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| Number | Title | Issue Date |
| 7605005 | Method of screening for agents that modulate Tysnd1 level or activity in a cell. The invention relates to a pharmaceutical composition for treating or diagnosing a disorder associated with production of peroxisome in a cell, comprising a polypeptide which has cysteine protease activity and directly processes peroxisomal enzymes targeted by PTS1 ... | 10/20/2009 |
| 7354733 | Method for sorting and separating living cells We disclose methods of sorting or separating mixtures of living cells (e.g., eukaryotic, prokaryotic, mammalian, pathogenic, bacterial, viral, etc.). We perform our methods by activating cell-selective photophoric labels, which photosensitize and chemically reduce a... | 04/08/2008 |
| 7344849 | Assay The present invention relates to assay methods for the determination of cobalamin or vitamin B12 in a body fluid and in particular to assay methods for the metabolically active pool of cobalamin, comprising contacting a cell free sample of a body fluid wi... | 03/18/2008 |
| 7327867 | Methods for recognizing nucleus area and constructing cell lineage A cell lineage can be constructed in a less labor intensive manner and in less time by using a computer. Areas, which are misidentified as nuclei, are efficiently removed. The invention comprises the steps of: selecting one or more nuclei for making a forward link f... | 02/05/2008 |
| 7312089 | Detection of erythropoietin and erythropoietin receptor The invention is based on the development of several sensitive and simple methods for detecting erythropoietin and the erythropoietin receptor and associated antibodies. The methods and reagents are useful for differential diagnosis in Epo and EpoR related clinical ... | 12/25/2007 |
| 7297554 | Immunoassay system A competitive immunoassay, dye and method for rapidly detecting the presence of one or more target ligands within a fluid sample suspected of containing such ligand or ligands. The immunoassay comprises a protein-binding membrane, a first absorbent pad, a second abs... | 11/20/2007 |
| 7288368 | Membrane receptor reagent and assay A membrane receptor reagent and assay is disclosed in which liposomes are bound to an evanescent wave emitting surface. Membrane receptors on the liposome's fluid lipid bilayer membrane are labeled with a fluorescent or luminescent moiety. These membrane receptors a... | 10/30/2007 |
| 7238537 | Assays An analytical test device incorporating a dry porous carrier to which a liquid sample, eg. urine, suspected of containing an analyte such as HCG or LH can be applied indirectly, the device also incorporating a labelled specific binding reagent which is freely mobile... | 07/03/2007 |
| 7148332 | High affinity monoclonal antibody for recognizing the estrogen receptor (ER) and method for creating the antibody High affinity monoclonal antibodies for recognizing estrogen receptor (clone SP1) with immunohistochemistry and methods for creating such an antibody are disclosed. The lagomorph derived ER antibody provides a significant advantage over the currently available mouse... | 12/12/2006 |
| 7148028 | Methods and means relating to atherosclerosis The present invention relates to the identification of lipid oxidising antibodies as a key pathogenic factor in atherosclerotic disorders. The presence of such antibodies is a important marker for the diagnosis and prognosis of such disorders and methods and means f... | 12/12/2006 |
| 7138280 | Masking of the background fluorescence and luminescence in the optical analysis of biomedical assays In a process for the quantitative optical analysis of biological cells labelled with a fluorescent dye, the sensitivity of analytical detection can be considerably improved if a masking dye, which absorbs the excitation light for the fluorescent dye and/or its emiss... | 11/21/2006 |
| 7090988 | Optoelectronic sensor A device for detecting the presence of an antigen including (1) a cell having antibodies which are expressed on the surface of the cell and are specific for the antigen to be detected, where binding of the antigen to the antibodies results in an increase in calcium ... | 08/15/2006 |
| 7067127 | GIcNAc phosphotransferase of the lysosomal targeting pathway The present invention provides nucleotide and amino sequences of the lysosomal targeting pathway enzyme GlcNAc-phosphotransferase, methods of producing and methods of purifying this enzyme. ... | 06/27/2006 |
| 7060453 | Method and kit for the determination of analyte concentration in blood A method is provided for determining the level of an analyte in the blood of an individual based on determination of the level of the same analyte in non-blood sample (e.g. urine, saliva and hair) obtained from the individual. The non-blood sample contains red blood... | 06/13/2006 |
| 7056746 | Array cytometry A method and apparatus for the manipulation of colloidal particulates and biomolecules at the interface between an insulating electrode such as silicon oxide and an electrolyte solution. Light-controlled electrokinetic assembly of particles near surfaces relies on t... | 06/06/2006 |
| 7041287 | Compositions and methods for selective dissolution of nascent intravascular blood clots Compositions and methods for prevention and treatment of uncontrolled formation of intravascular fibrin clots, which are capable of selective dissolution of pathological nascent clots formed intravascularly, with minimal risk of unwanted dissolution of pre-existing ... | 05/09/2006 |
| 7015465 | Parallel concentration, desalting and deposition onto MALDI targets A method and apparatus for the continuous deposition of RP HPLC eluent, from isocratic or gradient elutions, on to a MALDI target using a parallel sample desalting method, allows increased sensitivity of the MALDI sample by pre-concentration of the analyte, separati... | 03/21/2006 |
| 6972198 | Methods and compositions using protein binding partners The invention relates to a method for determining the conformational state of a protein, comprising the steps of: a) providing a first binding partner which is capable of binding to the protein in a manner dependent on the conformational state of the protein and whi... | 12/06/2005 |
| 6969612 | Reagent and method for measuring a concentration of protein The object of the present invention is to measure a concentration of protein stably at a temperature not higher than 25° C., which is a possible ambient temperature at home, and further to expand the measurable concentration range while preventing an obstruction du... | 11/29/2005 |
| 6955889 | Simultaneous determination of forward and reverse ABO blood group Simultaneous forward and reverse blood group testing is described using both a visual detection system and a fluorescent based labeling and detection system. Forward and reverse tests could be performed separately, but A and B agglutinates can be detected and discri... | 10/18/2005 |
| 6951716 | Anti-platelet immunoglobulin bead positive control Immunoassay methods and apparatus are provided which utilize flow cytometry, coated latex microspheres, and fluorochrome labeled antibodies, to simultaneously detect the presence and amount of one or more analytes in a sample. Beads of several different sizes, color... | 10/04/2005 |
| 6951727 | Methods and reagents for quantitation of cell-surface molecule expression on peripheral blood cells Improved methods, reagents, and kits for quantitation of HLA-DR and/or CD11b expression on peripheral blood cells are presented. Inclusion of a lysosomotropic amine, such as chloroquine, during staining stabilizes HLA-DR and CD11b expression. Use of a novel anti-CD1... | 10/04/2005 |
| 6951682 | Porous coatings bearing ligand arrays and use thereof Articles comprising substantially uniform porous coatings, which may be photopatterned, are provided. The use of such porous coatings increases the surface density of attached compounds within, for example, ligand arrays prepared by methods such as regionally select... | 10/04/2005 |
| 6946260 | Allergen/inflammatory testing and diagnosis The invention relates to the use of a secretor variant cell-line expressing the alpha moiety of human IgE binding protein to determine the allergic status of a given individual. Moreover, the cell-line is also used to provide an assay system for determining the alle... | 09/20/2005 |
| 6933106 | Platelet immunoglobulin bead suspension and flow cytometry Immunoassay methods and apparatus are provided which utilize flow cytometry, coated latex microspheres, and fluorochrome labeled antibodies, to simultaneously detect the presence and amount of one or more analytes in a sample. By combining FALS and fluorescence, it ... | 08/23/2005 |
| 6911305 | Method for chemiluminescent detection The invention provides chemiluminescent assays that incorporate a film including at least one chemiluminescent precursor immobilized therewith which produces a triggerable chemiluminescent compound, the film being free of compounds which generate singlet oxygen and ... | 06/28/2005 |
| 6878811 | Substance with antithrombotic activity and method for detecting glycokallidin A method for conveniently detecting binding between the von Willebrand factor and glycoprotein Ib and a means to be used therein. The von Willebrand factor fixed in a reactor immobilized in a reaction vessel in the presence of bottrocetin is bound to a chimeric prot... | 04/12/2005 |
| 6858439 | Compositions and methods for separation of moieties on chips The present invention recognizes that separation of components of a sample facilitate, and are often necessary for, sample analysis. Dielectrophoretic separation provides an efficient, reliable, nondisruptive, and automatable method for the separation of moieties in... | 02/22/2005 |
| 6835543 | Step agglutination immunoassay An immunoassay for detecting an antigen in a sample, by: (a) sequentially contacting the sample with (i) a first antibody which is capable of specifically binding to a first binding site on the antigen,... | 12/28/2004 |
| 6825000 | Immunoassay reagent and immunoassay method An immunoassay reagent is obtained whereby a microscale substance such as an antigen or antibody can be assayed at a high sensitivity, and whereby a need to separate a reacted substance, e.g., an immunoreacted substance, from an unreacted substance can be eliminated... | 11/30/2004 |
| 6811989 | Pancreatic islet cell antigens obtained by molecular cloning Pancreatic islet cell antigens (ICA) that bind with antibodies found in the sera of patients afflicted with insulin-dependent (Type I) diabetes mellitus (IDDM). ICA proteins are expressed by recombinant cloning vehicles comprising DNA inserts isolated from islet cel... | 11/02/2004 |
| 6800448 | Optoelectronic sensor A device for detecting the presence of an antigen including (1) a cell having antibodies which are expressed on the surface of the cell and are specific for the antigen to be detected, where binding of the antigen to the antibodies results in an increase in calcium ... | 10/05/2004 |
| 6777193 | Methods for diagnostic and/or treatment of antiphospholipids antibodies-related diseases, and devices Methods for detecting anti-lipidic particles antibodies and lipidic particles in cellular membranes for the diagnosis of diseases associated to the antiphospholipid syndrome are disclosed. Kits or sets to put these methods of diagnosis into practice are also disclos... | 08/17/2004 |
| 6753153 | Markers for identification and isolation of pancreatic islet α and β progenitors The differential expression of marker proteins in a targeted population provides a means of identifying and isolating cells. A population of cells associated with the regeneration of pancreatic islets is shown to express certain proteins, including the cell surface ... | 06/22/2004 |
| 6743595 | Method and diagnostic kit for diagnosis of endometriosis The invention relates to a method and a kit for the diagnosis of endometriosis using blood and endometrial leukocyte markers or a combination thereof. The marker is a surface antigen from endometrial or blood leukocytes. ... | 06/01/2004 |
| 6709833 | Monoclonal antibody recognizing phosphatidylinositol-3,4-diphosphate A novel monoclonal antibody that specifically recognizes phosphatidylinositol-3,4-biphosphate (PI-3,4-P2) but does not cross-react with structurally similar phospholipid antigens is advantageous for PI-3,4-P2-specific immunoassay. The gene in the variable regions of... | 03/23/2004 |
| 6686158 | Electronically-indexed solid-phase assay for biomolecules Disclosed are materials and methods for detecting biomolecules in samples employing transponders associated with the bead(s) used as the solid phase in the assay, and information pertinent to the assay is encoded on the transponders memory elements. A ded... | 02/03/2004 |
| 6677123 | Process for detecting increased risk of fetal chromosomal abnormality An increased risk of a fetal chromosomal abnormality, for example, fetal Down syndrome can be detected by separating or discriminating -fetoproteins present in the body fluid of a pregnant woman, and measuring the proportion of one or more of the &... | 01/13/2004 |
| 6670115 | Devices and methods for detecting analytes using electrosensor having capture reagent The present invention relates to devices comprising electrosensors containing capture reagents, their preparation thereof, and their use for detecting, preferably, quantitative measurement, of analyte in a liquid sample. In particular, the invention relat... | 12/30/2003 |
| 6667149 | PROCEDURE FOR THE ANALYSIS OF THE FUNCTIONAL ACTIVATION OF LEUKOCYTES, PLATELETS AND OTHER CELLS, INDUCED IN VIVO OR IN VITRO, BASED ON THE STABILIZATION OF CYTOPLASMIC MEMBRANE PROTEINS AND ITS DETECTION USING QUANTITATIVE CYTOMETRIC METHODS IN THE ABSENCE OF ADDITIONAL SAMPLE MANIPULATION Procedure for the study of the functional activation of leukocytes, platelets and other cells, produced in vivo or induced in vitro, based on the stabilization of cytoplasmic membrane proteins and its detection using quantitative cytometric methods in the... | 12/23/2003 |
