Famous Patents
Felix Hoffmann, a German chemist, was searching for something to relieve his father's arthritis. In doing so, he "rediscovered" acetylsalicylic acid and in 1900, patented a stable process for developing it. Hence, we have aspirin.
PatentStorm News
Make the Most of Our Site
See this month's Top Inventors and Most Cited Patents.
Stay on top of the latest innovations by subscribing to an RSS feed.
Registered users: Manage your profile.
| Number | Title | Issue Date |
| 8030035 | D-psicose production method by D-psicose epimerase Provided is a method of producing D-psicose using a D-psicose epimerase derived from Agrobacterium tumefaciens. Provided are a protein having an amino acid sequence of SEQ ID NO:1 and having a psicose 3-epimerase activity, a gene encoding the protein, a recom... | 10/04/2011 |
| 7923222 | Methods of using isolated glucose isomerase This invention provides a series of recombinant Thermoanaerobacterium saccharolyticum glucose isomerases with improved catalytic activity and thermostability obtained by using recombinant techniques. These recombinant glucose isomerases comprise amino acid va... | 04/12/2011 |
| 7556945 | Method for converting sucrose to β-D-glucose Disclosed is an apparatus and method for continuously converting sucrose to β-D-glucose. The method comprises a three-stage enzymatic reactor in which an aqueous solution of sucrose is first converted into a solution of fructose and α-D-glucose by passing it throu... | 07/07/2009 |
| 7524654 | Isomaltulose synthases, polynucleotides encoding them and uses therefor The invention is directed to novel enzymes that convert sucrose to isomaltulose. More particularly, the present invention discloses novel sucrose isomerases, polynucleotides encoding these sucrose isomerases, methods for isolating such polynucleotides and nucleic ac... | 04/28/2009 |
| 7354733 | Method for sorting and separating living cells We disclose methods of sorting or separating mixtures of living cells (e.g., eukaryotic, prokaryotic, mammalian, pathogenic, bacterial, viral, etc.). We perform our methods by activating cell-selective photophoric labels, which photosensitize and chemically reduce a... | 04/08/2008 |
| 7329514 | Process for producing n-acetylneuraminic acid In the process for producing N-acetylneuraminic acid by using a microorganism having the ability to produce N-acetylneuraminic acid, the present invention provides economical and efficient process for producing N-acetylneuraminic acid by using a microorganism in whi... | 02/12/2008 |
| 7294498 | Glycosidase enzymes A thermostable glycosidase enzymes derived from various Thermococcus, Staphylothermus and Pyrococcus organisms is disclosed. The enzymes are produced from native or recombinant host cells and can be utilized in the food processing industry, pharmaceuti... | 11/13/2007 |
| 7291480 | Device and method for detecting antibiotic-inactivating enzymes A method for determining whether a microorganism produces an AmpC β-lactamase is disclosed in which a culture of a microorganism suspected of producing a β-lactamase that inactivates a β-lactam-containing antibiotic is admixed with an effective amount of each of ... | 11/06/2007 |
| 7282359 | Plant 1-deoxy-D-xylulose 5-phosphate reductoisomerase This invention relates to an isolated nucleic acid fragment encoding a 1-deoxy-D-xylulose 5-phosphate reductoisomerase. The invention also relates to the construction of a chimeric gene encoding all or a portion of the 1-deoxy-D-xylulose 5-phosphate reductoisomerase... | 10/16/2007 |
| 7264962 | Enzymatic cascade bioreactor Disclosed is an apparatus and method for continuously converting sucrose to β-D-glucose. The method comprises a three stage enzymatic reactor in which an aqueous solution of sucrose is first converted into a solution of fructose and α-D-glucose by passing it throu... | 09/04/2007 |
| 7256047 | Measurement of gluconeogenesis and intermediary metabolism using stable isotopes The present invention provides a combination of carbon-13 and deuterium metabolic tracers and methods that when used in conjunction with nuclear magnetic resonance spectroscopy, provide a measurement of metabolic fluxes in the target organisms. The tracers of the pr... | 08/14/2007 |
| 7238473 | TTP-related zinc finger domains and methods of use The present invention provides methods of regulating the destruction of mRNA molecules containing an AU-rich element (ARE), for example, methods of stimulating the degradation of an mRNA molecule encoding TNF-α, and methods of inhibiting the degradation of an mRNA ... | 07/03/2007 |
| 7226731 | PB 39, a gene dysregulated in prostate cancer, and uses thereof A novel gene, PB39, that is up-regulated, or over-expressed, in prostate cancer has been identified. The gene has been identified by means of its cDNA obtained by reverse transcription of the corresponding mRNA. Microdissection of prostate glands that had been surgi... | 06/05/2007 |
| 7208307 | Preparation of acariogenic sugar substitutes The invention relates to sucrose isomerases, to DNA sequences that code for sucrose isomerases, and to novel processes for the production of non-cariogenic sugars. ... | 04/24/2007 |
| 7182912 | Fluid handling apparatus for an automated analyzer An analyzer for performing automated assay testing. The analyzer includes a storage and conveyor system for conveying cuvettes to an incubation or processing conveyor, a storage and selection system for test sample containers, a storage and selection system for reag... | 02/27/2007 |
| 7176293 | Compositions and methods to enhance sensitivity of cancer cells to mitotic stress An isolated nucleic acid sequence of a mitotic checkpoint gene, chfr, encodes a Chfr protein having a Forkhead-associated domain and a Ring Finger. This protein is required for regulation of the transition of cells from prophase to metaphase during mitosis. The chfr... | 02/13/2007 |
| 7144716 | Recovery method for immobilized biocatalysts Processes for the production of a product by the enzymatic treatment of a soluble or particulate substrate with a particulate, immobilized enzyme, by treating a process liquor containing the substrate in a bioreactor to produce a slurry of effluent immobilized enzym... | 12/05/2006 |
| 7070709 | Dust suppressant and soil stabilization composition Disclosed are dust suppressant and aggregate stabilization compositions. In accordance with the subject disclosure, hemicellulose is used as a dust suppressant and/or as a stabilization composition for aggregates such as a road bed or soil field. Other ingredients m... | 07/04/2006 |
| 7052898 | Thermostable isomerase and use hereof, in particular for producing tagatose A novel L-arabinose isomerase active enzyme and its corresponding gene, derived from a thermophilic source are provided. The enzyme is suitable for the production of D-tagatose, a useful low-calorie sweetener. The enzyme may be obtained from a Thermoanaerobacter ... | 05/30/2006 |
| 7052840 | Reversible association of nucleic acid with a carboxylated substrate The present invention is directed to methods and compositions wherein nucleic acids are associated with a solid phase that comprises a carboxylated substrate. In specific embodiments, precipitation of the nucleic acids occurs in the absence of salt. ... | 05/30/2006 |
| 7026142 | Methods for enzymatic conversion of GDP-mannose to GDP-fucose This invention provides methods for practical enzymatic conversion of GDP-mannose to GDP-fucose. These methods are useful for efficient synthesis of reactants used in the synthesis of fucosylated oligosaccharides. ... | 04/11/2006 |
| 7011943 | Method for detecting a designated genetic sequence in murine genomic DNA The present invention provides a method and apparatus for to conduct transgenic and targeted mutagenesis screening of genomic DNA. This invention also provides a system for screening DNA for a designated genetic sequence. The system includes a computer having a proc... | 03/14/2006 |
| 6991923 | Process for manufacturing of tagatose Tagatose is manufactured by hydrolyzing lactose to galactose and glucose and isomerizing galactose to tagatose and chromatographic separation and recycling any unconverted compounds. Thereby high yields of pure tagatose are obtained. ... | 01/31/2006 |
| 6977178 | System and method for transgenic and targeted mutagenesis screening The present invention provides a method and apparatus for to conduct transgenic and targeted mutagenesis screening of genomic DNA. This invention also provides a system for screening DNA for a designated genetic sequence. The system includes a computer having a proc... | 12/20/2005 |
| 6974671 | Methods for indentifying compounds that modulate gluconeogenesis through the binding of CREB to the PGC-1 promoter In accordance with the present invention, it has been discovered that CREB regulates hepatic gluconeogenesis via the co-activator, PGC-1. PGC-1 potentiated glucocorticoid induction of the gene for PEPCK, the rate limiting enzyme in gluconeogenesis, via the glucocort... | 12/13/2005 |
| 6960457 | Reversible immobilization of arginine-tagged moieties on a silicate surface This invention provides materials and methods for the site specific attachment of virtually any moiety to a layered silicate surface. The methods involve covalently attaching the moiety to an arginine tag; and contacting the arginine tag with the layered silicate (e... | 11/01/2005 |
| 6960466 | Composite membrane containing a cross-linked enzyme matrix for a biosensor An electrochemical sensor system and membrane and method thereof for increased accuracy and effective life of electrochemical and enzyme sensors. ... | 11/01/2005 |
| 6960433 | Method of diagnosing, monitoring, staging, imaging and treating prostate cancer The present invention provides a new method for detecting, diagnosing, monitoring, staging, prognosticating, imaging and treating prostate cancer. ... | 11/01/2005 |
| 6953550 | Affinity binding-based system for detecting particulates in a fluid This invention provides methods and apparatus for detecting and quantifying particulate matter suspended in a fluid. Specifically, the invention provides an integrated, affinity-binding based, analytical system comprising a platform for performing an affinity-bindin... | 10/11/2005 |
| 6946281 | N-acetylglucosamine 2-epimerase and DNA encoding the same The present invention provides a novel protein having N-acetylglucosamine 2-epimerase activity; a DNA encoding the protein; a recombinant vector containing the DNA; a transformant obtainable by introducing the recombinant vector into a host cell; and a process for p... | 09/20/2005 |
| 6933138 | Thermostable L-arabinose isomerase and process for preparing D-tagatose Disclosed are a novel gene coding for L-arabinose isomease derived from Thermotoga neapolitana 5068, a thermostable arabinose isomerase expressed from the said gene, a recombinant expression vector containing the said gene, a microorganism transformed with th... | 08/23/2005 |
| 6924104 | Methods for identifying genes associated with diseases or specific phenotypes An improved method for screening genomic, cDNA, or any DNA fragments in general is described. Novel adapters are ligated to the ends of DNA fragments from two different individuals or two different pools of individuals. The DNA fragment-adapter complexes are mixed, ... | 08/02/2005 |
| 6919176 | Polypeptides and nucleic acids associated with cancer The present invention provides methods, reagents, and kits for diagnosing and treating cancer in a mammal, e.g., a human. This invention is based upon the discovery that G2A, GPR4, GPR65, and OGR1 are overexpressed and/or amplified in cancer. Methods to detect cance... | 07/19/2005 |
| 6913878 | Method of detecting DNA single strand breaks A method of detecting increased levels of DNA single strand breaks in a eukaryotic cell sample, comprising the steps of: (a) contacting a eukaryotic cell sample to a water-soluble tetrazolium salt under conditions in which said tetrazolium salt is converted to a for... | 07/05/2005 |
| 6911565 | Process for the production of xylitol The present invention relates to a process for the production of xylitol. The process utilises ribulose for the preparation of xylitol and involves several different conversion reactions, such as reduction, epimerisation and/or isomerisation. The present invention a... | 06/28/2005 |
| 6902903 | Helicobacter pylori diagnostics Novel methods, membrane supports and immunodiagnostic test kits for diagnosing Helicobacter pylori infection, are disclosed. The methods can also be used to monitor the progress of treatment of an infection. The methods, supports and kits employ both type-com... | 06/07/2005 |
| 6897018 | DLC-1 gene deleted in cancers A cDNA molecule corresponding to a newly discovered human gene is disclosed. The new gene, which is frequently deleted in liver cancer cells and cell lines, is called the DLC-1 gene. Because the gene is frequently deleted in liver cancer cells, but present in normal... | 05/24/2005 |
| 6897047 | Heat-resistant mannose isomerase, process for producing the same and process for producing mannose by using the same A thermostable mannose isomerase generated from a bacterium belonging to the genus Agrobacterium, excellent in thermostability, capable of being continuously used at a temperature of 55° C. to 60° C. for a prolonged period of time, and has, for example, the... | 05/24/2005 |
| 6894199 | Process for the production of xylitol The present invention relates to the production of xylitol. In particular, processes utilising L-xylose as an intermediate for xylitol production are described. The present invention also relates to process for the preparation or L-xylose, as an intermediate, by-pro... | 05/17/2005 |
| 6893818 | Gene upregulated in cancers of the prostate The present invention relates to a novel protein designated 20P2H8 which shares homology with several heterogenous nuclear ribonucleoproteins (hnRNPs). A full length approximately 3600 bp 20P2H8 cDNA (SEQ ID NO: 10, encoding a 517 amino acid open reading frame (SEQ ... | 05/17/2005 |
