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| Number | Title | Issue Date |
| 7442553 | Method for determining the amount of the maleimidyl groups of a particle A method for quantitatively determining the amount of maleimidyl groups on a polymer fine particle containing at least maleimidyl groups, by allowing a fluorescent material having an SH group to react with the maleimidyl groups and determining the amount of maleimid... | 10/28/2008 |
| 7390677 | Immunoassay and immunoassay apparatus An immunoassay comprises the steps of: (a) mixing a whole blood sample with sensitized insoluble carrier particles smaller than erythrocytes to cause an immune agglutination reaction; (b) introducing the resulting immune agglutination reaction mixture including aggl... | 06/24/2008 |
| 7371829 | Haptens, immunogens, antibodies and conjugates to ketamine and its metabolites The invention provides haptens, immunogens comprising such haptens coupled to an antigenicity-conferring carrier material, conjugates comprising such haptens bonded to a labelling agent as well as, antibodies raised against such immunogens and capable of binding wit... | 05/13/2008 |
| 7364906 | Products and methods for single parameter and multiparameter phenotyping of cells A method of single parameter and multiparameter characterizing of cells, particularly immunophenotyping of cells, is provided. The method preferably uses antibody-coated microspheres which are adapted to bind to specific types of cells. One or more sets of coated mi... | 04/29/2008 |
| 7354733 | Method for sorting and separating living cells We disclose methods of sorting or separating mixtures of living cells (e.g., eukaryotic, prokaryotic, mammalian, pathogenic, bacterial, viral, etc.). We perform our methods by activating cell-selective photophoric labels, which photosensitize and chemically reduce a... | 04/08/2008 |
| 7351589 | Products and methods for single parameter and multiparameter phenotyping of cells A method of single parameter and multiparameter characterizing of cells, particularly immunophenotyping of cells, is provided. The method preferably uses antibody coated microspheres which are adapted to bind to specific types of cells. One or more sets of coated mi... | 04/01/2008 |
| 7338813 | Carrier particle latex for assay reagent and assay reagent An objective of the invention is to provide a carrier particle latex for an assay reagent capable of assaying a biological sample at a wide range of the concentration in an immunoserological test and capable of being stored stably for a prolonged period, as well as ... | 03/04/2008 |
| 7332349 | Detection of cell membrane-associated proteins using membrane fragments displayed on encoded microparticle arrays Disclosed are methods relating to cell membrane fragments associated with microbeads, so that the characteristics of the cells the fragments originated from can be determined. The fragments can be oriented with what was the outer surface of the cell membrane facing ... | 02/19/2008 |
| 7316905 | Method for measurement of hepatitis C virus A method for measurement of the hepatitis C virus (HCV) characterized by measuring HCV core antigen and HCV core antibody by their binding with probes in the presence of an anionic surfactant or a non-ionic surfactant, or both. ... | 01/08/2008 |
| 7315378 | Optical arrangement for assay reading device Disclosed, in one aspect, is an assay result reading device for reading the result of an assay performed using a test strip, the device comprising: a light source or sources, said light source/s emitting light incident upon at least two, spatially separated zones of... | 01/01/2008 |
| 7309723 | Redox polymer nanoparticles The invention provides nanoparticles comprising one or more redox-active species, methods of making such nanoparticles, and methods for using such nanoparticles, for example, as diagnostic agents for the detection of various analytes. ... | 12/18/2007 |
| 7297554 | Immunoassay system A competitive immunoassay, dye and method for rapidly detecting the presence of one or more target ligands within a fluid sample suspected of containing such ligand or ligands. The immunoassay comprises a protein-binding membrane, a first absorbent pad, a second abs... | 11/20/2007 |
| 7270970 | Point of care diagnostic systems Systems and methods for medical diagnosis or risk assessment for a patient are provided. These systems and methods are designed to be employed at the point of care, such as in emergency rooms and operating rooms, or in any situation in which a rapid and accurate res... | 09/18/2007 |
| 7262063 | Directed assembly of functional heterostructures The present invention relates to a systematic process for the creation of functionally organized, spatially patterned assemblies polymer-microparticle composites including the AC electric field-mediated assembly of patterned, self supporting organic (polymeric) film... | 08/28/2007 |
| 7253006 | Device and method for manufacturing bead array, and method for detecting target substance A device for manufacturing a bead array is provided including a container, a liquid including a bead having a biological substance fixed on a surface of the bead, and means for ejecting the liquid including the bead on a desired position on a solid-phase base. A met... | 08/07/2007 |
| 7244622 | Device and method for multiple analyte detection The invention is directed to a method and device for simultaneously testing a sample for the presence, absence, and/or amounts of one or more of a plurality of selected analytes. The invention includes, in one aspect, a device for detecting or quantitating a plurali... | 07/17/2007 |
| 7229835 | Amine detection method and materials A compound linked to a solid support (R) through a divalent linker moiety (X) and which is represented by the following formula: is disclosed. In particular, the 1-hydroxybenzotriazole-6-carboxylic acid is direct... | 06/12/2007 |
| 7227688 | Apparatus for applying optical gradient forces An apparatus and method for manipulating small dielectric particles. The apparatus and method involves use of a diffractive optical element which receives a laser beam and forms a plurality of light beams. These light beams are operated on by a telescope lens system... | 06/05/2007 |
| 7217531 | Multiplex analysis using membrane-bound sensitizers The present invention is directed to methods and compositions for determining the presence, absence, and/or amounts of one or more membrane-associated analytes in a sample. In accordance with the invention, binding compounds derivatized with releasable molecular tag... | 05/15/2007 |
| 7202092 | Indinavir derivatives useful in immunoassay Derivatives and conjugates of indinavir for generation of antibodies and labeled conjugates for use for detection of indinavir in biological samples. The derivatives are synthesized out of the indane ring hydroxyl group or the pyridine ring nitrogen of indinavir. Al... | 04/10/2007 |
| 7202348 | Monoclonal antibody antagonists for treating medical problems associated with d-amphetamine-like drugs The present invention provides synthetic immunochemical haptens for the generation of antibodies that are designed to recognize the common molecular features of d-methamphetamine-like abused stimulants with insignificant cross-reactivity to endogenous substrates (e.... | 04/10/2007 |
| 7198702 | Method for separating substances using dielectrophoretic forces The present invention has an object of providing a method by which two kinds or more of molecules can be separated each other by using dielectrophoretic forces. The present invention comprises two methods. The first method is a method comprising forming a complex su... | 04/03/2007 |
| 7192724 | Method for differentiating irritable bowel syndrome from inflammatory bowel disease (IBD) and for monitoring persons with IBD using total endogenous lactoferrin as a marker A method for aiding in differentiating irritable bowel syndrome from inflammatory bowel disease by determining the level of total endogenous human lactoferrin in clinical specimens, such as feces, mucus and bile, wherein an elevated level of lactoferrin substantiall... | 03/20/2007 |
| 7192786 | Biospecific assay method This invention relates to a biospecific assay method, in which microparticles coated with the bioaffinity reactant A binding the analyte to be assayed; the sample to be analyzed, and the labelled bioaffinity reactant B are mixed. After the binding reaction the signa... | 03/20/2007 |
| 7179660 | Carriers coated with polysaccharides, their preparation and use A polysaccharide coated carrier having a coating of at least two successive layers of polysaccharide. The first polysaccharide layer spontaneously associates with a second polysaccharide layer and, optionally, the carrier. Each successive layer of polysaccharide spo... | 02/20/2007 |
| 7176036 | Electroactive microspheres and methods Methods and devices for electrochemical detection of a specific binding pair member utilizing a microsphere with an incorporated electroactive marker, wherein a member of the specific binding pair to be detected is bound, directly or through one or more intermediate... | 02/13/2007 |
| 7176174 | Water-in-oil emulsion A water-in-oil emulsion composition is disclosed. The composition contains (A) a solvent, (B) water, and (C) a surfactant. This composition is suitable for removing non-aqueous coatings such as paints and the like as well as waxes and greases from substrates. ... | 02/13/2007 |
| 7166477 | Muscle sample prepared for prion assay A method of preparing a sample of muscle tissue and of assaying the prepared sample to determine the presence of prions in the sample is disclosed. The muscle tissue is homogenized and mixed with a complexing agent which forms a complex with a higher specific gravit... | 01/23/2007 |
| 7148196 | Anticancer compounds and methods The testing of tumor cells, including human tumors capable of metastases, in assays employing fibronectin-depleted substrates is described. Ex vivo induction of cells, including biopsied human cells, is performed with invasion-inducing agents. Additionally, anti-can... | 12/12/2006 |
| 7148024 | Busulfan immunoassay Novel conjugates of busulfan and novel busulfan immunogens derived from α-substituted derivatives of busulfan and antibodies generated by these busulfan linked immunogens are useful in immunoassays for the quantification and monitoring of busulfan in biological flu... | 12/12/2006 |
| 7144742 | Quantitative lateral flow assays and devices This invention provides solid phase specific binding lateral flow assay methods, devices and kits for quantitating high and low molecular weight analytes. The methods and devices of the invention employ labelled reagents which are either analyte analogs or complemen... | 12/05/2006 |
| 7144823 | Thermal treatment apparatus The present invention is a thermal processing unit including: a heating-furnace body whose upper end has an opening; a heating unit provided on an inside wall of the heating-furnace body; a reaction container consisting of a single tube contained in the heating-furn... | 12/05/2006 |
| 7144119 | System and method for programmable illumination pattern generation An apparatus providing programmable illumination pattern generation for the manipulation of colloidal particulates and biomolecules in suspension between electrodes, is disclosed. The apparatus implements LEAPS (Light-controlled electrokinetic assembly of particles ... | 12/05/2006 |
| 7141431 | Microparticles with multiple fluorescent signals and methods of using same This invention provides a novel fluorescent particle including a core or carrier particle having on its surface a plurality of smaller polymeric particles or nanoparticles, which are stained with different fluorescent dyes. When excited by a light source they are ca... | 11/28/2006 |
| 7138280 | Masking of the background fluorescence and luminescence in the optical analysis of biomedical assays In a process for the quantitative optical analysis of biological cells labelled with a fluorescent dye, the sensitivity of analytical detection can be considerably improved if a masking dye, which absorbs the excitation light for the fluorescent dye and/or its emiss... | 11/21/2006 |
| 7115383 | Assays for amphetamine and methamphetamine Methods, compositions and kits are disclosed. The compounds disclosed comprise an amphetamine moiety and a methamphetamine moiety linked together by a first linking group. A second linking group depends from the first linking group and comprises a functional group. ... | 10/03/2006 |
| 7109042 | Assays An analytical test device useful for example in pregnancy testing, comprises a hollow casing (500) constructed of moisture-impervious solid material, such as plastics materials, containing a dry porous carrier (510) which communicates indirectly with t... | 09/19/2006 |
| 7104659 | Apparatus for using optical tweezers to manipulate materials A method and apparatus for control of optical trap arrays and formation of particle arrays using light that is in the visible portion of the spectrum. The method and apparatus provides a laser and a time variable diffractive optical element to allow dynamic control ... | 09/12/2006 |
| 7097983 | Method for detecting the presence of an analyte in a sample The invention features a method of determining whether one or more members of an analyte family are present in a sample. The method makes use of a test zone binder, e.g., a receptor that can bind one or a plurality of analytes within an analyte family, the analytes ... | 08/29/2006 |
| 7083914 | Color-encoding and in-situ interrogation of matrix-coupled chemical compounds A method and apparatus for the physico-chemical encoding of a collection of beaded resin (“beads”) to determine the chemical identity of bead-anchored compounds by in-situ interrogation of individual beads. The present invention provides method and apparatus to ... | 08/01/2006 |
