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| Number | Title | Issue Date |
| 7410768 | Test methods and devices A method and test device for differentiating between states of an analyte that can exist in different forms, such as follicle stimulating hormone (FSH). The method or test device uses a pair of specific binding agents, especially monoclonal antibodies, in two assays... | 08/12/2008 |
| 7368277 | Method for assay of antibodies and antibody assay device The invention relates to a technology by which antibodies directed to sources of infection in body fluids can be assayed with high accuracy, expediency and specificity. More particularly, the invention provides an antibody immunoassay method in which the antigen-ant... | 05/06/2008 |
| 7361462 | Method for efficiently determining a DNA strand break The present invention is directed to directly measure distribution in vivo and the frequency of generation in vivo of DNA strand breaks which induce cell death and mutations. The present inventors accomplished the present invention by providing a method for detectin... | 04/22/2008 |
| 7354733 | Method for sorting and separating living cells We disclose methods of sorting or separating mixtures of living cells (e.g., eukaryotic, prokaryotic, mammalian, pathogenic, bacterial, viral, etc.). We perform our methods by activating cell-selective photophoric labels, which photosensitize and chemically reduce a... | 04/08/2008 |
| 7332290 | Dectection of AMACR cancer markers in urine The present invention relates to compositions and methods for cancer diagnostics, including but not limited to, cancer markers. In particular, the present invention provides gene expression profiles associated with prostate cancers. The present invention also provid... | 02/19/2008 |
| 7291473 | Screening process for atopic dermatitis The present invention provides a process of screening patients for atopic dermatitis. The process includes the step of determining, in sera of the patient, the presence of antibodies against nuclear antigens such as transcription co-activator p75, wherein the presen... | 11/06/2007 |
| 7211396 | Antibody pairs and kits for immunochemical determination of mannan-binding lectin Various antibodies with different binding characteristics for MBL A or MBL B bound to mannan or MBL A or MBL B bound to an antibody against MBL are provided. Also provided are methods for selecting antibodies against MBL with different binding characteristics and me... | 05/01/2007 |
| 7148332 | High affinity monoclonal antibody for recognizing the estrogen receptor (ER) and method for creating the antibody High affinity monoclonal antibodies for recognizing estrogen receptor (clone SP1) with immunohistochemistry and methods for creating such an antibody are disclosed. The lagomorph derived ER antibody provides a significant advantage over the currently available mouse... | 12/12/2006 |
| 7122322 | Endometriosis-specific secretory protein A method and kit of diagnosing endometriosis in a female patient suspected of having endometriosis. The method includes obtaining a sample from the patient. The sample is analyzed to detect the presence of a purified and isolated endometriotic haptoglobin designated... | 10/17/2006 |
| 7077996 | Methods and apparatus for blood separation and analysis using membranes on an optical bio-disc Optical bio-discs for biochemical analysis, bio-disc analysis systems and biochemical analysis methods are described herein. In one embodiment, the bio-disc includes a sample analysis circuit that includes a separation membrane for separating an investigational feat... | 07/18/2006 |
| 7074903 | Monoclonal antibody specific to tartrate-resistant acid phosphatase 5b and use thereof Monocolonal antibodies having a higher reactivity with tartrate-resistant acid phosphatase 5b (TRACP 5b) than tartrate-resistant acid phosphatase 5a (TRACP 5a) and having a higher specificity to TRACP 5b can be obtained by cell fusion using as antigens TRACP 5b puri... | 07/11/2006 |
| 7052855 | Anti-APO-B-48 monoclonal antibody, hybridoma producing the same, and method for measuring APO-B-48 using the same A novel monoclonal antibody which specifically binds to apo-B-48 is disclosed. The monoclonal antibody specifically binds to apo-B-48 but does not bind to apo-B-100. ... | 05/30/2006 |
| 6861212 | NANBV diagnostics and vaccines A family of cDNA sequences derived from hepatitis C virus (HCV) are provided. These sequences encode antigens which react immunologically with antibodies present in individuals with non-A non-B hepatitis (NANBH), but which are absent from individuals infected with h... | 03/01/2005 |
| 6815078 | Substrate for protein microarray containing functionalized polymer A gelatin-based substrate for fabricating protein arrays, the substrate comprising: gelatin having at least one surface; a polymer scaffold affixed to the gelatin surface; wherein the polymer in the scaff... | 11/09/2004 |
| 6750005 | Reagent system and method for increasing the luminescence of lanthanide(III) macrocyclic complexes Disclosed are a spectrofluorimetrically detectable luminescent composition and processes for enhancing the luminescence of one or more lanthanide-containing macrocycles. The luminescent composition comprises a micelle-producing amount of at least one surfactant, at ... | 06/15/2004 |
| 6743595 | Method and diagnostic kit for diagnosis of endometriosis The invention relates to a method and a kit for the diagnosis of endometriosis using blood and endometrial leukocyte markers or a combination thereof. The marker is a surface antigen from endometrial or blood leukocytes. ... | 06/01/2004 |
| 6727072 | EGF-r detection kit A kit containing the reagents necessary for the qualitative or quantitative demonstration of epidermal growth factor receptor (EGFR) in formalin-fixed, paraffin-embedded tissue sections. A immunohistochemical staining procedure is employed which utilizes a primary m... | 04/27/2004 |
| 6645734 | Serine protease specific monoclonal antibodies and their use A monoclonal antibody binding selectively to neurosin obtained from hybridomas, in particular, strain 2B2-6 and strain S2E5 showing stable proliferation ability. These hydridomas are obtained by fusing mouse spleen cells having a high antibody titer again... | 11/11/2003 |
| 6638723 | Method for diagnosing autoimmune diseases A method of diagnosing an autoimmune disease is disclosed which involves determining whether autoantibodies from a body fluid react with a microtubule organizing center (MTOC). This diagnostic procedure provides a simple, highly specific, and highly relia... | 10/28/2003 |
| 6613564 | Enzyme-protein complex The invention relates to a complex of enzyme, protein and carrier comprising two or more molecules of an enzyme conjugated through amino group or other group to a carrier such as polylysine, and a protein (for example, antibody) with a specific binding po... | 09/02/2003 |
| 6582928 | Carbohydrate-directed cross-linking reagents The invention provides heterobifunctional cross-linking reagents and methods of using the cross-linking reagents. The cross-linking reagents of the invention combine a nucleophilic hydrazide residue with an electrophilic maleimide residue allowing couplin... | 06/24/2003 |
| 6580056 | Biological specimen heating device and quality control method for immunohistochemistry heat retrieval procedures A heating device for heating biological specimens is comprised of an electric pressure cooker with a pressure gauge, and a temperature sensor connected to a controller with a temperature display and a temperature alert. The controller is arranged to heat ... | 06/17/2003 |
| 6579687 | Methods for the assay of troponin I and T complexes of troponin I and T and selection of antibodies for use in immunoassays Methods and compositions are described for the detection and quantitation of cardiac specific troponin I and troponin T in samples. Cardiac-specific troponin isoforms exist in various forms in the blood, including free and complexed forms. By selecting an... | 06/17/2003 |
| 6482600 | Breast cancer associated nucleic acid sequences and their associated proteins This invention relates to the discovery of the association of certain nucleic acid sequences and proteins with breast cancer, the use of such sequences as a diagnostic indicator and treatments based on the association.... | 11/19/2002 |
| 6465197 | Assay for sperm quality A method for evaluating sperm quality is disclosed. The first step of the method is to obtain a quantity of sample mammalian sperm and a sample of mature mammalian oocytes. The oocytes are fertilized with the sperm and the cumulus cells are removed from t... | 10/15/2002 |
| 6432656 | Calcilytic compounds The present invention features calcilytic compounds. "calcilytic compounds" refer to compounds able to inhibit calcium receptor activity. Also described are the use of calcilytic compounds to inhibit calcium receptor activity and/or achieve a beneficial e... | 08/13/2002 |
| 6423503 | Forms of free prostate-specific antigen (PSA) and their association with prostate tissues from prostate peripheral zone and transition zone A method of distinguishing prostate cancer from benign prostatic hyperplasia (BPH) is provided. The mathematical combination or ratio of proPSA and BPSA serum or tissue markers may be used for distinguishing benign prostatic hyperplasia (BPH) from prostat... | 07/23/2002 |
| 6383740 | Methods for simultaneously detecting both members of a binding pair Methods and kits for simultaneously measuring both members of a binding pair are described.... | 05/07/2002 |
| 6376201 | Use of ligands specific to major histocompatibility complex-class I antigens for diagnosing endometriosis It is an object of the present invention to provide the clinicians with a new application for ligands specific to MHC-class I antigens, especially HLA-ABC antigens, this new application residing in the detection and diagnosis of endometriosis. It is also ... | 04/23/2002 |
| 6355443 | 4-(4-hydroxystyryl) pyridine-containing substrates for an analyte dependent enzyme activation system 4-(4-hydroxystyryl) pyridine-containing compounds are disclosed as substrates for use in assays. Also, a method for detecting or quantitating an analyte is provided which includes reacting an enzyme with a 4-(4-hydroxystyryl) pyridine-containing compound ... | 03/12/2002 |
| 6316265 | Determination of % glycated hemoglobin A glycated hemoglobin assay utilizes a simple procedure for the determination of standardized %GHb in whole blood samples correlated to the Diabetes Control and Complications Trial (DCCT). First, a lysed whole blood sample is incubated with a solid phase ... | 11/13/2001 |
| 6281004 | Quality control for cytochemical assays The invention describes quality control devices for assays that measure analytes in cells and tissue samples, and methods of use thereof. In particular, the quality control device comprises a matrix affixed with synthetic controls in different concentrati... | 08/28/2001 |
| 6251584 | Specific binding assays using methyl orange The present invention relates to a method for improving the specificity of a specific binding assay by adding methyl orange to a coating solution in an amount sufficient for improving specificity of an immunoassay conducted using said coating. The present... | 06/26/2001 |
| 6252053 | Enzyme-antibody complex and a method for manufacturing the same The present invention relates to an enzyme-antibody complex where one or more molecule(s) of enzyme into which a maleimide group or a thiol group is introduced is/are covalently conjugated to a carrier (polylysine, aminodextyan and so forth) in which a th... | 06/26/2001 |
| 6235536 | Analysis of quiescent anticoagulated whole blood samples Formed constituents of a quiescent anticoagulated whole blood sample are optically or visually analyzed in a sample chamber which has a varying through plane thickness due to convergent opposing sample chamber walls. At least one of the convergent walls o... | 05/22/2001 |
| 6183972 | Method for the determination of analyte concentration in a lateral flow sandwich immunoassay exhibiting high-dose hook effect Disclosed is a method for determining the concentration of an analyte in a fluid test medium by use of an immunochromatographic test strip through which the test fluid can flow by capillarity. The test strip has at least two capture bands and optionally o... | 02/06/2001 |
| 6180333 | Determination of cyclin-dependent kinase inhibitor P27 levels as a prognostic factor in cancer patients Methods of grading tumors and prognosticating survival rates of cancer patients by determination of p27 expression levels in tissues samples from tumors are provided.... | 01/30/2001 |
| 6174688 | Multiassay method for determining the concentrations of antigens and interferants A method of determining the concentration of a sample antigen in the presence of an interferant by (1) running two immunoassays on the sample: one assay where the interferant influences the binding of both the sample antigen and a labeled antigen and a se... | 01/16/2001 |
| 6174686 | Methods for the assay of troponin I and T and complexes of troponin I and T and selection of antibodies for use in immunoassays Assay systems and specialized antibodies for the detection and quantitation of troponin I and troponin T in body fluids as an indicator of myocardial infarction. Since troponin I and T exist in various conformations in the blood, the ratios of the monomer... | 01/16/2001 |
| 6162645 | Determination of % glycated hemoglobin A glycated hemoglobin assay utilizes a simple procedure for the determination of standardized %GHb in whole blood samples correlated to the Diabetes Control and Complications Trial (DCCT). First, a lysed whole blood sample is incubated with a solid phase ... | 12/19/2000 |
