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| Number | Title | Issue Date |
| 7361480 | Method and means for detecting gluten-induced diseases The invention is directed to a method of detecting gluten-induced diseases such as e.g. celiac disease and dermatitis herpetiformis. Said diseases are indicated by the presence of autoantibodies against tissue transglutaminase tTG in the blood The test is carried ou... | 04/22/2008 |
| 7320867 | Linker compound, ligand, and producing method thereof A linker compound has a structure represented by general formula (1) below, where n is an integer of 1 to 6, and X has a structure serving as a multi-branched structure moiety including three or four hydrocarbon derivative chains each having an aromatic amino group ... | 01/22/2008 |
| 7217530 | Process for detecting PrP using a macrocyclic adjuvant ligand A process for detecting the forms of the prion pathogens responsible for subacute, transmissible, spongiform encephalopathies, including a macrocyclic adjuvant ligand (AML), free or bound to a support, that is added to a biological sample capable of containing PrP | 05/15/2007 |
| 7205116 | 5-Fluoro-uracil immunoassay Novel conjugates of 5-fluoro-uracil and novel 5-fluoro-uracil immunogens and monoclonal antibodies generated by these immunogens which are useful in immunoassays for the quantification and monitoring of 5-fluoro-uracil in biological fluids. ... | 04/17/2007 |
| 7202041 | Immunoreaction measurement method The present invention relates to an immunoreaction measuring method for measuring an antigen or antibody contained as a subject substance in a sample, wherein the sample was mixed with at least one compound selected from the group consisting of dicarboxylic acids ha... | 04/10/2007 |
| 7202093 | Method for labeling phosphorylated peptides, method for selectively adsorbing phosphorylated peptides, complex compounds used in the methods, process for producing the complex compounds, and raw material compounds for the complex compounds Provided are a method for easily detecting phosphorylated peptides, namely, proteins, in samples derived from living organisms or the like, a method for selectively adsorbing the phosphorylated peptides, and compounds that are highly coordinated to the phosphorylate... | 04/10/2007 |
| 7183067 | Versatile linker compound, ligand, and producing method thereof A versatile linker compound has a structure represented by following general formula (1), wherein Y has a structure represented by O or NH, and X has a structure serving as a multi-branched moiety including four hydrocarbon derivative chains each of which has an aro... | 02/27/2007 |
| 7166423 | Direct selection of cells by secretion product Cells can be labeled with products which they secrete and release in an efficient manner by coupling the cells at their surface to a specific binding partner for the product and allowing the product to be captured by the specific binding partner as it is secreted an... | 01/23/2007 |
| 7166476 | Highly reproducible agglutination immunoassay method and reagents The present invention provides an agglutination immunoassay, wherein the agglutination of insoluble carrier particles such as latex are stabilized and uniformized to give good reproducibility, and a reagent therefor. In the agglutination immunoassay which comprises ... | 01/23/2007 |
| 7148024 | Busulfan immunoassay Novel conjugates of busulfan and novel busulfan immunogens derived from α-substituted derivatives of busulfan and antibodies generated by these busulfan linked immunogens are useful in immunoassays for the quantification and monitoring of busulfan in biological flu... | 12/12/2006 |
| 7115383 | Assays for amphetamine and methamphetamine Methods, compositions and kits are disclosed. The compounds disclosed comprise an amphetamine moiety and a methamphetamine moiety linked together by a first linking group. A second linking group depends from the first linking group and comprises a functional group. ... | 10/03/2006 |
| 7105643 | Monoclonal antibodies specific for crack cocaine metabolites, a cell line producing the same, and crack cocaine conjugates A monoclonal antibody, and a cell line capable of producing the same, has been produced with the ability to detect the primary metabolites generated from the pyrolysis of smokeable, or “crack”, cocaine. This monoclonal antibody, while being highly specific for a... | 09/12/2006 |
| 7070941 | Methods and compositions for tagging via azido substrates The invention provides methods and compositions for azide tagging of biomolecules. In one embodiment of the invention, proteins are tagged by metabolic incorporation of prenylated azido-analog substrates. Examples of such analogs are azido farnesyl diphosphate and a... | 07/04/2006 |
| 7052855 | Anti-APO-B-48 monoclonal antibody, hybridoma producing the same, and method for measuring APO-B-48 using the same A novel monoclonal antibody which specifically binds to apo-B-48 is disclosed. The monoclonal antibody specifically binds to apo-B-48 but does not bind to apo-B-100. ... | 05/30/2006 |
| 7037669 | Assays for amphetamine and methamphetamine using stereospecific reagents Methods, compositions and kits are disclosed. Enzyme conjugates of Formula I may be employed in assays for the determination of an amphetamine and/or a methamphetamine. Immunogenic conjugates of Formula I may be employed to prepare antibodies for an amphetamine and/... | 05/02/2006 |
| 7038021 | Anti-dioxins monoclonal antibody suitable for assaying dioxins in environment and hybridoma producing the same The object of present invention is to provide an immunoassay for dioxins which can rapidly and simply afford measured values having a good correlation with analytical values of dioxins by the official method (GC/MS method). The above object is achieved by using the ... | 05/02/2006 |
| 7026166 | Fluorogenic dyes The present invention relates to the use of fluorogenic or chromogenic dyes as reporter molecules for detecting cell entry by a specific molecule. ... | 04/11/2006 |
| 7022492 | Ecstasy haptens and immunogens Methods, compositions and kits are disclosed. Enzyme conjugates of Formula I are employed in assays for the determination of an methylenedioxyamphetamine, a methylene-dioxyethamphetamine, and/or a methylenedioxymethamphetamine. Immunogenic conjugates of Formula I ar... | 04/04/2006 |
| 6995018 | Complex formed by N-linked glycoproteins (SIBLINGS)and Factor H The invention provides methods and compositions for exploiting the discovery that members of the small integrin-binding ligand, n-linked glycoproteins family termed SIBLINGS bind to complement Factor H, and moreover that SIBLINGS proteins, such as BSP, exist in rela... | 02/07/2006 |
| 6991907 | Methods for the assay of troponin I and T and complexes of troponin I and T and selection of antibodies for use in immunoassays Antibodies and methods are described for the detection and quantitation of cardiac specific troponin I in samples. Cardiac-specific troponin isoforms exist in various forms in the blood, including free and complexed forms. By selecting antibodies that are insensitiv... | 01/31/2006 |
| 6991911 | Assay for entactogens Methods, compositions and kits are disclosed. The methods are directed to determining the presence of entactogen analytes such as, for example, 3,4-methylenedioxyamphetamine (MDA), 3,4-methylenedioxy-methamphetamine (MDMA), 3,4-methylenedioxy-ethylamphetamine (MDEA)... | 01/31/2006 |
| 6960457 | Reversible immobilization of arginine-tagged moieties on a silicate surface This invention provides materials and methods for the site specific attachment of virtually any moiety to a layered silicate surface. The methods involve covalently attaching the moiety to an arginine tag; and contacting the arginine tag with the layered silicate (e... | 11/01/2005 |
| 6951727 | Methods and reagents for quantitation of cell-surface molecule expression on peripheral blood cells Improved methods, reagents, and kits for quantitation of HLA-DR and/or CD11b expression on peripheral blood cells are presented. Inclusion of a lysosomotropic amine, such as chloroquine, during staining stabilizes HLA-DR and CD11b expression. Use of a novel anti-CD1... | 10/04/2005 |
| 6939678 | Methods for the assay of troponin I and T and complexes of troponin I and T and selection of antibodies for use in immunoassays Assay systems and specialized antibodies for the detection and quantitation of troponin I and troponin T in body fluids as an indicator of myocardial infarction. Since troponin I and T exist in various conformations in the blood, the ratios of the monomeric troponin... | 09/06/2005 |
| 6893881 | Method for detection of specific target cells in specialized or mixed cell population and solutions containing mixed cell populations The invention relates to a method for detecting specific target-cells in a simple and time saving way, using paramagnetic particles, antibodies recognizing the Fc portions of target-cell associating antibodies and target-cell associating antibodies directed to speci... | 05/17/2005 |
| 6887669 | Reagents for assays for ligands The present invention relates to a method for releasing a ligand from a complex of the ligand with an endogenous protein using a releasing agent. ... | 05/03/2005 |
| 6884628 | Multifunctional polymeric surface coatings in analytic and sensor devices Multifunctional, polyionic copolymers with molecular architectures and properties optimized for specific applications are synthesized on/or applied to substrate surfaces for analytical and sensing purposes. The coatings are particularly useful for suppression of non... | 04/26/2005 |
| 6828157 | Products and methods for single parameter and multiparameter phenotyping of cells A method of single parameter and multiparameter characterizing of cells, particularly immunophenotyping of cells, is provided. The method preferably uses antibody coated microspheres which are adapted to bind to specific types of cells. One or more sets of coated mi... | 12/07/2004 |
| 6740494 | Nuclear matrix protein fluid assay Disclosed is a method for detecting and quantitating soluble nuclear matrix proteins in body fluids and extracellular media. The method is useful for monitoring the viability of cells and tissue, for evaluating the progress of a disease or its treatment, and for eva... | 05/25/2004 |
| 6706486 | Method for the quantitative release of natural or recombinant proteins, polypeptides or peptides The present invention relates to a method for the quantitative release of natural or recombinant proteins, polypeptides (thermostable immunoligands) able to bind to the Fc-part of immunoglobulins (antibodies, in particular of the IgG class and primarily becoming bou... | 03/16/2004 |
| 6682940 | Products and methods for single parameter and multiparameter phenotyping of cells A method of single parameter and multiparameter characterizing of cells, particularly immunophenotyping of cells, is provided. The method preferably uses antibody-coated microspheres which are adapted to bind to specific types of cells. One or more sets o... | 01/27/2004 |
| 6613582 | Methods for rapid and efficient protein cross-linking The present application describes novel uses of ruthenium bipyridyls or palladium porphyrins as photo-activatable crosslinking agents. Crosslinking can be between any two molecules including peptides, proteins, or compounds. Crosslinking occurs in the pre... | 09/02/2003 |
| 6607891 | Method of assaying insulin-like growth factor A pretreatment method for assaying a substance which comprises mixing a biological specimen with at least one pretreating agent selected from among surfactants and alkali agents, thus releasing binding proteins in the biological specimen from the substanc... | 08/19/2003 |
| 6534270 | Biochip and method for fabricating the same Disclosed are biochips having a high detecting sensitivity with readiness in fabrication of microarray, and a method for fabricating the same, in which a solid support wound with fibers is immersed in a solution containing biomolecules to immobilize the b... | 03/18/2003 |
| 6503702 | Rapid immunoassay for detection of antibodies or antigens incorporating simultaneous sample extraction and immunogenic reaction The present invention is drawn to an immunoassay capable of the rapid detection of a variety of test substances that may be present in a test sample. One feature of the invention is that extraction or isolation of the test substance occurs simultaneously ... | 01/07/2003 |
| 6410247 | Nuclear matrix protein fluid assay Disclosed is a method for detecting and quantitating soluble nuclear matrix proteins in body fluids and extracellular media. The method is useful for monitoring the viability of cells and tissue, for evaluating the progress of a disease or its treatment, ... | 06/25/2002 |
| 6395500 | Antibodies for the detection of beer spoilage lactic acid bacteria and kit employing the antibodies Antibodies capable of detecting a beer spoilage lactic acid bacterium. Lactic acid bacteria possessing beer spoilage ability are grown in beer, a mammal is immunized to produce antibodies for the detection of beer spoilage lactic acid bacteria, and the be... | 05/28/2002 |
| 6358753 | Method of coupling ligands to a solid phase in acidic solution and anionic surfactant The present invention relates to a method for binding antibody or antigen molecules to solid phase. The reactive compound comprising an antibody or antigen molecule and a solide phase are formed by coupling a specific antibody or antigen molecule to a sol... | 03/19/2002 |
| 6350620 | Method for producing micro-carrier and test method by using said micro-carrier The invention provides a method for producing a micro-carrier, which includes patterning pluralities of bar code on a mask; exposing the bar code to a substrate coated with photoresist; etching and removing residual photoresist and electroforming to a nic... | 02/26/2002 |
| 6350582 | Hair analysis method A method for the direct analysis of the presence of an analyte which becomes embedded in keratinized structures, e.g., hair, fingernails and toenails, from the bloodstream of a subject which comprises preparing a mixture containing dithiothreitol or dithi... | 02/26/2002 |
