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| Number | Title | Issue Date |
| 8114682 | Method for the quantitative evaluation of sex hormones in a serum sample This invention discloses using SPR technology to simultaneously and quantitatively measure the concentrations of different sex hormones in a serum sample, which can be used to evaluate different clinical situations. It also discloses an efficient formula to make a m... | 02/14/2012 |
| 8110409 | Method to measure serum biomarkers for the diagnosis of liver fibrosis This invention discloses using SPR technology to simultaneously and quantitatively measure the concentrations of different liver fibrosis-associated serum biomarkers in a serum sample, which can be used for the diagnosis of liver fibrosis. It also discloses an effic... | 02/07/2012 |
| 8110408 | Method for quantitative detection of diabetes related immunological markers This invention discloses using SPR technology to simultaneously and quantitatively measure the concentrations of diabetes related immunological makers in a serum sample, which can be used to diagnose and/or early diagnose diabetes as well as to predict the onset ris... | 02/07/2012 |
| 8105847 | Nano-sized optical fluorescence labels and uses thereof A composition is disclosed which is capable of being used for detection, comprising an encapsulated noble metal nanocluster. Methods for preparing the encapsulated noble metal nanoclusters, and methods of using the encapsulated noble metal nanoclusters are also disc... | 01/31/2012 |
| 8088631 | Lanthanide-doped NaYFnanocrystals, method of preparing and uses thereof The present invention relates to a method of preparing lanthanide-doped NaYF4 nanocrystals, the method comprising: (A) providing a first solution comprising a non-coordinating solvent, a fatty acid coordinating ligand, sodium trifluoroacetate, yttrium tri... | 01/03/2012 |
| 8080430 | Target substance detection material and method and kit for detecting target substance In the present invention, a target substance detection material, which includes a metal structure, a target substance capturing unit, and a polymer matrix retaining the metal structure and the target substance capturing unit, captures a target substance, and as a re... | 12/20/2011 |
| 8080431 | Nanoparticles Materials and methods for studying and modulating the interaction of carbohydrate-containing moieties with other species are described, in particular, small particles, e.g. clusters of metal or semiconductor atoms, which can be employed as a substrate for immobilisi... | 12/20/2011 |
| 8039271 | Assays employing randomly distributed microbeads with attached biomolecules A method and apparatus for the manipulation of colloidal particulates and biomolecules at the interface between an insulating electrode such as silicon oxide and an electrolyte solution. Light-controlled electrokinetic assembly of particles near surfaces relics on t... | 10/18/2011 |
| 8039272 | Rapid quantification assay involving concentrated and ligand-coated gold colloid A concentrated and ligand-coated gold colloid and a method of preparing it. Also disclosed is a rapid biomolecule quantification assay involving the use of the concentrated gold colloid and an apparatus for performing the assay. ... | 10/18/2011 |
| 8034633 | Microwave accelerated assays The present invention provides for increasing fluorescence detection in surface assay systems while increasing kinetics of a bioreaction therein by providing low-power microwaves to irradiate metallic materials within the system in an amount sufficient to increase h... | 10/11/2011 |
| 8026108 | Detection of biotargets using bioreceptor functionalized nanoparticles An ultra sensitive method for detection of biomolecules includes the step of providing a plurality of bioreceptor functionalized nanoparticle probes. The nanoparticles can include metal, semiconductor, radioactive isotope or fluorescent dye molecules. A sample solut... | 09/27/2011 |
| 8003408 | Modification of metal nanoparticles for improved analyte detection by surface enhanced Raman spectroscopy (SERS) A SERS active particle having a metal-containing particle and a cationic coating on the metal-containing particle, wherein the SERS active particle carries a positive charge is disclosed. Also, a SERS active particle having a metal-containing particle and a non-meta... | 08/23/2011 |
| 8003409 | Semiconductor nanoparticle fluorescent reagent and fluorescence determination method The present invention measures defect fluorescence exhibited from a defect level mainly on a semiconductor nanoparticle surface site which has an energy level existing inside the forbidden band of energy levels inside the semiconductor nanoparticle. ... | 08/23/2011 |
| 7989220 | Metal-enhanced fluorescence for polarization-based affinity assays A method and kit for determining the quantity of an analyte include providing a functionalized substrate and a reagent. The functionalized substrate includes metallic nanoparticles and a plurality of substantively identical bioactive target molecules affixed to a su... | 08/02/2011 |
| 7981695 | Diagnostic methods using plasmon resonant particles A method and apparatus for interrogating a target having a plurality of plasmon resonant particles (PREs) distributed in the target are disclosed. In the method, a field containing the target is illuminated, and one or more spectral emission characteristics of the l... | 07/19/2011 |
| RE42524 | Colloidal metal compositions and methods The present invention comprises compositions and methods for delivery systems of agents, including therapeutic compounds, pharmaceutical agents, drugs, detection agents, nucleic acid sequences and biological factors. In general, these vector compositions comprise a ... | 07/05/2011 |
| 7951614 | Methods and compositions for the production of monoclonal antibodies The present invention comprises compositions and methods for making monoclonal antibodies. The present invention further comprises vectors that replicate the immune system components, particularly an antigen-presenting cell (APC) element of the immune synapse. Addit... | 05/31/2011 |
| 7939345 | Versatile substrate for SPR detection A substrate for testing a carrier liquid for biomolecules using SPR or other techniques provides a metallic island surrounded by a hydrophobic layer, the islands being a location for the attachment of probe molecules. The hydrophobic layer may also be a dielectric m... | 05/10/2011 |
| 7935540 | Water-soluble polymeric substrate having metallic nanoparticle coating A metallic nanoparticle coated water-soluble polymeric substrate and the process for preparing and using the same is described. ... | 05/03/2011 |
| 7935539 | Generic method for latex agglutination assays An improved agglutination immunoassay is characterized by reacting a sample fluid which may contain an analyte with a generic antibody conjugated to latex particles and then adding an antibody specific to the analyte to be determined. Agglutination resulting from ad... | 05/03/2011 |
| 7919332 | Biological molecule-immobilized chip and its use A biological molecule-immobilized chip is produced by: allowing a biological molecule having a portion capable of forming coordination bond to a metal ion to form a coordination bond to a metal ion, bringing the resultant complex adjacent to an electrically c... | 04/05/2011 |
| 7906344 | Localized plasmon resonance sensor and examining device The metal fine particles 33 are sparsely fixed on the surface of the transparent substrate 32, and the acceptor 35 for attaching the specific ligand is immobilized on the transparent substrate 32 or the metal fine particles 33. The... | 03/15/2011 |
| 7892854 | Multianalyte molecular analysis using application-specific random particle arrays The present invention provides methods and apparatus for the application of a particle array in bioassay format to perform qualitative and/or quantitative molecular interaction analysis between two classes of molecules (an analyte and a binding agent). The methods a... | 02/22/2011 |
| 7892855 | Surface plasmon resonance sensors and methods for detecting samples using the same Disclosed is an optical sensing device including a source unit providing a beam of light with continuously modulated phase retardation between p- and s-polarization components of the light by employing a LCM; a reference unit receiving a first part of the light to p... | 02/22/2011 |
| 7863059 | Target substance detection method and target substance detection kit A target substance detection method for detecting a target substance in a specimen, comprises the steps of contacting with a specimen a target substance detecting element comprised of a base, a metal structure and a first capturing body for capturing a target substa... | 01/04/2011 |
| 7858398 | Optical biosensor The present invention relates to an optical biosensor comprising a porous matrix. In the specific case, reference is made to anodized porous alumina, on the surface of which the biological component specific for the analyte in question is immobilized, and to an opti... | 12/28/2010 |
| 7842516 | Detectable labels, methods of manufacture and use Labels, methods of making labels and methods of using labels are disclosed. The labels can be manufactured using fiber drawing techniques or by shutter masking. The labels can be used for detecting the presence of an analyte in a sample and for detecting interaction... | 11/30/2010 |
| 7829349 | Base carrier for detecting target substance, element for detecting target substance, method for detecting target substance using the element, and kit for detecting target substance An element to be used for detecting a target substance by using a capturing body for target substance and using surface plasmon resonance has a structure in which the metal structure having a particular pattern is located on a spherical support. Thus configured elem... | 11/09/2010 |
| 7829348 | Raman-active reagents and the use thereof The present invention provides a new class of Raman-active reagents for use in biological and other applications, as well as methods and kits for their use and manufacture. Each reagent includes a Raman-active reporter molecule, a binding molecule, and a surface enh... | 11/09/2010 |
| 7824926 | Raman-active reagents and the use thereof The present invention provides a new class of Raman-active reagents for use in biological and other applications, as well as methods and kits for their use and manufacture. Each reagent includes a Raman-active reporter molecule, a binding molecule, and a surface enh... | 11/02/2010 |
| 7785901 | Method of attaching hydrophilic species to hydrophilic macromolecules and immobilizing the hydrophilic macromolecules on a hydrophobic surface The present invention is related to a method of attaching hydrophilic species to hydrophilic macromolecules and immobilizing the hydrophilic macromolecules on a hydrophobic surface, to a nano-assembly and to uses of the nano-assembly. ... | 08/31/2010 |
| 7759134 | Magnetostrictive ligand sensor A magnetostrictive ligand sensor device (MLSD), system and method are provided having at least one magnetostrictive particle (MSP) to which is bound at least one binding element. The MSP may be dispersed in a sample containing a target ligand such that the target li... | 07/20/2010 |
| 7754500 | Asymmetrically branched polymer conjugates and microarray assays Asymmetrically branched polymers are combined with bioactive agents for a variety of purposes including drug delivery and conjugation to one member of a binding pair for use in an assay. ... | 07/13/2010 |
| 7736910 | One-step production of gold sols The present invention comprises novel “one-step” methods for the production of gold sol and gold sol conjugates. The methods disclosed herein produce gold sol and colloidal gold conjugates with product with yields on the order of about 20 ODs. Since current meth... | 06/15/2010 |
| 7732219 | Detection and amplification of ligands A system for the detection of ligands comprising at least one receptor and an amplification mechanism coupled to the receptor wherein an amplified signal is produced as a result of receptor binding a ligand. Examples of suitable amplification mechanisms include anti... | 06/08/2010 |
| 7723126 | Plasma-enhanced functionalization of inorganic oxide surfaces Methods for producing plasma-treated, functionalized inorganic oxide surfaces are provided. The methods include the steps of subjecting an oxide surface to a plasma to create hydroxyl functionalities on the surface and reacting the hydroxyl functionalities with epox... | 05/25/2010 |
| 7704755 | Differential labelling method The invention relates to a method for differentially labelling one or more entities, together comprising distinct reactive sites. The invention further relates to an entity that has been labelled by a method according to the invention and to a diagnostic kit compris... | 04/27/2010 |
| 7700374 | Device for capturing target substance It is intended to provide a target substance-capturing body comprising: a base consisting of a soluble protein; and two or more functional domains capable of binding to different target substances. ... | 04/20/2010 |
| 7695979 | Biomolecule diagnostic devices A biosensor includes a substrate with a layer of receptive material disposed thereon overlying a layer containing a photo-reactive agent. The receptive material is specific for an analyte of interest. A pattern of active and inactive areas of the receptive material ... | 04/13/2010 |
| 7691647 | Compositions for use as a signal generation component and methods of using same Compositions suitable for use as signal generation components of an immunoassay, and methods for their use. According to one aspect of the invention, the composition includes a carrier having a coating of an aminodextran and a metal chelate incorporated therein. The... | 04/06/2010 |
