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| Number | Title | Issue Date |
| 7235369 | Enzyme-protein complex A complex of enzyme, protein and carrier comprising two or more molecules of an enzyme conjugated through an amino group or other group to a carrier such as polylysine, and a protein (for example, antibody) with a specific binding potency to other substance(s) (for ... | 06/26/2007 |
| 7070941 | Methods and compositions for tagging via azido substrates The invention provides methods and compositions for azide tagging of biomolecules. In one embodiment of the invention, proteins are tagged by metabolic incorporation of prenylated azido-analog substrates. Examples of such analogs are azido farnesyl diphosphate and a... | 07/04/2006 |
| 7045296 | Process for analyzing protein samples Methods using gel electrophoresis and mass spectrometry for the rapid, quantitative analysis of proteins or protein function in mixtures of proteins derived from two or more samples in one unit operation are disclosed. In one embodiment the method includes (a) prepa... | 05/16/2006 |
| 6830897 | High throughput screen for reducing drug candidate attrition This invention provides a high throughput method for identifying drug candidates which produce reactive metabolites that contribute to toxicity of the drug product. ... | 12/14/2004 |
| 6825000 | Immunoassay reagent and immunoassay method An immunoassay reagent is obtained whereby a microscale substance such as an antigen or antibody can be assayed at a high sensitivity, and whereby a need to separate a reacted substance, e.g., an immunoreacted substance, from an unreacted substance can be eliminated... | 11/30/2004 |
| 6613582 | Methods for rapid and efficient protein cross-linking The present application describes novel uses of ruthenium bipyridyls or palladium porphyrins as photo-activatable crosslinking agents. Crosslinking can be between any two molecules including peptides, proteins, or compounds. Crosslinking occurs in the pre... | 09/02/2003 |
| 6576430 | Detection of ligands by refractive surface methods Methods for detection and analysis of allosteric receptor/ligand binding by changes in surface refractive index are provided. When analyzed by surface plasmon resonance, binding of such allosteric binding agents to their ligands may result in a negative d... | 06/10/2003 |
| 6406858 | System for the reduction of interferences in immunoassays The present invention is an improvement to the method of determining the concentration of an analyte in body fluid using at least two immunoreactants which specifically bind with separate epitopes of the analyte one of which immunoreactant is immobilized ... | 06/18/2002 |
| 6299881 | Uronium salts for activating hydroxyls, carboxyls, and polysaccharides, and conjugate vaccines, immunogens, and other useful immunological reagents produced using uronium salts A method for producing a conjugate vaccine includes mixing a uronium salt reagent with a first moiety (e.g., a polysaccharide). According to the invention, the uronium salt reagent has a chemical structure corresponding to formula I: ##STR1## wherein... | 10/09/2001 |
| 6287785 | Homogenous enzyme immunoassay process An improved homogeneous enzyme immunoassay process for quantitatively analyzing an antigen by determining the change in the enzymatic activity caused by a reaction between the antigen and an enzyme-labeled antibody. The antigen is reacted with an enzyme-l... | 09/11/2001 |
| 6194161 | Staphylococcus aureus antigen A negatively-charged S. aureus antigen contains ଲ-hexosamine as a major carbohydrate component. S. aureus strains that carry the antigen account for nearly all of the clinically significant strains of S. aureus that are not Type 5 or Type 8 strains.... | 02/27/2001 |
| 5989842 | Method of marking biomolecules using horseradish peroxidase The invention is a method for the enzymatic labeling of biomolecules, such as immunoglobulin, peptide, hormone, or hapten, which involves oxidizing horseradishperoxidase (HRP) with a periodate, crosslinking the oxidized HRP with an ,Ω-diaminoalkan... | 11/23/1999 |
| 5935805 | Measurement of bilirubin albumin binding The present invention is directed to the determination of unconjugated and unbound bilirubin in a sample.... | 08/10/1999 |
| 5876954 | Cytotoxic factor as is associated with multiple sclerosis, its detection and its quantification Gliotoxic factor in the isolated or purified state, characterized in that it possesses toxic activity with respect to human or animal astrocytic cells, having the effect of a cytomorphological disorganization of their network of intermediate filaments and... | 03/02/1999 |
| 5851778 | Analyte assay using a trifunctional conjugate A trifunctional conjugate is provided having three chemical moieties attached through a spacer moeity. At least two of the chemical moieties are relatively small molecules, usually less than about 7,000 Daltons in size. The spacer moiety is selected to im... | 12/22/1998 |
| 5789179 | Cat assay A method of assaying for CAT in a fluid involves the use of a complex of chloramphenicol with a member of a specific binding pair such as a hapten or biotin. Biotinylated chloramphenicol is claimed as new. A scintillation proximity assay involves use of t... | 08/04/1998 |
| 5783673 | Method of preferential labelling of a phycobiliprotein with an aminereactive dye for use in a multiple color assay and product for such use A method for preparing phycobiliprotein/amine-reactive dye conjugates is disclosed in which the conjugates so prepared overcome the energy transfer/fluorescent quenching dilemma encountered in the use of prior art conjugates. A phycobiliprotein, for examp... | 07/21/1998 |
| 5661019 | Trifunctional conjugates A trifunctional conjugate is providing having three chemical moieties attached through a spacer moiety. At least two of the chemical moieties are relatively small molecules, usually less than about 7,000 Daltons in size. The spacer moiety is selected to i... | 08/26/1997 |
| 5595732 | Polyethylene-protein conjugates The present invention is a physiologically active, substantially non-immunogenic water soluble polyethylene glycol protein conjugate having the same utility as the protein which forms the conjugate, without having the same properties of producing an immun... | 01/21/1997 |
| 5468486 | Vaccine containing a protein alkaloid conjugate for the treatment of fescue toxicosis A method for the treatment of the symptoms of fescue toxicosis in mammals comprising injecting a subject mammal with a vaccine which includes from about 5 μg to about 1 mg of a protein-alkaloid conjugate per mL of a physiologically acceptable carrier. Th... | 11/21/1995 |
| 5468622 | Salt stabilization of antibody-enzyme conjugates heat-dried into paper New and useful methods of producing stabilized enzyme antibody conjugates are disclosed which are particularly useful in forming multi-layer immunoassay test devices. In particular, the invention concerns the formation of a manganese ion and enzyme-antibo... | 11/21/1995 |
| 5447846 | Homogeneous Immunoassay process using covalent conjugate of enzyme and plural monoclonal antibodies for different epitopes on analyte An enzyme-labelled antibody adapted for use in a homogeneous immunoassay is provided. The enzyme-labelled antibody is a conjugate of an enzyme with two or more different monoclonal antibodies, each of the monoclonal antibodies being capable of specificall... | 09/05/1995 |
| 5441867 | Pre-activated proteins for labelling oligonucleotide probes Pre-activated stable protein reagents are provided. The reagents can be made by reaction of the protein and a heterobifunctional linker and have extended stability especially after lyophilisation. The reagents can be used in assay kits to form conjugates ... | 08/15/1995 |
| 5401649 | 2-methyl-4-hexene-and 3-methyl-5-heptene-1,2-diol derivatives 2-methyl-4-hexene- and 3-methyl-5-heptene-l,2-diol derivatives are disclosed together with methods for preparing such derivatives. Where the derivative is a 2-methyl-4-nexene- or 3-methyl-5-heptene-l,2-diol conjugated to a label, the conjugates are useful... | 03/28/1995 |
| 5399672 | Process for preparing immunoconjugates The invention relates to a novel process for preparing immunoconjugates consisting of haptens which are sparingly soluble or insoluble in aqueous solution and proteins/polypeptides using special solvents, in particular diethylene glycol monoalkyl ethers.... | 03/21/1995 |
| 5352616 | Analyte variant analysis The present invention provides a method of assessment of the concentration of a subset of variants in a population of proteinaceous analyte variants capable of separation by a fractionation system, wherein said population of variants are contacted with a ... | 10/04/1994 |
| 5350674 | Intrinsic factor - horse peroxidase conjugates and a method for increasing the stability thereof This invention presents a non-isotopic competitive assay for Vitamin B12 (B12), utilizing intrinsic factor (IF) labelled with horse radish peroxidase (HRP), by coupling via heterobifunctional cross-linking agents. In addition, a method for stabilizing the... | 09/27/1994 |
| 5350574 | Derivatives of cyclosporina A, antibodies directed thereto and uses thereof This invention provides a molecule comprising cyclosporine A or a congener of cyclosporine A which is photochemically attached to a ligand containing a reactive group. This invention also provides a composition of matter which comprises a conjugate of a c... | 09/27/1994 |
| 5342771 | Functionalized imidazolinone haptens and protein conjugates thereof useful in assays for the detection of imidazolinone herbicides This invention provides enzyme conjugates, antigens, antibodies and diagnostic test kits used in an enzyme-linked immunosorbent assay method for determining the presence and concentration of imidazolinone compounds.... | 08/30/1994 |
| 5331109 | Phencyclidine derivatives and protein and polypeptide phencyclidine derivative conjugates and labels The present invention is directed to novel PCP derivatives which are synthesized for the covalent attachment to antigens or receptors (proteins or polypeptides) for the preparation of antibodies or receptors to PCP and PCP analogue metabolites. The result... | 07/19/1994 |
| 5324650 | Situ process for production of conjugates In situ process for production of conjugates using a deblocking agent which allows conjugation to occur and two compositions wherein one composition is functionalized with a group capable of reacting efficiently with free thiols, and a second composition ... | 06/28/1994 |
| 5302703 | Tetrahydrocannabinol derivatives and protein and polypeptide tetrahydrocannabinol derivative conjugates and labels The present invention is directed to novel THC derivatives which are synthesized for the covalent attachment to antigens (proteins or polypeptides) for the preparation of antibodies or receptors to the THC metabolites. The resulting novel antigens may be ... | 04/12/1994 |
| 5272257 | Method of preferential labelling of a phycobiliprotein with an amine-reactive dye for use in a multiple color assay and product for such use A method for preparing phycobiliprotein/amine-reactive dye conjugates is disclosed in which the conjugates so prepared overcome the energy transfer/fluorescent quenching dilemma encountered in the use of prior art conjugates. A phycobiliprotein, for examp... | 12/21/1993 |
| 5239118 | Cyclic conjugated enediynes The synthesis of stable, ten-membered, cyclic conjugated enediynes is described. Said compounds were successfully employed to cleave double-stranded DNA spontaneously at ambient temperatures.... | 08/24/1993 |
| 5217881 | Hyperglycosylated cytokine conjugates Ligand reagents are disclosed which consist essentially of recombinant hyperglycosylated cytokines, expressed in yeast, which are purified and conjugated to various functional moieties, for example, biotin groups, via oligosaccharide residues.... | 06/08/1993 |
| 5182203 | Bifunctional compounds useful in catalyzed reporter deposition Novel bifunctional hydroxyphenylazobenzoic acid analogues (HABA-type and conjugates) and biotin analogues probiotin-type conjugates) useful as reagents in assays employing catalyzed reporter deposition are described as well as intermediates useful in synt... | 01/26/1993 |
| 5180815 | Modified protein for carrying hapten Modified proteins for carrying hapten are provided. These carriers are prepared by blocking the amino groups of the original protein and then introducing amino groups into the carboxyl groups of the original protein. The blocking groups may be eliminated ... | 01/19/1993 |
| 5168057 | Trifunctional conjugates A trifunctional conjugate is provided having three chemical moieties, attached through a spacer moiety. At least two of the chemical moieties are relatively small molecules, usually less than about 7,000 Daltons in size. The spacer moiety is selected to i... | 12/01/1992 |
| 5164311 | Preparation of an antibody-enzyme conjugate An antibody-enzyme conjugate is prepared having an enzyme to antibody ratio of approximately 3. The conjugate is produced by adding sulfhydryl groups to an antibody and maleimidyl groups to an enzyme to produce a modified antibody and enzyme, and reacting... | 11/17/1992 |
| 5135863 | Compositions and methods for determining the presence of amphetamines in a sample suspected of containing amphetamine and/or methamphetamine The instant invention is directed toward an immunoassay which can determine the presence of amphetamines in a sample suspected of containing amphetamine and/or methamphetamine by employing at least two conjugates, each comprised of a functionally similar ... | 08/04/1992 |
