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| Number | Title | Issue Date |
| 7820413 | Incrementally truncated nucleic acids and methods of making same A series of methods that utilize the incremental truncation of nucleic acids are described to create a plurality of modified nucleic acids and hybrid polypeptides. A plurality of substantially all possible single base-pair deletions of a given nucleic acid sequence ... | 10/26/2010 |
| 7790420 | Method for determining protein solubility The present invention relates to methods of screening for expression of a soluble candidate protein within an expression library of candidate proteins. The method involves fusing each candidate protein in the library to a peptide substrate and identifying cells that... | 09/07/2010 |
| 7425337 | Alphavirus replicon vector systems The present invention provides compositions useful in and methods for producing populations of infectious, replication-defective alphavirus replicon particles that contain no replication competent alphavirus particles, as determined by passage on cells in culture. T... | 09/16/2008 |
| 7361641 | Methods and compositions for genomic modification The present invention provides methods of site-specifically integrating a polynucleotide sequence of interest in a genome of a eucaryotic cell, as well as, enzymes, polypeptides, and a variety of vector constructs useful therefore. In the method, a targeting constru... | 04/22/2008 |
| 7332308 | Incrementally truncated nucleic acids and methods of making same A series of methods that utilize the incremental truncation of nucleic acids are described to create a plurality of modified nucleic acids and hybrid polypeptides. A plurality of substantially all possible single base-pair deletions of a given nucleic acid sequence ... | 02/19/2008 |
| 7314746 | Apparatus and method for preparative scale purification of nucleic acids Apparatus and methods are described for pharmaceutical grade manufacture extrachromosomal nucleic acids from cell lysates using flotation to separate and eliminate undesired insoluble cellular debris including chromosomal DNA from the lysates. A gas is introduced to... | 01/01/2008 |
| 7297533 | Recombinant feline herpesvirus type 1 and polyvalent vaccine using the same An attenuated feline recombinant herpesvirus 1 (FHV-1), which is prepared by identifying gene regions in the genome wherein inserted foreign genes can be expressed without affecting the replication of FHV-1 and has least two types of foreign nucleic acid sequences i... | 11/20/2007 |
| 7291498 | Methods of generating chimeric adenoviruses and uses for such chimeric adenoviruses A method for providing an adenovirus from a serotype which does not grow efficiently in a desired cell line with the ability to grow in that cell line is described. The method involves replacing the left and right termini of the adenovirus with the corresponding ter... | 11/06/2007 |
| 7285414 | Viruses targeted to hypoxic cells and tissues The present invention relates to compositions comprising a novel recombinant virus which replicates selectively in cells or tissues that are hypoxic or have an activated HIF pathway. The novel compositions of the invention comprise a recombinant virus genetically en... | 10/23/2007 |
| 7273854 | Pharmaceutical compositions and utilization thereof particularly for the treatment of neurodegenerative disorders The present invention relates to pharmaceutical compositions that act on the p53 protein or its gene and methods of use for the treatment of neurodegenerative diseases. ... | 09/25/2007 |
| 7244560 | Methods and compositions for synthesis of nucleic acid molecules using multiple recognition sites The present invention provides compositions and methods for recombinational cloning. The compositions include vectors having multiple recombination sites and/or multiple topoisomerase recognition sites. The methods permit the simultaneous cloning of two or more diff... | 07/17/2007 |
| 7115391 | Production of recombinant AAV using adenovirus comprising AAV rep/cap genes This invention relates to novel adenoviruses useful in the production of high titers of recombinant adeno-associated virus (rAAV) comprising a foreign DNA insert and methods of making these adenoviruses. The adenovirus comprises the AAV rep gene in which the p5 prom... | 10/03/2006 |
| 7105346 | Packaging systems for human recombinant adenovirus to be used in gene therapy Presented are ways to address the problem of replication competent adenovirus in adenoviral production for use with, for example, gene therapy. Packaging cells having no overlapping sequences with a selected vector are suited for large scale production of recombinan... | 09/12/2006 |
| 7101541 | Utilization of non-viral sequences for minus-strand DNA transfer and gene reconstitution A retroviral vector for gene reconstitution is provided that includes a 3′ portion of a heterologous nucleic acid sequence 5′ of a first att site and a 5′ portion of the heterologous nucleic acid sequence 3′ of a second att site. A sub-portion of the 3′ po... | 09/05/2006 |
| 7078029 | Herpes simplex virus strains The present invention provides an HSV having a genome with a mutation of a TAATGARAT sequence such that, in the presence of a ICP4 gene product, a native immediate early gene is expressed from the genome with delayed kinetics, the genome having a further inactivatin... | 07/18/2006 |
| 7067310 | Method for the preparation of a viral vector by inter-molecular homologous recombination The present invention encompasses methods of preparing a recombinant viral vector, within a procaryotic cell, by intermolecular homologous recombination, methods of preparing an infectious viral particle containing the recombinant viral vector and pharmaceutical com... | 06/27/2006 |
| 7026113 | EIA vaccine and diagnostic The invention provides an equine infectious anemia (EIA) vaccine that provides immunity to mammals, especially equines, from infection with equine infectious anemia virus (EIAV) and which allows differentiation between vaccinated and non-vaccinated, but exposed, mam... | 04/11/2006 |
| 7022501 | Ligation of double-stranded DNAs The present invention relates to a DNA ligation method. Specifically, a DNA complex comprising a three-stranded structure in each of the ends of double-stranded DNAs, one of which has single-stranded regions at the end, and the other of which does not have single-st... | 04/04/2006 |
| 7018833 | Linear and circular expression elements The present invention relates to linear expression elements (LEEs) and circular expression elements (CEEs), which are useful in a variety of molecular biology protocols. Specifically, the invention relates to the use of LEEs and CEEs to screen for gene function, bio... | 03/28/2006 |
| 6979568 | Vector for the expression of two foreign genes A vector expressing two foreign genes by using RRE sequence and controlling the ratio of the expression doses of these genes owing to the modification is provided. This vector, which can be provided as a lentivirus vector based on SIVagm, is constructed by modifying... | 12/27/2005 |
| 6977165 | Sequence specific recombinase-based methods for producing intron containing vectors and compositions for use in practicing the same Methods are provided for producing a vector that includes at least one splicable intron. In the subject methods, intron containing vectors are produced from donor and acceptor vectors that each include a site specific recombinase site, where the subject donor and ac... | 12/20/2005 |
| 6964861 | Enhanced in vitro recombinational cloning of using ribosomal proteins The present invention relates generally to compositions and methods for enhancing recombinational cloning of nucleic acid molecules. In particular, the invention relates to compositions comprising one or more ribosomal proteins and one or more additional protein com... | 11/15/2005 |
| 6955902 | High throughput DNA sequencing vector High throughput DNA sequencing vectors for generating nested deletions using enzymatic techniques and/or transposition-based techniques are disclosed. Methods of constructing contigs of long DNA sequences and methods of generating nested deletions are also disclosed... | 10/18/2005 |
| 6908762 | Method of preparing a eukaryotic viral vector The inventive method of producing a eukaryotic viral vector comprises contacting a eukaryotic cell, which comprises a unique enzyme that nicks or cleaves a DNA molecule, with a recombinant phage vector, or contacting a eukaryotic cell, which does not comprise a uniq... | 06/21/2005 |
| 6893865 | Methods, compositions, and cells for encapsidating recombinant vectors in AAV particles Isolated recombinant polynucleotides comprising elements which promote encapsidation into AAV particles, packaging cells comprising the recombinant polynucleotides, and methods for their use are provided in the present invention. These isolated recombinant polynucle... | 05/17/2005 |
| 6866853 | Interferon inducing genetically engineered attenuated viruses The present invention relates to genetically engineered attenuated viruses and methods for their production. In particular, the present invention relates to engineering live attenuated viruses which contain a modified NS gene segment. Recombinant DNA techniques can ... | 03/15/2005 |
| 6838285 | Site specific recombinase based method for producing adenoviral vectors Site-specific recombinase based methods for making a recombinant adenoviral genome, as well as kits for practicing the same and the recombinant adenovirus vectors produced thereby, are provided. In the subject methods, the subject genomes are prepared from donor and... | 01/04/2005 |
| 6830920 | Rapid generation of recombinant adenoviral vectors The invention provides a novel Adenovirus backbone plasmid, which when co-transfected with a shuttle vector, allows for production of recombinant viruses quickly and easily. The present invention also provides host cells and a cloning system for generating recombina... | 12/14/2004 |
| 6825012 | DNA molecules, preparation and use in gene therapy The invention provides double-stranded circular DNA molecules having one or more genes of interest, but lacking an origin of replication and a selectable marker, and methods for making such molecules. ... | 11/30/2004 |
| 6821759 | Methods of performing homologous recombination based modification of nucleic acids in recombination deficient cells and use of the modified nucleic acid products thereof A simple method for modifying genes in a recombination deficient host cell is disclosed. Such modifications include generating insertions, deletions, substitutions, and/or point mutations at any chosen site in the independent origin based cloning vector. The modifie... | 11/23/2004 |
| 6818209 | Retroviral delivery system A retroviral delivery system capable of transducing a target site is described. The retroviral delivery system comprises a first nucleotide sequence coding for at least a part of an envelope protein; and one or more other nucleotide sequences derivable from a retrov... | 11/16/2004 |
| 6737234 | Structure of adenovirus bound to cellular receptor car Disclosed is a mutant adenovirus which has a genome comprising one or more mutations in sequences which encode the fiber protein knob domain wherein the mutation causes the encoded viral particle to have significantly weakened binding affinity for CARD1 relative to ... | 05/18/2004 |
| 6723323 | Vibrio Cholerae vaccine candidates and method of their constructing Vibrio cholerae vaccine strains which have a disrupted hap gene and which are tagged with celA coding functions from Clostridium thermocellum are described. A contained, genetically defined thyA mutant of Vibrio cholerae and the general methodol... | 04/20/2004 |
| 6709844 | Avoidance of undesirable replication intermediates in plasmid propagation Disclosed herein are improved plasmid shuttle vectors, vaccines based on them, and methods related to their construction and use. Particular arrangements of functional elements of such plasmids, namely origins of replication and eukaryotic transcription/translation ... | 03/23/2004 |
| 6696278 | Method for transfer of DNA segments The present invention provides a method of transfer of a gene of interest from a first vector to a product vector comprising contacting a first and second vector in vitro with a site-specific recombinase so as to generate a co-integrate vector comprising ... | 02/24/2004 |
| 6692736 | Cell-specific adenovirus vectors comprising an internal ribosome entry site Disclosed herein are replication-competent adenovirus vectors comprising co-transcribed first and second genes under transcriptional control of a heterologous, target cell-specific transcriptional regulatory element (TRE), wherein the second gene is under... | 02/17/2004 |
| 6673580 | Identification and modification of immunodominant epitopes in polypeptides The invention provides for methods of modifying immunodominant epitopes on polypeptides, preferably polypeptides intended for therapeutic use. Knowledge of immunodominant epitopes prior to clinical use of polypeptides would be useful to design and enginee... | 01/06/2004 |
| 6670154 | Automatic eukaryotic artificial chromosome vector The present invention is directed to novel recombinant nucleic acids for introducing yeast chromosomal elements into the genomes of bacteria. The invention provides methods to convert the modified bacterial genomes into artificial yeast chromosomes by fus... | 12/30/2003 |
| 6660275 | Chlamydia antigens and corresponding DNA fragments and uses thereof The present invention provides a method of nucleic acid, including DNA, immunization of a host, including humans, against disease caused by infection by a strain of Chlamydia, specifically C. pneumoniae, employing a vector, containing a nucleotide sequenc... | 12/09/2003 |
| 6653074 | Methods for identifying agents which affect cellular morphology, locomotion and death An isolated nucleic acid molecule is provided which encodes a mammalian signal mediator protein, HEF-1, involved in regulation of cellular morphological alterations. The encoded protein comprises an amino-terminal SH3 domain, an internal domain containing... | 11/25/2003 |
