Did You Know...
...that Charles Goodyear performed some of his experiments on rubber while in debtor's prison? He was there so often he referred to it as his "hotel". Chronically in debt because of poor business sense and ill health, Goodyear depended on the generosity of friends and family. Even after he unlocked the secret to vulcanizing rubber, he was unable to improve his financial situation. When he died, his estate was $200,000 in debt.
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| Number | Title | Issue Date |
| 8003406 | Methods for detecting attention-deficit/hyperactivity disorder The invention provides a method of determining a susceptibility of a subject for development of ADHD. The method comprises obtaining a sample from the subject, analyzing the sample for an ADHD susceptibility haplotype of LPHN3 receptor which is associated with at le... | 08/23/2011 |
| 7820453 | Cardiovascular safety assay The present invention provides assays and kits for the screening of test compounds for their capability to induce cardiotoxicity in a subject. Said assays and kits are based on the finding that the interaction of astemizole with the HERG potassium channel can be exp... | 10/26/2010 |
| 7709270 | Vascular endothelial growth factor C (VEGF-C) protein diagnostic Provided are purified and isolated VEGF-C polypeptides capable of binding to at least one of KDR receptor tyrosine kinase (VEGFR-2) and Flt4 receptor tyrosine kinase (VEGFR-3); analogs of such peptides that have VEGF-C-like or VEGF-like biological activities or that... | 05/04/2010 |
| 7384748 | Compositions and methods for detecting and treating motor neuron disorders The present invention relates to the NTE proteins and nucleic acids encoding the NTE proteins. The present invention further provides assays for the detection of NTE polymorphisms and mutations associated with disease states, as well as methods of screening for liga... | 06/10/2008 |
| 7368253 | Pre-symptomatic markers for diseases associated with transmissible spongiform encephalopathies Markers for TSE that are present prior to formation of detectable pathological prion protein are useful to detect this infection prior to clinical signs. Additional markers are useful to detect the stage of TSE infection and distinguish it from other conditions whic... | 05/06/2008 |
| 7357915 | Method of imaging cell death in vivo A method of imaging apoptosis in vivo, using radiolabeled annexin, is described. ... | 04/15/2008 |
| 7358063 | Method of detecting PS2V A method of detecting PS2V characterized by comprising reacting PS2V in a sample with a primary antibody which is bonded to a solid phase and specifically recognizes PA2V, then reacting with a secondary antibody recognizing PS2 or PS2V by any of the following proced... | 04/15/2008 |
| 7326772 | Peptide for assaying hERG channel binding The present invention provides compositions and methods useful for assaying binding of compounds to the hERG K+ channel. According to a method of the present invention, a compound of interest is added to the hERG K+ channel in the presence of a... | 02/05/2008 |
| 7323298 | Microarray for determining the relative abundances of polynuceotide sequences A method of determining the relative amounts of individual polynucleotides in a complex mixture of different-sequence polynucleotides is disclosed. The polynucleotides, after fluorescent labeling, are contacted under hybridization conditions with an array of differe... | 01/29/2008 |
| 7317102 | Diarylmethyl and related compounds This invention provides compounds of formula I: wherein R1, R2, R3, R4, R5, R6, R7, Ar1, Ar2, E, a, b, c and z are ... | 01/08/2008 |
| 7316902 | Compositions that specifically bind to colorectal cancer cells and methods of using the same A unique transcription product, CRCA-1, and alternative translation products generated therefrom, are disclosed. The transcript and its translation products are markers for colorectal cells. Screening and diagnostic reagents, kits and methods for metastasized colore... | 01/08/2008 |
| 7303895 | Choline transport like (CTL) membrane proteins involved in choline transport The invention concerns the identification of a novel family of CTL (Choline Transporter Like) genes, in particular hCTL1 and hCTL2, involved in the metabolism and/or transport of choline in cells such as the intestinal tract cells, nervous cells, in particular moton... | 12/04/2007 |
| 7303885 | Screening method for candidate drugs The present invention relates to methods for screening molecules and methods to detect protein-protein interactions and means used therein. More specifically, the present invention relates to methods for screening candidate drugs for treating or detecting MIF (macro... | 12/04/2007 |
| 7294477 | Allergen and treatment The present invention is related to novel nucleoli sequences encoding a louse allergen and a methods for diagnosing, treating and preventing lice infestation and associated allergic disease with the nucleoli sequences and protein allergen of the invention. The prese... | 11/13/2007 |
| 7285648 | IL-1 delta DNA and polypeptides DNA encoding IL-1 delta polypeptides and methods for using the DNA and encoded polypeptides are disclosed. ... | 10/23/2007 |
| 7270960 | Diagnosis of ovarian carcinomas The invention is directed to compositions and methods for the detection of a malignant condition, and relates to the discovery of soluble and cell surface forms of HE4a polypeptides, including HE4a that is overexpressed in ovarian carcinomas. In partic... | 09/18/2007 |
| 7250265 | Method of detecting and evaluating angiotensinogen receptor-modulating compounds using placental cells Disclosed is a method of screening a substance for angiotensinogen receptor-modulatory activity. The method includes the steps of contacting placental-derived cells with labeled angiotensinogen and a candidate substance; and then determining whether the candidate su... | 07/31/2007 |
| 7223846 | Urocortin proteins and uses thereof A human urocortin-related peptide with significant sequence homology to the CRF neuropeptide family was identified. A mouse cDNA was isolated from whole brain poly (A+) RNA that encodes a predicted 38 amino acid peptide protein designated herein as urocortin II. Bot... | 05/29/2007 |
| 7179603 | Detection and identification of enteric bacteria The invention provides probes, antibodies and methods for detecting a gene that is only found in Enterobacteriaceae, the deoxyguanosine triphosphate triphosphohydrolase gene. These probes and methods are useful for the detecting whether test samples, including food ... | 02/20/2007 |
| 7172863 | Nucleic acid probes and methods for detecting A method for preparing probes, as well as several probes for use in qualitative or quantitative hybridization assays are disclosed. The method comprises constructing an oligonucleotide that is sufficiently complementary to hybridize to a region of rRNA selected to b... | 02/06/2007 |
| 7148016 | Immunoassays to detect diseases or disease susceptibility traits Disclosed are immunoassay methods for the diagnosis/prognosis of diseases and disease susceptibility traits associated with gene mutations that cause protein truncation or allelic loss. The levels of one or more targeted wild-type proteins expressed by a subject gen... | 12/12/2006 |
| 7138516 | Oligonucleotide probes for the detection and/or quantitation of non-viral organisms A method for preparing probes, as well as several probes for use in qualitative or quantitative hybridization assays are disclosed. The method comprises constructing an oligonucleotide that is sufficiently complementary to hybridize to a region of rRNA selected to b... | 11/21/2006 |
| 7135333 | Compositions that specifically bind to colorectal cancer cells and methods of using the same A unique transcription product, CRCA-1, and alternative translation products generated therefrom, are disclosed. The transcript and its translation products are markers for colorectal cells. Screening and diagnostic reagents, kits and methods for metastasized colore... | 11/14/2006 |
| 7135298 | Screening assay for agents that alter target of Rapamycin activity The present invention provides an assay for the identification of agents which can modulate TOR-mediated phosphorylation of substrate proteins. The assays of the invention utilize substrate proteins whose amino acid sequence contains the Ser/Thr motif recognized by ... | 11/14/2006 |
| 7115728 | Human peroxisome proliferator activated receptor γ The present invention relates to a novel human peroxisome proliferator activated receptor, hPPARγ. hPPARγ differs from the mouse peroxisome proliferator activated receptor γ in the nucleotide sequence and the amino acid sequence. The invention provides isolated, ... | 10/03/2006 |
| 7101989 | DsrA protein and polynucleotides encoding the same DsrA is an outer membrane protein of H. ducreyi that confers serum resistance to the bacteria. Isolated polynucleotides encoding the protein, end expression vectors and host cells encoding the same, are described. Also described is a mutant H. ducreyi ... | 09/05/2006 |
| 7098025 | Human peroxisome proliferator activated receptor gamma (pparγ) gene regulatory sequences and uses therefor This invention relates to the isolation and cloning of the promoter and other control regions of human PPARγ gene. It provides a method for identifying and screening for agents useful for the treatment of diseases and pathological conditions affected by the level o... | 08/29/2006 |
| 7094535 | Nucleic acid ligands to integrins Methods are described for the isolation of nucleic acid ligands to integrins using the SELEX process. SELEX is an acronym for Systematic Evolution of Ligands by EXponential enrichment. The nucleic acid ligands of the present invention are useful as therapeutic and d... | 08/22/2006 |
| 7064248 | Method of preparing fertile transgenic corn plants by microprojectile bombardment A method of preparing fertile transgenic Zea mays (corn) plants which stably express DNA encoding a Bacillus thuringiensis endotoxin, so as to impart insect resistance to the fertile transgenic plants is taught. The method comprises bombarding regenera... | 06/20/2006 |
| 7064197 | System, array and non-porous solid support comprising fixed or immobilized nucleic acids Nucleic acids are fixed or immobilized to non-porous solid supports (substrates), and include systems containing such supports and arrays with fixed or immobilized nucleic acids. These compositions are useful for nucleic acid analyses and a host of applications, inc... | 06/20/2006 |
| 7060275 | Use of protein biomolecular targets in the treatment and visualization of brain tumors The present invention relates to the use of proteins which are differentially expressed in primary brain tumor tissues, as compared to normal brain tissues, as biomolecular targets for brain tumor treatment therapies. Specifically, the present invention relates to t... | 06/13/2006 |
| 7045130 | Antibodies against antigens of human immunodeficiency virus (HIV-1) This invention is in the field of lymphadenopathy virus, which has been designated Human Immunodeficiency Virus Type 1 (HIV-1). This invention relates to a diagnostic means and method to detect the presence of DNA, RNA or antibodies of the lymphadenopathy retrovirus... | 05/16/2006 |
| 7045309 | 9-substituted adenine derivatives as prodrug regulators of cell and tissue function The present invention relates to 9-substituted adenine derivatives represented by formula (I) wherein W is selected from the group consisting of H, halogen, azido and amino group; X is selected from the group consistin... | 05/16/2006 |
| 7041811 | Method for detecting Specific nucleic acid sequences, e.g., SEQ ID NOs: 1–8, for detecting Escherichia coli. Also disclosed is a method of detecting Escherichia coli. The method includes providing a sample having a nucleic acid from an unknown microorganism; amplifying t... | 05/09/2006 |
| 7037675 | Nucleic acid molecules encoding SIGIRR polypeptides The invention is directed to purified and isolated SIGIRR polypeptides and fragments thereof, the nucleic acids encoding such polypeptides, processes for production of recombinant forms of such polypeptides, antibodies generated against these polypeptides, fragmente... | 05/02/2006 |
| 7029855 | Radioactive multiplexing analytical methods for biomarkers discovery A novel analytical method involves labeling samples with different radioactive labeling agents, mixing and subjecting the mixture to any separation technique, and then differentially detecting and quantifying subcomponents from each sample for comparison. The novel ... | 04/18/2006 |
| 6995257 | Gene involved in CADASIL, method of diagnosis and therapeutic application The invention concerns the Notch3 gene and the corresponding protein, which are involved in CADASIL. The invention concerns, in particular, methods for demonstrating mutations in this gene, which are linked to the risk of developing CADASIL. The invention also conce... | 02/07/2006 |
| 6991908 | Antiobestic agents methods for screening antiobestic agents and kits comprising same The present invention provides a method for screening a compound or its salt that alters the binding property between MCH or its salt and SLC-1 or its salt, characterized by using MCH or its derivative or a salt thereof and SLC-1 or its salt is useful for screening ... | 01/31/2006 |
| 6979535 | Human immunodeficiency virus type 2 (HIV-2) env polypeptide and diagnostic assays A method for diagnosing an HIV-2 (LAV-II) infection and a kit containing reagents for the same is disclosed. These reagents include cDNA probes which are capable of hybridizing to at least a portion of the genome of HIV-2. In one embodiment, the DNA probes are capab... | 12/27/2005 |
| 6979543 | Method for detecting biological agents A sensor is provided including a polymer capable of having an alterable measurable property from the group of luminescence and electrical conductivity, the polymer having an intermediate combination of a recognition element, a tethering element and a property-alteri... | 12/27/2005 |
