Did You Know...
...that when IBM conducted a market study of Chester Carlson's invention in 1959, the company concluded that it would take only 5000 units of his new product to saturate the market? IBM therefore declined to be part of the new product introduction. Too bad for IBM. Carlson's invention was the xerography process, and his new product was the beginning of the Xerox Corporation. It is estimated that every day, worldwide, 3,000,000,000 copies are made!!
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| Number | Title | Issue Date |
| 8105844 | Apparatus and method of using porous material for antigen separation, identification, and quantification with electrophoresis techniques An apparatus includes a porous membrane for retaining antigens from a sample as the sample passes through the membrane. The apparatus also includes a first binding region within the membrane. The first binding region includes antibodies associated with a first antig... | 01/31/2012 |
| 7824923 | Neuregulin-β isoforms associated with neuronal processes The invention relates to novel neuregulin-β isoforms associated with neuronal processes. ... | 11/02/2010 |
| 7407764 | Plasma C5A levels as an indicator of asthma severity This invention provides the first blood test which characterizes asthma severity. More specifically, the present invention provides methods of determining the severity of acute asthma in a patient by determining the levels of C5a or C5a-desArg in the patient's blood... | 08/05/2008 |
| 7355079 | Thyronamine derivatives and analogs and methods of use thereof Thyronamine derivatives and analogs, methods of using such compounds, and pharmaceutical compositions containing them are disclosed. Methods of preparing such compounds are also disclosed. ... | 04/08/2008 |
| 7323092 | Multichannel microscale system for high throughput preparative separation with comprehensive collection and analysis While the present invention has been described in conjunction with a preferred embodiment, one of ordinary skill, after reading the foregoing specification, will be able to effect various changes, substitutions of equivalents, and other alterations to the compositio... | 01/29/2008 |
| 7321829 | Method for the identification and/or the quantification of a target compound obtained from a biological sample upon chips The present invention is related to a method for the identification and/or the quantification of a target compound obtained from a sample, preferably a biological sample, comprising the steps of putting into contact the target compound with a capture molecule in ord... | 01/22/2008 |
| 7285199 | Apparatus and method for electrophoretic microspot concentration A method and apparatus for concentrating dilute biomolecules in samples using electrophoresis are described. The method involves using the charged nature of the biomolecules to localize them to a microspot containing a dialysis membrane. The method and apparatus may... | 10/23/2007 |
| 7261800 | Automatic in situ electrophoresis method and apparatus A method of in situ electrophoresis of biological samples has the steps of preparing a sample plate and a gel plate, applying reagent onto the gel plate, moving an applicator to the sample plate so as to receive a sample onto the applicator, moving the applicator to... | 08/28/2007 |
| 7250100 | Two dimensional electrophoresis cassette A device for two-dimensional electrophoresis includes a cassette comprising two opposing plates. The two opposing plates form a first elongated portion for receiving a first elongated electrophoretic separation medium and a second portion extending away from the fir... | 07/31/2007 |
| 7250767 | Method for introducing a liquid sample into an NMR spectrometer A method for introducing a liquid sample into an NMR spectrometer to measure an NMR spectrum of the liquid sample, wherein the liquid sample is injected into a supply line and wherein further liquids are supplied into the supply line following the liquid sample, whi... | 07/31/2007 |
| 7217574 | Method and apparatus for biosensor spectral shift detection Performing high-resolution determination of the relative shift of the spectral properties of a biosensor. The shift in the resonance peak of the biosensor is indicative of the amount of material bound to the surface of the biosensor. A preferred biosensor is a Guide... | 05/15/2007 |
| 7217505 | Method for determining whether condition is symptom of metabolic syndrome The use of cortisol agonist for preparing a system for diagnosis of the metabolic syndrome and related conditions as belly fatness, insulin resistancy including increased risk of developing senile diabetes, i.e. diabetes type II, high blood fats and high blood press... | 05/15/2007 |
| 7214477 | Layered device with capture regions for cellular analysis The present invention involves methods, systems, and devices for analyzing a biological material, such as a cellular or other specimen. The method includes placing the specimen on a substrate having different capture regions, such as contiguous layers, wherein the d... | 05/08/2007 |
| 7202044 | Method for detecting a progressive, chronic dementia disease, and corresponding peptides and detection agents The invention relates to defined peptides and the quantitative determination thereof in body fluids of patients suffering from progredient chronic dementia, in relation to the concentration of said peptides in a control group. The inventive peptides come from a prot... | 04/10/2007 |
| 7179639 | Thermal strip thermocycler This is a self-contained disposable thermal cycler device in which target sequence is amplified as the samples passes over a grid of alternating temperature and then at the completion of the reaction, the amplified material is captured by probes complementary to the... | 02/20/2007 |
| 7179612 | Method for detecting a lipoprotein-acute phase protein complex and predicting an increased risk of system failure or mortality A method for diagnosing a condition of a patient involves the steps of (a) adding one or more reagents to a test sample from a patient, the test samples comprising at least part of a blood sample from the patient, in order to cause formation of a complex comprising ... | 02/20/2007 |
| 7157223 | Method and apparatus for detecting enzymatic activity using molecules that change electrophoretic mobility The activity of intracellular chemical reactions of molecules is measured by the use of fluorescently labeled substrate molecules that undergo a change in electrophoretic mobility upon chemical reaction such as that catalyzed by an enzyme. Specificity is achieved by... | 01/02/2007 |
| 7153701 | Method for quantitatively detecting antigen A method for quantitatively detecting an antigen which comprises (1) a first step of providing an Fab′ antibody having a uniform isoelectric point, said antibody forming an immune complex with an antigen in an analytical sample and being modified by adding an amin... | 12/26/2006 |
| 7135300 | Profiling frequencies of receptor heterodimers Methods are provided for detecting formation of oligomeric complexes of molecules on the surface of cell membranes. These methods employ pairs of tagged probes and cleaving probes, each of which binds specificly to a cell surface molecule. The tagged probe includes ... | 11/14/2006 |
| 7115422 | Separation apparatus including porous silicon column A sample separation apparatus including a porous, or rough, capillary column. The porous capillary column includes a matrix which defines pores, and may be formed rough surface of hemispherical grain silicon. The capillary column is defined in a surface of a substra... | 10/03/2006 |
| 7105308 | Detecting receptor oligomerization Methods are provided for detecting formation of oligomeric complexes of molecules on the surface of cell membranes. These methods employ pairs of tagged probes and cleaving probes, each of which binds specificly to a cell surface molecule. The tagged probe includes ... | 09/12/2006 |
| 7026002 | Element, method and kit for the determination of an analyte in a liquid The invention concerns an element for the determination of an analyte in a liquid by means of a specific binding reaction of two bioaffine binding partners containing in or on material which enables liquid transport between the zones. The element comprises a sample ... | 04/11/2006 |
| 6955908 | Organism associated with nongonococcal urethritis The invention features a biologically pure culture of a newly identified single-celled organism Spiky Rotating Cells (SPR), methods to diagnose an SPR infection in a human patient, an instrument for collecting and detecting an SPR infection, and methods for treating... | 10/18/2005 |
| 6949347 | Multiplex analysis using membrane-bound sensitizers The present invention is directed to methods and compositions for determining the presence, absence, and/or amounts of one or more membrane-associated analytes in a sample. In accordance with the invention, binding compounds derivatized with releasable molecular tag... | 09/27/2005 |
| 6936150 | Methods and apparatus for electrophoresis of prior-cast, hydratable separation media Methods and apparatus are presented that facilitate electrophoresis of prior-cast, hydratable separation media, usefully immobilized pH gradient (IPG) strips. The method exploits the swelling of prior-cast, hydratable separation media upon rehydration to help lodge ... | 08/30/2005 |
| 6890720 | Antigens derived from filaggrin and their use for diagnosing rheumatoid polyarthritis The invention concerns an artificial antigen specifically identified by the anti-filaggrin autoantibodies present in the serum of patients suffering from rheumatoid polyarthritis, and consisting of one polypeptide comprising all or part of the sequence of one filagg... | 05/10/2005 |
| 6860980 | Polyelectrolyte derivatization of microfluidic devices A microchannel device is provided with a plastic substrate having a microchannel formed therein. Polyelectrolyte multilayers are disposed along selected surfaces of the microchannel. The polyelectrolyte layers comprise alternating net positively charged layers and n... | 03/01/2005 |
| 6837977 | Capillary electrophoresis method for screening for affinity ligands using a detectable competitive ligand The invention relates to a capillary electrophoresis-based method of screening complex materials for any unidentified affinity ligand that binds to a target of interest. The method subjects a plug of a mixture of the target and a complex material sample, and a separ... | 01/04/2005 |
| 6824988 | Method and compositions for use in diagnosing and characterizing chronic immune disease Methods are provided for diagnosing and/or characterizing chronic immune disease activity in a subject. In the subject methods, a sample is obtained from a subject suspected of having or known to have a chronic immune disease. The sample is then assayed for the pres... | 11/30/2004 |
| 6818409 | Isolation and purification of Clostridium botulinum toxins A method for separating and purifying HA-positive progenitor toxin(s) (LL and/or L toxins) and HA-negative progenitor toxin (M toxin) from a Clostridium botulinum strain is provided. The method comprises applying a liquid containing both the HA-positive proge... | 11/16/2004 |
| 6812033 | Method for identifying risk cardiovascular disease patients The invention provides a method for identifying patients with normal NCEP lipid levels who are in need of treatment for cardiovascular disease comprising measuring one or more LDL or HDL particle subclass levels and identifying abnormal LDL or HDL subclass levels. | 11/02/2004 |
| 6780596 | Methods for determining the activity of complex mixtures According to the present invention, the biological or pharmacological activity of a test material like a plant or herbal material, an extract of a plant or herbal material, a natural or synthetic compound or some combination thereof, can be quantified by observing t... | 08/24/2004 |
| 6762057 | Separation apparatus including porous silicon column A sample separation apparatus including a porous, or rough, capillary column. The porous capillary column includes a matrix which defines pores, and may be formed from a material such as porous silicon. Alternatively, the capillary column may have a rough surface of... | 07/13/2004 |
| 6713308 | System for electrochemical quantitative analysis of analytes within a solid phase The analytical process utilized in the system of this invention comprises three (3) step distinct steps wherein an analyte of interest in a test sample is initially labeled and subsequently isolated within a porous medium of a test device. Once isolated within the m... | 03/30/2004 |
| 6673561 | Diagnostic test for thrombotic or thromboembolic disease Thrombotic or thromboembolic disease is detected or monitored by determining the presence or amount B in a urine sample.... | 01/06/2004 |
| 6670466 | Human endogenous retrovirus in breast cancer The present invention is related to mammary tumor virus (MTV). MTV represents a group of retroviruses which possess very high homology to mouse mammary tumor virus (MMTV), a virus known to cause neoplastic mammary disease in mice. As described herein, MTV... | 12/30/2003 |
| 6649419 | Method and apparatus for protein manipulation A method and apparatus for extracting, identifying, and manipulating proteins or peptides from a solution uses paramagnetic beads having a coating with an affinity for the target component. In one embodiment, paramagnetic beads coated with C18 are used to... | 11/18/2003 |
| 6641995 | Methods for identifying cell cycle regulators A method is disclosed for identifying a substance capable of disrupting an interaction between (i) a herpes simplex virus (HSV) ICP34.5 polypeptide or a homologue thereof, or a derivative thereof, and (ii) proliferating cell nuclear antigen (PCNA) or a ho... | 11/04/2003 |
| 6558959 | Analytical assay device and methods using surfactant treated membranes to increase assay sensitivity An analytical device comprising a surfactant-treated porous reaction membrane having an exposed sample-contacting surface and at least one receptor area located in a limited region of the exposed sample-contacting surface. The limited region has a higher ... | 05/06/2003 |
| 6551645 | Process for manufacturing a pasta product A process for preparing a pasta product by extruding dry or semi-dry ground cereal. The dry or semi-dry ground cereal has a water content of less than about 20 percent by weight of the ground cereal. A pasta product prepared by the process is disclosed.... | 04/22/2003 |
