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| Number | Title | Issue Date |
| 8076163 | Isoelectric particles and uses therefore A plurality of particles of from about 5 nm to 100 μm possessing predetermined isoelectric points in the pH range of from about 2.5 to 11 is used in a method of detection of a plurality of analytes, wherein the isoelectric particles of each isoelectric point furthe... | 12/13/2011 |
| 7998756 | Use of perfluoropolymer submicrometric latexes in the determination of molecular interactions by laser light scattering (LLS) Use of a latex of perfluorinated polymers having particles with an average diameter between 5 and 200 nm for determining the binding constant of two interacting molecular species by Laser Light Scattering (LLS), said polymeric particles comprising on the surface an ... | 08/16/2011 |
| 7985600 | Use of perfluoropolymers in the determination of the receptor-ligand binding constant Use of flat surfaces comprising perfluorinated polymers in the determination of the binding constant of two interacting molecular species by using measurements of reflected light intensity, said surface comprising at least one molecule with the receptor function ads... | 07/26/2011 |
| 7968349 | Use of holographic sensor The present invention relates to a process for the detection of an analyte in a sample, comprising a) bringing the sample into contact with a first ligand which binds specifically to the analyte and which is immobilized on a substrate, and b) prior to or subsequent ... | 06/28/2011 |
| 7964415 | Stable water-soluble polyethylenimine conjugates and methods of use thereof Water soluble, polyethylenimine polymers, conjugated to one or more active moiety are taught. Also taught are methods of making same, kits comprising same, and use of same in immunoassay systems. ... | 06/21/2011 |
| 7867784 | Chromatography ligand The present invention relates to a chromatography ligand defined by the following formula (I) R1—R2—N(R3)—R4—R5 wherein R1 is a substituted or non-substituted phenyl group; R2 is a ... | 01/11/2011 |
| 7498178 | Carrier of a diamond fine particle for immobilizing virus The present invention provides a carrier for immobilizing a bio-derived polymer, and especially, the present invention provides a carrier of diamond fine particle for immobilizing a DNA, RNA, protein and peptide, as well as a DNA chip substrate, a carrier for trappi... | 03/03/2009 |
| 7491554 | Carrier of a diamond fine particle for immobilizing virus The present invention provides a carrier for immobilizing a bio-derived polymer, and especially, the present invention provides a carrier of diamond fine particle for immobilizing a DNA, RNA, protein and peptide, as well as a DNA chip substrate, a carrier for trappi... | 02/17/2009 |
| 7442553 | Method for determining the amount of the maleimidyl groups of a particle A method for quantitatively determining the amount of maleimidyl groups on a polymer fine particle containing at least maleimidyl groups, by allowing a fluorescent material having an SH group to react with the maleimidyl groups and determining the amount of maleimid... | 10/28/2008 |
| 7432046 | Methods for the determination of antibody IgG avidity The present invention relates to methods of determining anti-infectious agent IgG avidity, for example, human anti-cytomegalovirus and human anti-toxoplasma IgG avidity, using a competitive assay format. ... | 10/07/2008 |
| 7423131 | Busulfan immunoassay Novel conjugates of busulfan and novel busulfan immunogens derived from α-substituted derivatives of busulfan and antibodies generated by these busulfan linked immunogens are useful in immunoassays for the quantification and monitoring of busulfan in biological flu... | 09/09/2008 |
| H2223 | Patterned, micrometer-sized antibody features A biosensor has a micrometer sized antibody substrate surface which may include patterned single or multiple antibody substrates. The substrate is capable of detecting multiple chemical species simultaneously and/or continuously monitoring a single chemical species.... | 09/02/2008 |
| 7417021 | Biologically active conjugate of a biopolymer and therapeutic agent A biologically active conjugate is disclosed comprising a biopolymer and a therapeutic agent joined by a disulfide bond. The conjugate, when formulated in a pharmaceutical composition with a suitable carrier, has improved in vivo stability and activity, and can be t... | 08/26/2008 |
| 7413868 | Use of particulate labels in bioanalyte detection methods New applications for the use of distinguishable particulate labels available in a variety of hues and sized in the submicron range are described. These applications include profiling of cellular components, obtaining secretion patterns, identifying a multiplicity of... | 08/19/2008 |
| 7407796 | Interrogation of changes in the contents of a sealed container A device and method allowing evaluation of the contents of a sealed primary container by means of an integral sensor which is separated from the contents of the sealed primary container yet provides information on quality of the contents of the primary container wit... | 08/05/2008 |
| 7407816 | Isoelectric particles and uses thereof A plurality of particles of from about 5 nm to 100 μm possessing predetermined isoelectric points in the pH range from about 2.5 to 11 is used in a method of detection of a plurality of analytes, wherein the isoelectric particles of each isoelectric point further c... | 08/05/2008 |
| 7402381 | Method of immobilizing molecules onto a solid phase substrate and method of fabricating a biosensor using the method Aspects of the invention can provide a method capable of easily realizing immobilization with the optimum density derived from a concentration control and without phase separation in coadsorption of a number of molecules. The immobilization method can include the st... | 07/22/2008 |
| 7399636 | Diagnostic kit for predicting pregnancy outcome The present invention provides a method of predicting pregnancy outcome in a subject by determining the amount of an early pregnancy associated molecular isoform of hCG in a sample. The present invention further provides a method for determining the amount of early ... | 07/15/2008 |
| 7396691 | Method for the detection of fluoride or hydrogen fluoride and detection kit The present invention relates to a method for detecting and/or measuring the concentration of fluoride (F−) or hydrogen fluoride (HF) in a sample, comprising the steps consisting of bringing said sample, in aqueous solution, into contact with a silylate... | 07/08/2008 |
| 7390677 | Immunoassay and immunoassay apparatus An immunoassay comprises the steps of: (a) mixing a whole blood sample with sensitized insoluble carrier particles smaller than erythrocytes to cause an immune agglutination reaction; (b) introducing the resulting immune agglutination reaction mixture including aggl... | 06/24/2008 |
| 7384779 | Porous substrate plates and the use thereof A substrate plate or device adapted for use with biological or chemical assays is disclosed. The device may take the form of a multi-well plate having a three-dimensional, porous layer as part of a support surface within each well for immobilizing probe species. The... | 06/10/2008 |
| 7371585 | Membranes incorporating recognition moieties The present invention provides a thiosulfonate-activated ionophore comprising an ionophore, a spacer group, and an alkylthiosulfonate moiety. A preferred ionophore is gramicidin A. A preferred alkylthiosulfonate is methanethiosulfonate. The present invention also pr... | 05/13/2008 |
| 7368281 | Label-free evanescent-field detection of biological and chemical agents An evanescent-field sensor system and method of using the system to detect either liquid- or airborne biological pathogens, chemical agents, and other harmful or toxic species is provided. The sensor system involves 1) an evanescent-field sensor having a substrate s... | 05/06/2008 |
| 7368280 | Detection of biospecific interactions using amplified differential time domain spectroscopy signal A method for detecting specific associations between a tethered molecule and an untethered target molecule. The method comprises (1) selecting a tethered molecule; (2) alternately impinging THz radiation onto the tethered molecule and onto a sample including the tet... | 05/06/2008 |
| 7364898 | Customized micro-array construction and its use for target molecule detection The present invention relates to a detection and quantification method of different sets of target molecules (1, 3), being possibly present simultaneously in a biological sample by the use of a microarray present upon a solid support surface (6) and co... | 04/29/2008 |
| 7364918 | Colorimetric sensors constructed of diacetylene materials Colorimetric sensors comprising a receptor incorporated within polydiacetylene assemblies to form a transducer capable of indicating a color change when contacted with an analyte are disclosed. Methods of using the colorimetric sensor and a kit for the colorimetric ... | 04/29/2008 |
| 7364906 | Products and methods for single parameter and multiparameter phenotyping of cells A method of single parameter and multiparameter characterizing of cells, particularly immunophenotyping of cells, is provided. The method preferably uses antibody-coated microspheres which are adapted to bind to specific types of cells. One or more sets of coated mi... | 04/29/2008 |
| 7361516 | Field of modular multifunctional ligands This invention pertains to a surface ligand; preparation of the ligand; colloidal nanoparticle, such as quantum dot bearing one or more of the ligand; and a bioconjugate characterized by a nanoparticle bearing one or more of the ligand conjugated to a biomolecule. T... | 04/22/2008 |
| 7361479 | Assay The present invention provides a method of determining the presence or amount of newly synthesized antibody in a sample in response to an immunogen by detecting the released antibodies or parts thereof in a sample containing lymphocytes which have been disrupted whe... | 04/22/2008 |
| 7358097 | Making a matrix of random encoded arrays Disclosed is an apparatus and method of maintaining chips or arrays of particles, or arrays of particles deposited on chip surfaces, in a designated area on a substrate surface. This is accomplished by having hydrophilic chips or arrays of particles, and a substrate... | 04/15/2008 |
| 7358485 | Zirconia toughened alumina composition and use in ion and electron optical systems An ion optical system including an ionizer for ionizing one or more compounds, the ionizer including a plurality of components, a mass separator for separating ions of the one or more compounds, the mass separator including a plurality of components, and a detector ... | 04/15/2008 |
| 7354776 | Method of processing and testing powdered samples using immunochromatographic strip tests A method and kit for processing and testing powdered samples are provided herein. The powdered sample is combined with a fluid to produce a slurry or liquid suspension, and the slurry is contacted with an immunochromatographic test strip containing detectable reagen... | 04/08/2008 |
| 7354733 | Method for sorting and separating living cells We disclose methods of sorting or separating mixtures of living cells (e.g., eukaryotic, prokaryotic, mammalian, pathogenic, bacterial, viral, etc.). We perform our methods by activating cell-selective photophoric labels, which photosensitize and chemically reduce a... | 04/08/2008 |
| 7351589 | Products and methods for single parameter and multiparameter phenotyping of cells A method of single parameter and multiparameter characterizing of cells, particularly immunophenotyping of cells, is provided. The method preferably uses antibody coated microspheres which are adapted to bind to specific types of cells. One or more sets of coated mi... | 04/01/2008 |
| 7348157 | Immunoassay A method for detection and/or quantification of cardiac troponin I (cTnI) in a sample derived from an individual's blood, the method being based on a sandwich immunoassay employing at least two capture antibodies and at least one tracer antibody, in which a first ca... | 03/25/2008 |
| 7344848 | Methods for determining adequacy of heat processing of a cooked meat sample Monoclonal antibodies are provided which bind to heat-treated proteins of meats. The antibodies are useful in detecting the presence of an exogenous meat in a cooked or raw meat sample. Furthermore, the antibodies can be used to determine the end point temperature o... | 03/18/2008 |
| 7338812 | Biochemical labeling materials and manufacturing method thereof A biochemical labeling material and manufacturing method thereof. The manufacturing method provides a plurality of nanoparticles, bonding the nanoparticles to template molecules by molecular imprinting, polymerizing the nanoparticles to form a matrix with uniformly-... | 03/04/2008 |
| 7338809 | Method for assaying whole blood In a method for measuring an analyte, which comprises a reaction step of forming a reaction system including a sample containing whole blood, a first substance carried by a solid carrier and specifically binding to an analyte contained in the sample and a second sub... | 03/04/2008 |
| 7332349 | Detection of cell membrane-associated proteins using membrane fragments displayed on encoded microparticle arrays Disclosed are methods relating to cell membrane fragments associated with microbeads, so that the characteristics of the cells the fragments originated from can be determined. The fragments can be oriented with what was the outer surface of the cell membrane facing ... | 02/19/2008 |
| 7332295 | Multidimensional leukocyte differential analysis This invention relates to an improved procedure for the multiparameter analysis of leukocyte subpopulations from peripheral blood, bone marrow or any body fluid containing blood nucleated cells, including the quantification of each subpopulation in terms of cells pe... | 02/19/2008 |
