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Class 436/11 - Blood gas standard or control


Subclass of Class 436 - Chemistry: analytical and immunological testing
Definition: Compositions and processes which simulate the effect of
No. of patents: 105
Last issue date: 09/09/2008


1      
NumberTitleIssue Date
7422903Multi-analyte reference solutions
The present invention provides a reference solution for use in instruments that determine hematocrit levels in biological samples by measuring the resistance and/or conductivity of the biological samples. A reference solution according to the invention achieves cond...
09/09/2008
7361513Cellular controls for glycated hemoglobin Hb A1c
Disclosed are cellular hemoglobin A1c (Hb A1c) normal and abnormal (high) controls for use in detecting Hb A1c levels. The present invention also relates to methods for generating cellular Hb A1c controls using red blood cells and methods for using the cellular cont...
04/22/2008
7357937Perfluorocarbon emulsions with non-fluorinated surfactants
A stable FC emulsion is described. The FC emulsion of the present invention comprises a continuous FC immiscible hydrophilic liquid phase and a dispersed phase comprising FC suspended as droplets within the continuous phase. The emulsion further comprises an emulsif...
04/15/2008
7291502Method for performing a non-invasive blood gas test
A non-invasive blood gas test is carried out by a method that utilizes a venous blood sample together with a pulse oximeter and a plurality of mathematical equations. The method generates the following data points of the blood: (i) the pH level; (ii) the [H+] concen...
11/06/2007
7262061Test element analysis system
Test element analysis system for the analytical investigation of a sample, in particular of a body liquid of human beings or animals, comprising test elements (2) with a carrier film (5) and a test field (7) fixed to the flat side (6) of ...
08/28/2007
7247470Method and apparatus for measuring nitric oxide production and oxygen consumption in cultures of adherent cells
An apparatus and method for measuring nitric oxide production and oxygen consumption in cultures of adherent cells continuously and without destroying the cells. The method involves flowing growth media through a tube having adherent cells are adhered to the inner s...
07/24/2007
7209605Packaged optical sensors on the side of optical fibers
The present invention concerns an optical sensor located on a preferred azimuthal portion of the side of an optical fiber. An optical fiber having two opposite ends, a core and a cladding and at least one sensing area is disclosed. Each of the sensing areas is locat...
04/24/2007
7163616Reagents and methods for detecting analytes, and devices comprising reagents for detecting analytes
Reagents for detecting an analyte are described. A reagent comprises (a) an enzyme selected from the group consisting of a flavoprotein, a quinoprotein, and a combination thereof; and (b) a mediator selected from the group consisting of a phenothiazine, a phenoxazin...
01/16/2007
7070793Antigen protein and nucleic acid coding for said protein
To provide a novel antigenic protein and a nucleic acid encoding the antigenic protein, which are useful for prophylaxis, treatment and diagnosis of diseases caused by fungi including Candida albicans. An antigenic protein characterized in that the antigenic ...
07/04/2006
7022219Automated system for continuously and automatically calibrating electrochemical sensors
An electrochemical sensor system that continuously monitors and calibrates the sensors included in the system. The invention also includes a method for determining failure patterns of a sensor and incorporating into an electrochemical sensor system the ability to re...
04/04/2006
6942867Antigen protein and nucleic acid coding for said protein
To provide a novel antigenic protein and a nucleic acid encoding the antigenic protein, which are useful for prophylaxis, treatment and diagnosis of diseases caused by fungi including Candida albicans. An antigenic protein characterized in that the antigenic ...
09/13/2005
6835571Multi-analyte reference solutions with stable pO2 in zero headspace containers
Multi-analyte reference solutions having a stable partial pressure of oxygen (pO2) in zero headspace packaging and methods for preparing such solutions are disclosed. The solutions have long shelf and use lives when stored at room temperature and are pack...
12/28/2004
6828152Quality control material for reagentless measurement of analytes
The present invention provides a method of monitoring calibration of a spectrophotometric apparatus that comprises one or more calibration algorithms for one or more analytes. This method comprises measuring absorbance of a quality control material with the apparatu...
12/07/2004
6632675Multi-analyte reference solutions with stable pO2 in zero headspace containers
Multi-analyte reference solutions having a stable partial pressure of oxygen (pO2) in zero headspace packaging and methods for preparing such solutions are disclosed. The solutions have long shelf and use lives when stored at room temperature a...
10/14/2003
6509192Quality control method
A method of quality control to diagnose the cause of a malfunction of an instrument. The method uses measurements of the physical property of a sample to diagnose the cause of a malfunction of an instrument. The spatial position of a control product sampl...
01/21/2003
6485979Electronic system for tracking and monitoring articles to be sterilized and associated method
A electronic system for tracking and monitoring articles to be subjected to a sterilization cycle is disclosed. The method uses a sterilization indicator and electronically links sterilization information with the articles subjected to the sterilization p...
11/26/2002
6482648Stable troponin preparation and the use thereof as a calibrator/control in immunoassays
The present invention relates to methods for the production of a stable troponin preparation and its use as a calibrator and/or control in immunoassays. The formulation is prepared from mammalian, preferably bovine, heart tissue which provides a calibrato...
11/19/2002
6372503Calibrator material for instruments which measure interferents in serum and plasma specimens
A quality control material is disclosed which is used to monitor the calibration or used for recalibration of instruments used to screen for interferents in serum or plasma specimens. In particular, the quality control material disclosed is used to monito...
04/16/2002
6174728Control or calibration standard for use with instruments for optical measurement of hemoglobin concentration in blood samples
A control or calibration standard for use with instruments for the optical measurement of the hemoglobin content in blood samples, features scattering particles or beads dispersed in aqueous electrolyte solution. To prevent sedimentation of the beads duri...
01/16/2001
6136607Multi-analyte reference solutions with stable pO2 in zero headspace containers
Multi-analyte reference solutions having a stable partial pressure of oxygen (pO2) in zero headspace packaging and methods for preparing such solutions are disclosed. The solutions have long shelf and use lives when stored at room temperature a...
10/24/2000
6123827Method for calibrating sensors used in diagnostic testing
A method is disclosed for reliably calibrating a sensor used in diagnostic sensing of a predetermined parameter, e.g., CO2 partial pressure, O2 partial pressure, or pH, of a solution such as blood, the method compensating for expecte...
09/26/2000
6066249Method for calibrating an instrument for measuring electrolytes and metabolites by analysis of blood gases
A method for calibrating an instrument for the analysis of blood gases which possesses ion-sensitive electrodes and gas-sensitive electrodes and is used for the determination, in a biological fluid, of the concentration of electrolytes and metabolites in ...
05/23/2000
6060319Temperature stabilized fluid reference system
A method and system for controlling the concentration of one or more gaseous species of interest in a fluid reference medium throughout a range of temperatures in which a temperature related, dominant independent source of the gaseous species of interest ...
05/09/2000
5913232reference solution container for blood gas/electrolyte measuring system
A reference solution container for an analyzer for measuring gas and/or electrolyte levels in a fluid. The vessel includes a fluid container for holding a reference solution and a self-sealing fluid port for repeatedly accessing the reference solution in ...
06/15/1999
5891730Method to prepare dye-based reference material
Provided is a method of preparing dye-based reference materials useful for calibrating or qualifying instrument systems that are diagnostic spectroscopically for hemoglobin and CO-ox fractions. The dye-based reference materials are non-proteinaceous and m...
04/06/1999
5882936Method of making a sensor with improved drift stability
The present invention provides an optical fluorescence based sensor for measuring the concentration of a gas (e.g., CO2 or ammonia) in a medium such as blood which has improved drift stability. In a preferred embodiment, the sensors of the pres...
03/16/1999
5789253Methods for rapid equalibration of dissolved gas composition
An apparatus and method of equilibrating the dissolved gas composition of an aqueous fluid to reflect the predetermined gas composition contained in a gas equilibration reservoir. The equilibrated aqueous fluid can be used in a method of determining the c...
08/04/1998
5780302Method of packaging oxygen reference solution using flexile package with inside valve
A novel flexible package for an oxygen reference solution has been developed. This package is made from a laminated film including preferably polypropylene as the inner layer, aluminum foil as the middle layer, and polyester as the outer layer. The seams ...
07/14/1998
5736401Stabilized standards and calibrators containing rapamycin and tactrolimus bound to FK binding proteins
The present invention is directed to an in vitro aqueous composition comprising a drug, preferably tacrolimus or rapamycin, having enhanced stability. The invention utilizes a binding protein, preferably FKBP, to stabilize the drug in an aqueous matrix....
04/07/1998
5658451Method for calibration of a pH measuring element
In a method for calibration of a pH measuring element whose ion-permeable, hydrophilic polymer layer is brought into contact with an aqueous solution prior to calibration, the aqueous solution is displaced or replaced by a gaseous calibrating medium, and ...
08/19/1997
5637505Method to prepare dye-based reference material
Provided is a method of preparing dye-based reference materials useful for calibrating or qualifying instrument systems that are diagnostic spectroscopically for hemoglobin and CO-ox fractions. The dye-based reference materials are non-proteinaceous and m...
06/10/1997
5633166Method of analyzing medical specimens with improved length of analytical run determination
In high volume laboratory analysis of patient medical specimens, control materials are inserted at periodical intervals (e.g. once per eight hours) and analyzed. If the results of the analysis deviate from the mean according to statistical rules, the run ...
05/27/1997
5609824Methods and apparatus for rapid equilibration of dissolved gas composition
Disclosed is an apparatus and method of equilibrating the dissolved gas composition of an aqueous fluid to reflect the predetermined gas composition contained in a gas equilibration reservoir. The equilibrated aqueous fluid can be used in a method of dete...
03/11/1997
5605664Methods and apparatus for rapid equilibration of dissolved gas composition
Disclosed is an apparatus and method of equilibrating the dissolved gas composition of an aqueous fluid to reflect the predetermined gas composition contained in a gas equilibration reservoir. The equilibrated aqueous fluid can be used in a method of dete...
02/25/1997
5578194Calibration of electrodes
A CO2 electrode can be calibrated with two PCO2 calibration standard solutions having known pH values and known bicarbonate ion source concentrations. An O2 electrode can be calibrated using air as one calibration standard...
11/26/1996
5558985Stable hemoglobin reference solution
A reference solution for calibrating and monitoring blood gas instrumentation that has a shelf line of two years or greater is disclosed. The solution is contained in a closed container having a gas or gas mixture that is inert to the reference solution a...
09/24/1996
5518929Method of making a blood gas/electrolyte control
Aqueous solutions containing buffers and electrolytes are adjusted to levels required for calibration of both blood gas analyzers and ion selective electrolyte analyzers. A control material, composed of similar matrix, is adjusted to three levels of blood...
05/21/1996
5518928Leukocyte differentiation method
A method is disclosed for differentiating white blood cells. The method uses at least one surfactant and at least one dilute acid which together selectively strip the cytoplasm from certain classes of white blood cells and not others. More particularly, t...
05/21/1996
5512485Hematology control composition including leukocyte analogs; and methods for their preparation and use
A hematology control product comprising leukocyte analogs is described. The analogs comprise red blood cells which simulate at least two physical properties of human leukocytes. A method for making leukocyte analogs from blood cells having desired physica...
04/30/1996
5506148Method for activation of polyanionic fluorescent dyes in low dielectric media with quaternary onium compounds
The invention pertains to a method for generating the fluorescence of polyanionic fluorophores in low dielectric media with fluorescence activation produced by specific quaternary onium compounds. The method may be used for measuring an analyte and may be...
04/09/1996
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