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| Number | Title | Issue Date |
| 7425421 | Method for the enumeration of micronucleated erythrocyte populations while distinguishing platelets and/or platelet-associated aggregates A method for the enumeration of micronucleated erythrocyte populations while distinguishing platelet and platelet-associated aggregates involves the use of a first fluorescent labeled antibody having binding specificity for a surface marker for reticulocytes, a seco... | 09/16/2008 |
| 7410802 | Methods for simultaneously detecting both members of a binding pair Methods and kits for simultaneously measuring both members of a binding pair are described. ... | 08/12/2008 |
| 7393697 | Diagnostic test for analytes in a sample Diagnostic devices and methods are provided. The diagnostic devices preferably comprise a test strip with a test area. The sample to be analyzed contacts the test area, which comprises a specific binding partner for the analyte of interest. Analyte, if present in th... | 07/01/2008 |
| 7393656 | Methods and compositions for risk stratification The present invention provides an approach for the simultaneous determination of the activation states of a plurality of proteins in single cells. This approach permits the rapid detection of heterogeneity in a complex cell population based on activation states, and... | 07/01/2008 |
| 7390631 | Diagnosis and monitoring of systemic lupus erythematosus and of scleroderma Methods for diagnosing and monitoring systemic lupus erythematosus (SLE) or scleroderma by determining, in a blood sample from the individual being diagnosed or monitored, complement component C4d deposited on surfaces of red blood cells in the sample, and optionall... | 06/24/2008 |
| 7381535 | Methods and compositions for detecting receptor-ligand interactions in single cells The invention provides methods and compositions for simultaneously detecting the activation state of a plurality of proteins in single cells using flow cytometry. The invention further provides methods and compositions of screening for bioactive agents capable of co... | 06/03/2008 |
| 7374950 | Immunoassay device for diagnosing congestive heart failure and predicting mortality in congestive heart failure patients An immunochemical assay device for determining the presence of NT-proBNP alone or conjunctively with Cardiac Troponin I comprising a base member, an array disposed on the base member, and at least one assay indicia zone. The array comprises (i) a reservoir pad to re... | 05/20/2008 |
| 7358059 | Simultaneous quantification of PIG-A associated proteins in red cells, platelets and leukocyte subsets using a single measurement A single measurement can quantify phosphatidyl-inositol glycan complementation class A (PIG-A) associated proteins in red cells, platelets and the major leukocyte subsets present in blood (lymphocytes, monocytes, neutrophils and eosinophils). The single measurement ... | 04/15/2008 |
| 7358415 | Methods and compositions relating to modulation of hepatocyte growth, plasma cell differentiation or T cell subset activity by modulation of XBP-1 activity The invention demonstrates that the transcription factor XBP-1 is a regulator of hepatocyte growth, plasma cell differentiation and T cell subset activity. Methods for identifying modulators of hepatocyte growth, plasma cell differentiation and/or T cell subset acti... | 04/15/2008 |
| 7351546 | Flow cytometric, whole blood dendritic cell immune function assay The invention provides a flow cytometric method for measuring dendritic cell function in whole blood, comprising: (a) contacting a whole blood sample with a dendritic cell activator; (b) adding to the sample a plurality of dendritic cell-distinguishing antibodies an... | 04/01/2008 |
| 7348157 | Immunoassay A method for detection and/or quantification of cardiac troponin I (cTnI) in a sample derived from an individual's blood, the method being based on a sandwich immunoassay employing at least two capture antibodies and at least one tracer antibody, in which a first ca... | 03/25/2008 |
| 7341837 | Soluble analyte detection and amplification The present invention relates to a method of detection of a compound of interest that is present at low levels in a sample. In particular, the present invention relates to a method of detection of a compound of interest in solution by a nucleic acid-labelled binding... | 03/11/2008 |
| 7332329 | Versatile substrate for SPR detection A substrate for testing a carrier liquid for biomolecules using SPR or other techniques provides a metallic island surrounded by a hydrophobic layer, the islands being a location for the attachment of probe molecules. The hydrophobic layer may also be a dielectric m... | 02/19/2008 |
| 7326578 | Urine assay for ovarian reserve It has been found that a urine test for ovarian reserve can be provided which is equivalent in sensitivity to current laboratory methods which determine ovarian reserve based on FSH levels in serum. A lateral flow device for indicating ovarian reserve is disclosed. ... | 02/05/2008 |
| 7297312 | Simultaneous multianalyte electrochemical assay based on spatial resolution A simultaneous multianalyte electrochemical assay includes a cell which has a surface and the surface includes analyte binding sites i.e., antibodies or antigens on a solid phase at distinct separate locations. Separate working electrodes are located within proximit... | 11/20/2007 |
| 7297554 | Immunoassay system A competitive immunoassay, dye and method for rapidly detecting the presence of one or more target ligands within a fluid sample suspected of containing such ligand or ligands. The immunoassay comprises a protein-binding membrane, a first absorbent pad, a second abs... | 11/20/2007 |
| 7279287 | Analytical method The instant invention describes an analytical assay to accurately measure an analyte in the presence of an interfering substance. ... | 10/09/2007 |
| 7271009 | Multi-analyte diagnostic test for thyroid disorders Immunological assays for several biological markers for thyroid disorders in a biological sample are performed in a single test with a combination of sandwich-type, sequential competitive, and serological assays by the use of particles classified into groups that ar... | 09/18/2007 |
| 7267994 | Element-coded affinity tags The present invention provides compositions and methods for detecting, analyzing, and identifying biomolecules. More particularly, the invention provides Element Coded Affinity Tags comprising a metal chelate and a metal ion and methods of using the tags to detect, ... | 09/11/2007 |
| RE39816 | Conjunctive analysis of biological marker expression for predicting cardiac mortality A diagnostic tool is disclosed for accurately and rapidly diagnosing the condition of an ailing organ. Although applicable to numerous organ and organ systems, this application particularly illustrates the concept of conjunctive marker utilization as it relates to d... | 09/04/2007 |
| 7247469 | Non-specific binding resistant protein arrays and methods for making the same Arrays of protein-capture agents useful for the simultaneous detection of a plurality of proteins which are the expression products, or fragments thereof, of a cell or population of cells in an organism are provided. A variety of antibody arrays, in particular, are ... | 07/24/2007 |
| 7214545 | Element-coded affinity tags The present invention provides compositions and methods for detecting, analyzing, and identifying biomolecules. More particularly, the invention provides Element Coded Affinity Tags comprising a metal chelate and a metal ion and methods of using the tags to detect, ... | 05/08/2007 |
| 7211441 | Lipoprotein assay A method of assaying to determine the identity and/or concentration or relative concentration in a sample solution of a particular one of a number of different target molecule types, comprise the steps of: i) adding to the sample a probe substance which binds to the... | 05/01/2007 |
| 7205159 | Diagnostic testing process and apparatus A method and apparatus for use in a flow through assay process is disclosed. The method is characterised by a “pre-incubation step” in which the sample which is to be analysed, (typically for the presence of a particular protein), and a detection analyte (typica... | 04/17/2007 |
| 7195923 | Ratiometric determination of glycated protein The present invention provides methods for determining a ratio of an amount of a glycated form of a protein to a total amount of the protein in a sample containing the glycated protein, the glycosylated protein, or the glycoprotein. The method incorporates lateral f... | 03/27/2007 |
| 7192786 | Biospecific assay method This invention relates to a biospecific assay method, in which microparticles coated with the bioaffinity reactant A binding the analyte to be assayed; the sample to be analyzed, and the labelled bioaffinity reactant B are mixed. After the binding reaction the signa... | 03/20/2007 |
| 7189516 | Method for characterizing autoimmune disorders The invention relates to methods of characterizing autoimmune diseases by detecting and measuring at least one analyte using multiplexed assay systems. According to one embodiment, a target is detected and measured by different bead sets having different reactants. ... | 03/13/2007 |
| 7189515 | Human antibodies as detection reagents The invention provides in vitro methods of detection using human antibodies. The methods are particularly useful for analyzing human samples containing HAMA or heterophilic antibodies. A human antibody can bind to an analyte in such samples without binding to HAMA o... | 03/13/2007 |
| 7166469 | Detection and determination of the stages of coronary artery disease A method having clinically sufficient degree of diagnostic accuracy for detecting the presence of coronary artery disease in a human patient from the general population and for distinguishing between the stages of the disease in that patient is disclosed. The stages... | 01/23/2007 |
| 7144742 | Quantitative lateral flow assays and devices This invention provides solid phase specific binding lateral flow assay methods, devices and kits for quantitating high and low molecular weight analytes. The methods and devices of the invention employ labelled reagents which are either analyte analogs or complemen... | 12/05/2006 |
| 7144705 | Diagnostic assay for stroke Heart and brain fatty acid binding proteins (H-FABP, B-FABP) are markers for stroke. The invention provides a diagnostic assay for either of these markers, preferably by ELISA using anti-H-FABP or B-FABP antibody. Since H-FABP is also a marker for acute myocardial i... | 12/05/2006 |
| 7138237 | Diagnosis, prevention and treatment of Crohn's disease using the OmpC antigen The present invention provides a method of diagnosing Crohn's disease in a subject by determining the presence or absence of IgA anti-OmpC antibodies in the subject, where the presence of the IgA anti-OmpC antibodies indicates that the subject has Crohn's disease. | 11/21/2006 |
| 7135329 | Immunoassay device for diagnosing congestive heart failure and predicting mortality in congestive heart failure patients An immunochemical assay device for determining the presence of NT-proBNP alone or conjunctively with Cardiac Troponin I comprising a base member, an array disposed on the base member, and at least one assay indicia zone. The array comprises (i) a reservoir pad to re... | 11/14/2006 |
| 7125674 | Microfabricated flowthrough porous apparatus for discrete detection binding reactions An improved apparatus for conducting a multiplicity of individual and simultaneous binding reactions is described. The apparatus comprises a substrate on which are located discrete and isolated sites for binding reactions. The apparatus is characterized by discrete ... | 10/24/2006 |
| 7112453 | Retentate chromatography and protein chip arrays with applications in biology and medicine This invention provides methods of retentate chromatography for resolving analytes in a sample. The methods involve adsorbing the analytes to a substrate under a plurality of different selectivity conditions, and detecting the analytes retained on the substrate by d... | 09/26/2006 |
| 7109023 | Immunossay device for diagnosing congestive heart failure and predicting mortality in congestive heart failure patients An immunochemical assay device for determining the presence of NT-proBNP alone or conjunctively with Cardiac Troponin I comprising a base member, an array disposed on the base member, and at least one assay indicia zone. The array comprises (i) a reservoir pad to re... | 09/19/2006 |
| 7097974 | Support for a method for determining an analyte and a method for producing the support A method for producing a support for determining analytes. The method comprises the steps of (a) providing a support comprising at least one channel, comprising a conduit having an intake and an outlet for passing fluid from the intake to the outlet, in the support ... | 08/29/2006 |
| 7091046 | Multiplexed protein expression and activity assay A system for analyzing expression levels and activity of a plurality of proteins is provided. A bio-displayed polypeptide binding component associated with a predetermined marker is used to bind the proteins of interest. The predetermined marker components are then ... | 08/15/2006 |
| 7070943 | Detection of protein conformations in single cells Methods, reagents, and kits are provided that permit flow cytometric determination of the phosphorylation status of retinoblastoma susceptibility gene protein (pRB) in individual cells. Methods are described that permit the hypophosphorylated, active, form of pRB to... | 07/04/2006 |
| 7052831 | Detection of multiple analytes from a single sample using a multi-well, multi-analyte flow-through diagnostic test device The present invention provides a method and device for conducting a rapid in vitro enzyme immunoassay test for the direct and qualitative detection of two or more viral antigens from specimens of symptomatic patients. The method for immunoassay of viral antigens is ... | 05/30/2006 |
