Famous Patents
The first commercial microwave oven was nearly 6 feet tall and weighed in at 750 pounds.
PatentStorm News
Make the Most of Our Site
See this month's Top Inventors and Most Cited Patents.
Stay on top of the latest innovations by subscribing to an RSS feed.
Registered users: Manage your profile.
| Number | Title | Issue Date |
| 7501287 | Transcobalamin II assay method An assay method for determining transcobalamin saturation wherein a transcobalamin containing liquid sample is contacted with a porous substrate with immobilized thereon a transcobalamin immobilizing ligand and with a reporter-labelled transcobalamin binding partner... | 03/10/2009 |
| 7294514 | Diagnostic method for alzheimer's disease based on holo-transcobalamin II The invention provides a diagnostic or prognostic assay method for Alzheimer's Disease by assaying a body fluid sample or a test sample derived therefrom for holo-trancobalamin II. ... | 11/13/2007 |
| 7285418 | Method and kit for the diagnosis of troponin I The invention provides a method for assaying for troponin I in a sample such as serum, the method comprising a determination of the troponin I concentration in a sample using a standard preparation that comprises a complete native troponin complex. One exemplary ass... | 10/23/2007 |
| 7232805 | Cobalamin conjugates for anti-tumor therapy The present invention provides a cobalamin-drug conjugate suitable for the treatment of tumor related diseases. Cobalamin is indirectly covalently bound to an anti-tumor drug via a cleavable linker and one or more optional spacers. Cobalamin is covalently bound to a... | 06/19/2007 |
| 7148016 | Immunoassays to detect diseases or disease susceptibility traits Disclosed are immunoassay methods for the diagnosis/prognosis of diseases and disease susceptibility traits associated with gene mutations that cause protein truncation or allelic loss. The levels of one or more targeted wild-type proteins expressed by a subject gen... | 12/12/2006 |
| 7056747 | Process for removing endogenous Vitamin B12 and folate from albumin preparations Processes for removing endogenous Vitamin B12 and folate are provided. The albumin preparations produced by the process are suitable for use as reference control samples in assays for determining these analytes in a test sample. Kits and methods related to the album... | 06/06/2006 |
| 7005426 | Folic acid-polysaccharide complex, its preparation method and pharmaceutical composition containing the same as active component The present invention relates to folic acid-polysaccharide complexs and method of preparation thereof, more particularly relates to folic acid-Dextran complexs, method of preparation thereof, pharmaceutical compositions having said complex as active component and us... | 02/28/2006 |
| 6942977 | Immunoassays for determining vitamin b12, and reagents and kits therefor Methods are described for the development of monoclonal antibodies to intrinsic factor and the application of said antibodies in the development of B12 immunoassays. In particular, antibodies are described that are capable of binding to intrinsic factor only in the ... | 09/13/2005 |
| 6797521 | Fluorescent cobalamins and uses thereof The present invention relates to fluorescent cobalamins and uses of these compounds. More particularly, this invention relates to fluorescent cobalamins that comprise a fluorescent, phosphorescent, luminescent or light-producing compound covalently linked to cobalam... | 09/28/2004 |
| 6555388 | Binding protein capture assay This invention relates to binding protein assays. In particular, this invention relates to binding protein assays for B12 and folate in serum or plasma. More specifically, this invention provides a sequential assay that uses a combination of specific bind... | 04/29/2003 |
| 6083926 | Water soluble vitamin B12 receptor modulating agents and methods related thereto Vitamin B12 receptor modulating agents capable of modulating cell surface receptors by affecting the cell surface receptor trafficking pathway are disclosed. The vitamin B12 receptor modulating agents are comprised of a covalently bo... | 07/04/2000 |
| 6080549 | Methods and materials for the diagnosis and treatment of schizophrenia and related disorders Methods for detecting schizophrenia or depression based on modifications of the contribution of the D4 receptor to phospholipid methylation levels are described herein. Individuals with schizophrenia or depression have a deficiency in phospholi... | 06/27/2000 |
| 5861319 | Immobilization of specific binding assay reagents Methods and compositions are provided for specific binding assays in which specific binding reagents are immobilized on a solid phase. Immobilization is facilitated by covalently coupling specific binding assay reagents such as polypeptide receptors or an... | 01/19/1999 |
| 5589327 | Method and composition for the determination of red blood cell floate A composition is described which is useful in the assay of folate from a hemolysate prepared from red blood cells using non-radiolabeled assay techniques such as fluorometric, colorimetric, enzymatic or chemiluminescent assay methods. Methods to ready hem... | 12/31/1996 |
| 5538901 | Nucleophilic polysubstituted aryl acridinium ester conjugates uses thereof This invention is directed to the novel assay methods utilizing nucleophilic polysubstituted aryl acridinium ester conjugates as the tracers. Conjugates prepared by covalent coupling of novel nucleophilic polysubstituted aryl acridinium esters with biolog... | 07/23/1996 |
| 5506109 | Vitamin B12 assay Immunoassays for vitamin B12 using novel monoclonal antibodies to the intrinsic factor:vitamin B12 complex and to the vitamin B12 binding site on intrinsic factor.... | 04/09/1996 |
| 5434087 | Folate immunoassay utilizing folate binding protein in a multiclonal antibody format An improved method for performing immunoassays whereby specific binding proteins for vitamin B12, folate and other target analytes are utilized with antibodies with different specificities for the binding proteins. Antibodies bridge the specific binding p... | 07/18/1995 |
| 5227311 | Intrinsic factor to determine B12 A method for purifying an aqueous intrinsic factor solution which contains R-protein is disclosed. The method involves adding to the intrinsic factor solution an amount of colloidal silica to disperse lipid emulsion, an amount of cobinamide sufficient to ... | 07/13/1993 |
| 5187107 | B12 enzyme imunoassay and sample pretreatment Denaturing agents used to pretreat test samples for immunoassays are neutralized and deactivated by the addition of a treatment agent which is a combination of a buffering agent in acid form and an agent for converting the sulfhydryl groups of the denatur... | 02/16/1993 |
| 5104815 | Assay for cobalamins The current invention is a method, kit and reagents for detecting cobalamins in a sample. The method involves introducing into the sample a first conjugate of a latex or latex-like solid phase linked to affinity purified intrinsic factor with a first link... | 04/14/1992 |
| 5032503 | Liquid single reagent for air enzyme complementation assay A method is provided for combining normally interacting reagents in a liquid single reagent and preventing complex formation using a surfactant and then reversing the inhibition by adding a cyclodextrin. The method finds particular use in diagnostic immun... | 07/16/1991 |
| 5001072 | Compositions and methods for multiple simultaneous immunoradiometric assay (IRMA) of analytes using radioisotope chelate labels Compositions and methods are disclosed for multiple simultaneous assays of different analytes using radioactive labeled antibodies to the analytes, at least one portion of the assay being an immunoradiometric assay in which there is employed a metal isoto... | 03/19/1991 |
| 4950612 | Peroxy acid pretreatment in vitamin B12 assay Serum samples for vitamin B12 analysis can be pretreated using a combination of peroxy acid and dithiothreitol. The pretreatment makes vitamin B12 bound to serum binding proteins available for analysis by any of a variety of currentl... | 08/21/1990 |
| 4918005 | Method of quantitative assay for vitamin B12 and reagent for assaying vitamin B12 The present invention is directed to a method of quantitative assay for a vitamin B12 -containing substance which comprises culturing marine methanol-utilizing bacteria having B12 auxotrophy in a medium for quantitative assay of the ... | 04/17/1990 |
| 4904583 | Cascade immunoassay by multiple binding reactions A method for enzyme immunoassay includes contacting under binding conditions a liquid suspected of containing an analyte, an antianalyte affixed to a solid support and a tracer having an enzyme conjugated thereto. A bound fraction is separated from the li... | 02/27/1990 |
| 4839299 | Assay for the free portion of substances in biological fluids A biological sample containing an analyte, partly free and partly bound to natural binders, is incubated with a labelled specific binder for the analyte and a derivative of the analyte which does not react with the natural binders. Part of the labelled sp... | 06/13/1989 |
| 4806493 | Stabilizers for use in serum folate assays A serum folate assay wherein the serum folate is stabilized with dimercaptosuccinic acid or thioctic acid.... | 02/21/1989 |
| 4801530 | Nucleotide hybridization assay for protozoan parasites The present invention provides a method for detection of protozoan parasites in blood or other specimen from their mammalian hosts. The method comprises nucleic acid hybridization of repetitive nuclear DNA fragments of the parasites. Hybridization probes ... | 01/31/1989 |
| 4680273 | Assay for vitamin B12 deficiency An assay for Vitamin B12 deficiency by determining for a blood sample that essentially all of the Vitamin B12 is carried by a combination of TCI and TCIII and/or essentially no Vitamin B12 is carried by TCII. TCII may be c... | 07/14/1987 |
| 4672028 | Compositions and method for simultaneous multiple array of analytes using radioisotope chelate labels Compounds useful in a simultaneous multiple assay for analytes such as steroids, proteins, peptides, carbohydrates or drugs. The compound or compounds are prepared by labelling an individual analyte with a radioisotope through a chelating agent to form a ... | 06/09/1987 |
| 4474891 | Mini-iodinated polypeptide hormone tracer and method for its use This invention relates to a highly-sensitive mini-iodinated radioactive hormone tracer which has both initial low iodine-to-hormone molar ratios and low specific activity. This invention also relates to methods for preparing and using such tracers in a ra... | 10/02/1984 |
| 4465775 | Vitamin B12 and labelled derivatives for such assay Vitamin B12 in liquid samples, such as human serum or human plasma, is assayed by a competitive binding technique using intrinsic factor and certain labelled vitamin B12 derivatives. The labelled derivatives are formed from the (d)-m... | 08/14/1984 |
| 4465776 | Monoclonal antibodies to vitamin B6 and immunoassay method A continuous hybridoma cell line which secretes recoverable quantities of monoclonal antibodies having specificity against Vitamin B6, which antibodies are useful in a method for detecting the presence of vitamin B6 in an animal samp... | 08/14/1984 |
| 4456689 | Competitive protein binding assay using an organosilane-silica gel separation medium An improved competitive protein binding assay comprising; incubating an analyte in the presence of labeled analyte and a protein binder suitable for competitive binding activity by the analyte and the labeled analyte to provide a mixture having free analy... | 06/26/1984 |
| 4451571 | Preparation of samples for vitamin B12 and/or folate assay and assay Vitamin B12 (cobalamin) and/or folate (folic acid) assay techniques can be simplified, by eliminating the step of heating or boiling the to-be-tested sample prior to its assay. This is accomplished by utilizing compositions and procedures: (1) ... | 05/29/1984 |
| 4427780 | Method for assaying vitamin-containing compositions for vitamin analogues Vitamin-containing multicomponent compositions are assayed to determine the extent of conversion of the vitamin to one or more analogues thereof due to interaction between the vitamin and the other components of the composition, employing a radioactive la... | 01/24/1984 |
| 4426455 | Assay of vitamin B12 A method of assaying for vitamin B12 achieves denaturation of serum binding proteins which normally bind the vitamin B12 by treatment with alkali at ambient temperature. The assay is characterized by the use, in the alkali denaturation step, of a dithiopo... | 01/17/1984 |
| 4423154 | Simultaneous radioassay of folate and vitamin B12 A serum sample is heated at an alkaline pH to release folate and vitamin B12 from endogenous binders. A simultaneous radioassay for folate and vitamin B12 is effected by contacting the sample with binder for folate, binder for vitami... | 12/27/1983 |
| 4418151 | Assay process with non-boiling denaturation Competitive protein binding radioassay for sera (or cell) vitamin B12 and/or serum folate (target components, or analytes) or other target components in liquid ambient utilizing a highly alkaline (pH 12-14) environment and reducing agent for de... | 11/29/1983 |
| 4399228 | Polate competitive protein binding assay Improvement in a competitive protein binding assay for N-5-methyltetrahydrofolic acid wherein any folate standard used is N-5-methyltetrahydrofolic acid complexed with folate binder protein. The protein of the complex is destroyed prior to the addition of... | 08/16/1983 |
