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| Number | Title | Issue Date |
| 8148157 | Reference, calibrator, or control composition of PIGF-1 and sFlt-1 Disclosed herein are compositions and methods comprising two or more proteins in which at least one of the proteins has been altered to reduce their mutual recognition and binding. Such compositions are useful as reference, calibrators or controls in methods and ass... | 04/03/2012 |
| 8119407 | Hemoglobin based bilirubin reference material What is described is a single reference material and method of making useful for calibrating or qualifying instruments that are diagnostic spectroscopically for bilirubin, hemoglobin, and hemoglobin fractions, and, optionally, diagnostic for other blood analytes by ... | 02/21/2012 |
| 8053239 | Digital microfluidic method for protein extraction by precipitation from heterogeneous mixtures A method for extracting proteins from heterogeneous fluids by precipitation using microfluidics. The method uses an automated protocol for precipitation of proteins onto surfaces, rinsing the precipitates to remove impurities, and resolubilization in buffer for furt... | 11/08/2011 |
| 7820444 | Method for sample identification in a mammal as well as a kit for performing this method Method as well a kit for the performance of the method for the investigation of biological samples from a mammal for at least one component, wherein the method includes the following steps: (a) Administering at least one marker substance to a mammal; (b) Waiting for... | 10/26/2010 |
| 7674623 | Method of stabilizing human natriuretic peptides The present invention relates to methods for making stable test samples that can be used in ligand-binding assays for measuring natriuretic peptides. ... | 03/09/2010 |
| 7560282 | System for the internal qualitative and quantitative validation of marker indices The present invention relates to the qualitative and quantitative validation of marker indices, especially for medical diagnosis and particularly for the determination of the growth fraction in a sample with antibodies against the Ki-67 protein. Diagnostic kit for t... | 07/14/2009 |
| 7560283 | Storage-stable cellular whole blood composition containing elevated amounts of D-dimer The present invention provides a cellular whole-blood D-dimer composition for use with diagnostic test procedures for D-dimer, and a method of its preparation. The composition comprises human erythrocytes and processed plasma to which D-dimer, and stabilizers, and o... | 07/14/2009 |
| 7547552 | Indication composition for surgical instrument cleaning evaluation The present invention provides an indicator composition for evaluating cleaning of a medical instrument that includes an extracellular matrix component and hemoglobin, as a contamination model having cleaning profile resembling an actual contaminant adhered to a med... | 06/16/2009 |
| 7521244 | Standard reference solutions Standard reference materials and related methods are described for quality testing and calibration of instruments used for the qualitative and quantitative determination of hemoglobin and glycated hemoglobin as well as other analytes of interest in animal tissue sam... | 04/21/2009 |
| 7445933 | Stable calibrators or controls for measuring human natriuretic peptides The present invention relates to a stable liquid calibrator or control for use in ligand-binding assays wherein the calibrator or control comprises at least one human synthetic natriuretic peptide and has a pH of from about 4.0 to about 6.5 and remains... | 11/04/2008 |
| 7432105 | Self-calibration system for a magnetic binding assay A self-calibrated, magnetic binding assay (e.g., sandwich, competitive, etc.) for detecting the presence or quantity of an analyte residing in a test sample is provided. The magnetic binding assay includes detection probes capable of generating a detection signal (e... | 10/07/2008 |
| 7368288 | Detection and recognition of analytes based on their crystallization patterns The invention contemplates a method for recognition of proteins and other biological molecules by imaging morphology, size and distribution of crystalline and amorphous dry residues in droplets (further referred to as “crystallization pattern”) containing predet... | 05/06/2008 |
| 7361513 | Cellular controls for glycated hemoglobin Hb A1c Disclosed are cellular hemoglobin A1c (Hb A1c) normal and abnormal (high) controls for use in detecting Hb A1c levels. The present invention also relates to methods for generating cellular Hb A1c controls using red blood cells and methods for using the cellular cont... | 04/22/2008 |
| 7351586 | Method of making stable calibrators or controls for measuring human natriuretic peptides The present invention relates methods for making stable calibrators and controls that can be used in ligand-binding assays. ... | 04/01/2008 |
| 7320963 | Methods and compositions for delivery of pharmaceutical agents Methods and compositions for delivering pharmaceutical agents into cells, in particular urothelial cells of the bladder, are provided. In the methods and compositions of the invention, a solubilized cholesterol composition is used to facilitate delivery of pharmaceu... | 01/22/2008 |
| 7316931 | Mass defect labeling for the determination of oligomer sequences Mass tagging methods are provided that lead to mass spectrometer detection sensitivities and molecular discriminations that are improved over other methods. In particular the methods are useful for discriminating tagged molecules and fragments of molecules from chem... | 01/08/2008 |
| 7291501 | Stable compositions for measuring human natriuretic peptides The present invention relates to methods for making stable compositions, such as, but not limited to, test samples, that can be used in ligand-binding assays. ... | 11/06/2007 |
| 7285418 | Method and kit for the diagnosis of troponin I The invention provides a method for assaying for troponin I in a sample such as serum, the method comprising a determination of the troponin I concentration in a sample using a standard preparation that comprises a complete native troponin complex. One exemplary ass... | 10/23/2007 |
| 7262018 | Agents that bind to and inhibit human cytochrome P450 2C19 The invention provides monoclonal antibodies and other binding agents to human cytochrome P450 2C19 having advantageous properties, including capacity substantially to inhibit enzyme activity of human cytochrome P450 2C19 and lack of specific binding to other human ... | 08/28/2007 |
| 7250306 | Method for distinguishing between protein variants Disclosed is a method for distinguishing between protein variants using high field asymmetric waveform ion mobility spectrometry (FAIMS). A method according to the instant invention includes the steps of providing a FAIMS analyzer region defined by a space between t... | 07/31/2007 |
| 7235368 | CHP for use as marker for sepsis-type inflammatory diseases Use of calcineurin B homologous protein (CHP) from body fluids or body tissues as a marker peptide for diagnosis, for prognosis and for monitoring the course of inflammations and infections and/or as a target for therapeutically influencing the course of inflammatio... | 06/26/2007 |
| 7232689 | Calibration procedure for investigating biological systems Use of calibrant in extraction phase is described for quantification of components of interest in samples in laboratory application as well as in on-site monitoring. This approach is particularly useful for in-vivo investigation of living systems. ... | 06/19/2007 |
| 7195923 | Ratiometric determination of glycated protein The present invention provides methods for determining a ratio of an amount of a glycated form of a protein to a total amount of the protein in a sample containing the glycated protein, the glycosylated protein, or the glycoprotein. The method incorporates lateral f... | 03/27/2007 |
| 7172902 | Quality control material for reagentless measurement of analytes A method of monitoring calibration of a spectrophotometric apparatus that includes one or more than one calibration algorithm for one or more than one analyte, involves measuring absorbance of a quality control material with the apparatus to obtain a measurement, ca... | 02/06/2007 |
| 7169562 | Immunologic assay to determine C-peptide containing impurities in samples of human insulin and derivatives thereof The invention relates to a process for detecting or determining a C-peptide-containing impurity in a sample of recombinantly produced human insulin or a derivative thereof, by a non-radioactive assay, comprising the steps: (a) prep... | 01/30/2007 |
| 7166469 | Detection and determination of the stages of coronary artery disease A method having clinically sufficient degree of diagnostic accuracy for detecting the presence of coronary artery disease in a human patient from the general population and for distinguishing between the stages of the disease in that patient is disclosed. The stages... | 01/23/2007 |
| 7163802 | Copolymer 1 related polypeptides for use as molecular weight markers and for therapeutic use The present invention provides processes for determining the molecular weight of glatiramer acetate and other copolymers. The present invention further provides a plurality of molecular weight markers for determining the molecular weight of glatiramer acetate and ot... | 01/16/2007 |
| 7157282 | Quality control material for reagentless measurement of analytes A method of monitoring calibration of a spectrophotometric apparatus having one or more than one calibration algorithm for one or more than one analyte. This method involves measuring an absorbance of a quality control material to obtain a measurement, calculating o... | 01/02/2007 |
| 7153403 | Protein market pellets and method of making and using the same A protein marker pellet for use in a gel electrophoresis system includes one or more protein markers including a protein of known molecular weight with ionic components to provide electrical conductance, and a non-protein, gel-forming material having a porosity suff... | 12/26/2006 |
| 7144705 | Diagnostic assay for stroke Heart and brain fatty acid binding proteins (H-FABP, B-FABP) are markers for stroke. The invention provides a diagnostic assay for either of these markers, preferably by ELISA using anti-H-FABP or B-FABP antibody. Since H-FABP is also a marker for acute myocardial i... | 12/05/2006 |
| 7133544 | Reference database Data acquisition and cataloging are used to classify polypeptides into a reference index or database. The database can be used to identify previously unidentified samples. New polypeptides are characterized and added to the database. ... | 11/07/2006 |
| 7122377 | Acid-labile isotope-coded extractant (ALICE) and its use in quantitative mass spectrometric analysis of protein mixtures The method of the invention provides novel compounds, termed acid-labile isotope-coded extractants (ALICE), for quantitative mass spectrometric analysis of protein mixtures. The compounds contain a thiol-reactive group that is used to capture cysteine-containing pep... | 10/17/2006 |
| 7115378 | Peptide biomarker and method of identification A method for identifying and quantifying peptides resulting from enzyme cleavage of collagen type II by mass spectrometric analysis to detect characteristic peptide fragments of a carboxy-terminus having known mass to charge ratios to identify the peptide having tha... | 10/03/2006 |
| 7097983 | Method for detecting the presence of an analyte in a sample The invention features a method of determining whether one or more members of an analyte family are present in a sample. The method makes use of a test zone binder, e.g., a receptor that can bind one or a plurality of analytes within an analyte family, the analytes ... | 08/29/2006 |
| 7091311 | Peptides and compounds that bind to a receptor Described are peptides and peptide mimetics that bind to and activate the thrombopoietin receptor. Such peptides and peptide mimetics are useful in methods for treating hematological disorders and particularly, thrombocytopenia resulting from chemotherapy, radiation... | 08/15/2006 |
| 7078486 | Single-chain polypeptides comprising troponin I and troponin C This invention relates to single-chain polypeptides and their genetic sequences comprising human cardiac troponin I and troponin C. The single-chain polypeptide may be expressed recombinantly, and a linker peptide may be interposed between the troponin sequences. A ... | 07/18/2006 |
| 7074580 | Copolymer 1 related polypeptides for use as molecular weight markers and for therapeutic use The present invention provides processes for determining the molecular weight of glatiramer acetate and other copolymers using molecular weight markers. The present invention further provides a plurality of molecular weight markers for determining the molecular weig... | 07/11/2006 |
| 7067321 | Polyglutamine repeat sequences Several neurodegenerative diseases result from the aggregation of polyglutamine repeat proteins into insoluble neuronal intranuclear inclusions. The invention provides methods with which to study the processes of these diseases, including methods for solubilizing po... | 06/27/2006 |
| 7045310 | Redox reversible bipyridyl-osmium complex conjugates Novel bipyridyl-osmium complex conjugates and their use in electrochemical assays are described. The redox reversible-osmium complexes can be prepared to exhibit unique reversible redox potentials and can thus be used in combination with other electroactive redox re... | 05/16/2006 |
| 7011940 | Quality control for cytochemical assays The invention describes quality control devices for assays that measure analytes in cells and tissue samples, and methods of use thereof. In particular, the quality control device comprises a matrix affixed with synthetic controls in different concentrations, or dif... | 03/14/2006 |
