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"What, sir, would you make a ship sail against the wind and currents by lighting a bonfire under her deck? I pray you, excuse me, I have not the time to listen to such nonsense."
Napoleon Bonaparte ; When told of the Robert Fulton steamboat
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| Number | Title | Issue Date |
| 7425421 | Method for the enumeration of micronucleated erythrocyte populations while distinguishing platelets and/or platelet-associated aggregates A method for the enumeration of micronucleated erythrocyte populations while distinguishing platelet and platelet-associated aggregates involves the use of a first fluorescent labeled antibody having binding specificity for a surface marker for reticulocytes, a seco... | 09/16/2008 |
| 7399643 | Method and apparatus for aligning microbeads in order to interrogate the same A method and apparatus are provided for aligning optical elements or microbeads, wherein each microbead has an elongated body with a code embedded therein along a longitudinal axis thereof to be read by a code reading device. The microbeads are aligned with a positi... | 07/15/2008 |
| 7354773 | Method and apparatus for preparing cell samples for intracellular antigen detection using flow cytometry A method and apparatus for preparing biological cell samples for intracellular analysis. The invention is based upon the recognition that many of the steps of the conventional methods for such sample preparation can be eliminated, leading to a process that readily l... | 04/08/2008 |
| 7044919 | Test methods, devices and test kits A method for determining the time of maximum fertility in the mammalian ovulation cycle, for the purpose of assisting conception, wherein testing is conducted over a period of days in the current ovulation cycle on samples of body fluid obtained from an individual h... | 05/16/2006 |
| 7026131 | Methods and apparatus for blood typing with optical bio-discs This invention relates to clinical diagnostic assays, related optical bio-discs, and a disc-reading apparatus. The invention is directed to methods and apparatuses for performing immunohematology assays using an optical bio-disc analysis system. The invention is fur... | 04/11/2006 |
| 6673629 | Neutralization of polycations in a chromatographic device for whole blood use A chromatography assay device and method for use with whole blood samples utilizing a red blood cell separating agent to aggregate red blood cells and permit plasma or serum to flow by capillary action and a neutralizing agent to neutralize any effects th... | 01/06/2004 |
| 6534008 | In situ heat induced antigen recovery and staining apparatus and method An automated in situ heat induced antigen recovery and staining method and apparatus for treating a plurality of microscope slides. The process of heat induced antigen recovery and the process of staining the biological sample on the microscope slide are ... | 03/18/2003 |
| 6534279 | Reagent and method for the permeabilization and identification of erythrocytes A process for permeabilizing erythrocytes in which the erythrocytes are subjected successively to the action of (a) a fixing agent containing an aliphatic aldehyde and oligosaccharide, (b) a permeabilizing agent containing a detergent and an oligosaccharide, kit fo... | 03/18/2003 |
| 6303390 | Method for antigen and antibody determination in bloodgroup serology Method and test kit for assaying in a sample an analyte which is a bloodgroup antigen present on erythrocytes or an antibody binding to such a bloodgroup antigen. To that end, the sample is treated with a reagent containing a binding partner for the analy... | 10/16/2001 |
| 6219584 | Method and system for determining an effective amount of light energy to delivery to fluids having targets for the light energy Systems and methods for determining an effective amount of light energy to deliver to fluids, particularly fluids having target and non-target materials. The systems and methods specifically relate to phototherapy and photopheresis systems where an effect... | 04/17/2001 |
| 6100038 | Method for the enumeration of micronucleated erythrocyte populations with a single laser flow cytometer A single laser flow cytometric method for the enumeration of micronuclei in erythrocyte populations, wherein a sample of peripheral blood or bone marrow is obtained and the cell populations in the sample are fixed. Reticulocytes in the fixed samples are t... | 08/08/2000 |
| 5985543 | Compositions and methods for detection of antibody binding to cells The invention relates to methods of agglutinating or capturing cells comprising providing a mixture comprising a population of cells and a population of bacteriophage expressing a first antibody on the surface of the bacteriophage, the first antibody bein... | 11/16/1999 |
| 5981761 | Crosslinked polyaspartate salts a process for their production A first embodiment comprises reacting PSI with polyhydrazide selected from the group consisting of dihydrazides and trihydrazides and mixtures thereof, subsequently hydrolyzing the crosslinked PSI with base to produce crosslinked polyaspartate. A second e... | 11/09/1999 |
| 5849510 | Factor Xa inhibitors The invention provides compounds which specifically inhibit factor Xa activity. The compounds consist of the structure X1 -YIR-X2, wherein X1 is H, acyl, alkyl, acylalkyl, arylalkyl or one or more amino acids, and X2 | 12/15/1998 |
| 5840588 | Agglutination inhibition assay methods and reagents for psychoactive substances Immunoassays of psychoactive drugs including psychotomimetic drugs, narcotic drugs, and tetrahydrocannabinols and treatment methods based on the antigenic properties of protein conjugates of these drugs. These methods are based upon treating the psychoact... | 11/24/1998 |
| 5800983 | Peptides for HIV-1 detection HIV-1 peptides having at least one point mutation between position 593 and 611 of the HIV-1 gp160 amino acid sequence. The point mutation either is at position 604 or 610, or both positions. Immunoassays which utilize these peptides are provided, as well ... | 09/01/1998 |
| 5773222 | Solid phase immunological assay A solid phase method of detection or assay of the presence or amount in a serum or plasma sample of a target antibody specific to a cell surface antigen. The sample is contacted with an immobilised preparation of cells bearing the antigen and antibody bou... | 06/30/1998 |
| 5677132 | Immunological assay reagent package Immunoassays of psychoactive drugs including psychotomimetic drugs, narcotic drugs, and tetrahydrocannabinols and treatment methods based on the antigenic properties of protein conjugates of these drugs. These methods are based upon treating the psychoact... | 10/14/1997 |
| 5650270 | Molecular analytical release tags and their use in chemical analysis Analytical reagents designated "release tags", for labeling molecular species with a highly detectable signal group which can be released in the form of a volatile compound at a desired point in an analytical procedure. In one embodiment, the release tags... | 07/22/1997 |
| 5643732 | Immunological assay methods Immunoassays of psychoactive drugs including psychotomimetic drugs, narcotic drugs, and tetrahydrocannabinols and treatment methods based on the antigenic properties of protein conjugates of these drugs. These methods are based upon treating the psychoact... | 07/01/1997 |
| 5637472 | Hydrazine derivatized cells A method is provided for the preparation of semisolid particles or cells that have been chemically derivatized resulting in hydrazide functionalities covalently incorporated onto cell surface membrane molecules of the semisolid particles or cells, as well... | 06/10/1997 |
| 5591596 | Process for preparing a purified treponemal antigen and use thereof A process for preparing a purified syphilis antigen which comprises adsorbing an extract originated from Treponemda pallidum on a hydroxyapatite gel, followed by elution, while an aqueous medium is used.... | 01/07/1997 |
| 5529933 | Suspension media for hematological composition and method for its use A hematology control product comprising leukocyte analogs and an aqueous solution of a plasma substance for use in a blood counting instrument is described. The instrument employs a lytic reagent system for the lysable red blood cells in the control produ... | 06/25/1996 |
| 5318913 | Reagent for the determination by hemagglutination of antibodies to bacterial toxins, method of preparation and application thereof The invention relates to a method of preparing a reagent for the determination by hemagglutination of antibodies to bacterial toxins. According to this method erythrocytes are treated with glutaraldehyde and then with the bacterial toxins in the presence ... | 06/07/1994 |
| 5316936 | Method for preparation of human serum albumin-sensitized sheep erythrocytes (HSA-cell) for detection of pre-S2 antigen A method for preparation in a large quantity of human serum albumin-sensitized sheep erythrocytes is described. The sensitized cells are useful for detecting Hepatitis B virus pre-S2 antigen. The method uses human serum albumin sensitized gluta... | 05/31/1994 |
| 5192663 | Article having an organic dye and a monolayer of dried mammalian cells and a method for utilizing the article A method for drying mammalian cells, such as erythrocytes, lymphocytes, leukocytes and platelets onto a solid-phase support for use in solid-phase immunoassays through use of a drying solution and an article for use in immunoassays prepared by such method... | 03/09/1993 |
| 5166051 | Membranes, membrane overlays for exclusion of erythrocytes, and method for immunoassay of whole blood analytes A diagnostic test strip for chemically determining whole blood analytes comprises a support, a porous detection zone membrane affixed to the support, and an overlay membrane affixed to the support and in overlying and continuous contact with the detection... | 11/24/1992 |
| 5122453 | Method for discriminating surface stained lymphocytes A flow cytometry method for reproducibly detecting and counting a lymphocyte population of interest in a leukocyte suspension or whole blood sample in which the red cells are subsequently lysed. The suspension (or sample) is combined with a reagent compri... | 06/16/1992 |
| 5079173 | Methods, hybridomas, monoclonal antibodies and sensitized cells for measuring HBS antigen This invention provides anti-HBs monoclonal antibodies HBs 8Cl, HBs 18E9 and HBs 22B7, an anti-human IgM monoclonal antibody HIgM 10C9 and an anti-mumps virus monoclonal antibody MPV 10G3 capable of inhibiting nonspecific reaction in the reverse passive a... | 01/07/1992 |
| 4994373 | Method and structures employing chemically-labelled polynucleotide probes Polynucleotide sequences in a sample of biological or nonbiological material are detected by a method involving fixing of the sequences on a solid support and forming an entity between the fixed sequences and chemically-labeled polynucleotide or oligonucl... | 02/19/1991 |
| 4816413 | Solid phase indicator red blood cells and method A method and composition for use in preparing red blood cells for use as indicator cells to detect the presence of antigens and antibodies in biological fluids is the subject of the present invention. Freshly collected human or animal erythrocytes are was... | 03/28/1989 |
| 4729961 | Process for the detection and assay by erythroadsorption A process for the detection and assay of a biological substance by erythroadsorption by immobilizing a substance having a binding affinity for the biological substance to be assayed; incubating the immobilized substance with a liquid medium containing the... | 03/08/1988 |
| 4713348 | Fluorescent multiparameter particle analysis Methods are provided for rapidly determining a number of parameters in a few determinations. Particularly, the method is applicable to blood typing, determining the blood type as to the ABO and Rh type, as well as the determination of isoantibodies to the... | 12/15/1987 |
| 4686194 | Serioimmunological process for determining the in-vivo effectiveness of cytostatic agents The in-vivo effectiveness of cytostatic agents against immunological active tumors is determined by measuring immune markers and/or immune parameters in the serum before and up to 3 days after the application of the cytostatic agent. Preferably the deviat... | 08/11/1987 |
| 4668637 | Method for detecting and dosing by erythroadsorption a biological substance A process for the detection of a biological substance immobilized on a support including (1) incubating, after washing, the substance immobilized on a support with the product of coupling of a specific ligand with a ligand capable of reacting with erythro... | 05/26/1987 |
| 4659655 | Method for isolating product-producing cells The invention relates to techniques for isolating from a mixed population of cells disired living cells either producing and releasing a particular product or having a characteristic molecule on their surface. The isolation techniques depend upon the loca... | 04/21/1987 |
| 4624927 | Reagent for determination of blood coagulation factor XIII A reagent for determination of human blood coagulation factor XIII for reversed passive hemagglutination reaction which comprises sensitized erythrocytes prepared by sensitizing animal erythrocytes with specific anti-human factor XIII antibody, and a kit ... | 11/25/1986 |
| 4620977 | Treatment methods, particularly for psychoactive drug dependence Immunoassays of psychoactive drugs including psychotomimetic drugs, narcotic drugs, and tetrahydrocannabinols and treatment methods based on the antigenic properties of protein conjugates of these drugs. These methods are based upon treating the psychoact... | 11/04/1986 |
| 4609630 | Method for improving the specificity of immunoassays A method and serological reagent for determining antigens or antibodies with enhanced sensitivity and specificity techniques acts in an interdependent manner in one diagnostic unit of two separately acting components. This action can be simultaneous or co... | 09/02/1986 |
| 4608246 | Testing for a blood group immunological reaction A method of forward blood grouping is presented wherein known antibodies are attached to a solid surface and the red blood cells presented for immunological reaction are activated with a proteolytic enzyme. A reverse blood grouping procedure utilizes synt... | 08/26/1986 |
