488 | Gel-shell beads with adsorbed or bound biomolecules Disclosed are gel-coated beads (including Hydrogel™-coated beads), which are capable of adsorbing, or absorbing, proteins and other biomolecules onto or into the gel coating. The gel-coated beads with absorbed or adsorbed biomolecules are suitable for use in an as... | 09/01/2009 |
| 7527981 | Bioweapon-detecting fibrous-network products and methods for making same Methods are disclosed for producing a bioweapon-sensitive fibrous-network product, wherein the subject products exhibit a color change in response to exposure to a biological agent (or portion thereof) as used in a biological weapon. Also disclosed are fibrous-netwo... | 05/05/2009 |
| 7442498 | Method of examining specimen and specimen container to be used in the examination method A method of immunologically examining a specimen which comprises attaching a cap having a filter impregnated with a labeled antibody enclosed therein to a container body containing a diluted liquid specimen, pouring the diluted liquid specimen from the container int... | 10/28/2008 |
| 7390676 | System and method for programmable illumination pattern generation A method and apparatus for the manipulation of colloidal particulates and biomolecules at the interface between an insulating electrode such as silicon oxide and an electrolyte solution. Light-controlled electrokinetic assembly of particles near surfaces relies on t... | 06/24/2008 |
| 7354614 | Diagnostic device A diagnostic device 1 for performing an immunochromatographic analysis of a sample is disclosed. The diagnostic device 1 comprises a porous substrate 10 for performing the analysis and a pre-filter 30 to remove solid components, such as s... | 04/08/2008 |
| 7354768 | Volume-differential assay using hydrophilic gel Systems and methods for measuring the moisture and sediment content of a petroleum sample. In one embodiment, a sample to be tested is collected in a field bottle. The sample from the field bottle is then transferred from the field bottle, and into and through a mea... | 04/08/2008 |
| 7312073 | Method for the detection of viable microorganisms Method for the detection and enumeration of viable microorganisms. A liquid that comprises one or more markers incorporated in a liquid sol-gel precursor, is provided. A transparent slide is coated with a thin uniform layer of the liquid sol-gel precursor compositio... | 12/25/2007 |
| 7311832 | Adsorption membranes, method of producing same and equipment, including the adsorption membranes The present invention relates to adsorption membranes comprising microporous polymer membranes in which adsorbent particles are incorporated. Furthermore, the present invention relates to a method of producing the inventive adsorption membranes as well as devices wh... | 12/25/2007 |
| 7288368 | Membrane receptor reagent and assay A membrane receptor reagent and assay is disclosed in which liposomes are bound to an evanescent wave emitting surface. Membrane receptors on the liposome's fluid lipid bilayer membrane are labeled with a fluorescent or luminescent moiety. These membrane receptors a... | 10/30/2007 |
| 7279323 | Method for conducting receptor-ligand association reaction and reactor used therefor A method for conducting a receptor-ligand association reaction includes the steps of dipping a biochemical analysis unit including a substrate formed with a plurality of absorptive regions which contain receptors or ligands and are formed to be spaced apart from eac... | 10/09/2007 |
| 7226753 | Displacement assay for selective biological material detection The present invention relates to displacement assay type bioassay materials useful for the detection of toxic substances and, more particularly, to packaging materials for food and other products, along with methods for their manufacture and use. The invention provi... | 06/05/2007 |
| 7211444 | Waveguide and assay A fluidic waveguide comprising a container and a fluid that fills said container, wherein said fluid has a refractive index greater than the refractive index of the wall of said container and wherein said fluid can act as a waveguide for electromagnetic radiation wh... | 05/01/2007 |
| 7205162 | Artificial antibodies, method of producing the same and use thereof Artificial antibodies or antibody mimics are described. They consist of polymers that carry specific binding sites mimicking the properties of antibodies. There is also described a method for producing artificial antibodies, in which polymerisable monomers carrying ... | 04/17/2007 |
| 7184894 | Quantitative measurement method and quantitative measurement chip for target substance The present invention provides a quantitative measurement method and quantitative measurement chip which can perform quantitative measurement of a target substance in a short period of time. The invention provides a quantitative measurement method in which a three d... | 02/27/2007 |
| 7153682 | Microarrays on mirrored substrates for performing proteomic analyses Provided are peptidomimetic protein-binding arrays, their manufacture, use, and application. The protein-binding array elements of the invention include a peptidomimetic segment linked to a solid support via a stable anchor. The invention contemplates peptidomimetic... | 12/26/2006 |
| 7151167 | Open channel solid phase extraction systems and methods The invention provides, inter alia, methods of extracting an analyte from a solution comprising the steps of: passing a solution containing an analyte through an extraction channel having a solid phase extraction surface, whereby analyte adsorbs to the extraction su... | 12/19/2006 |
| 7148058 | Protein microarrays on mirrored surfaces for performing proteomic analyses Provided are protein microarrays, their manufacture, use, and application. Protein microarrays in accordance with the present invention are useful in a variety preoteomic analyses. Various protein arrays in accordance with the present invention may immobilize large ... | 12/12/2006 |
| 7141436 | Immunoassay and reagents and kits for performing the same A sandwich immunoassay is disclosed that provides simple to perform yet sensitive identification of analytes in samples. All assay constituents needed (except analyte to be detected) for one assay are dried. Upon reconstitution with sample, a 10 to 15 minute incubat... | 11/28/2006 |
| 7135300 | Profiling frequencies of receptor heterodimers Methods are provided for detecting formation of oligomeric complexes of molecules on the surface of cell membranes. These methods employ pairs of tagged probes and cleaving probes, each of which binds specificly to a cell surface molecule. The tagged probe includes ... | 11/14/2006 |
| 7118900 | Directed assembly of functional heterostructures The present invention relates to a systematic process for the creation of functionally organized, spatially patterned assemblies of polymer-microparticle composites including the AC electric field-mediated assembly of patterned, self-supporting organic (polymeric) f... | 10/10/2006 |
| 7112453 | Retentate chromatography and protein chip arrays with applications in biology and medicine This invention provides methods of retentate chromatography for resolving analytes in a sample. The methods involve adsorbing the analytes to a substrate under a plurality of different selectivity conditions, and detecting the analytes retained on the substrate by d... | 09/26/2006 |
| 7108472 | Cartridge loader and methods A device for transporting cartridges comprises a housing for holding a plurality of cartridges in a temperature controlled environment. A transport system is also provided and has a grasping mechanism for grasping one of the cartridges. The transport system is furth... | 09/19/2006 |
| 7105289 | Inverse emulsion methods of making polymeric imprint beads The present invention provides imprint bead compositions useful for capturing, isolating, detecting, analyzing and/or quantifying molecules in a sample. The imprint bead compositions comprise a matrix material having imprint cavities of a template molecule or molecu... | 09/12/2006 |
| 7105308 | Detecting receptor oligomerization Methods are provided for detecting formation of oligomeric complexes of molecules on the surface of cell membranes. These methods employ pairs of tagged probes and cleaving probes, each of which binds specificly to a cell surface molecule. The tagged probe includes ... | 09/12/2006 |
| 7097983 | Method for detecting the presence of an analyte in a sample The invention features a method of determining whether one or more members of an analyte family are present in a sample. The method makes use of a test zone binder, e.g., a receptor that can bind one or a plurality of analytes within an analyte family, the analytes ... | 08/29/2006 |
| 7094351 | Purification of substances by reaction affinity chromatography The invention relates to the separation of at least one target from a sample composition using a naturally reversible reaction comprising the formation of at least one covalent bond. One embodiment of the invention is a chromatographic method in which the affinity o... | 08/22/2006 |
| 7087236 | Method for inducing a cell-mediated immune response and improved parenteral vaccine formulations thereof A method of inducing either a TH1 polarized immune response, a TH2 polarized immune response or a combined TH1 and TH2 response to an antigen and associated vaccine formulations are disclosed. A method is provided for indu... | 08/08/2006 |
| 7063952 | Masking background flourescence and luminescence in optical analysis of biomedical assays In a process for the quantitative optical analysis of fluorescently labelled biological cells 5, a cell layer on a transparent support at the bottom 2 of a reaction vessel 1 is in contact with a solution 3 containing the fluorescent dye | 06/20/2006 |
| 7052854 | Application of nanotechnology and sensor technologies for ex-vivo diagnostics Systems and methods for the ex vivo diagnostic analysis of samples of bodily fluids, including exhaled breath and blood. The present invention uses nanostructure-based assemblies in combination with sensor technology to provide an efficient and accurate means for id... | 05/30/2006 |
| 7049150 | Binding assay device with non-absorbent carrier material A binding assay device includes a porous membrane comprising a material enabling capillary movement of a liquid sample from a first area on the membrane on a second area on the membrane. A detection site is disposed on the membrane between the first and second areas... | 05/23/2006 |
| 7049152 | Color and shape changing polymeric ribbons and sheets The present invention herein provides the design, synthesis and characterization of compositions comprising asymmetric bolaamphiphilic lipids that form extended polymeric ribbons and wide sheets. These compositions may be doped, or interspersed, with various compoun... | 05/23/2006 |
| 7045342 | Diagnostic detection device and method The invention provides an improved test cell for detecting the presence of an analyte in a liquid sample. The device has an elongate casing defining a liquid sample inlet, a reservoir volume, a test volume, and a window through the casing at the test volume. Dispose... | 05/16/2006 |
| 7037729 | Porous materials embedded with nanospecies, methods of fabrication thereof, and methods of use thereof Briefly described, embodiments of this disclosure include structures, methods of forming the structures, and methods of using the structures. One exemplary structure, among others, includes a nanospecies and a porous material. The nanospecies has a first characteris... | 05/02/2006 |
| 7022529 | Particles for diagnostic and therapeutic use Methods, compositions and kits are disclosed. The compositions are light emitting and comprise a polymeric matrix having dissolved therein a photoactive compound. The composition has the characteristic that, after activation of the photoactive compound, the rate of ... | 04/04/2006 |
| 7015034 | Materials and procedures for the purification of cells The subject invention provides new materials and methods for the efficient isolation and purification of stem cells. Specifically, conductive immunopolymers with stem cell specific antibodies can be used to remove stem cells from biological fluids. ... | 03/21/2006 |
| 7011948 | Detection of ligand-antiligand complex formation by electromagnetically detectable bulk property measurement Disclosed are methods for analyzing molecular binding events in which the formation of ligand/antiligand complexes can be directly detected in a mixture without requiring separation of the components of the mixture from each other by measuring bulk properties of the... | 03/14/2006 |
