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| Number | Title | Issue Date |
| 8187894 | Method and apparatus for controlling the flow resistance of a fluid on nanostructured or microstructured surfaces A method and apparatus is disclosed wherein the flow resistance of a droplet disposed on a nanostructured or microstructured surface is controlled. A closed-cell feature is used in a way such that, when the pressure of at least a first fluid within one or more of th... | 05/29/2012 |
| 8168140 | Microfluidic apparatuses with nanochannels In some embodiments of the present invention, the buried silicon oxide technology is employed in the fabrication of fluid channels, particularly nanochannels. For example, a fluid channel can be made in a buried silicon oxide layer by etching the buried oxide layer ... | 05/01/2012 |
| 8168444 | Substrate having channel portion including chambers, and method of transferring liquid by using the substrate A substrate having a channel portion in which a liquid transfers, wherein, even if the channel portion has no micro-channel interconnecting chambers, a liquid can transfer stepwise from one region to the next region according to the speed of rotation of the substrat... | 05/01/2012 |
| 8168138 | Cryogenic vial Provided is a cryogenic vial for storing at least one sample, the vial including a pipette, a cap assembly, and a container having at least one opening in a body portion of the container to allow liquid and/or gas to enter and/or exit the vial to balance the pressur... | 05/01/2012 |
| 8168139 | Recirculating fluidic network and methods for using the same The present invention provides a variety of microfluidic devices and methods for conducting assays and syntheses. The devices include a solid substrate layer having a surface that is capable of attaching ligand and or anti-ligand, and an elastomeric layer attached t... | 05/01/2012 |
| 8158083 | Precision liquid dispensing system A system for dispensing microdrops of reagent in small, precisely metered quantities maintains the fluid reagent to be dispensed in a reservoir under a controlled pressure. The reagent is dispensed through multiple nozzles connected to solenoid-actuated valves that ... | 04/17/2012 |
| 8142736 | Reaction bottle with pressure release A reaction bottle which includes a container, container top, container interior a bottle cap removeably attachable to the container top, the bottle cap having a cap top and a cap cavity; a septa attached to the bottle cap and configured to releasably seal the contai... | 03/27/2012 |
| 8133456 | Microreactor and method of liquid feeding making use of the same A microreactor capable of reaction between a sample and a mixed reagent containing a mixture of multiple reagents, which microreactor avoids the interposition of air between driving solution and reagents and realizes high-precision controlling of the timing of mixin... | 03/13/2012 |
| 8128891 | Automated analyzer An automated analyzer includes pipetting means for discharging a sample and reagent into an empty reaction vessel without causing contact to occur between the leading end of a sample probe and the bottom of the reaction vessel. The sample probe is inserted into the ... | 03/06/2012 |
| 8129196 | Parallel loading of arrays The present inventions provides an apparatus and method for the parallel loading of multiple samples in a microarray containing a plurality of sub-arrays. The method makes use of a microarray containing multiple sub-arrays, a loading channel array, and a fluid handl... | 03/06/2012 |
| 8124026 | Lateral flow diagnostic devices with instrument controlled fluidics Devices with lateral flow elements and integral fluidics are disclosed. The integral fluidics consist of injector pumps comprised of fluidic elements under instrument control. The fluidic element of an injector pump is fluidically connected to lateral flow elements ... | 02/28/2012 |
| 8124423 | Method and apparatus for controlling the flow resistance of a fluid on nanostructured or microstructured surfaces A method and apparatus is disclosed wherein the flow resistance of a droplet disposed on a nanostructured or microstructured surface is controlled. A closed-cell feature is used in a way such that, when the pressure of at least a first fluid within one or more of th... | 02/28/2012 |
| 8119419 | Check valve-less fluid-transfer collection assembly and method of using the same A method of using a fluid transfer collection assembly includes providing an assembly including a base, a test media carried by the base, an inlet for receiving a sample fluid, an outlet, a fluid transfer path located between the inlet and the outlet, a movable firs... | 02/21/2012 |
| 8101428 | Microfluidic systems and control methods The systems and methods disclosed herein include a microfluidic system, comprising a pneumatic manifold having a plurality of apertures, and a chip manifold having channels disposed therein for routing pneumatic signals from respective ones of the apertures to a plu... | 01/24/2012 |
| 8097470 | Microchip analysis method and apparatus The analysis apparatus for microchips, each at least having a main flow path performing migration of a sample for analysis inside a sheet-like member, comprises a holding part holding microchips so that the multiple main flow paths are provided; a pretreatment part ... | 01/17/2012 |
| 8097471 | Sample processing devices Methods and devices for thermal processing of multiple samples at the same time are disclosed. The sample processing devices provide process arrays that include conduits useful in distributing sample materials to a group of process chambers located in fluid communic... | 01/17/2012 |
| 8084273 | Universal matrix The application relates to a method of depositing a patterning species from a nanoscopic tip to a substrate surface. The method is carried out at a sufficiently high humidity to facilitate the deposition. The deposition of the patterning species is facilitated by a ... | 12/27/2011 |
| 8075853 | Microchip The present invention provides a microchip which is made by bonding a first substrate having a groove provided at the substrate surface and a second substrate together, and has a fluid circuit therein, the fluid circuit having a separation portion for separating a f... | 12/13/2011 |
| 8071052 | Fluid handling assembly with valve position control based on fluid amount measurement An assembly for handling a fluid, comprising a valve and a controller. The valve has at least one revolving valve element and a coupling device. The coupling device comprises at least one port coupled to a flow path and is adapted for interacting with said at least ... | 12/06/2011 |
| 8062904 | Method and device for dosing and mixing small amounts of liquid A method or device for integrated dosing and intermixing of small amounts of liquid, has at least one dosing reservoir (3) connected to a reaction reservoir (1) via at least one joining structure (11) and entirely filled with a first liquid. The... | 11/22/2011 |
| 8062611 | Fluid processing device including composite material flow modulator A fluid processing device is provided that includes a substrate, a plurality of fluid retainment regions formed in or on the substrate, and a barrier at least partially separating two or more of the fluid retainment regions. The barrier includes a mixture of a seque... | 11/22/2011 |
| 8057757 | Sample mixing on a microfluidic device Mixing structures for use on sample processing devices are disclosed. The mixing structures include one or more mixing chambers in fluid communication with a process chamber, such that changing the rotational speed of the sample processing device forces sample mater... | 11/15/2011 |
| 8053249 | Method of pumping fluid through a microfluidic device A method is provided for pumping fluid through a channel of a microfluidic device. The channel has an input port and an output port. The channel is filled with fluid and a pressure gradient is generated between the fluid at the input port and the fluid at the output... | 11/08/2011 |
| 8048386 | Fluid processing and control A fluid control and processing system for controlling fluid flow among a plurality of chambers comprises a body including a fluid processing region continuously coupled fluidicly with a fluid displacement region. The fluid displacement region is depressurizable to d... | 11/01/2011 |
| 8043864 | Finger swipe fluid-transfer collection assembly and method of using the same A method of using a finger swipe fluid transfer collection assembly includes providing a finger swipe fluid transfer collection assembly including a base, a test media carried by the base, an inlet for receiving a sample fluid, an outlet, a finger swipe fluid transf... | 10/25/2011 |
| 8043865 | Metering doses of sample liquids A device and method of metering and mixing a dose of a sample liquid with a diluent liquid includes introducing a sample liquid into a channel defined in a housing. The housing defines a pocket open to the channel and sized to both collect a metered dose of the samp... | 10/25/2011 |
| 8034629 | High precision scanning of encoded hydrogel microparticles Techniques are provided for high precision scanning of hydrogel microparticles. The high precision is achieved by one or more modifications to the microparticle composition, or microfluidics apparatus that align the microparticles in a detection channel, or method o... | 10/11/2011 |
| 8017409 | Microflow analytical system A microflow analytical system includes a laminate pump assembly connectable with one or more sources of fluid, one or more pneumatic control pumps, a mixer, and a sensor. The laminate pump assembly is adapted to deliver predetermined volumes of the fluid(s) through ... | 09/13/2011 |
| 8012767 | Pipette tip loading assembly A method of loading a plurality of pipette tips on a plurality of mandrels of a pipetter is provided. A plurality of pipette tips are inserted in a plurality of receptacles of a tip loading assembly. The plurality of pipette tips are oriented with respect to each ot... | 09/06/2011 |
| 8012766 | Prediction of aspirated volume of a liquid Aspirating a liquid, includes: providing an aspirating probe comprising probe tip and piston pump, wherein the probe tip and piston pump are in fluid communication; measuring an initial gas pressure in the probe prior to liquid entering the liquid being aspirated; m... | 09/06/2011 |
| 8012768 | System and method for multi-analyte detection The present invention provides a system and method for the simultaneous detection of multiple analytes in a sample. The detection system includes a housing that holds a reagent carousel rotatably coupled thereto. Further included in the housing is an incubator carou... | 09/06/2011 |
| 8012431 | Closing blade for deformable valve in a microfluidic device and method A microfluidic manipulation system is provided that includes a blade for manipulating deformable material and at least one movable support that is capable of moving the blade into contact with a microfluidic device including a deformable feature. When the microfluid... | 09/06/2011 |
| 8008091 | Micro analysis system A micro integrated analysis system includes a testing chip, system main body and heat insulating section. The chip has a pump connecting section to communicate with micro pumps; a mixing flow path for mixing a specimen and reagent and for reaction processing by heat... | 08/30/2011 |
| 7998751 | Method and apparatus for aspirating and dispensing small liquid samples in an automated clinical analyzer Providing the desired volume of a liquid within a biochemical analyzer by aspirating an excess slug of liquid from a container into a probe, ejecting a portion of the excess liquid, and then dispensing the desired volume of liquid into a container. ... | 08/16/2011 |
| 7998435 | High density plate filler A filling apparatus for filling a microplate. The microplate having a plurality of wells each sized to receive an assay. The filling apparatus can comprise an output layer having a plurality of capillaries, wherein a first grouping of the capillaries is separated fr... | 08/16/2011 |
| 7976795 | Microfluidic systems The systems and methods disclosed herein include a microfluidic system, comprising a pneumatic manifold having a plurality of apertures, and a chip manifold having channels disposed therein for routing pneumatic signals from respective ones of the apertures to a plu... | 07/12/2011 |
| 7964160 | Pipetting apparatus with a computer program product and a method for accepting or rejecting pipetted liquid samples The invention relates to a pipetting apparatus (1) having a pipette tip (2) for aspirating and dispensing liquid samples; a pump (4) for generating negative pressure or positive pressure in the pipette tip (2) that is connected to the pip... | 06/21/2011 |
| 7960183 | Biochip manufacturing method and biochip manufacturing device Provided is a method of manufacturing a biochip using a droplet discharging device including a droplet discharging head having a cavity and a nozzle hole provided in communication with the cavity, and a liquid housing unit connected to the cavity via a passage, havi... | 06/14/2011 |
| 7955864 | Device and method for making discrete volumes of a first fluid in contact with a second fluid, which are immiscible with each other Various embodiments described in the application relate to an apparatus, system, and method for generating, within a conduit, discrete volumes of one or more fluids that are immiscible with a second fluid. The discrete volumes can be used for biochemical or molecula... | 06/07/2011 |
| 7955865 | Reagent delivery apparatus and methods Apparatus for dispensing droplets of reagent onto samples includes a probe tip to which droplets of reagent can adhere. The apparatus advances the probe tip toward a sample until a droplet of reagent touches the sample and is pulled off from the probe tip. A sensor ... | 06/07/2011 |
