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| Number | Title | Issue Date |
| 8071395 | Methods and apparatus for magnetic separation of cells Described here is an automated robotic device that isolates circulating tumor cells (CTCs) or other biological structures with extremely high purity. The device uses powerful magnetic rods covered in removable plastic sleeves. These rods sweep through blood samples,... | 12/06/2011 |
| 7985598 | Biomolecule-immobilized plate and method for fabricating biomolecule-immobilized plate There is provided a biomolecule-immobilized plate having a flat part, at least a surface of the flat part comprising a polymer material, wherein the flat part has an arithmetic average roughness of 0.1 nm˜5 nm, and a portion of the flat part has functional groups. ... | 07/26/2011 |
| 7943396 | Peptide-coated nanoparticles with graded shell compositions A peptide-coated nanoparticle that includes a nanocrystal core surrounded by a graded shell that is composed of at least two different semiconductor molecules. At least one peptide is attached to the surface of the graded shell to render the nanoparticle biocompatib... | 05/17/2011 |
| 7915053 | Substrate for target substance detecting device, target substance detecting device, target substance detecting apparatus and method using the same, and kit therefor A substrate for forming a target substance detecting device includes a supporting member, an underlying layer disposed on a surface of the supporting member, and a metal pattern layer, disposed on a surface of the underlying layer, for being bound to a target substa... | 03/29/2011 |
| 7906343 | Surface-enhanced lanthanide chelates A lanthanide chelate is linked to a noble metal substrate at a proximity wherein the substrate enhances a fluorescent emission of the lanthanide by at least 20-fold when the chelate is illuminated at an excitation wavelength that induces a transition in the lanthani... | 03/15/2011 |
| 7858397 | Dehydration/rehydration of derivatized, marker-loaded liposomes on a test device and method of use thereof The present invention relates to a method for making a test device for detecting or quantifying an analyte in a sample. This method involves contacting a membrane with a mixture including derivatized, marker-loaded liposomes, and substantially dehydrating the mixtur... | 12/28/2010 |
| 7842515 | Nano-structured device for analysis or separation, and its preparation and application This invention involves the nano-structured support used for separation or/and analysis, especially the chip substrate, ELISA plate substrate, planar chromatography strip and chromatography gel. Besides, it involves the functionalized nano-structured support of high... | 11/30/2010 |
| 7824925 | Multi-array, multi-specific electrochemiluminescence testing Materials and methods are provided for producing patterned multi-array, multi-specific surfaces for use in diagnostics. The invention provides for electrochemiluminescence methods for detecting or measuring an analyte of interest. It also provides for novel electrod... | 11/02/2010 |
| 7816149 | Nanobioprocessor for protein and cell therapy A nanobioprocessor for protein and cell therapy comprises a selectively coated quantum dot having selected band gap energies, characteristic absorption, emission spectra and outer coatings for therapy and diagnostic purposes in biophotonics and nanomedicine, and an ... | 10/19/2010 |
| 7811830 | Photosensitizers for photodynamic therapy at infrared excitation A photosensitizer that is excitable via infrared radiation and is adapted to be used to treat a selected biological target. The photosensitizer comprises a core nanoparticle adapted to convert infrared radiation into a visible light emission, and a coating disposed ... | 10/12/2010 |
| 7772013 | Enhancement of second-order non-linear optical susceptibilities in organic film materials using non-centrosymmetric nanoparticles A non-linear optical material comprising a plurality of non-centrosymmetric nanoparticles juxtaposed to non-linear optical (NLO) film at a localized surface Plasmon resonance (LSPR) of the nanoparticles. The LSPR is resonant at a wavelength of an incident light sour... | 08/10/2010 |
| 7763475 | Measurement and use of molecular interactions The present invention is based on the realization that the bonds between a target molecule, or a target molecule attached to a particle, and a surface, can be ruptured by mechanically oscillating the surface at increasing amplitude, leading to detachment of the targ... | 07/27/2010 |
| 7727776 | Core-shell nanoparticles for detection based on SERS A nanoparticle having a self assembly monolayer of molecules as a shell on the nanoparticle. The monolayer may include organic molecules working as surface enhanced Raman spectroscopy (SERS) reporters. Also, the core shell may include at least a receptor, and/or the... | 06/01/2010 |
| 7704754 | Method of plasmon-enhanced properties of materials and applications thereof Methods and applications of surface plasmon resonance-enhanced antibacterial, anti-adhere, adhere, catalytic, hydrophilic, hydrophobic, spectral change, biological and chemical decomposition properties of materials with embedded nanoparticles are disclosed. A method... | 04/27/2010 |
| 7682836 | Selective binding materials A template (a molecule preferably of molecular size >500 Da, or a larger entity such as a cell, virus or tissue sample) is dissolved or suspended in a fluid. The fluid is frozen, and the template is removed (e.g. by dissolution or electrophoresis, or mechanically) t... | 03/23/2010 |
| 7655478 | Sensor device, sensing method, biological substance sensor device, biological substance sensing method, secretion sensor device, secretion sensing method, emotion sensor device and emotion sensing method In a sensor device and a sensing method capable of simultaneously extracting plural pieces of information including information about the presence/absence, distribution, and so on, of targets, in case of measuring changes in nature of a detecting portion (11)... | 02/02/2010 |
| 7655479 | Luminescence characterization of quantum dots conjugated with biomarkers for early cancer detection Luminescent semiconductor quantum dots (QDs) conjugated with biomolecules to serve as sensitive probes for early detection of the cancer cells, specifically for ovarian cancer and lung cancer, which represents the most lethal malignancies. The luminescence character... | 02/02/2010 |
| 7625765 | Directed assembly of functional heterostructures The present invention relates to a systematic process for the creation of functionally organized, spatially patterned assemblies polymer-microparticle composites including the AC electric field-mediated assembly of patterned, self supporting organic (polymeric) film... | 12/01/2009 |
| 7611906 | Functionalized carbon nanotubes Carbon nanotubes are grown on a first substrate. The CNTs grown on the first substrate are immersed in a biological solution at a predetermined depth to functionalize ends of the CNTs with a biological molecule. The functionalized CNTs are harvested from the first s... | 11/03/2009 |
| 7575939 | Optical detection of label-free biomolecular interactions using microreplicated plastic sensor elements Methods and compositions are provided for detecting biomolecular interactions. The use of labels is not required and the methods can be performed in a high-throughput manner. The invention also provides optical devices useful as narrow band filters. ... | 08/18/2009 |
| 7572643 | Nanoparticle composite-coated glass microspheres for use in bioassays A microsphere for use in a bioassay comprising a glass core coated with a nanoparticle composite comprising a bioactive probe is provided. The nanoparticle composite coating enhances the density of bioprobe loading on the surface of the microspheres, resulting in en... | 08/11/2009 |
| 7563623 | Biosensor It is an object of the present invention to provide a biosensor on which a large amount of protein can be immobilized and nonspecific adsorption is less likely to occur with the use of a SAM compound having high water solubility and good performance in terms of supp... | 07/21/2009 |
| 7541197 | Planar optical waveguide based sandwich assay sensors and processes for the detection of biological targets including protein markers, pathogens and cellular debris An assay element is described including recognition ligands bound to a film on a single mode planar optical waveguide, the film from the group of a membrane, a polymerized bilayer membrane, and a self-assembled monolayer containing polyethylene glycol or polypropyle... | 06/02/2009 |
| 7541196 | Planar optical waveguide based sandwich assay sensors and processes for the detection of biological targets including early detection of cancers An assay element is described including recognition ligands adapted for binding to carcinoembryonic antigen (CEA) bound to a film on a single mode planar optical waveguide, the film from the group of a membrane, a polymerized bilayer membrane, and a self-assembled m... | 06/02/2009 |
| 7498177 | Quantum dots and their uses Quantum dots having ligands that comprise tiopronin capping groups are disclosed, along with a method for their preparation. The biocompatibility of these quantum dots is also demonstrated. The functionalization of the quantum dots of the present invention with targ... | 03/03/2009 |
| 7488607 | Electronically readable microarray with electronic addressing function Methods and apparatus for electronically addressing and interrogating microarrays are disclosed. The described microarrays include a plurality of features disposed on a substrate. Each of the features has a first electrode disposed on the substrate, a second electro... | 02/10/2009 |
| 7462496 | Plasmon-enhanced marking of fragile materials and other applications thereof The methods and applications of a surface plasmon resonance-enhanced marking technique are disclosed. The technique uses surface plasmon resonance (SPR) excited nanoparticles and a surface plasmon resonance source in nonlinear interactions with nearby chemical subst... | 12/09/2008 |
| 7439078 | Method for measuring dissociation rate coefficient by surface plasmon resonance analysis An object of the present invention is to provide a method for measuring the dissociation rate coefficient (Kd) by surface plasmon resonance analysis without measuring the theoretical maximum amount of binding (Rmax). The present invention provides a method for measu... | 10/21/2008 |
| 7432113 | Surface modification of metals for biomolecule detection using surface enhanced Raman scattering (SERS) The present invention is based on the discovery that the methods described herein for the production of metallic colloids result in colloids exhibiting increased signal enhancement and reproducibility for the SERS detection of biomolecules. Thus, using the methods o... | 10/07/2008 |
| 7432112 | Surface modification of metals for biomolecule detection using surface enhanced Raman scattering (SERS) The present invention is based on the discovery that the methods described herein for the production of metallic colloids result in colloids exhibiting increased signal enhancement and reproducibility for the SERS detection of biomolecules. Thus, using the methods o... | 10/07/2008 |
| 7429492 | Multiwell plates with integrated biosensors and membranes The invention provides compositions and methods of detecting binding of molecules to a biosensor. Compositions of the invention comprise a multiwell plate with an integrated biosensor and a membrane. ... | 09/30/2008 |
| 7427513 | Surface modification of metals for biomolecule detection using surface enhanced Raman scattering (SERS) The present invention is based on the discovery that the methods described herein for the production of metallic colloids result in colloids exhibiting increased signal enhancement and reproducibility for the SERS detection of biomolecules. Thus, using the methods o... | 09/23/2008 |
| 7425455 | Biosensor, magnetic molecule measurement device A biosensor not requiring washing of an unbonded label molecular by analyzing an object to be measured such as an antigen, an antibody, a DNA, and an RNA through magnetic field sensing. The biosensor is small in size, low in price, and high in sensing accuracy. Semi... | 09/16/2008 |
| 7425454 | Biosensor It is an object of the present invention to provide a detection surface used for biosensors, in which non-specific adsorption is suppressed and the generation of pinholes is also suppressed. The present invention provides a biosensor, which comprises a substrate coa... | 09/16/2008 |
| 7413868 | Use of particulate labels in bioanalyte detection methods New applications for the use of distinguishable particulate labels available in a variety of hues and sized in the submicron range are described. These applications include profiling of cellular components, obtaining secretion patterns, identifying a multiplicity of... | 08/19/2008 |
| 7413607 | Templated semiconductor particles and methods of making Composite particles of a semiconductor particle such as a metal chalcogenide within a crosslinked, cored dendrimer are described. Additionally, methods of making the composite particles and compositions that contain the composite particles are described. ... | 08/19/2008 |
| 7413911 | Method for measuring reaction rate coefficient by surface plasmon resonance analysis An object of the present invention is to provide a method for measuring a rate coefficient by surface plasmon resonance analysis with excellent accuracy, reliability, and cost performance that can improve the assay accuracy and simplify the apparatus. The present in... | 08/19/2008 |
| 7413892 | Systems and methods for molecular recognition Acoustic wave devices coated with a biolayer are described for the detection target bio-molecules. The acoustic wave device is connected in an oscillator circuit, and the frequency shift Δf resulting from a biomolecular event is recorded. Further described are the ... | 08/19/2008 |
| 7410808 | Method and assay for detection of residues Embodiments described herein include methods and assays for detecting an analyte in a sample using a plurality of control zone capture agents. Some embodiments include detection of multiple analytes in a sample utilizing a plurality of analyte binders and a control ... | 08/12/2008 |
| 7410811 | Analytical method and device utilizing magnetic materials The present invention relates to an analytical method and device utilizing magnetic materials and acoustics sensor. The invention employs a magnetic material modified with specific recognizable molecules to capture a substance in a sample and provides an external ma... | 08/12/2008 |
