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| Number | Title | Issue Date |
| 7919280 | Method for isolation of DNA, RNA and proteins from formalin-fixed paraffin-embedded tissue specimens Methods are disclosed for rapid, reliable and simple isolation of RNA from formalin-fixed paraffin-embedded tissue samples. RNA purified in this manner can be used to monitor gene expression levels. The tissue sample can be a tumor or other pathological tissue. ... | 04/05/2011 |
| 7883871 | Compositions and methods for reverse transcriptase-polymerase chain reaction (RT-PCR) The present invention is directed to compositions and methods useful for the amplification of nucleic acid molecules by reverse transcriptase-polymerase chain reaction (RT-PCR). Specifically, the invention provides compositions and methods for the amplification of n... | 02/08/2011 |
| 7838270 | Target-dependent transcription using deletion mutants of N4 RNA polymerase The present invention comprises novel methods, compositions and kits that use N4 vRNAP deletion mutants to detect and quantify analytes comprising one or multiple target nucleic acid sequences, including target sequences that differ by as little as one nucleotide or... | 11/23/2010 |
| 7794986 | Method for amplification of RNA sequences The invention relates to a method for amplification of a target RNA sequence, wherein the first primer comprises a hybridizing sequence of 7 to 14 nucleotides, which is capable of binding to a first segment of the target RNA sequence, a transcription enhancing seque... | 09/14/2010 |
| 7432084 | Methods for preparing nucleic acid samples In one aspect the present invention provides methods of synthesizing a preparation of nucleic acid molecules, the methods comprising the steps of: (a) utilizing an RNA template to enzymatically synthesize a first DNA molecule that is complementary to at least 50 con... | 10/07/2008 |
| 7422849 | Method for determining expression of a PI3 kinase gene This invention relates to new polypeptides which exhibit kinase activity or, more specifically, which show phosphoinositide (PI) 3-kinase activity. Such polypeptides are involved in pathways responsible for cellular growth and differentiation. An isolated polypeptid... | 09/09/2008 |
| 7364846 | Gene expression profiling from FFPE samples Methods and compositions relating to the generation and use of gene expression data from tissue samples that have been fixed and embedded are provided. The data can electronically stored and implemented as well as used to augment diagnosis and treatment of diseases.... | 04/29/2008 |
| 7361465 | Methods and compositions for tailing and amplifying RNA The present invention provides methods and compositions that enable tagging and amplification of targeted RNA molecules. A targeted RNA molecule is any non-polyadenylated RNA molecule including, for example, miRNA, siRNA, rRNA, tRNA, synthetic RNA, or non-polyadenyl... | 04/22/2008 |
| 7323319 | RNA containing coenzymes, biotin, or fluorophores, and methods for their preparation and use Materials and methods for incorporating adenosine derivatives into the 5′ end of transcribed RNA are disclosed. Adenosine derivatives include naturally occurring compounds such as Coenzyme A, NAD, and FAD, as well as various non-naturally occurring compounds. The ... | 01/29/2008 |
| 7309588 | Nucleic acid assays The present invention relates to the detection of specific nucleic acid sequences after an amplification process, or directly without amplification. In particular, the invention provides for the automation of the amplification and detection process, the amplificatio... | 12/18/2007 |
| 7270982 | antigens in blood The present invention provides methods for detecting Helicobacter pylori (H. pylori) DNA and/or fragments thereof in blood. The first method involves extracting DNA from a blood sample, preferably plasma, by amplifying the DNA using a polymerase chain ... | 09/18/2007 |
| 7262008 | Nucleic acid assays The present invention relates to the detection of specific nucleic acid sequences, either by a process of amplification of specific nucleic acid sequences or not. More particularly the invention provides for improved compositions and methods for reducing the chance ... | 08/28/2007 |
| 7250252 | Amplification based polymorphism detection An improved method of amplifying nucleic acids comprising the use of four discrete temperature steps in a thermocyclic amplification reaction, as well as, a method of detecting large nucleic acid insertions or deletions such as those that occur from gene duplication... | 07/31/2007 |
| 7229765 | Random-primed reverse transcriptase-transcription method for RNA amplification A random-primed reverse transcriptase-in vitro transcription method of linearly amplifying RNA is provided. According to the methods of the invention, source RNA (or other single-stranded nucleic acid), preferably, mRNA, is converted to double-stranded cDNA using tw... | 06/12/2007 |
| 7229760 | mRNA amplification The present invention relates to a method for the amplification of mRNA of a sample, comprising the steps of i.) generating cDNA from polyadenylated RNA employing at least one primer hybridizing to said polyadenylated RNA and comprising a 5′ poly(C) or a 5′ poly... | 06/12/2007 |
| 7214529 | Nucleic acid amplification reaction station for disposable test devices An instrument for conducting nucleic acid amplification reactions in a disposable test device. The test device includes a first reaction chamber containing a first nucleic acid amplification reagent (e.g., primers and nucleotides) and a second reaction chamber eithe... | 05/08/2007 |
| 7208272 | Multiplex PCR primer set for human HNF-1α gene amplification A primer pool for amplifying a target sequence of a human HNF-1α gene, including at least one set of primers or variant primers thereof, each set of primers being identified by two consecutive SEQ ID NOS, the SEQ ID NOS being given as from SEQ ID NO.3 to SEQ ID NO.... | 04/24/2007 |
| 7202022 | Method for identification, separation and quantitative measurement of nucleic acid fragments The invention relates to a new method for sequence-specific identification, separation and quantitative measurement of nucleic acid fragments. The invention is based on the use of restriction endonucleases that have degenerate bases in their recognition or cleavage ... | 04/10/2007 |
| 7189505 | Methods of assessing HIV integrase inhibitor therapy The present invention relates to methods and products for the evaluation of HIV treatment. The methods are based on evaluating molecular events at the HIV integrase resulting in altered therapeutic efficacy of the investigated compounds. The methods rely on providin... | 03/13/2007 |
| 7186507 | Fluorescent in situ RT-PCR The present invention describes an in situ reverse transcriptase PCR method in which the background fluorescence is greatly reduced as compared to traditional in situ PCR. ... | 03/06/2007 |
| 7179590 | High temperature reverse transcription using mutant DNA polymerases The present invention relates to improved reverse transcription methods using a modified thermostable DNA polymerases, particularly in a magnesium ion buffer. These methods are particularly useful in combined reverse-transcription/amplification reactions. ... | 02/20/2007 |
| 7176002 | Universal-tagged oligonucleotide primers and methods of use The present invention relates to universal-tagged oligonucleotide primers, and to methods of using the primers for amplifying the genome. ... | 02/13/2007 |
| 7163789 | Cancer diagnosis method The invention concerns a method for the diagnosis and/or the follow up of the evolution of cancer comprising the analysis of the RNA components of the telomerase enzyme present in the plasma or serum of the blood. ... | 01/16/2007 |
| 7135302 | Method for predicting transplant rejection The present invention relates to a method for predicting whether or not transplant recipients are likely to reject tissue allografts. It is based, at least in part, on the discovery that, based on analysis of three immunologic factors, cardiac transplant recipients ... | 11/14/2006 |
| 7132238 | Method of determining a chemotherapeutic regimen based on ERCC1 expression The present invention relates to prognostic methods which are useful in medicine, particularly cancer chemotherapy. The object of the invention to provide a method for assessing ERCC1 expression levels in fixed or fixed and paraffin embedded tissues and determine a ... | 11/07/2006 |
| 7122314 | Methods for detecting vancomycin-resistant microorganisms and compositions therefor A method for detecting the presence of a vancomycin-resistant microorganism in a biological sample using a single chimeric probe in a cycling probe reaction. ... | 10/17/2006 |
| 7112423 | Nucleic acid amplification using nicking agents The present invention provides methods and kits for amplifying target nucleic acids (including whole genomes) using nicking agents. In certain aspects, the amplification does not require the use of any external oligonucleotide primers that are capable of annealing t... | 09/26/2006 |
| 7112404 | Process for high throughput DNA methylation analysis There is disclosed an improved high-throughput and quantitative process for determining methylation patterns in genomic DNA samples based on amplifying modified nucleic acid, and detecting methylated nucleic acid based on amplification-dependent displacement of spec... | 09/26/2006 |
| 7094541 | Assay for detection of human parvovirus B19 nucleic acid Nucleic acid oligomers specific for human parvovirus B19 genomic DNA are disclosed. An assay for amplifying and detecting human parvovirus B19 nucleic acid in biological specimens is disclosed. Compositions for detecting the presence of parvovirus B19 genomic DNA in... | 08/22/2006 |
| 7094536 | Methods and compositions for amplification of RNA sequences The invention provides methods for linear and exponential amplification of RNA. They are particularly suitable for amplifying a plurality of RNA species in a sample. The methods are based on hybridization of polynucleotide comprising a propromoter sequence to a prim... | 08/22/2006 |
| 7090804 | Amplification of nucleic acids with electronic detection The invention relates to compositions and methods useful in the detection of nucleic acids using a variety of amplification techniques, including both signal amplification and target amplification. Detection proceeds through the use of an electron transfer moiety (E... | 08/15/2006 |
| 7090975 | Pyrophosphorolysis and incorporation of nucleotide method for nucleic acid detection Processes are disclosed using the depolymerization of a nucleic acid hybrid and incorporation of a suitable nucleotide to qualitatively and quantitatively analyze for the presence of predetermined nucleic acid target sequences. Applications of those processes includ... | 08/15/2006 |
| 7083922 | Detection of HIV The present invention relates to oligonucleotides for use in amplifying and detecting HIV nucleic acid in a sample. ... | 08/01/2006 |
| 7078170 | Reaction mixtures for target amplification of nucleic acid with mutant RNA polymerase This invention provides a reaction mixture to amplify a nucleic acid. The mixture includes a double stranded DNA molecule with one or more primer recognition sites and a mutant RNA polymerase designed to transcribe deoxynucleotides. ... | 07/18/2006 |
| 7074558 | Nucleic acid amplification using an RNA polymerase and DNA/RNA mixed polymer intermediate products This invention provides for a novel amplification procedure for nucleic acid. The method uses a wild type or mutant RNA polymerase designed to transcribe both deoxyribonucleotides and ribonucleotides. ... | 07/11/2006 |
| 7067324 | Photon reducing agents for fluorescence assays The present invention provides a method for reducing undesirable light emission from a sample using at least one photon producing agent and at least one photon reducing agent (e.g. dye-based photon reducing agents). The present invention further provides a method fo... | 06/27/2006 |
| 7052890 | Transglutaminase gene products The invention provides a nucleotide sequence comprising at least a portion of the nucleotide sequence of FIG. 10A, FIG. 6B or FIG. 10A or FIG. 10B; nucleotides which hybridise to the nucleotide sequences of FIG. 6A, FIG. 6B ... | 05/30/2006 |
| 7049067 | Oligonucleotide for detection of HIV-1 and detection method An oligonucleotide useful for detection of an RNA derived from HIV-1 consisting of at least 10 consecutive bases in any of SEQ ID NOS:1, 2, 4 to 10 and 13 to 17, which can bind to a specific site of the RNA. ... | 05/23/2006 |
| 7037661 | Compositions and methods for labeling of nucleic acid molecules The present invention is generally related to compositions, kits and methods for labeling nucleic acid molecules using reverse transcriptases, preferably multi-subunit reverse transcriptases such as ASLV reverse transcriptases. Specifically, the invention relates to... | 05/02/2006 |
| RE39031 | RNA amplification method requiring only one manipulation step An RNA amplification method is particularly useful for diagnosing bacterial or viral infections or genetic disorders and for cell typing. The method includes the steps of denaturing a solution containing RNA, synthesizing a first cDNA strand from a suitable primer i... | 03/21/2006 |
