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| Number | Title | Issue Date |
| 8026099 | Lipid profile as a biomarker for early detection of neurological disorders The present invention relates to compositions and methods for the early detection or monitoring of neurodegenerative diseases and neurological disorders including Alzheimer's disease. The invention provides biomarkers based on lipid profiles of biological samples an... | 09/27/2011 |
| 7846735 | Compositions and methods for lipoprotein uptake assays Provided herein are compositions and methods for lipoprotein uptake assay. These compositions and methods may be used for lipoprotein uptake assays, including high-throughput assays. The disclosed compositions and method may further be used to characterize the activ... | 12/07/2010 |
| 7638336 | Assay and method for quantifying the levels of steryl esters and free sterols in starch-containing food products The present invention relates to an assay for determining the levels of sterols, stanols, steryl esters, fatty acid derivatives and combinations thereof in a starch-containing food product. The assay is particularly useful in supporting product health and/or nutriti... | 12/29/2009 |
| 7476542 | Method and apparatus for video poker using alternate draw strategies In accordance with one or more embodiments of the present invention, a method is provided that comprises determining a first strategy for play of a game and a second strategy for play of the game, selecting at least one final outcome of the game that cannot result f... | 01/13/2009 |
| 7416895 | Method for identifying at risk cardiovascular disease patients This invention is directed to a data base which contains data for HDL2b, LDL IIIa & LDL IIIb and LDL IVb subclasses all in mg/Dl and which is correlated to cardiovascular disease. ... | 08/26/2008 |
| 7285297 | Method of reducing low density liproprotein cholesterol concentration The present invention is a composition comprising a plant sterol and a soy protein material and/or and isoflavone selected from genistein, daidzein, glycitein, biochanin A, formononetein, and their naturally occurring glycosides, where the plant sterol comprises at ... | 10/23/2007 |
| 7259018 | Ion mobility analysis of lipoproteins A medical diagnostic method and instrumentation system for analyzing noncovalently bonded agglomerated biological particles is described. The method and system comprises: a method of preparation for the biological particles; an electrospray generator; an alpha parti... | 08/21/2007 |
| 7244618 | Stable lipid standards The invention describes materials useful for calibrating methods, and standards, calibration verification, linearity, and quality control materials for any method used to detect lipids and/or lipoproteins. This invention describes methods for producing, and composit... | 07/17/2007 |
| 7226792 | Method for selecting an optimal diet and exercise regimen based on LDL and HDL subclass determination The invention provides novel methods for selecting an optimal diet and exercise regimen for a patient based on the consideration of several factors, including low density lipoprotein (LDL) and high density lipoprotein (HDL) subclass levels. Furthermore, the inventio... | 06/05/2007 |
| 7211438 | Method and apparatus for predicting the presence of haemostatic dysfunction in a patient sample Methods for predicting the presence of haemostatic dysfunction in a patient from a time-dependent measurement profile include performing a time-dependent measurement on an unknown sample and measuring a respective property over time so as to derive a time-dependent ... | 05/01/2007 |
| 7166469 | Detection and determination of the stages of coronary artery disease A method having clinically sufficient degree of diagnostic accuracy for detecting the presence of coronary artery disease in a human patient from the general population and for distinguishing between the stages of the disease in that patient is disclosed. The stages... | 01/23/2007 |
| 7157259 | Murine lecithin-cholesterol acyltransferase protein This invention relates to a novel protein having a lecithin-cholesterol acyltransferase-like activity, etc. or its salt, a precursor protein of the protein or its salt, a partial peptide of the protein or its salt; a DNA coding for the protein; a recombinant vector;... | 01/02/2007 |
| 7144705 | Diagnostic assay for stroke Heart and brain fatty acid binding proteins (H-FABP, B-FABP) are markers for stroke. The invention provides a diagnostic assay for either of these markers, preferably by ELISA using anti-H-FABP or B-FABP antibody. Since H-FABP is also a marker for acute myocardial i... | 12/05/2006 |
| 7052855 | Anti-APO-B-48 monoclonal antibody, hybridoma producing the same, and method for measuring APO-B-48 using the same A novel monoclonal antibody which specifically binds to apo-B-48 is disclosed. The monoclonal antibody specifically binds to apo-B-48 but does not bind to apo-B-100. ... | 05/30/2006 |
| 7053176 | Combination of C1-INH and lung surfactant for the treatment of respiratory disorders Pharmaceutical composition for the treatment of infant respiratory distress syndrome and acute lung injury (including adult respiratory distress syndrome) which contains C1 esterase inhibitor (C1-INH) and lung surfactant which comprises a lung surfactant protein. | 05/30/2006 |
| 6964771 | Method for stably incorporating substances within dry, foamed glass matrices The invention provides methods for producing foamed glass and the compositions obtained thereby. The compositions are suitable for stable storage of a wide variety of substances, particularly biological and pharmaceutical. ... | 11/15/2005 |
| 6939713 | Assay and method for quantifying the levels of steryl esters and free sterols in starch-containing food products The present invention relates to an assay for determining the levels of sterols, stanols, steryl esters, fatty acid derivatives and combinations thereof in a starch-containing food product. The assay is particularly useful in supporting product health and/or nutriti... | 09/06/2005 |
| 6893018 | Game machine A game machine is provided with first, second and third reel rows, and each of the reel rows executes slot game independent from each other. The number of reel rows to be actuated is increased in proportion to the number of bet coins. When less than three coins are ... | 05/17/2005 |
| 6861260 | Lipid membrane, method for measuring membrane permeability, and method for screening The object of the present invention is to provide a lipid membrane whose permeability to substances is high and strongly correlated with the permeability of biomembranes to drugs and which therefore is suitable for rapid measurement. The present invention provides a... | 03/01/2005 |
| 6780849 | Lipid-based nitric oxide donors Novel nitric-oxide releasing lipid molecules are provided which comprise a lipid molecule selected from (a) phosphoglycerides, (b) lipids having a sphingosine base as a backbone, (c) monoacylglyerols, (d) diacylglycerols, (e) glycosylacylglycerols, wherein the lipid... | 08/24/2004 |
| 6767708 | Stabilized aqueous steroid immunoassay standards Aqueous solutions of steroid compounds which have biological activity and have a tendency to oxidative degradation at temperatures between 2 and 8° C. on storage in excess of several months are stabilized by the addition of chelators. Aqueous solutions of particula... | 07/27/2004 |
| 6653140 | Methods for providing personalized lipoprotein-based risk assessments Methods for assessing a patient's risk of having or developing coronary heart disease based on lipoprotein measurements measure and identify values for lipoprotein subclass constituents and analyze according to predetermined test criteria to identify when... | 11/25/2003 |
| 6579682 | Methods and tools for identifying compounds which modulate atherosclerosis by impacting LDL-proteoglycan binding The present invention relates to the study and control of atherosclerosis through the modulation of LDL-proteoglycan binding at Site B (amino acids 3359-3369) of the apo-B100 protein in LDL. The invention encompasses methods of identifying compounds which... | 06/17/2003 |
| 6576471 | Methods, systems, and computer program products for analyzing and presenting NMR lipoprotein-based risk assessment results A method for analyzing a patient's risk of coronary heart disease by determining the presence of NMR-derived or based lipoprotein constituent value abnormalities includes determining the presence of atherogenic dyslipidemia based on the existence of a clu... | 06/10/2003 |
| 6498038 | Loss of sialic acid from apolipoprotein j as an indicator of alcohol intake and/or alcohol related liver damage Disclosed is a method for determining alcohol intake or alcohol induced liver damage in a subject by quantifying the content of sialic acid in apolipoprotein J (Apo J). In particular the present invention involves the steps of (a) providing a sample conta... | 12/24/2002 |
| 6498019 | Lecithin-cholesterol acyltransferase protein This invention relates to a novel protein having a lecithin-cholesterol acyltransferase-like activity, etc. or its salt, a precursor protein of the protein or its salt, a partial peptide of the protein or its salt; a DNA coding for the protein; a recombin... | 12/24/2002 |
| 6492185 | Immunoassay for detection of very low density lipoprotein and antibodies useful therefor The present invention provides a method for directly measuring apolipoprotein B-100 (apoB) or cholesterol associated with very low density lipoprotein (VLDL) in a fluid sample. In one embodiment the method involves the specific capture of intact VLDL part... | 12/10/2002 |
| 6482648 | Stable troponin preparation and the use thereof as a calibrator/control in immunoassays The present invention relates to methods for the production of a stable troponin preparation and its use as a calibrator and/or control in immunoassays. The formulation is prepared from mammalian, preferably bovine, heart tissue which provides a calibrato... | 11/19/2002 |
| 6440747 | Stabilization of biological fluids by addition of sterol esters The present invention relates to the use of sterol esters for the long-term stabilization of biological fluids, in particular even those which are obtained by lyophilization and subsequent reconstitution.... | 08/27/2002 |
| 6362003 | Hematological reference control composition containing leukocyte analogs, methods of making, and uses thereof A method of quality control to diagnose the cause of a malfunction of an instrument. The method uses measurements of the physical property of a sample to diagnose the cause of a malfunction of an instrument. The spatial position of a control product sampl... | 03/26/2002 |
| 6309888 | Detection and determination of the stages of coronary artery disease A method having clinically sufficient degree of diagnostic accuracy for detecting the presence of coronary artery disease in a human patient from the general population and for distinguishing between the stages of the disease in that patient is disclosed.... | 10/30/2001 |
| 6309844 | Anti-apo-B-48 monoclonal antibody, hybridoma producing the same, and method for measuring apo-B-48 using the same A novel monoclonal antibody which specifically binds to apo-B-48 is disclosed. The monoclonal antibody specifically binds to apo-B-48 but does not bind to apo-B-100.... | 10/30/2001 |
| 6214570 | Method for separating non-HDLs from HDLs, and determining, HDL cholesterol The subject matter of the application is a method for the separation of non-HDL lipoproteins from biological fluids in a carrier through which liquids can flow. The carrier contains a precipitating agent for non-high density lipoproteins (non-HDLs).... | 04/10/2001 |
| 6121425 | Metal-lipid molecules Novel metal-lipid molecules have the formula M-Or-L. M represents a cluster or colloid of atoms of Au, Ag, Pt, Pd, or combinations thereof. Or is an organic group covalently attached to the metal atoms. L represents a lipid moiety. In a preferred embodime... | 09/19/2000 |
| 6017721 | Chromatographic method and device for preparing blood serum for compatibility testing The invention provides a new method for antiglobulin testing from serum of a potential blood transfusion recipient in which warm autoantibodies are removed from serum so as to allow identification of alloantibodies present. The method involves contacting ... | 01/25/2000 |
| 6015716 | Detection of endotoxin levels in liposomes, lipid bilayers and lipid complexes Endotoxin incorporated into liposomes, lipid bilayers or lipid complexes can be detected by combining an aqueous suspension of the liposomes, lipid complexes or lipid bilayers with a suitable detergent. Preferable detergents, e.g., Lubrol-PX™ or a polyo... | 01/18/2000 |
| 5989916 | Direct cholesterol assay reagent The present invention relates to the direct quantitative determination of cholesterol and involves the formation of a spectrophotometrically active product of cholesterol obtained by contacting cholesterol with an acyl compound and a perchlorate effective... | 11/23/1999 |
| 5948610 | Use of matrices comprising liquids and light absorbing particles for analysis of microorganisms by laser desorption mass spectrometry The present invention is directed to a method of using a liquid matrix containing a black body light absorbing powder to facilitate the analysis of biomarkers from representative microorganisms by laser desorption mass spectrometry. Both an IR laser (1064... | 09/07/1999 |
| 5922594 | Method of producing bilayer lipid membranes Methods are disclosed for producing a substrate surface supporting a continuous planar bilayer lipid membrane by covalently binding a plurality of micellar of vesicle liposomes, optionally comprising a membrane protein or other biologically active membran... | 07/13/1999 |
| 5888827 | Method for determination of cholesterol in low-density lipoprotein or very low-density lipoprotein Cholesterol in low-density lipoprotein (LDL) or very low-density lipoprotein (VLVL) in a sample is determined in the presence of a sugar compound and/or a protein-solubilizing agent.... | 03/30/1999 |
