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| Number | Title | Issue Date |
| 7202043 | Detecting cell membrane protein endocytosis Methods and reagents are provided for determining endocytosis, using a cell expressing an externally polypeptide labeled cell membrane receptor, and as a reagent an antibody to said label conjugated to a fragment of an enzyme fragment complementation pair. Compounds... | 04/10/2007 |
| 7186568 | Electrochemiluminescence from acridan compounds Methods are disclosed for producing electrochemiluminescence by electrochemically oxidizing an acridan compound at an electrode in the presence of a peroxide. Maintaining a sufficiently positive potential results in continuous oxidation of the acridan compound to an... | 03/06/2007 |
| 6989240 | Method for detecting hemolysis This invention provides a method for determining the presence of hemolyzed erythrocytes in blood by detecting erythrocyte adenylate kinase in a serum sample from the blood. This invention also provides a method for diagnosing a hemolytic condition in a subject suspe... | 01/24/2006 |
| 6767708 | Stabilized aqueous steroid immunoassay standards Aqueous solutions of steroid compounds which have biological activity and have a tendency to oxidative degradation at temperatures between 2 and 8° C. on storage in excess of several months are stabilized by the addition of chelators. Aqueous solutions of particula... | 07/27/2004 |
| 6756234 | Stabilization of particles and reduction of sample discordance in immunoassays using casein coating of particles It has been found that casein and salts of casein are useful as replacements for, or in addition to, BSA as materials for coating solid phases, particularly magnetic particles, used for immunoassays and other binding assays for separation of the desired analyte. By ... | 06/29/2004 |
| 6750033 | Positive response biosensors and other sensors A sensor for detecting an analyte in an environment includes a first reaction system including a first enzyme and a substrate for the first enzyme. The analyte inhibits the reaction of the substrate catalyzed by the first enzyme (in other words, the analyte inhibits... | 06/15/2004 |
| 6642004 | Method for measuring nucleotides The present invention discloses a one-pot, high-throughput method for the measurement of the amount of a nucleotide generated in a cell. The method is particularly effective in measuring changes in cyclic adenosine 3',5'-monophosphate (cAMP) coupled to ce... | 11/04/2003 |
| 6555391 | Methods of conditioning an affinity resin after storage This invention relates methods for conditioning affinity chromatography resins to decrease leaching of the ligand during purification. The methods involve incubating the resin in a buffered solution of a hydroxyalkylamine compound (e.g., ethanolamine) pri... | 04/29/2003 |
| 6541195 | Correction of genetic defects using chemical chaperones A method of improving a phenotypic defect in a cell that contains a conformationally defective target protein wherein the conformational defect causes the phenotype defect, comprising contacting a first cell that expresses said conformationally defective ... | 04/01/2003 |
| 6537760 | Receptor binding assay for detecting TSH-receptor auto-antibodies In a competitive receptor binding assay for detecting TSH-receptor auto-antibodies in a biological sample, the sample is reacted in a reaction mixture which contains (i) a TSH-receptor or TSH-receptor preparation; (ii) a primary competitor, for example la... | 03/25/2003 |
| 6461874 | Stabilization of particles and reduction of sample discordance in immunoassays using casein coating of particles It has been found that casein and salts of casein are useful as replacements for, or in addition to, BSA as materials for coating solid phases, particularly magnetic particles, used in immunoassays and other binding assays for separation of the desired an... | 10/08/2002 |
| 6461832 | Method of detecting procarboxypeptidase A and carboxypeptidase A levels in biological fluids Methods of enhancing sensitivity and specificity of an assay measuring enzymatic activity in a sample by measuring enzymatic activity in the sample in the presence and absence of a specific inhibitor of the enzymatic activity are provided. Methods of meas... | 10/08/2002 |
| 6428974 | Microplate for drug susceptibility testing containing a drug, a color reagent, and color suppressant A reagent for a drug susceptibility testing which is simple and highly reproducible is provided. A microplate for a drug susceptibility testing wherein a drug and a color reagent containing a tetrazolium salt, 1-methoxy-5-methylphenazinium methylsulfate (... | 08/06/2002 |
| 6406876 | Immobilized enzymes biosensors for chemical toxins Methods, compositions and materials useful in the detection of organophosphorous and organosulfur compounds are disclosed. In particular, biosensors wherein a porous or a non-porous support having an enzyme immobilized upon or within are disclosed. The bi... | 06/18/2002 |
| 6387646 | Reagent compositions for measuring electrolyte The present invention provides a combination of reagent compositions for measuring an electrolyte which are excellent in stability, precision and quantitativity and have high solution stability sufficient to withstand distribution. In the combination of t... | 05/14/2002 |
| 6342389 | Modified phycobilisomes and uses therefore This invention provides modified phycobilisomes and phycobilisome complexes that are supramolecular complexes with diverse spectral properties, and which may optionally be immobilized on a manufactured solid support. The invention provides a versatile set... | 01/29/2002 |
| 6309850 | Method of detecting procarboxypeptidase A and carboxypeptidase A levels in biological fluids Methods of measuring carboxypeptidase A levels and total carboxypeptidase A levels, wherein procarboxypeptidase A is converted to carboxypeptidase A by addition of clostripain, in a biological fluid with a carboxypeptidase A substrate, specificity of whic... | 10/30/2001 |
| 6306577 | Method for measuring enzyme reaction A method for measuring an enzyme reaction to determine an amount of a substance involved in the enzyme reaction, which comprises measuring a time course of a parameter of the enzyme reaction, measuring a time required for the parameter of the enzyme react... | 10/23/2001 |
| 6287785 | Homogenous enzyme immunoassay process An improved homogeneous enzyme immunoassay process for quantitatively analyzing an antigen by determining the change in the enzymatic activity caused by a reaction between the antigen and an enzyme-labeled antibody. The antigen is reacted with an enzyme-l... | 09/11/2001 |
| 6270954 | Correction of genetic defects using chemical chaperones A method of improving a phenotypic defect in a cell that contains a conformationally defective target protein wherein the conformational defect causes the phenotype defect, comprising contacting a first cell that expresses said confonnationally defective ... | 08/07/2001 |
| 6238664 | Process for stabilizing proteins An aqueous protein solution buffered with a potassium phosphate buffer, in which the ratio of potassium ions to sodium ions in the solution is at least 10:1, is resistant to the formation of protein aggregates and particles under conditions of freezing, t... | 05/29/2001 |
| 6051389 | Enzyme sensor The present invention relates to an enzyme sensor for measuring the concentration or activity of an analyte in a test fluid. The sensor has at least one enzyme layer comprising an immobilized enzyme for which the analyte is a substrate. The immobilized en... | 04/18/2000 |
| 6030802 | Liquid reagent set for L-lactate determination The invention provides sets of liquid reagents that afford calibration stability in an enzyme based spectrophotometric assay for the measurement of lactate in patient samples. The reagent sets include a lactate oxidase, a peroxidase, a hydrogen donor, an ... | 02/29/2000 |
| 6010868 | Method for stabilizing hydrolysis-sensitive molecules or molecular moieties The invention concerns a method of stabilizing molecules, or parts of molecules, which are sensitive to hydrolysis, in particular hydrolysis-sensitive labels or label-containing tracers in aqueous solutions. The invention also concerns kits for carrying o... | 01/04/2000 |
| 5989844 | Method for evaluating drug metabolism and reagent compositions therefor This invention relates to a method for evaluating the susceptibility of pharmaceutical drugs to metabolism by a specific cytochrome P-450 isozyme, which comprises contacting the sample compound with a reagent composition prepared by adding the specific cy... | 11/23/1999 |
| 5981210 | Method for determining a presence or absence of a nonparaffinophilic hydrophobic microorganism in a body specimen by using a DNA extraction procedure and a novel DNA extraction procedure The method of the invention involves providing a first receptacle and a second receptacle. The first receptacle contains a sterile aqueous broth and the second receptacle contains an aqueous broth including a carbon source. The method then includes placin... | 11/09/1999 |
| 5962247 | Assay for microorganisms and device for use therein An assay device comprising a centrifugation tube and, as a sliding fit therein, a less deep inner tube whose base has one or more apertures sufficiently large to allow the passage of particles. This device can be used in an assay for microorganisms in a l... | 10/05/1999 |
| 5932434 | Method for identifying weeds resistant to inhibitors of acetolactate synthase Resistance of given plant tissue to an inhibitor of acetolactate synthase is identified by (a) combining in an aqueous medium a sample of the plant tissue, the inhibitor of acetolactate synthase, and an inhibitor of keto acid reductoisomerase; (b) allowin... | 08/03/1999 |
| 5928883 | Eosinophil granole proteins as indicators of inflammatory bowel disorders A diagnostic method is provided for inflammatory bowel disorders (IBD), based on the relative levels of eosinophil granule proteins in physiological samples obtained from the GI tract of mammals suspected of having an IBD.... | 07/27/1999 |
| 5928886 | Reduction in first slide bias and improved enzyme stability by incorporation of diaryl tellurides in the gravure layer of dry-film, immunoassay elements The present invention relates to a dry immunoassay analytical element for assaying a ligand, comprising a support bearing: (a) a label zone comprising an enzyme labeled ligand or an enzyme labeled receptor; (b) a spreading zone; (c) a receptor zone compri... | 07/27/1999 |
| 5919620 | Heat shock protein HSP72 of Streptococcus pneumoniae A heat shock protein of Streptococcus pneumoniae named HSP72 and immunologically related polypeptides, the nucleotide and derived amino acid sequences of HSP72 (SEQ ID NO:4; SEQ ID NO:5), antibodies that bind to HSP72, and recombinant DNA methods for the ... | 07/06/1999 |
| 5916746 | Formazan-based immunoassay This invention relates to an improved method for detecting and quantifying the presence of a target molecule, such as an antigen, an antibody or a polynucleotide, in a sample which method uses alkaline phosphatase as the reporter enzyme and the reduction ... | 06/29/1999 |
| 5861265 | Binding assay method using a signal preventing reagent A device for performing an enzyme-labelled binding assay comprises an absorbent material and a developing solution containing a substrate for said enzyme, wherein the absorbent material is provided with a plurality of reagent zones including an indicator ... | 01/19/1999 |
| 5856117 | Method for measuring the concentration of protease inhibitors, kit for use in such a method and method for dissolving a substrate This invention provides a method for measuring the concentration of urinary trypsin inhibitors which is excellent in precision and reproducibility, whose operation is simple, and in which a possibility of damaging a plastic cell is eliminated. The method ... | 01/05/1999 |
| 5840505 | Method for inhibiting adenylosuccinate synthetase activity in methylthioadenosine phosphorylase deficient cells An in vivo method for depleting mammalian cells of adenosine 5'-monophosphate (AMP) useful in the treatment of certain cancers is provided. According to the method, a population of cells is obtained from a host and assayed for loss of methylthioadenosine ... | 11/24/1998 |
| 5821074 | Method and compositions for enhancing aminolevulinic acid dehydratase assay The present invention provides a method of improving the sensitivity and accuracy of a lead assay. The method enhances the recovery of lead during isolation of the lead from interfering compounds by maintaining the lead in a sample solution and making the... | 10/13/1998 |
| 5804402 | Reagent This invention relates to a reagent for enzymatic determination of an analyte concentration in a patient wherein the degree of oxidation of a coenzyme is measured, characterized in that said reagent is stabilized against oxidation by a coenzyme reduction ... | 09/08/1998 |
| 5770393 | Biological indicator for detection of early metabolic activity A bacteria impermeable container or ampule (10) contains a liquid growth medium and a substrate-indicator complex. The complex includes a substrate component, e.g., starch, and an indicator molecule, e.g., a dye, a fluorescent molecule, or the like, which... | 06/23/1998 |
| 5759858 | Calibrator and use thereof in an immunoassay The invention relates to a composition comprising among others a fibrinopeptide A releasing compound. Furthermore the invention relates to the use of the composition as calibrator in plasma containing fibrinogen. A test kit comprising the said composition... | 06/02/1998 |
| 5756289 | Protein kinases Protein kinase mutant and wild-type genes encoding polypeptides of the class heretofore designated "casein kinase I" and useful in screening compositions which may affect DNA double-strand break repair activity are disclosed. Also disclosed are methods us... | 05/26/1998 |
