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Class 436/12 - Bilirubin or uric acid standard or control


Subclass of Class 436 - Chemistry: analytical and immunological testing
Definition: Compositions and processes which simulate the chemical effect
No. of patents: 49
Last issue date: 07/17/2007


1    
NumberTitleIssue Date
7244618Stable lipid standards
The invention describes materials useful for calibrating methods, and standards, calibration verification, linearity, and quality control materials for any method used to detect lipids and/or lipoproteins. This invention describes methods for producing, and composit...
07/17/2007
7172902Quality control material for reagentless measurement of analytes
A method of monitoring calibration of a spectrophotometric apparatus that includes one or more than one calibration algorithm for one or more than one analyte, involves measuring absorbance of a quality control material with the apparatus to obtain a measurement, ca...
02/06/2007
7157282Quality control material for reagentless measurement of analytes
A method of monitoring calibration of a spectrophotometric apparatus having one or more than one calibration algorithm for one or more than one analyte. This method involves measuring an absorbance of a quality control material to obtain a measurement, calculating o...
01/02/2007
6949384Method for monitoring degradation of Hb-based blood substitutes
The present invention provides a method for monitoring degradation of Hb-based blood substitutes, in a sample. This method involves determining a concentration of met-Hb within the sample, by applying a calibration algorithm for met-Hb to an absorbance obtained from...
09/27/2005
6828152Quality control material for reagentless measurement of analytes
The present invention provides a method of monitoring calibration of a spectrophotometric apparatus that comprises one or more calibration algorithms for one or more analytes. This method comprises measuring absorbance of a quality control material with the apparatu...
12/07/2004
6696297Non-oxidizable bilirubin substitutes and uses therefor
Compositions and methods are disclosed for use in the analysis and quantitation of conjugated and unconjugated bilirubin in patient or other samples. The compositions have the general formula: ##STR1## wherein: R1 and R2 are ...
02/24/2004
6692923Tapasin-like protein
The invention provides a cDNA which encodes tapasin-like protein. It also provides for the use of the cDNA, protein, and antibody in the diagnosis, prognosis, treatment and evaluation of therapies for cancer. The invention further provides vectors and hos...
02/17/2004
6637257Micromachined fluid analysis device and method
A method and device for performing fluid analysis by separating cells and/or particles from a fluid, such as a biological, vehicular or industrial fluid. The device is a micromachined filtering device comprising a substrate with through-thickness vias hav...
10/28/2003
6613577Use of bathocuproine for the evaluation of the antioxidant power in liquids and solutions
The antioxidant power of an organic or inorganic liquid is determined by causing it to enter into competition with bathocuproine (BC) in a copper sulphate solution. Bathocuproine (BC) forms stable complexes with the monovalent Cu. Such a reaction is speci...
09/02/2003
6482648Stable troponin preparation and the use thereof as a calibrator/control in immunoassays
The present invention relates to methods for the production of a stable troponin preparation and its use as a calibrator and/or control in immunoassays. The formulation is prepared from mammalian, preferably bovine, heart tissue which provides a calibrato...
11/19/2002
6372503Calibrator material for instruments which measure interferents in serum and plasma specimens
A quality control material is disclosed which is used to monitor the calibration or used for recalibration of instruments used to screen for interferents in serum or plasma specimens. In particular, the quality control material disclosed is used to monito...
04/16/2002
5955374Method of detection of bilirubin in urine on an automated analyzer
Method for detecting total bilirubin in urine using a chemical detection means with an indicator that will produce a detectable quantitative response in the presence of bilirubin in urine on an automated analyzer....
09/21/1999
5935805Measurement of bilirubin albumin binding
The present invention is directed to the determination of unconjugated and unbound bilirubin in a sample....
08/10/1999
5935861Diazonium ion assay reagents and methods for their use
Diazonium ions which are useful as reagents for the assay of bilirubin content in a sample, such as a body fluid sample, are provided. In one preferred embodiment, 2-methyl-3-nitroaniline diazonium ion is provided, having the structure: ##STR1## ...
08/10/1999
5866424Stable liquid urobilinogen control composition
The present invention addresses the need to ensure that clinical tests for urobilinogen in urine are properly working. The invention specifically provides a novel liquid urobilinogen composition which remains stable in liquid form for eighteen months and ...
02/02/1999
5858644Analysis of analytes in biological fluids
A method for detecting an analyte in a sample uses both the specificity of an enzymatic reaction and the separation power of capillary electrophoresis. In general, the method comprises: (1) subjecting a first aliquot of the sample to an analytical techniq...
01/12/1999
5854073Stabilization of bilirubin in control sera and calibrators
The invention concerns a stable control serum or calibration serum containing bilirubin to analytically examine the methodical accuracy of individual parameters in human sera or patients. The control serum or calibration serum according to the invention i...
12/29/1998
5633166Method of analyzing medical specimens with improved length of analytical run determination
In high volume laboratory analysis of patient medical specimens, control materials are inserted at periodical intervals (e.g. once per eight hours) and analyzed. If the results of the analysis deviate from the mean according to statistical rules, the run ...
05/27/1997
5580747Non-radioactive enzyme assay
The present invention is directed to the assay and purification of proteins, and particularly to the non-radioactive assay and purification of protein kinases, phosphatases and protease by incubating the enzyme with a substrate modified peptide to form a ...
12/03/1996
5559003Assay method for biological components
The method is directed to assaying for biological components in a sample comprising step (A) generating an oxidase substrate in the presence of an amphoteric surfactant and in the absence of ferrocyanide; (B) initially generating hydrogen peroxide through...
09/24/1996
5453378Diagnostic test system verification method using serum free glucose control containing quaternary ammnonium polymer
Disclosed is a serum free control reagent formulation useful for the determination of a pre-selected analyte. The formulation involves an aqueous solution of a predetermined amount of the analyte together with a polymerized quaternary salt of di- or mono-...
09/26/1995
5308767Method for control or calibration in a chemical analytical determination
A method for control or calibration in a chemical analytical determination using a dry analysis element comprising at least one color-producing reagent and a porous layer, wherein the method comprises applying an aqueous dispersion onto the porous layer a...
05/03/1994
5281536Stable liquid control serum or calibration system for use in clinical diagnostics
A stable liquid control and/or calibration serum for use in clinical diagnostics containing a liquid-stable bilirubin derivative and a known concentration of at least one analyte. The invention further addresses a process for the preparation of the stable...
01/25/1994
5278073Method of bilirubin assay
In the assaying of direct and indirect bilirubin, it is has been found that organic compounds, capable of undergoing diazotization to products having absorption spectrum substantially identically to bilirubin, can be used as a calibration standard. Typica...
01/11/1994
5262304Method for optical measurement of bilirubin and reagent therefor
A method for optical measurement of bilirubin which comprises reacting a bilirubin-containing sample with a zinc compound, a coloring agent and bilirubin oxidase in a buffer, wherein a stable green pigment having a large molecular extinction coefficient i...
11/16/1993
4839279Method for the quantitative determination of physiological components in biological fluids
A novel enzyme of bilirubin oxidase and a conventional enzyme of laccase are found to oxidize bilirubin to biliverdin without formation of hydrogen peroxide, thereby permitting the content of conjugated bilirubin in biological fluid to be quantitatively d...
06/13/1989
4703013Urobilinogen control
A stable control solution is provided for the determination of urobilinogen. The control solution comprises an aqueous solution of about 3-12% ethylene glycol, about 0.1% protein and preferably about 40-400 mg/dl urobilinogen, said composition buffered to...
10/27/1987
4683208Method for the determination of bilirubin
The present invention provides a method for the determination of bilirubin which comprises reacting the bilirubin with a compound represented by the formula ##STR1## and determing the pigment thus formed....
07/28/1987
4677075Urobilinogen control
A stable control solution is provided for the determination of urobilinogen. The control solution comprises an aqueous solution of about 3-12% ethylene glycol, about 0.1% protein and preferably about 40-400 mg/dl urobilinogen, said composition buffered to...
06/30/1987
4465770Stabilized enzymic solutions for determining urea
A stabilized urease solution is disclosed comprising water, buffering agents, a bacteriostat, chelating agent, polyhydroxy organic compound and urease. The preferred buffering agents are selected from low conductivity Zwitterionic buffer salts, such as N-...
08/14/1984
4405718Method and composition for urobilinogen control standard
A urobilinogen control standard composition, control standard device and a method for preparing such composition are disclosed. The composition comprises a substituted indole:nonionic detergent solution which is reactive with p-diethylaminobenzaldehyde an...
09/20/1983
4344864Method for increasing shelf-life of a serum conjugated bilirubin reference composition and composition produced thereby
A stable blood serum conjugated bilirubin reference composition characterized in that the composition possess a pH of from about 8.2 to bout 9.2 and comprises (a) a sulfhydryl compound in an amount sufficient to enhance the stability of the conjugated bil...
08/17/1982
4336157Process for reclaiming biliverdin-containing fluids
The green shade imparted to serum or plasma by biliverdin is eliminated by contacting the contaminated fluid with dithionite ion....
06/22/1982
4298498Control reagent for test strips for determining urobilinogen in urine
The present invention provides a control reagent for test strips for the detection of urobilinogen and possibly of other diagnostically relevant components, such as bilirubin, ketone bodies, glucose, protein, nitrite and blood, and possibly also of pH, wh...
11/03/1981
4288343Method for increasing shelf-life of a serum bilirubin reference composition and composition produced thereby
A stable blood serum bilirubin reference composition characterized in that the composition possess a pH of from about 8.2 to about 9.2 and comprises (a) a sulfhydryl compound in an amount sufficient to enhance the stability of the bilirubin and (b) a chel...
09/08/1981
4260579Device and method for simulating bilirubin in urine
A device and method are disclosed for preparing a bilirubin-containing control solution. The device comprises a carrier vehicle having incorporated with it unconjugated bilirubin and certain dyes. Upon contact with a predetermined quantity of water a cont...
04/07/1981
4246133Stabilized diazotized sulfanilic acid solutions
Nitrilotris (methylene) triphosphonic acid and 1,3,6-napthalenetrisulfonic acid are used to stabilize solutions containing diazotized sulfanilic acid....
01/20/1981
4230601Calibrator composition based upon dialyzed blood serum
A calibrator composition is disclosed in which a bias due to a dialyzed blood serum matrix is reduced to an acceptable level by the addition of a compatible, organic material. Methods of preparing and using the same are also disclosed....
10/28/1980
4207203Uric acid standard solutions
Stable aqueous solutions useful as standards in the determination of uric acid are disclosed. The solutions have a pH of about 6-7 and contain a buffer and a known concentration of uric acid present in solution as a salt of the pH-controlling buffer compo...
06/10/1980
4201694Method for increasing shelf-life of a serum bilirubin reference composition and composition produced thereby
A stable blood serum bilirubin reference composition characterized in that said composition either (1) possesses a pH of from about 8.3 to about 9.5 or (2) further comprises a sulfhydryl compound in an amount sufficient to enhance the stability of the bil...
05/06/1980
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