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"I watched his countenance closely, to see if he was not deranged ... and I was assured by other senators after he left the room that they had no confidence in it."
U.S. Senator Smith of Indiana ; After seeing Samuel Morse demonstrate the telegraph.
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| Number | Title | Issue Date |
| 7316901 | Method of efficiently detecting double-stranded nucleic acid This invention relates to a method for efficiently detecting double-stranded nucleic acids. More particularly, this invention relates to a method for reducing signals derived from an intercalator bound to a single-stranded nucleic acid, wherein a compound that react... | 01/08/2008 |
| 7285288 | Inhibition of Bcl-2 protein expression by liposomal antisense oligodeoxynucleotides The present invention provides novel compositions and methods for use in the treatment of Bcl-2-associated diseases like cancer, specifically, in the treatment of follicular lymphoma (FL). The compositions contain antisense oligonucleotides that hybridize to Bcl-2 n... | 10/23/2007 |
| 7276348 | Compositions and methods relating to F1F0-ATPase inhibitors and targets thereof The present invention relates to novel chemical compounds, methods for their discovery, and their therapeutic use. In particular, the present invention provides benzodiazepine derivatives and methods of using benzodiazepine derivatives as therapeutic agents to treat... | 10/02/2007 |
| 7220739 | Therapeutic application of pro-apoptotic benzodiazepines Benzodiazepine compounds, and methods for using those compounds are provided. Some of the benzodiazepine compounds include 1,4-benzodiazepine-2-one and 1,4-benzodiazepine-2,5-dione compounds of the following structures: | 05/22/2007 |
| 7186712 | Compositions and methods relating to novel compounds and targets thereof The present invention relates to novel chemical compounds, methods for their discovery, and their therapeutic use. In particular, the present invention provides benzodiazepine derivatives and methods of using benzodiazepine derivatives as therapeutic agents to treat... | 03/06/2007 |
| 7144880 | Compositions relating to novel compounds and targets thereof The present invention relates to novel chemical compounds, methods for their discovery, and their therapeutic use. In particular, the present invention provides benzodiazepine derivatives and methods of using benzodiazepine derivatives as therapeutic agents to treat... | 12/05/2006 |
| 7048908 | Particles for inhalation having sustained release properties The invention generally relates to a method for pulmonary delivery of therapeutic, prophylactic and diagnostic agents to a patient wherein the agent is released in a sustained fashion, and to particles suitable for use in the method. In particular, the invention rel... | 05/23/2006 |
| 6977244 | Inhibition of Bcl-2 protein expression by liposomal antisense oligodeoxynucleotides The present invention provides novel compositions and methods for use in the treatment of Bcl-2-associated diseases like cancer, specifically, in the treatment of follicular lymphoma (FL). The compositions contain antisense oligonucleotides that hybridize to Bcl-2 n... | 12/20/2005 |
| 6881589 | Electrochemiluminescent localizable complexes for assay compositions The invention provides compositions and kits for performing a binding assay for an analyte of interest present in a sample based upon electrochemiluminescence. The compositions and kits comprise an electrochemiluminescent label, collectable particles, binding reagen... | 04/19/2005 |
| 6692915 | Sequencing a polynucleotide on a generic chip The present invention describes methods and devices for sequencing a polynucleotide by determining subsets of composite subsequences present in nucleic acid subsamples generated from the sample polynucleotide. A hairpin primer interrogates the composite s... | 02/17/2004 |
| 6638723 | Method for diagnosing autoimmune diseases A method of diagnosing an autoimmune disease is disclosed which involves determining whether autoantibodies from a body fluid react with a microtubule organizing center (MTOC). This diagnostic procedure provides a simple, highly specific, and highly relia... | 10/28/2003 |
| 6627458 | Nuclear envelope protein recognized by atypical p-ANCA in patients with inflammatory bowel disease and autoimmune liver diseases The present invention is directed to the molecular characterization of the nuclear antigen recognized by atypical p-antineutrophil cytoplasmic antibodies (p-ANCA) in order to better diagnose patients with inflammatory bowel diseases such as ulcerative col... | 09/30/2003 |
| 6596501 | Method of diagnosing autoimmune disease The present invention relates to diagnostic applications. For autoimmune diseases more particularly, it is demonstrated herein that individuals with SLE, APLA, MCDS and PSS have antibodies that are specific for SR proteins. Thus, in particular aspects the... | 07/22/2003 |
| 6537768 | Diagnosis, prevention and treatment of ulcerative colitis, and clinical subtypes thereof, using microbial UC panca antigens The present invention relates to microbial UC pANCA antigens. The invention provides methods of diagnosing ulcerative colitis (UC) and methods of inducing tolerance in a pANCA-positive patient with UC using a histone H1-like antigen. The invention further... | 03/25/2003 |
| 6287521 | Methods and devices for obtaining and assaying mammary fluid samples for evaluating breast diseases, including cancer Non-invasive methods are provided for obtaining biological samples of mammary fluid or mammary fluid components by administering oxytocin to a patient to stimulate expression of mammary fluid. During or after mammary fluid expression, a biological sample ... | 09/11/2001 |
| 6268128 | Immobilized oligonucleotide probes and uses thereof The invention is a method of detecting nucleic acids in a sample using oligonucleotide probes which are noncovalently bound to solid supports for rapid, sensitive, hybridization assays. The method involves coating the support surface with a polynucleotide... | 07/31/2001 |
| 6083761 | Method and apparatus for transferring and combining reagents The invention provides exemplary systems, methods, and apparatus for distinctly allocating liquids containing chemical compositions or compounds to known locations in an organized manner so that assays may be performed on the compositions, or so that the ... | 07/04/2000 |
| 6080588 | Therapeutic methods for benzodiazepine derivatives This invention provides an antibody with high affinity for single-stranded DNA, low or no affinity for double-stranded DNA, and capable of specifically binding a DNA hairpin and the hybridoma cell lines which produces these monoclonal antibodies. A chimer... | 06/27/2000 |
| 6074835 | Diagnosis, prevention and treatment of ulcerative colitis, and clinical subtypes thereof, using histone H1 The present invention provides a method of diagnosing ulcerative colitis (UC) in a subject suspected of having inflammatory bowel disease by by obtaining a sample from the individual; contacting the sample with human histone H1, or pANCA-reactive fragment... | 06/13/2000 |
| 6060024 | Automatic dissolution testing system A dissolution testing system including a base; a plurality of vessels mounted on the base; an agitation mechanism for agitating a liquid content of the vessels; and a head supported above each of the vessels and operable to automatically inject a liquid m... | 05/09/2000 |
| 6057097 | Marker for pathologies comprising an auto-immune reaction and/or for inflammatory diseases The present invention comprises a marker for inflammatory diseases and/or pathologies comprising an autoimmune reaction, which is the plasmatic membrane and/or a portion therof, in particular the plasmatic DNA. The present invention concerns also the meth... | 05/02/2000 |
| 6001657 | Antibodies that selectively bind quadruplex nucleic acids Antibodies that selectively bind to quadruplex nucleic acids are described. Isolated cells that produce such antibodies, and methods utilizing these antibodies, are also described.... | 12/14/1999 |
| 5932429 | Methods of diagnosing clinical subtypes of crohn's disease Provided herein is a method of diagnosing a clinical subtype of Crohn's disease (CD) by determining whether perinuclear anti-neutrophil antibody (pANCA) is present in a patient with CD, where the presence of pANCA indicates a clinical subtype of CD with f... | 08/03/1999 |
| 5861260 | Diagnostic methods for screening patients for scleroderma Disclosed are diagnostic methods for screening a patient for sclerotic disease. One diagnostic method includes obtaining a biological sample from the patient; obtaining a substantially pure CP140 polypeptide fragment; contacting the sample with the CP140 ... | 01/19/1999 |
| 5846532 | Method and composition for the treatment of disorders involving immunological dysfunction A method and composition are provided for treatment of disorders involving immunological dysfunction. The invention comprises the administration of a low level of ribonucleotide polymerase protein or a derivative thereof to a human or animal with an immun... | 12/08/1998 |
| 5804188 | Method and composition for treatment of disorders involving immunological dysfunction A method and composition are provided for treatment of disorders involving immunological dysfunction. The invention comprises the administration of a low level of ribonucleotide polymerase protein or a derivative thereof to a human or animal with an immun... | 09/08/1998 |
| 5783148 | Nucleic acid amplification method and apparatus The present invention relates to an apparatus for performing a biological process and is particularly useful for processes which include amplicon decontamination and nucleic acid amplification steps. The apparatus includes a sample well for introduction a... | 07/21/1998 |
| 5725831 | Nucleic acid amplification apparatus An apparatus for containing a liquid biological sample and for performing a biological process thereon comprises a sample area for receiving the sample, at least one reaction area in fluid communication with the sample area, a pneumatic area in pneumatic ... | 03/10/1998 |
| 5721110 | Methods and compositions useful in the diagnosis and treatment of autoimmune diseases A method for producing a protein antigen which is reactive with an autoantibody associated with an autoimmune disease in a host, which comprises introducing genetic information from a cross-reactive donor gene library, into plural cells thereby producing ... | 02/24/1998 |
| 5700641 | Diagnostic method, test kit, drug and therapeutic treatment for autoimmune diseases Synthesized telomeric sequences bind to and can be used for detecting anti-DNA antibodies in serum. Autoimmune diseases such as Lupus Erythematosus, Rheumatoid Arthritis, and Scleroderma, can be detected by detecting an elevated level of anti-DNA antibodi... | 12/23/1997 |
| 5691151 | Methods of screening for ulcerative colitis and crohn's disease by detecting VH3-15 autoantibody and panca The present invention provides novel methods of screening for ulcerative colitis and Crohn's disease which include the detection of two disparate autoantibodies: pANCA and VH3-15 autoantibody. The present invention also provides kits for screening ulcerat... | 11/25/1997 |
| 5681700 | Assay for pathogenicity of anti-DNA antibodies Assays that are prognostic for patients that will develop nephritis have been developed where patient serum is screened for the presence of anti-dsDNA antibodies that are cross reactive with A and D SnRNP proteins. The assays are based on the use of eithe... | 10/28/1997 |
| 5650334 | Fluorescent labelling compositions and methods for their use A fluorescent labelling composition comprises a linear polysaccharide backbone molecule having a plurality of target-binding molecules, such as antibodies or nucleic acids, attached at spaced-apart intervals thereon. Each of the target-binding molecules, ... | 07/22/1997 |
| 5583053 | Macrophage cell line for use in the detection of antinuclear antibodies The macrophage cell line, IT-1 (KCCM-10038) was derived from normal human bone marrow. IT-1 cells are characterized by excellent adherence onto glass slides used in immunofluorescence assays, and the cells provide a positive result in the antinuclear anti... | 12/10/1996 |
| 5573911 | Methods and materials for detecting autoimmune antibodies The subject invention pertains to a method of binding proteins and double-stranded DNA to the same membrane matrix. The DNA bound to the membrane matrix remains in double-stranded form. The subject invention further concerns an assay procedure for detecti... | 11/12/1996 |
| 5552285 | Immunoassay methods, compositions and kits for antibodies to oxidized DNA bases Compositions, immunoassay methods, and kits are provided for detecting antibodies specific for oxidized DNA bases, including diagnosis of inflammatory diseases and related conditions, as well as monitoring of the progress or therapy of such diseases and c... | 09/03/1996 |
| 5550263 | X-ray contrast agent The present invention refers to a phospholipid-based compound, that is a phospholipid to which an X-ray contrast-giving moiety has been covalently linked, liposomes comprising said compound as well as the use of said liposomes as a diagnostic or contrast ... | 08/27/1996 |
| 5457029 | Nuclear antigen La A diagnostic test for detection of antinuclear antibody anti-La in a serum sample, comprises contacting the serum sample with a support having immobilised thereon a synthetic polypeptide displaying the antigenicity of all or a portion of the human autoant... | 10/10/1995 |
| 5407833 | Peptides of the SM-D antigen and their use for diagnosis of systemic lupus erythematosus Peptides comprising between 20 and 39 amino acids capable of reacting with antibodies against the Sm-D polypeptide. These peptides may be used in a diagnostic method to detect of antibodies against the Sm-D polypeptide in a biological sample from a person... | 04/18/1995 |
| 5385824 | Method for detection of anti-RNA-antibodies Method for monitoring patients having connective tissue autoimmune diseases comprising contacting patient specimens with (U1)RNA and detecting immune complexes formed, the level of reaction indicating the severity of the disease.... | 01/31/1995 |
