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| Number | Title | Issue Date |
| 7425421 | Method for the enumeration of micronucleated erythrocyte populations while distinguishing platelets and/or platelet-associated aggregates A method for the enumeration of micronucleated erythrocyte populations while distinguishing platelet and platelet-associated aggregates involves the use of a first fluorescent labeled antibody having binding specificity for a surface marker for reticulocytes, a seco... | 09/16/2008 |
| 7381572 | Reagents and procedures for multi-label high-specificity labeling A detectable complex and methods for use thereof are provided herein. The detectable complex includes: at least one target material; a first peptide tag bound to the at least one target material; and a second peptide tag bound to the at least one target material. Th... | 06/03/2008 |
| 7371524 | Substituted azaporphyrins as fluorescence labels The present invention relates to marker components, fluorescent probes, oligonucleotides, hybridization assays, and immunoassays using such products, and methods for making such products. According to the present invention, detectably labeled marker components are p... | 05/13/2008 |
| 7354733 | Method for sorting and separating living cells We disclose methods of sorting or separating mixtures of living cells (e.g., eukaryotic, prokaryotic, mammalian, pathogenic, bacterial, viral, etc.). We perform our methods by activating cell-selective photophoric labels, which photosensitize and chemically reduce a... | 04/08/2008 |
| 7332354 | Compounds for chemiluminescense procedures The present invention relates to a chemical compound comprising a light emitting moiety precursor and a precursor of a leaving group, bound to each other by an amide or by an ester bond and characterized in that the leaving group precursor upon oxidation is converte... | 02/19/2008 |
| 7332344 | Luminescence assays A method of detecting an analyte is described in which an up-converting luminescent species that is excited by absorption of long wavelength light is provided as a donor of energy to an acceptor species that can be bound to, or generated in proximity to, the lumines... | 02/19/2008 |
| 7319041 | Applications of acridinium compounds and derivatives in homogeneous assays Chemiluminescent acridinium compounds are used in homogeneous assays to determine the concentration of an analyte in a sample without strong acid or strong base treatment. The chemiluminescent acridinium compounds include acridinium esters with electron donating fun... | 01/15/2008 |
| 7312073 | Method for the detection of viable microorganisms Method for the detection and enumeration of viable microorganisms. A liquid that comprises one or more markers incorporated in a liquid sol-gel precursor, is provided. A transparent slide is coated with a thin uniform layer of the liquid sol-gel precursor compositio... | 12/25/2007 |
| 7309615 | High quantum yield acridinium compounds and their uses in improving assay sensitivity The present invention relates to hydrophilic, high quantum yield acridinium compounds. It has been discovered that the placement of electron-donating groups in the acridinium ring system increases the amount of light that is emitted by the corresponding acridinium c... | 12/18/2007 |
| 7303926 | Methods and compositions for dual phototherapy The present invention discloses dye-azide derivatives and their bioconjugates for dual phototherapy of tumors and other lesions. The compounds of the present invention may contain either a mixture of Type 1 and Type 2 agents or a single entity that integrates both u... | 12/04/2007 |
| 7297555 | Hydrophilic chemiluminescent acridinium labeling reagents In accordance with the present invention, it has been discovered that introduction of hydrophilic sulfoalkyl substituents and/or hydrophilic linkers derived from homocysteic acid, cysteic acid, glycine peptides, tetraethylene oxide, and the like, offset the hydropho... | 11/20/2007 |
| 7291474 | Hydrolytic substrates for an analyte-dependent enzyme activation system Disclosed are compounds of the general formulas: wherein Y is a moiety capable of being cleaved by a hydrolytic enzyme; L is a detectable label; X is a linking group; Z is a halogen; and R is hydrogen, an alkyl, ... | 11/06/2007 |
| 7288368 | Membrane receptor reagent and assay A membrane receptor reagent and assay is disclosed in which liposomes are bound to an evanescent wave emitting surface. Membrane receptors on the liposome's fluid lipid bilayer membrane are labeled with a fluorescent or luminescent moiety. These membrane receptors a... | 10/30/2007 |
| 7282339 | Competitive immunoassay The present invention provides ligand-detection reagents, ligand analogs and methods for determining the presence of a ligand in a sample. The ligand-detection reagent comprises a ligand-binding antibody and a ligand analog to form an antibody-ligand analog complex ... | 10/16/2007 |
| 7282373 | Ultra-high specificity fluorescent labeling A self-assembled relay probe for detecting a target material is provided including: a first peptide tag bound to the target material; and a first fluorescent conjugate including a first fluorochrome and a first tag binding group; wherein the first fluorescent conjug... | 10/16/2007 |
| 7279585 | Lipophilic electrophoretic probes Compounds, compositions, and methods for labeling membranes are disclosed. Compounds of formula G-L-E are described wherein G is a lipophilic group, L is a cleavable linkage and E is an electrophoretic group. The compounds become associated with membranes, and can b... | 10/09/2007 |
| 7255998 | High sensitivity immunoassay method A method for detecting a cytokine in a biological fluid sample with a high sensitivity is provided. A time-resolved fluoroimmunoassay (TR-FIA) method including a step of forming on a solid phase a composite in which a cytokine is captured and which includes a fluore... | 08/14/2007 |
| 7247726 | Compounds for generating chemiluminescence with a peroxidase Novel compounds comprising a C—C double bond substituted at one carbon with two sulfur atom-containing groups are disclosed. The compounds are useful in methods and compositions for generating chemiluminescence rapidly by reaction with a peroxidase enzyme and a pe... | 07/24/2007 |
| 7235370 | Site-specific aminoglycoside derivatives for use in immunodiagnostic assays A method of making a derivatized aminoglycoside includes reacting an aminoglycoside with at least 2 equivalents of a divalent metal ion in an aprotic solvent to complex two neighboring amino group and hydroxyl group pairs; reacting the non-complexed amino groups wit... | 06/26/2007 |
| 7202089 | Early diagnosis of stroke A method is described for the early detection of stroke which uses a reagent which includes a fluorescently modified fatty acid binding protein. A fluorescence difference is noted between the bound and unbound condition. Elevated levels of unbound free fatty acids f... | 04/10/2007 |
| 7192786 | Biospecific assay method This invention relates to a biospecific assay method, in which microparticles coated with the bioaffinity reactant A binding the analyte to be assayed; the sample to be analyzed, and the labelled bioaffinity reactant B are mixed. After the binding reaction the signa... | 03/20/2007 |
| 7169574 | Fluorescence detection of proteases or peptidases The invention concerns the use of a PyA-(Z)x-pNF group in a substrate for detecting, identifying and/or analyzing by fluorometry peptidases or proteases capable of cleaving the or a bond between a PyA and pNF and/or compounds with inhibiting or activating... | 01/30/2007 |
| 7118878 | Method for increasing luminescence assay sensitivity The invention provides kits and methods for increasing the sensitivity of a bio-luminescent assay, which employ an organic compound that, for instance, reduces luminescence that is not dependent on the presence of an analyte by at least about 10 fold and reduces lum... | 10/10/2006 |
| 7109043 | Fluorescent probe for magnesium ion determination A fluorescent probe for measuring magnesium ion, which can selectively form a complex with magnesium ion in aqueous system is disclosed. The fluorescent probe for measuring magnesium ion according to the present invention has the structure represented by the followi... | 09/19/2006 |
| 7105310 | Detection of biomolecules by sensitizer-linked substrates Methods and compositions for detecting and characterizing target biomolecules using sensitizer-linked substrate molecules are disclosed. High throughput screening assays and therapeutic applications of the inventions are also included ... | 09/12/2006 |
| 7101667 | Lanthanide binding tags The present invention provides lanthanide binding tags (LBT) that selectively complex trivalent lanthanide (Ln) ions and afford stable complexes with desirable physical properties, including at least one of fluorescence and anomalous x-ray scattering. ... | 09/05/2006 |
| 7101677 | Receptor assay The present invention relates to receptor/reporter fusion protein based assays for detecting the effect test compounds have on a particular membrane receptor, as well as to receptor/reporter fusion proteins for use in such assays and compounds identified by the assa... | 09/05/2006 |
| 7091051 | Chemiluminescence method of 1,2-dioxetane and composition for chemiluminescence A chemiluminescence method characterized in that when a 1,2-dioxetane derivative of the formula 1: wherein each of R1, R2, R3, R4 and R5 which are independen... | 08/15/2006 |
| 7074554 | Antibodies specific for NEBR1 and methods of use thereof Materials and methods are provided to inhibit HIV replication in targeted host cells. ... | 07/11/2006 |
| 7052861 | Graphitic nanotubes in luminescence assays Graphitic nanotubes, which include tubular fullerenes (commonly called “buckytubes”) and fibrils, which are functionalized by chemical substitution, are used as solid supports in electrogenerated chemiluminescence assays. The graphitic nanotubes are chemically m... | 05/30/2006 |
| 7045311 | Whole cell assay systems for cell surface proteases The activity of a cell surface protease, particularly an ADAM, is determined in a rapid and sensitive assay employing a whole cell system. The assays are effective to identify effector molecules that affect the activity of a cell surface protease directly or indirec... | 05/16/2006 |
| RE39047 | Luminescence by reacting an acridinium ester with superoxide A light emitting method of an acridinium ester, comprising reacting said acridinium ester and a superoxide anion, and a method of detecting a substance to be examined, comprising detecting a light emitted by reacting a superoxide anion with an acridinium ester used ... | 03/28/2006 |
| 6995023 | Labeling proteins with dyes that are insoluble or only sparingly soluble in water The proteins in a biological sample that is sought to be analyzed for its protein composition by an electrophoretic or chromatographic procedure are coupled to a dye in an unusually efficient manner by combining the sample with a solid dry composition containing the... | 02/07/2006 |
| 6991914 | Silent marker for an oil product and associated detection method A silent marker, method of marking a petroleum product with the silent marker, and method of detecting the silent marker. The marker is an ester derivative of fluorescent material, and the silent marker may be detected by measuring the fluorescence generated from th... | 01/31/2006 |
| 6984498 | Method of cancer screening primarily utilizing non-invasive cell collection, fluorescence detection techniques, and radio tracing detection techniques A cancer screening method is provided, wherein the method is characterized by administering a compound to a patient, the compound being a complex of a fluorescent marker and a radioactive marker, in a dose emitting between 5 Gy and 20 Gy radiation. Cells are then co... | 01/10/2006 |
| 6979553 | Use of Nernstein voltage sensitive dyes in measuring transmembrane voltage Transmembrane potential measurement methods using cationic dyes, and anionic dyes are provided. Compositions of the cationic and anionic dyes and microfluidic systems which include the dyes and membranes are provided in conjunction with processing elements for trans... | 12/27/2005 |
| 6972198 | Methods and compositions using protein binding partners The invention relates to a method for determining the conformational state of a protein, comprising the steps of: a) providing a first binding partner which is capable of binding to the protein in a manner dependent on the conformational state of the protein and whi... | 12/06/2005 |
| 6955886 | Scintillation proximity assay for the detection of peptidoglycan synthesis The invention provides a scintillation proximity assay for detecting peptidoglycan synthesis. The assay is especially suitable for high throughput screening of compounds affecting peptidoglycan synthesis. ... | 10/18/2005 |
| 6951760 | Diagnostic neodymium(III), ytterbium(III), or erbium(III) ion-ligand complexes The invention relates to a method for detection of an analyte in a test sample by a specific binding reaction among the analyte, a specific binding partner for the analyte, and an (immuno)reactant provided with a label, characterized in that the label is a lanthanid... | 10/04/2005 |
| 6949508 | Molecular tag reader Foreign proteins are placed into the blood of an animal so that they can be recovered at a later time and used for identification. Proteins are administered to the animal from a water bath via the animal's gills (where appropriate), gut and, through the skin. The fo... | 09/27/2005 |
