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3M employee and church chorister Art Fry needed something to temporarily mark pages in his hymnal. He was in luck because his colleague, Spencer Silver, accidentally developed a glue that was too weak for other purposes. After initially discouraging consumer response, Post-it Notes became a hit in 1979.
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| Number | Title | Issue Date |
| 6979543 | Method for detecting biological agents A sensor is provided including a polymer capable of having an alterable measurable property from the group of luminescence and electrical conductivity, the polymer having an intermediate combination of a recognition element, a tethering element and a property-alteri... | 12/27/2005 |
| 6630296 | Multiplexed enzymatic assays A multiplexed enzyme assay method and substrate set for performing the method are disclosed. The method includes performing a plurality of enzyme reactions in the presence of a plurality of enzymes substrates, under conditions effective to convert an enzy... | 10/07/2003 |
| 6589731 | Method for detecting biological agents A sensor element is provided including a polymer exhibiting a measurable property from the group of luminescence and electrical conductivity, the polymer being complexed with a unit including a recognition element, a tethering element and a property-alter... | 07/08/2003 |
| 6448029 | Method and reagent for quantitative determination of 1,5-anhydroglucitol The present invention provides a simple method for the determination of a specific component, e.g. 1,5-anhydroglucitol (1,5-AG) in a sample containing glucose, and a reagent and a reagent kit useful in the method. In one embodiment, a method for the deter... | 09/10/2002 |
| 6309852 | Method and reagent for quantitative determination of 1,5-anhydroglucitol The present invention provides a simple method for the determination of a specific component, e.g. 1,5-anhydroglucitol (1,5-AG) in a sample containing glucose, and a reagent and a reagent kit useful in the method. In one embodiment, a method for the deter... | 10/30/2001 |
| 6287767 | Chemiluminescent energy transfer assays A chemiluminescent assays for the determination of the presence or amount of a biopolymer in bound assays using 1,2-dioxetanes in connection with AttoPhos™ as chemiluminescent substrates for enzyme-labeled targets or probes is provided. Further disclose... | 09/11/2001 |
| 6255061 | Analytical element for the analysis of whole blood An analytical element for quantitative analysis of glucose, cholesterol, or lactic acid in whole blood, composed of a porous layer which has a void volume of 30 to 80% and containing peroxidase, a leuco dye which gives coloring having an absorption peak i... | 07/03/2001 |
| 6159699 | Enzyme linked chemiluminescent assay A method is provided for determining in a medium the presence or amount of an analyte which is capable of binding to a ligand partner to form a ligand complex, which method comprises: (a) contacting the medium with either: (i) a ligand partner conjugated ... | 12/12/2000 |
| 6015683 | Dry analytical element for acetaminophen assay A spectrophotometric assay for the detection of acetaminophen in aqueous fluids can be carried out with a dry analytical element. The element comprises a support having thereon one or more reagent layers containing a first enzyme, aryl acylamidase, to cle... | 01/18/2000 |
| 6015679 | Process for measuring complement activity and reagent used therefor A reagent composition comprising (a) liposomes encapsulating a marker therein, immobilizing a hapten on liposome membranes and having a size in the range of 100 to 500 nm in terms of mean particle size plus twice the standard derivation, and (b) an antibo... | 01/18/2000 |
| 5998155 | Stable composition of immobilized protein having affinity for biotin Compositions and methods for avidin or protein having affinity for biotin immobilized on an inert support material, e.g., agarose, are disclosed. The compositions have high activity levels for binding biotin and may include a bulking agent, e.g., maltose,... | 12/07/1999 |
| 5871948 | Alkaline reagent solution for eliminating ammonia in an assay The invention relates to an ammonia elimination reagent for use in an enzymatic assay of a biological substance which produces ammonia as the reaction product. The reagent is an alkaline solution of pH 9 to 11 and contains Sulfolobus-derived thermostable ... | 02/16/1999 |
| 5792617 | Cell proliferation-based amplified detection of analytes A test kit and method for the highly sensitive detection of specific analytes in a sample is provided. The presence of the analyte in the sample results in a decrease in the concentration of a growth inhibiting substance leading to proliferation of cells ... | 08/11/1998 |
| 5736394 | Cellular uptake of modified peptides Disclosed herein is a cell containing a modified peptide. More specifically, the N-terminal amino acid residue of the peptide is modified by the addition of an aryl ketone group which, when contacted with an appropriate substrate, and exposed to light hav... | 04/07/1998 |
| 5723295 | Methods, acridan compounds and kits for producing light A chemiluminescent assay method, compositions, kits and chemiluminescent acridan compounds are described which use a two-step chemiluminescent reaction process. The reaction involves an acridan compound, preferably a derivative of an N-alkylacridan-9-carb... | 03/03/1998 |
| 5686258 | Chemiluminescent detection of hydrolytic enzymes using an acridan A chemiluminescent assay method, compositions and kits are described which use a protected phenolic enhancer compound which is deprotected by a hydrolytic enzyme and then enhances a chemiluminescent reaction. The reaction involves an acridan compound, pre... | 11/11/1997 |
| 5654159 | Assay with signal detection in the presence of a suspended solid support An assay for photometrically detecting and/or quantitating the presence of an analyte in a sample in which the signal generated by a label associated with the analyte is photometrically detected in the presence of a suspended solid support.... | 08/05/1997 |
| 5650284 | Enhancing the sensitivity of immunoassay procedures by use of antibodies directed to the product of a reaction between probe labels and assay substrates The subject invention provides an antibody which specifically binds to the product of a reaction between a labeling substance and a substrate. The subject invention also provides a method of making an immunogen used to produce the antibody of the subject ... | 07/22/1997 |
| 5633143 | Method for the quantitative determination of D-3-hydroxybutyric acid and acetoacetic acid, and analytical reagent therefor Disclosed is a method for the quantitative determination of D-3-hydroxybutyric acid and acetoacetic acid, which comprises reacting a biological sample containing D-3-hydroxybutyric acid and acetoacetic acid, with a reagent comprising: (1) a D-3-hydroxybut... | 05/27/1997 |
| 5627038 | Factor IX chromogenic assay A chromogenic assay for determination of blood coagulation Factor IX (christmas factor) utilizes Factor Xa formed by the conversion of Factor X by activated Factor IX and Factor VIII to cleave a chromogenic substrate. The sample is combined into a mixture... | 05/06/1997 |
| 5569589 | Immunoassay element and process and immunoassay An immunoassay element for quantitatively analyzing a ligand by determining the change in enzymatic activity caused by a reaction between the ligand, a linked product of the ligand and a high molecular weight compound and an enzyme-labelled antibody. The ... | 10/29/1996 |
| 5552298 | Enzyme-catalyzed chemiluminescence from hydroxyaryl cyclic diacylhydrazide compounds An assay method, compositions and test kits using a hydroxyaryl cyclic diacylhydrazide is described. A hydrogen peroxide and peroxidase enzyme. The preferred compositions incorporate enhancer compounds and a chelating agent which suppresses light producti... | 09/03/1996 |
| 5478723 | Method and apparatus for determining the role of cytochrome P450 and related enzymes in the metabolism of drugs and other chemicals A method and apparatus for determining the enzyme or enzymes in the human body which metabolize a particular drug. Microsomes are obtained from each of several donors. The microsome for one donor is reacted with a test drug and the quantity of metabolites... | 12/26/1995 |
| 5434054 | Devices for determining hydrolase activity through its hydrolytic release of an immobilized indicator enzyme Subject matter of the invention is a new method of detecting a substance with hydrolase activity in a sample, characterized in that the sample is brought into contact with an indicator enzyme, which is covalently bound to an insoluble carrier material and... | 07/18/1995 |
| 5434051 | Assay with signal detection in the presence of a suspended solid support An assay for photometrically detecting and/or quantitating the presence of an analyte in a sample in which the signal generated by a label associated with the analyte is photometrically detected in the presence of a suspended solid support.... | 07/18/1995 |
| 5173406 | Liposome immunoassay method and kit therefor A liposome immunoassay comprising the steps of reacting an analyte antigen, a liposome bearing antibody comprising a first antibody to the analyte antigen and a liposome encapsulating a marker therein linked to the antibody, and a second antibody to the a... | 12/22/1992 |
| 5128241 | Microcapsule immunoassay and reagents therefor Microcapsule-reagents are prepared by previously reacting at least a part of an antigen or antibody attached to microcapsules encapsulating a labeling substance with an antibody or antigen which is specifically reactive therewith, and then the reagent thu... | 07/07/1992 |
| 5063151 | Immunoassay method and kit A method of binding an antibody with protein A cells is provided which includes a sequence of incubation and dilution steps to produce a preselected amount and concentration of antibody with a preselected distribution of antibody among the protein A cells... | 11/05/1991 |
| 5057412 | Enzymic method of detecting analytes and novel substrates therefor A small enzymically inactive peptide fragment of an enzyme (e.g. ribonuclease S-peptide) is used as the label and conjugated with the complementary fragment (S-protein) to form an enzyme which catalyses a primary reaction whose product is, or leads to, an... | 10/15/1991 |
| 4937188 | Enzyme activity amplification method for increasing assay sensitivity Enzyme amplification is achieved by covalently bonding enzyme to a supporting material via a molecular chain which is a substrate for the enzyme, then introducing a small amount of enzyme in the free state to this system, causing release of a large amount... | 06/26/1990 |
| 4849330 | Photoresponsive redox detection and discrimination Devices and methods are provided for making a plurality of determinations of the local (site-specific) redox state of a liquid system, by employing a photoresponsive element, which can be independently irradiated at different sites to provide independentl... | 07/18/1989 |
| 4812395 | Method for detecting enzymatic activity using particle agglutination A method is disclosed for determining enzymatic activity in a liquid sample by particle agglutination or inhibition of particle agglutination.... | 03/14/1989 |
| 4810631 | Signal enhancement in immunoassay by modulation of chemical catalysis A method for immunoassay for a ligand suspected to be present in a fluid includes use of an enzyme, a metal ion catalyst for an indicator reaction and a blocked modulator for the catalyst. Ligand present in the fluid binds to an antiligand. The resulting ... | 03/07/1989 |
| 4783400 | Homogeneous enzyme immunoassay system and method A liposome assay reagent for determination of an analyte in a homogeneous immunoassay. The reagent includes a suspension of oligolamellar lipid vesicles containing encapsulated glucose-6-phosphate dehydrogenase (G6PD), at a specific activity of between ab... | 11/08/1988 |
| 4740468 | Concentrating immunochemical test device and method A method and device for determining the presence of an analyte in a sample suspected of containing the analyte is disclosed. The method involves contacting a test solution containing the sample and a first member of a specific binding pair with an end por... | 04/26/1988 |
| 4714672 | Immunoassays involving complement lysing of chromophore containing microcapsules An immunoassay of the type which utilizes the hemolysis of microcapsules such as red blood cells. Microcapsules which can be lysed by complement activity, which contain an optically determinable substance, on whose surfaces an antibody to be quantified is... | 12/22/1987 |
| 4713324 | Inverted latency specific binding assay A specific binding assay composition and method for determining a ligand in a sample are disclosed. The composition comprises (a) a binding partner for the ligand; (b) a detection system which has at least two components; (c) a selectively accessible vesi... | 12/15/1987 |
| 4708933 | Immunoliposome assay-methods and products This invention is directed to a new membrane lytic immunoassay. In one embodiment of this assay, an antigen is first covalently coupled with lipids and this antigen-lipid complex is mixed with a hexagonal phase forming lipid to form bilayer liposome vesic... | 11/24/1987 |
| 4707443 | Soluble interleukin-2 receptor as a disease indicator and a method of assaying the same The present invention discloses a sandwich method and a kit for assaying interleukin-2 receptor (IL-2R) in a sample. The method comprises determining reactivity of said sample with a plurality of ligands, each said ligand having binding affinity for a spe... | 11/17/1987 |
| 4707441 | Binding assays in automated apparatus with liposome compatible surfactants Disclosed is a specific binding assay composition and method for determining a ligand in a sample. The composition comprises (a) a binding partner for the ligand; (b) a detection system which has at least two components; (c) a selectively accessible vesic... | 11/17/1987 |
