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| Number | Title | Issue Date |
| 8187812 | DNA recombination junction detection The present invention provides methods, compositions and kits for detecting the presence or absence of an integrated insertion polynucleotide. ... | 05/29/2012 |
| 8187841 | Method for evaluating or selecting agent for preventing or curing photodamage of skin A method for evaluating or selecting a substance capable of preventing or curing photodamage of skin is provided. Provided is a method for evaluating or selecting an agent for preventing or curing photodamage of skin, the method including: (A) contacting cells that ... | 05/29/2012 |
| 8187814 | Methods for concurrent identification and quantification of an unknown bioagent The present invention provides methods for the quantification of an unknown bioagent in a sample by amplification of nucleic acid of the bioagent, and concurrent amplification of a known quantity of a calibration polynucleotide from which are obtained a bioagent ide... | 05/29/2012 |
| 8187816 | Probe set, probe-immoblized carrier, and genetic testing method for detecting A nucleic acid probe for classification of pathogenic bacterial species is capable of collectively detecting bacterial strains of the same species and differentially detecting them from other bacterial species. Any one of the base sequences of SEQ ID NOS. 65 to 67 o... | 05/29/2012 |
| 8182993 | Methods and processes for calling bases in sequence by incorporation methods Computer implemented methods, and systems performing such methods for processing signal data from analytical operations and systems, and particularly in processing signal data from sequence-by-incorporation processes to identify nucleotide sequences of template nucl... | 05/22/2012 |
| 8182995 | Real time gene expression profiling The invention relates to methods of monitoring the amplification of one or more nucleic acid sequences of interest. More particularly, the invention relates to methods of monitoring the amplification of sequences of interest in real time. The methods disclosed herei... | 05/22/2012 |
| 8183015 | Biological reagents and methods to verify the efficiency of sample preparation and nucleic acid amplification and/or detection This invention relates to reagent comprising: any one of cells, viral particles, organelles, parasites, cells comprising organelles, cells comprising viral particles, cells comprising parasites, cells comprising bacterial cells and any combination thereof, the cells... | 05/22/2012 |
| 8182992 | Compositions for use in identification of adventitious viruses The present invention provides compositions, kits and methods for rapid identification and quantification of adventitious contaminant viruses by molecular mass and base composition analysis. ... | 05/22/2012 |
| 8182994 | Centroid markers for image analysis of high denisty clusters in complex polynucleotide sequencing Improved compositions, methods, apparatus, and kits for high-throughput nucleic acid amplification, detection and sequencing are disclosed. A nucleic acid cluster having an identifiable center is produced by generating on a solid support an immobilized nucleic acid ... | 05/22/2012 |
| 8182996 | Compositions and methods for detecting Four highly conserved genes, encoding translation elongation factor Tu, translation elongation factor G, the catalytic subunit of proton-translocating ATPase and the RecA recombinase, are used to generate species-specific, genus-specific, family-specific, group-spec... | 05/22/2012 |
| 8178294 | Method of haplotype-based genetic analysis for determining risk for developing insulin resistance, coronary artery disease and other phenotypes Disclosed is a method for determining haplotypes useful for large-scale genetic analysis, within a genomic reference sequence of interest, for a human subpopulation. The method can applied to statistically evaluating the genotypes of subjects for any statistically s... | 05/15/2012 |
| 8178299 | Method to determine the risk for side effects of an SSRI treatment in a person A new method is found to determine an increased risk for side effects of an SSRI treatment in a person by genotyping the person for the presence of the 102 C/C DNA sequence in the 5-HT2A receptor gene. This provides for a method to improve the treatment o... | 05/15/2012 |
| 8173400 | Method of detecting or quantitating endogenous wheat DNA and method of determining contamination rate of genetically modified wheat in test sample An object of the present invention is to discover an endogenous wheat sequence satisfying the conditions of: a) it is universally present in varieties of wheat, b) the amount present (detected amount) is not affected by the wheat variety, c) even if other grains are... | 05/08/2012 |
| 8173401 | Method for direct amplification from crude nucleic acid samples The present teachings relate to improved methods, kits, and reaction mixtures for amplifying nucleic acids. In some embodiments a novel direct buffer formulation is provided which allows for the direct amplification of the nucleic acids in a crude sample with minima... | 05/08/2012 |
| RE43365 | Apparatus for chemical amplification based on fluid partitioning in an immiscible liquid A system for nucleic acid amplification of a sample comprises partitioning the sample into partitioned sections and performing PCR on the partitioned sections of the sample. Another embodiment of the invention provides a system for nucleic acid amplification and det... | 05/08/2012 |
| 8168387 | Oligonucleotides, use thereof, detecting method and kit for diagnosing the presence of H5 and N1 genes of the Influenza A virus The present invention relates to a double pair of oligonucleotides for amplifying two target sequences located, respectively, in the H5 and N1 genes of the genome of the Influenza A virus, said oligonucleotides being of a length ranging between 10 and 50 nucleotides... | 05/01/2012 |
| 8168390 | Method and apparatus for diagnosing age-related macular degeneration Disclosed is a method for identifying an individual who has an altered risk for developing age-related macular degeneration comprising detecting an insertion/deletion polymorphism in the ARMS2 gene. ... | 05/01/2012 |
| 8163486 | Probe, probe set, probe carrier, and testing method A probe, a set of probes, and a probe carrier on which the probe or the set of probes is immobilized, are provided for classification of fungus species. The probe or the set of probes is capable of collectively detecting fungus of the same species and distinguishing... | 04/24/2012 |
| 8163524 | Comparative analysis of extracellular RNA species The invention provides methods for detecting tumor-associated RNA in plasma, serum, and other bodily fluids. In particular, the invention provides methods for detecting translocated gene RNA, including fusion gene RNA, in plasma or serum or other bodily fluids. ... | 04/24/2012 |
| 8163480 | Nucleic acid size detection method The present invention provides methods of determining the size of a particular nucleic acid segment of interest in a sample of nucleic acids through fragmentation of DNA, size fractionation, an optional second fragmentation, and identification using a marker sequenc... | 04/24/2012 |
| 8158388 | Repair of nucleic acids for improved amplification Methods and compositions are provided for repairing a polynucleotide so that it can be copied with improved fidelity and/or yield in, for example, an amplification reaction. This involves the use of a reaction mixture that includes a ligase and a cofactor selected f... | 04/17/2012 |
| 8158352 | Screening of a novel hepatic syndrome and its uses The invention concerns methods of screening for a hepatic syndrome occurring in the young adult and associating cholesterol biliary microlithiasis, intrahepatic cholestasis and several mutations of the MDR3 gene. The invention is also directed to methods for the tre... | 04/17/2012 |
| 8158353 | Species-specific and quantitative detection of CNS tissue in meat and meat products The present invention concerns a method for the species-specific and quantitative detection of CNS tissue in meat and meat products of the ruminant species bovine, ovine and caprine or porcine by a real-time PCR method, using glial fibrillary acidic protein (GFAP) m... | 04/17/2012 |
| 8153372 | Method for simultaneously determining in a single multiplex reaction gender of donors and quantities of genomic DNA and ratios thereof, presence and extent of DNA degradation, and PCR inhibition within a human DNA sample Methods are provided for determining, in a single polymerase chain reaction (PCR) reaction, the quantity, quality, and gender of origin of DNA in a sample, and whether or not the sample contains PCR amplification inhibitors. The methods involve carrying out a single... | 04/10/2012 |
| 8153373 | Capture and characterized co-localized chromatin (4C) technology The present invention relates in one aspect to a method for analyzing the frequency of interaction of a target nucleotide sequence with one or more nucleotide sequences of interest (e.g., one or more genomic loci) comprising the steps of: (a) providing a sample of c... | 04/10/2012 |
| 8153403 | Process for identifying existence of single nucleotide polymorphism without DNA sequencing A process for detecting the presence of a mutation in an oligonucleotide strand such as a DNA strand from a gene without the need for DNA sequencing is provided. The inventive process provides a rapid pre-test to screen for the presence or absence of a mutation in a... | 04/10/2012 |
| 8153402 | Emulsion compositions An emulsion is useful in allowing a wide variety of gene products to be expressed via eukaryotic in vitro expression. The emulsion comprises a silicone based surfactant, a hydrophobic phase and a hydrophilic phase; wherein the hydrophilic phase comprises a plurality... | 04/10/2012 |
| 8153401 | Method for direct amplification from crude nucleic acid samples The present teachings relate to improved methods, kits, and reaction mixtures for amplifying nucleic acids. In some embodiments a novel direct buffer formulation is provided which allows for the direct amplification of the nucleic acids in a crude sample with minima... | 04/10/2012 |
| 8153371 | Probe, probe set, probe carrier, and testing method A probe, a set of probes, and a probe carrier on which the probe or the set of probes is immobilized, are provided for classification of fungus species. The probe or the set of probes is capable of collectively detecting fungus of the same species and distinguishing... | 04/10/2012 |
| 8148078 | Copy number variation determination, methods and systems The present invention methods and systems for determining copy number variation of a target polynucleotide in a genome of a subject including amplification based techniques. Methods can include pre-amplification of the sample followed by distribution of sample and a... | 04/03/2012 |
| 8148079 | Method of producing amplification product by PCR and usage thereof A method of producing a PCR amplification product is provided that suppresses an effect of precipitate, turbidity, or the like derived from a whole blood sample on a detection in the detection of an amplified nucleic acid by an optical unit. The amplification produc... | 04/03/2012 |
| 8148116 | Sample processing device for pretreatment and thermal cycling A sample processing device may include an opening, a sample pretreatment unit, a thermal cycling reaction unit, and a detection unit. ... | 04/03/2012 |
| 8143007 | Nested primer sets for amplifying mouse immunoglobulin variable gene segments The present invention provides oligonucleotides for detection of rearrangement of immunoglobulin genes for identifying clonality of cells, cancer cells, hypermutation in immunoglobulin gene, antibody isotype producing cell and/or assaying B cell repertoire in a samp... | 03/27/2012 |
| 8143006 | Accelerated cascade amplification (ACA) of nucleic acids comprising strand and sequence specific DNA nicking Particular aspects provide nucleic acid amplification and detection methods comprising: providing a reaction mixture containing a target nucleic acid with an amplifiable target sequence, forward and reverse external nick-directing primers (ND-primers), at least one ... | 03/27/2012 |
| 8143030 | Intermittent detection during analytical reactions Methods, devices, and systems for performing intermittent detection during analytical reactions are provided. Such methods facilitate collection of reaction data from disparate reaction times. Further, such methods are useful for reducing photo-induced damage of one... | 03/27/2012 |
| 8143029 | Methods and means related to diseases The present invention relates to the fields of genetics and oncology and provides methods for detecting cutaneous T-cell lymphomas (CTCL) or susceptibility to CTCL. Specifically, the present invention relates to a novel method for the diagnosis and follow-up of CTCL... | 03/27/2012 |
| 8137937 | Method for bisulfite treatment The present application is directed to a method for performing a bisulfite reaction to determine methylation positions in a nucleic acid via treatment of the solid phase-bound nucleic acid with bisulfite, desulfonation and elution of the nucleic acid from the solid ... | 03/20/2012 |
| 8137917 | Droplet actuator devices, systems, and methods The invention relates to certain novel approaches to reducing or eliminating the movement of contaminants from one droplet to another on a droplet actuator via liquid filler fluid. In one application, droplet actuators are used to conduct genetic analysis using poly... | 03/20/2012 |
| 8137936 | Selected amplification of polynucleotides The invention provides methods and compositions for selectively amplifying one or more target polynucleotides in a sample. In one aspect, a plurality of selection oligonucleotides are provided that are capable of simultaneously annealing to separate regions of a tar... | 03/20/2012 |
| 8137911 | Preparation and use of single-stranded transcription substrates for synthesis of transcription products corresponding to target sequences The present invention provides methods, compositions and kits for using an RNA polymerase for making transcription products corresponding to a target sequence by obtaining single-stranded DNA transcription substrates that comprise a single-stranded promoter that is ... | 03/20/2012 |
